Combining magnetic resonance spectroscopy and molecular genomics offers better accuracy in brain tumor typing and prediction of survival than either methodology alone

International Journal of Oncology

Volumn 38, Issue 4, 2011, Pages 1113-1127

  Astrakas, Loukas ^a,b   Blekas, Konstantinos D ^b   Constantinou, Caterina ^a,c   Andronesi, Ovidiu C ^a   Mindrinos, Michael N ^d   Likas, Aristidis C ^b   Rahme, Laurence G ^c   Black, Peter M ^e   Marcus, Karen J ^f   Tzika, A Aria ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF IOANNINA   (Greece)

^c HARVARD MEDICAL SCHOOL   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Brain central nervous system cancers; Ex vivo high resolution magic angle spinning magnetic resonance spectroscopy; Genomics; Support vector machines; Tumor biomarkers

Indexed keywords

4 AMINOBUTYRIC ACID; ALANINE; ASPARTIC ACID; BINDING PROTEIN; CHOLINE; CLAUDIN 11; EPITHELIAL CELL ADHESION MOLECULE; ETHANOLAMINE; GLUTAMIC ACID; GLUTAMINE; GLYCEROPHOSPHORYLCHOLINE; GUANINE DEAMINASE; HISTONE H2AZ; INOSITOL; LACTIC ACID; LIPID; MUCIN 1; N ACETYLASPARTIC ACID; NEPHROBLASTOMA OVEREXPRESSED PROTEIN; NUCLEOSOME ASSEMBLY PROTEIN 1; PHOSPHOETHANOLAMINE; PHOSPHORYLCHOLINE; POLYUNSATURATED FATTY ACID; PROTEIN KINASE FYN; RNA; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNTAXIN; TACROLIMUS; TAURINE; UNCOUPLING PROTEIN 2;

ADENOCARCINOMA; ADOLESCENT; ADULT; ARTICLE; ASTROCYTOMA; BRAIN BIOPSY; BRAIN TUMOR; BREAST METASTASIS; CANCER CLASSIFICATION; CANCER SURVIVAL; CARBON NUCLEAR MAGNETIC RESONANCE; CLINICAL ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIFFERENTIAL DIAGNOSIS; DNA MICROARRAY; GENE; GENOME ANALYSIS; GLIOBLASTOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MENINGIOMA; METASTASIS; MICROARRAY ANALYSIS; NEURILEMOMA; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ARTIFICIAL INTELLIGENCE; BRAIN NEOPLASMS; COMPUTER SIMULATION; FEMALE; GENE EXPRESSION PROFILING; HUMANS; LOGISTIC MODELS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOME; PROGNOSIS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 79952329294     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.928     Document Type: Article

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