Prognostic significance of immunohistochemical biomarkers in oral squamous cell carcinoma

International Journal of Oral and Maxillofacial Surgery

Volumn 40, Issue 3, 2011, Pages 298-307

  Oliveira, L R ^a   Ribeiro Silva, A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

biomarkers; clinical outcome; oral cancer; oral squamous cell carcinoma; survival

Indexed keywords

ALPHA CATENIN; BETA CATENIN; BIOLOGICAL MARKER; CADHERIN; COLLAGENASE 3; CYCLIN D1; CYCLINE; ENDOGLIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERYTHROPOIETIN; GELATINASE B; GLUCOSE TRANSPORTER 1; HERMES ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KI 67 ANTIGEN; MATRILYSIN; MATRIX METALLOPROTEINASE 14; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P21; PROTEIN P27; PROTEIN P53; PROTEIN P63; SURVIVIN; VASCULOTROPIN; VERSICAN;

ACCELERATION; ANGIOGENESIS; APOPTOSIS; CANCER INHIBITION; CANCER SURVIVAL; CELL ADHESION; CELL CYCLE; CELL PROLIFERATION; HUMAN; HYPOXIA; IMMUNOHISTOCHEMISTRY; MEDLINE; MOUTH CARCINOMA; PREDICTION; PROGNOSIS; REVIEW; SQUAMOUS CELL CARCINOMA;

APOPTOSIS REGULATORY PROTEINS; CARCINOMA, SQUAMOUS CELL; CELL ADHESION; CELL CYCLE; CELL HYPOXIA; CELL PROLIFERATION; EXTRACELLULAR MATRIX PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MOUTH NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 79952312121     PISSN: 09015027     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijom.2010.12.003     Document Type: Review

References (83)

1. ABUKHDEIR AM, PARK BH. P21 and p27: roles in carcinogenesis and drug resistance. Expert Rev Mol Med 2008: 10: e19.
2. AGRA IM, CARVALHO AL, PINTO CA, MARTINS EP, FILHO JG, SOARES FA, KOWALSKI LP. Biological markers and prognostic in recurrent oral cancer after salvage surgery. Arch Otolaryngol Head Neck Surg 2008: 134: 743-749.
3. ARCASOY MO, AMIN K, CHOU SC, HAROON ZA, VARIA M, RALEIGH JA. Erythropoietin and erythropoietin receptor expression in head and neck cancer: relationship to tumor hypoxia. Clin Cancer Res 2005: 11: 20-27.
4. ARORA S, KAUR J, SHARMA C, MATHUR M, BAHADUR S, SHUKLA NK, DEO SV, RALHAN R. Stromelysin 3, Ets-1, and vascular endothelial growth factor expression in oral precancerous and cancerous lesions: correlation with microvessel density, progression, and prognosis. Clin Cancer Res 2005: 11: 2272-2284.
5. BARNETT SF, BILODEAU MT, LINDSLEY CW. The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation. Curr Top Med Chem 2005: 5: 109-125.
6. BOUCHET BP, DE FROMENTEL CC, PUISIEUX A, GALMARINI CM. p53 as a target for anti-cancer drug development. Crit Rev Oncol Hematol 2006: 58: 190-207.
7. BRENNAN PA, MACKENZIE N, QUINTERO M. Hypoxia-inducible factor 1alpha in oral cancer. J Oral Pathol Med 2005: 34: 385-389.
8. BULLWINKEL J, BARON-LÜHR B, LÜDEMANN A, WOHLENBERG C, GERDES J, SCHOLZEN T. Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells. J Cell Physiol 2006: 206: 624-635.
9. CAMISASCA DR, HONORATO J, BERNARDO V, DA SILVA LE, DA FONSECA EC, DE FARIA PA, DIAS FL, LOURENÇO SDE Q. Expression of Bcl-2 family proteins and associated clinicopathologic factors predict survival outcome in patients with oral squamous cell carcinoma. Oral Oncol 2009: 45: 225-233.
10. CAMPBELL TN, ROBBINS SM. The Eph receptor/ephrin system: an emerging player in the invasion game. Curr Issues Mol Biol 2008: 10: 61-66.
11. CHARI NS, PINAIRE NL, THORPE L, MEDEIROS LJ, ROUTBORT MJ, MCDONNELL TJ. The p53 tumor suppressor network in cancer and the therapeutic modulation of cell death. Apoptosis 2009: 14: 336-347.
12. CHIEN CY, SU CY, HWANG CF, CHUANG HC, CHEN CM, HUANG CC. High expressions of CD105 and VEGF in early oral cancer predict potential cervical metastasis. J Surg Oncol 2006: 94: 413-417.
13. CHOI SW, KIM JY, PARK JY, CHA IH, KIM J, LEE S. Expression of carbonic anhydrase IX is associated with postoperative recurrence and poor prognostic in surgically treated oral squamous cell carcinoma. Hum Pathol 2008: 39: 1317-1322.
14. CHUANG HC, SU CY, HUANG HY, CHIEN CY, CHEN CM, HUANG CC. High expression of CD105 as a prognostic predictor of early tongue cancer. Laryngoscope 2006: 116: 1175-1179.
15. CURRAN D, GIRALT J, HARARI PM, ANG KK, COHEN RB, KIES MS, JASSEM J, BASELGA J, ROWINSKY EK, AMELLAL N, COMTE S, BONNER JA. Quality of life in head and neck cancer patients after treatment with high-dose radiotherapy alone or in combination with cetuximab. J Clin Oncol 2007: 25: 2152-2155.
16. DE VICENTE JC, FRESNO MF, VILLALAIN L, VEGA JA, HERNÁNDEZ VALLEJO G. Expression and clinical significance of matrix metalloproteinase-2 and matrix metalloproteinase-9 in oral squamous cell carcinoma. Oral Oncol 2005: 41: 283-293.
17. DE VICENTE JC, OLAY S, LEQUERICA-FERNANDEZ P, SÁNCHEZ-MAYORAL J, JUNQUERA LM, Fresno MF. Expression of Bcl-2 but not Bax has a prognostic significance in tongue carcinoma. J Oral Pathol Med 2006: 35: 140-145.
18. DE VICENTE JC, LEQUERICA-FERNÁNDEZ P, SANTAMARÍA J, FRESNO MF. Expression of MMP-7 and MT1-MMP in oral squamous cell carcinoma as predictive indicator for tumor invasion and prognosis. J Oral Pathol Med 2007: 36: 415-424.
19. DINIZ-FREITAS M, GARCÍA-CABALLERO T, ANTÚNEZ-LÓPEZ J, GÁNDARA-REY JM, GARCÍA-GARCÍA A. Pharmacodiagnostic evaluation of EGFR expression in oral squamous cell carcinoma. Oral Dis 2007: 13: 285-290.
20. FILLIES T, WERKMEISTER R, VAN DIEST PJ, BRANDT B, JOOS U, BUERGER H. HIF1-alpha overexpression indicates a good prognostic in early stage squamous cell carcinomas of the oral floor. BMC Cancer 2005: 5: 84.
21. FILLIES T, WOLTERING M, BRANDT B, VAN DIEST JP, WERKMEISTER R, JOOS U, BUERGER H. Cell cycle regulating proteins p21 and p27 in prognostic of oral squamous cell carcinomas. Oncol Rep 2007: 17: 355-359.
22. GARCÍA-MONTESINOS-PEREA B, VAL-BERNAL JF, SAIZ-BUSTILLO R. Epidermoid carcinoma of the lip: an immunohistochemical study. Med Oral Patol Oral Cir Bucal 2005: 10: 454-461.
23. GEORGOLIOS A, BATISTATOU A, CHARALABOPOULOS A, MANOLOPOULOS L, CHARALABOPOULOS K. The role of CD44 adhesion molecule in oral cavity cancer. Exp Oncol 2006: 28: 94-98.
24. GONZÁLEZ-MOLES MA, GIL-MONTOYA JA, RUIZ-AVILA I, ESTEBAN F, DELGADO-RODRIGUEZ M, BASCONES-MARTINEZ A. Prognostic significance of p21WAF1/CIP1, p16INK4a and CD44s in tongue cancer. Oncol Rep 2007: 18: 389-396.
25. HOOGSTEEN IJ, MARRES HA, BUSSINK J, VAN DER KOGEL AJ, KAANDERS JH. Tumor microenvironment in head and neck squamous cell carcinomas: predictive value and clinical relevance of hypoxic markers. A review. Head Neck 2007: 29: 591-604.
26. WORLD HEALTH ORGANISATION. ICD-10. International Statistical Classification of Diseases and Related Health Problems. 10th revision. World Health Organisation: Geneva 1997.
27. JANSSEN KL, HAUSTERMANS KM, BALM AJ, BEGG AC. Hypoxia in head and neck cancer: how much, how important? Head Neck 2005: 27: 622-638.
28. JAYASURYA R, SATHYAN KM, LAKSHMINARAYANAN K, ABRAHAM T, NALINAKUMARI KR, ABRAHAM EK, NAIR MK, KANNAN S. Phenotypic alterations in Rb pathway have more prognostic influence than p53 pathway proteins in oral carcinoma. Mod Pathol 2005: 18: 1056-1066.
29. JONATHAN RA, WIJFFELS KI, PEETERS W, DE WILDE PC, MARRES HA, MERKX MA, OOSTERWIJK E, VAN DER KOGEL AJ, KAANDERS JH. The prognostic value of endogenous hypoxia-related markers for head and neck squamous cell carcinomas treated with ARCON. Radiother Oncol 2006: 79: 288-297.
30. KATO K, KAWASHIRI S, YOSHIZAWA K, KITAHARA H, YAMAMOTO E. Apoptosis-associated markers and clinical outcome in human oral squamous cell carcinomas. J Oral Pathol Med 2008: 37: 364-371.
31. KIM SH, CHO NH, KIM K, LEE JS, KOO BS, KIM JH, CHANG JH, CHOI EC. Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression. J Surg Oncol 2006: 93: 330-337.
32. KIM SJ, SHIN HJ, JUNG KY, BAEK SK, SHIN BK, CHOI J, KIM BS, SHIN SW, KIM YH, KIM JS, OOSTERWIJK E. Prognostic value of carbonic anhydrase IX and Ki-67 expression in squamous cell carcinoma of the tongue. Jpn J Clin Oncol 2007: 37: 812-819.
33. KOSUNEN A, PIRINEN R, ROPPONEN K, PUKKILA M, KELLOKOSKI J, VIRTANIEMI J, SIRONEN R, JUHOLA M, KUMPULAINEN E, JOHANSSON R, NUUTINEN J, KOSMA VM. CD44 expression and its relationship with MMP-9, clinicopathological factors and survival in oral squamous cell carcinoma. Oral Oncol 2007: 43: 51-59.
34. KUNKEL M, MOERGEL M, STOCKINGER M, JEONG JH, FRITZ G, LEHR HA, WHITESIDE TL. Overexpression of GLUT-1 is associated with resistance to radiotherapy and adverse prognostic in squamous cell carcinoma of the oral cavity. Oral Oncol 2007: 43: 796-803.
35. KYZAS PA, CUNHA IW, IOANNIDIS JP. Prognostic significance of vascular endothelial growth factor immunohistochemical expression in head and neck squamous cell carcinoma: a meta-analysis. Clin Cancer Res 2005: 11: 1434-1440.
36. KYZAS PA, DENAXA-KYZA D, IOANNIDIS JP. Almost all articles on cancer prognostic markers report statistically significant results. Eur J Cancer 2007: 43: 2559-2579.
37. LACASSE EC, MAHONEY DJ, CHEUNG HH, PLENCHETTE S, BAIRD S, KORNELUK RG. IAP-targeted therapies for cancer. Oncogene 2008: 27: 6252-6275.
38. LAIMER K, SPIZZO G, GASTL G, OBRIST P, BRUNHUBER T, FONG D, BARBIERI V, JANK S, DOPPLER W, RASSE M, NORER B. High EGFR expression predicts poor prognostic in patients with squamous cell carcinoma of the oral cavity and oropharynx: a TMA-based immunohistochemical analysis. Oral Oncol 2007: 43: 193-198.
39. LEE JI, JIN BH, KIM MA, YOON HJ, HONG SP, HONG SD. Prognostic significance of CXCR-4 expression in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009: 107: 678-684.
40. LIM J, KIM JH, PAENG JY, KIM MJ, HONG SD, LEE JI, HONG SP. Prognostic value of activated Akt expression in oral squamous cell carcinoma. J Clin Pathol 2005: 58: 1199-1205.
41. LIN PY, YU CH, WANG JT, CHEN HH, CHENG SJ, KUO MY, CHIANG CP. Expression of hypoxia-inducible factor-1 alpha is significantly associated with the progression and prognostic of oral squamous cell carcinomas in Taiwan. J Oral Pathol Med 2008: 37: 18-25.
42. LIPPERT BM, KNAUER SK, FETZ V, MANN W, STAUBER RH. Dynamic Survivin in head and neck cancer: molecular mechanism and therapeutic potential. Int J Cancer 2007: 121: 1169-1174.
43. LIU SY, CHANG LC, PAN LF, HUNG YJ, LEE CH, SHIEH YS. Clinicopathologic significance of tumor cell-lined vessel and microenvironment in oral squamous cell carcinoma. Oral Oncol 2008: 44: 277-285.
44. LO MUZIO L, SANTARELLI A, CALTABIANO R, RUBINI C, PIERAMICI T, TREVISIOL L, CARINCI F, LEONARDI R, DE LILLO A, LANZAFAME S, BUFO P, PIATTELLI A. p63 overexpression associates with poor prognostic in head and neck squamous cell carcinoma. Hum Pathol 2005: 36: 187-194.
45. LO MUZIO L, FARINA A, RUBINI C, PEZZETTI F, STABELLINI G, LAINO G, SANTARELLI A, PANNONE G, BUFO P, DE LILLO A, CARINCI F. Survivin as prognostic factor in squamous cell carcinoma of the oral cavity. Cancer Lett 2005: 225: 27-33.
46. LO MUZIO L, CAMPISI G, FARINA A, RUBINI C, PANNONE G, SERPICO R, LAINO G, DE LILLO A, CARINCI F. P-cadherin expression and survival rate in oral squamous cell carcinoma: an immunohistochemical study. BMC Cancer 2005: 5: 63.
47. LO MUZIO L, CAMPISI G, FARINA A, RUBINI C, PASTORE L, GIANNONE N, COLELLA G, LEONARDI R, CARINCI F. Effect of p63 expression on survival in oral squamous cell carcinoma. Cancer Invest 2007: 25: 464-469.
48. LUUKKAA M, VIHINEN P, KRONQVIST P, VAHLBERG T, PYRHÖNEN S, KÄhäRI VM, GRÉNMAN R. Association between high collagenase-3 expression levels and poor prognostic in patients with head and neck cancer. Head Neck 2006: 28: 225-234.
49. LYONS AJ, JONES J. Cell adhesion molecules, the extracellular matrix and oral squamous carcinoma. Int J Oral Maxillofac Surg 2007: 36: 671-679.
50. MAEDA G, CHIBA T, OKAZAKI M, SATOH T, TAYA Y, AOBA T, KATO K, KAWASHIRI S, IMAI K. Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression. Int J Oncol 2005: 27: 1535-1541.
51. MALLETT S, TIMMER A, SAUERBREI W, ALTMAN DG. Reporting of prognostic studies of tumour markers: a review of published articles in relation to REMARK guidelines. Br J Cancer 2010: 102: 173-180.
52. MǍRGǍRITESCU C, SIMIONESCU C, MOGOANTǍ L, BADEA P, PIRICI D, STEPAN A, CIUREA R. Endoglin (CD105) and microvessel density in oral squamous cell carcinoma. Rom J Morphol Embryol 2008: 49: 321-326.
53. MARIONI G, MARINO F, GIACOMELLI L, STAFFIERI C, MARIUZZI ML, VIOLINO E, DE FILIPPIS C. Endoglin expression is associated with poor oncologic outcome in oral and oropharyngeal carcinoma. Acta Otolaryngol 2006: 126: 633-639.
54. MASSANO J, REGATEIRO FS, JANUÁRIO G, FERREIRA A. Oral squamous cell carcinoma: review of prognostic and predictive factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006: 102: 67-76.
55. MCSHANE LM, ALTMAN DG, SAUERBREI W, TAUBE SE, GION M, CLARK GM. Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics. REporting recommendations for tumour MARKer prognostic studies (REMARK). Eur J Cancer 2005: 41: 1690-1696.
56. MUÑOZ-GUERRA MF, MARAZUELA EG, FERNÁNDEZ-CONTRERAS ME, GAMALLO C. P-cadherin expression reduced in squamous cell carcinoma of the oral cavity: an indicator of poor prognosis. Cancer 2005: 103: 960-969.
57. MYOUNG H, KIM MJ, LEE JH, OK YJ, PAENG JY, YUN PY. Correlation of proliferative markers (Ki-67 and PCNA) with survival and lymph node metastasis in oral squamous cell carcinoma: a clinical and histopathological analysis of 113 patients. Int J Oral Maxillofac Surg 2006: 35: 1005-1010.
58. NARYZHNY SN. Proliferating cell nuclear antigen: a proteomics view. Cell Mol Life Sci 2008: 65: 3789-3808.
59. NEMES JA, NEMES Z, MÁRTON IJ. p21WAF1/CIP1 expression is a marker of poor prognostic in oral squamous cell carcinoma. J Oral Pathol Med 2005: 34: 274-279.
60. OLIVEIRA LR, RIBEIRO-SILVA A, ZUCOLOTO S. Prognostic impact of p53 and p63 immunoexpression in oral squamous cell carcinoma. J Oral Pathol Med 2007: 36: 191-197.
61. OLIVEIRA LR, RIBEIRO-SILVA A, ZUCOLOTO S. Prognostic significance of p53 and p63 immunolocalisation in primary and matched lymph node metastasis in oral squamous cell carcinoma. Acta Histochem 2007: 109: 388-396.
62. OLIVEIRA LR, RIBEIRO-SILVA A, COSTA JP, SIMÕES AL, MATTEO MA, ZUCOLOTO S. Prognostic factors and survival analysis in a sample of oral squamous cell carcinoma patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008: 106: 685-695.
63. PASQUALE EB. Eph receptor signalling casts a wide net on cell behavior. Nat Rev Mol Cell Biol 2005: 6: 462-475.
64. PUKKILA M, KOSUNEN A, ROPPONEN K, VIRTANIEMI J, KELLOKOSKI J, KUMPULAINEN E, PIRINEN R, NUUTINEN J, JOHANSSON R, KOSMA VM. High stromal versican expression predicts unfavourable outcome in oral squamous cell carcinoma. J Clin Pathol 2007: 60: 267-272.
65. RAHMANI M, WONG BW, ANG L, CHEUNG CC, CARTHY JM, WALINSKI H, MCMANUS BM. Versican: signaling to transcriptional control pathways. Can J Physiol Pharmacol 2006: 84: 77-792.
66. RILEY RD, SAUERBREI W, ALTMAN DG. Prognostic markers in cancer: the evolution of evidence from single studies to meta-analysis, and beyond. Br J Cancer 2009: 100: 1219-1229.
67. ROH JL, CHO KJ, KWON GY, RYU CH, CHANG HW, CHOI SH, NAM SY, KIM SY. The prognostic value of hypoxia markers in T2-staged oral tongue cancer. Oral Oncol 2009: 45: 63-68.
68. SAKATA K, SOMEYA M, NAGAKURA H, NAKATA K, OOUCHI A, TAKAGI M, HAREYAMA M. Brachytherapy for oral tongue cancer: an analysis of treatment results with various biological markers. Jpn J Clin Oncol 2008: 38: 402-407.
69. SANTAMARIA D, ORTEGA S. Cyclins and CDKS in development and cancer: lessons from genetically modified mice. Front Biosci 2006: 11: 1164-1188.
70. SHANG ZJ, LI ZB, LI JR. VEGF is upregulated by hypoxic stimulation and related to tumour angiogenesis and severity of disease in oral squamous cell carcinoma: in vitro and in vivo studies. Int J Oral Maxillofac Surg 2006: 35: 533-538.
71. SHAO Z, ZHANG WF, CHEN XM, SHANG ZJ. Expression of EphA2 and VEGF in squamous cell carcinoma of the tongue: correlation with the angiogenesis and clinical outcome. Oral Oncol 2008: 44: 1110-1117.
72. SHIRAKI M, ODAJIMA T, IKEDA T, SASAKI A, SATOH M, YAMAGUCHI A, NOGUCHI M, NAGAI I, HIRATSUKA H. Combined expression of p53, cyclin D1 and epidermal growth factor receptor improves estimation of prognostic in curatively resected oral cancer. Mod Pathol 2005: 18: 1482-1489.
73. SILVA SD, PEREZ DE, ALVES FA, NISHIMOTO IN, PINTO CA, KOWALSKI LP, GRANER E. ErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: correlation with clinical outcomes. Oral Oncol 2008: 44: 484-490.
74. SILVA SD, CUNHA IW, NISHIMOTO IN, SOARES FA, CARRARO DM, KOWALSKI LP, GRANER E. Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas. Oral Oncol 2009: 45: e134-e139.
75. SMID EJ, STOTER TR, BLOEMENA E, LAFLEUR MV, LEEMANS CR, VAN DER WAAL I, SLOTMAN BJ, LANGENDIJK JA. The importance of immunohistochemical expression of EGFr in squamous cell carcinoma of the oral cavity treated with surgery and postoperative radiotherapy. Int J Radiat Oncol Biol Phys 2006: 65: 1323-1329.
76. SONI S, KAUR J, KUMAR A, CHAKRAVARTI N, MATHUR M, BAHADUR S, SHUKLA NK, DEO SV, RALHAN R. Alterations of rb pathway components are frequent events in patients with oral epithelial dysplasia and predict clinical outcome in patients with squamous cell carcinoma. Oncology 2005: 68: 314-325.
77. TASHIRO E, TSUCHIYA A, IMOTO M. Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression. Cancer Sci 2007: 98: 629-635.
78. UEDA G, SUNAKAWA H, NAKAMORI K, SHINYA T, TSUHAKO W, TAMURA Y, KOSUGI T, SATO N, OGI K, HIRATSUKA H. Aberrant expression of beta- and gamma-catenin is an independent prognostic marker in oral squamous cell carcinoma. Int J Oral Maxillofac Surg 2006: 35: 356-361.
79. VAN DE POL SM, DOORNAERT PA, DE BREE R, LEEMANS CR, SLOTMAN BJ, Langendijk JA. The significance of anemia in squamous cell head and neck cancer treated with surgery and postoperative radiotherapy. Oral Oncol 2006: 42: 131-138. (Pubitemid 43106877)
80. WIMMER-KLEIKAMP SH, LACKMANN M. Eph-modulated cell morphology, adhesion and motility in carcinogenesis. IUBMB Life 2005: 57: 421-431.
81. YU Z, WEINBERGER PM, HAFFTY BG, SASAKI C, ZERILLO C, JOE J, KOWALSKI D, DZIURA J, CAMP RL, RIMM DL, PSYRRI A. Cyclin d1 is a valuable prognostic marker in oropharyngeal squamous cell carcinoma. Clin Cancer Res 2005: 11: 1160-1166.
82. ZHANG M, ZHANG P, ZHANG C, SUN J, WANG L, LI J, TIAN Z, CHEN W. Prognostic significance of Bcl-2 and Bax protein expression in the patients with oral squamous cell carcinoma. J Oral Pathol Med 2009: 38: 307-313.
83. ZIOBER AF, FALLS EM, ZIOBER BL. The extracellular matrix in oral squamous cell carcinoma: friend or foe? Head Neck 2006: 28: 740-749.