메뉴 건너뛰기




Volumn 7, Issue 3, 2011, Pages 321-330

Phagocytosis of cells dying through autophagy induces inflammasome activation and IL-1β release in human macrophages

Author keywords

ATP; Autophagic death; IL 1 ; Inflammasome activation; MCF 7; Phagocytosis; Secretion

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; 3 METHYLADENINE; ADENOSINE TRIPHOSPHATE; CALRETICULIN; CRYOPYRIN; CYTOCHALASIN D; INFLAMMASOME; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; INTERLEUKIN 8; MYELOID DIFFERENTIATION FACTOR 88; POTASSIUM; PURINERGIC P2X7 RECEPTOR; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TAMOXIFEN; TUMOR NECROSIS FACTOR;

EID: 79952321917     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.7.3.14583     Document Type: Article
Times cited : (58)

References (37)
  • 1
    • 38049123476 scopus 로고    scopus 로고
    • Clearance of apoptotic cells by phagocytes
    • Erwig LP, Henson PM. Clearance of apoptotic cells by phagocytes. Cell Death Differ 2008; 15:243-50.
    • (2008) Cell Death Differ , vol.15 , pp. 243-250
    • Erwig, L.P.1    Henson, P.M.2
  • 2
    • 0036884424 scopus 로고    scopus 로고
    • A blast from the past: Clearance of apoptotic cells regulates immune responses
    • DOI 10.1038/nri957
    • Savill J, Dransfield I, Gregory C, Haslett C. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev 2002; 2:965-75. (Pubitemid 37323217)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.12 , pp. 965-975
    • Savill, J.1    Dransfield, I.2    Gregory, C.3    Haslett, C.4
  • 3
    • 36448961645 scopus 로고    scopus 로고
    • Engulfment of apoptotic cells: Signals for a good meal
    • DOI 10.1038/nri2214, PII NRI2214
    • Ravichandran KS, Lorenz U. Engulfment of apoptotic cells: signals for a good meal. Nat Rev 2007; 7:964-74. (Pubitemid 350166061)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.12 , pp. 964-974
    • Ravichandran, K.S.1    Lorenz, U.2
  • 4
    • 33644685227 scopus 로고    scopus 로고
    • Inflammation and the apopto-phagocytic system
    • DOI 10.1016/j.imlet.2005.11.016, PII S0165247805003615, Signal and Signaling Processing in the Immune System
    • Majai G, Petrovski G, Fesus L. Inflammation and the apopto-phagocytic system. Immunol Lett 2006; 104:94-101. (Pubitemid 43330714)
    • (2006) Immunology Letters , vol.104 , Issue.1-2 , pp. 94-101
    • Majai, G.1    Petrovski, G.2    Fesus, L.3
  • 5
    • 4444238267 scopus 로고    scopus 로고
    • The macrophage and the apoptotic cell: An innate immune interaction viewed simplistically?
    • Gregory CD, Devitt A. The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically? Immunology 2004; 113:1-14.
    • (2004) Immunology , vol.113 , pp. 1-14
    • Gregory, C.D.1    Devitt, A.2
  • 6
    • 0032519925 scopus 로고    scopus 로고
    • Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF
    • Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGFbeta, PGE2 and PAF. The J Clin Invest 1998; 101:890-8. (Pubitemid 28096086)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.4 , pp. 890-898
    • Fadok, V.A.1    Bratton, D.L.2    Konowal, A.3    Freed, P.W.4    Westcott, J.Y.5    Henson, P.M.6
  • 9
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • DOI 10.1038/nrm2239, PII NRM2239
    • Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007; 8:741-52. (Pubitemid 47312826)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.9 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 10
    • 34548082269 scopus 로고    scopus 로고
    • Phagocytosis of cells dying through autophagy evokes a pro-inflammatory response in macrophages
    • Petrovski G, Zahuczky G, Majai G, Fesus L. Phagocytosis of cells dying through autophagy evokes a pro-inflammatory response in macrophages. Autophagy 2007; 3:509-11. (Pubitemid 47293742)
    • (2007) Autophagy , vol.3 , Issue.5 , pp. 509-511
    • Petrovski, G.1    Zahuczky, G.2    Majai, G.3    Fesus, L.4
  • 11
    • 66749174867 scopus 로고    scopus 로고
    • The inflammasomes: Guardians of the body
    • Martinon F, Mayor A, Tschopp J. The inflammasomes: guardians of the body. Ann Rev Immunol 2009; 27:229-65.
    • (2009) Ann Rev Immunol , vol.27 , pp. 229-265
    • Martinon, F.1    Mayor, A.2    Tschopp, J.3
  • 12
    • 70350356853 scopus 로고    scopus 로고
    • Activating immunity: Lessons from the TLRs and NLRs
    • Monie TP, Bryant CE, Gay NJ. Activating immunity: lessons from the TLRs and NLRs. Trends Biochem Sci 2009; 34:553-61.
    • (2009) Trends Biochem Sci , vol.34 , pp. 553-561
    • Monie, T.P.1    Bryant, C.E.2    Gay, N.J.3
  • 13
    • 0036671894 scopus 로고    scopus 로고
    • The Inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • DOI 10.1016/S1097-2765(02)00599-3
    • Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002; 10:417-26. (Pubitemid 35007355)
    • (2002) Molecular Cell , vol.10 , Issue.2 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 15
    • 33646523798 scopus 로고    scopus 로고
    • A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death
    • Reef S, Zalckvar E, Shifman O, Bialik S, Sabanay H, Oren M, Kimchi A. A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Mol Cell 2006; 22:463-75.
    • (2006) Mol Cell , vol.22 , pp. 463-475
    • Reef, S.1    Zalckvar, E.2    Shifman, O.3    Bialik, S.4    Sabanay, H.5    Oren, M.6    Kimchi, A.7
  • 16
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19:5720-8.
    • (2000) EMBO J , vol.19 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3    Yamamoto, A.4    Kirisako, T.5    Noda, T.6
  • 17
    • 34047174085 scopus 로고    scopus 로고
    • A pilot study of IL-1 inhibition by anakinra in acute gout
    • So A, De Smedt T, Tschopp J. A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res Ther 2007; 9:28.
    • (2007) Arthritis Res Ther , vol.9 , pp. 28
    • So, A.1    De Smedt, T.2    Tschopp, J.3
  • 18
    • 70749138638 scopus 로고    scopus 로고
    • Apoptotic and necrotic cells as sentinels of local tissue stress and inflammation: Response pathways initiated in nearby viable cells
    • Patel VA, Lee DJ, Longacre-Antoni A, Feng L, Lieberthal W, Rauch J, et al. Apoptotic and necrotic cells as sentinels of local tissue stress and inflammation: response pathways initiated in nearby viable cells. Autoimmunity 2009; 42:317-21.
    • (2009) Autoimmunity , vol.42 , pp. 317-321
    • Patel, V.A.1    Lee, D.J.2    Longacre-Antoni, A.3    Feng, L.4    Lieberthal, W.5    Rauch, J.6
  • 19
    • 77649152255 scopus 로고    scopus 로고
    • Autoimmunity and the clearance of dead cells
    • Nagata S, Hanayama R, Kawane K. Autoimmunity and the clearance of dead cells. Cell 140:619-30.
    • Cell , vol.140 , pp. 619-630
    • Nagata, S.1    Hanayama, R.2    Kawane, K.3
  • 20
    • 62649139025 scopus 로고    scopus 로고
    • Immunological and inflammatory functions of the interleukin-1 family
    • Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Ann Rev Immunol 2009; 27:519-50.
    • (2009) Ann Rev Immunol , vol.27 , pp. 519-550
    • Dinarello, C.A.1
  • 21
    • 34250351211 scopus 로고    scopus 로고
    • PPARgamma-dependent regulation of human macrophages in phagocytosis of apoptotic cells
    • DOI 10.1002/eji.200636398
    • Majai G, Sarang Z, Csomos K, Zahuczky G, Fesus L. PPARgamma-dependent regulation of human macrophages in phagocytosis of apoptotic cells. Eur J Immunol 2007; 37:1343-54. (Pubitemid 46925318)
    • (2007) European Journal of Immunology , vol.37 , Issue.5 , pp. 1343-1354
    • Majai, G.1    Sarang, Z.2    Csomos, K.3    Zahuczky, G.4    Fesus, L.5
  • 23
    • 74549184092 scopus 로고    scopus 로고
    • The NLRP3 inflammasome: A sensor for metabolic danger?
    • Schroder K, Zhou R, Tschopp J. The NLRP3 inflammasome: a sensor for metabolic danger? Science 2010; 327:296-300.
    • (2010) Science , vol.327 , pp. 296-300
    • Schroder, K.1    Zhou, R.2    Tschopp, J.3
  • 24
    • 70249138036 scopus 로고    scopus 로고
    • Cutting edge: NFkappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
    • Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, et al. Cutting edge: NFkappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 2009; 183:787-91.
    • (2009) J Immunol , vol.183 , pp. 787-791
    • Bauernfeind, F.G.1    Horvath, G.2    Stutz, A.3    Alnemri, E.S.4    MacDonald, K.5    Speert, D.6
  • 25
    • 70249110860 scopus 로고    scopus 로고
    • Cutting edge: TNFalpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation
    • Franchi L, Eigenbrod T, Nunez G. Cutting edge: TNFalpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J Immunol 2009; 183:792-6.
    • (2009) J Immunol , vol.183 , pp. 792-796
    • Franchi, L.1    Eigenbrod, T.2    Nunez, G.3
  • 26
    • 60749104683 scopus 로고    scopus 로고
    • The inflammasome: A caspase-1-activation platform that regulates immune responses and disease pathogenesis
    • Franchi L, Eigenbrod T, Munoz-Planillo R, Nunez G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 2009; 10:241-7.
    • (2009) Nat Immunol , vol.10 , pp. 241-247
    • Franchi, L.1    Eigenbrod, T.2    Munoz-Planillo, R.3    Nunez, G.4
  • 29
    • 47849097202 scopus 로고    scopus 로고
    • Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
    • Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 2008; 9:847-56.
    • (2008) Nat Immunol , vol.9 , pp. 847-856
    • Hornung, V.1    Bauernfeind, F.2    Halle, A.3    Samstad, E.O.4    Kono, H.5    Rock, K.L.6
  • 30
    • 75649096002 scopus 로고    scopus 로고
    • Thioredoxin-interacting protein links oxidative stress to inflammasome activation
    • Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol 11:136-40.
    • Nat Immunol , vol.11 , pp. 136-140
    • Zhou, R.1    Tardivel, A.2    Thorens, B.3    Choi, I.4    Tschopp, J.5
  • 31
    • 33847404337 scopus 로고    scopus 로고
    • Autophagy Gene-Dependent Clearance of Apoptotic Cells during Embryonic Development
    • DOI 10.1016/j.cell.2006.12.044, PII S009286740700178X
    • Qu X, Zou Z, Sun Q, Luby-Phelps K, Cheng P, Hogan RN, et al. Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell 2007; 128:931-46. (Pubitemid 46341412)
    • (2007) Cell , vol.128 , Issue.5 , pp. 931-946
    • Qu, X.1    Zou, Z.2    Sun, Q.3    Luby-Phelps, K.4    Cheng, P.5    Hogan, R.N.6    Gilpin, C.7    Levine, B.8
  • 33
    • 0029741890 scopus 로고    scopus 로고
    • Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy
    • Bursch W, Ellinger A, Kienzl H, Torok L, Pandey S, Sikorska M, et al. Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis 1996; 17:1595-607. (Pubitemid 26280381)
    • (1996) Carcinogenesis , vol.17 , Issue.8 , pp. 1595-1607
    • Bursch, W.1    Ellinger, A.2    Kienzl, H.3    Torok, L.4    Pandey, S.5    Sikorska, M.6    Walker, R.7    Hermann, R.S.8
  • 37
    • 70350569295 scopus 로고    scopus 로고
    • Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors
    • Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med 2009; 15:1170-8.
    • (2009) Nat Med , vol.15 , pp. 1170-1178
    • Ghiringhelli, F.1    Apetoh, L.2    Tesniere, A.3    Aymeric, L.4    Ma, Y.5    Ortiz, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.