Correlation of proliferative markers (Ki-67 and PCNA) with survival and lymph node metastasis in oral squamous cell carcinoma: a clinical and histopathological analysis of 113 patients

International Journal of Oral and Maxillofacial Surgery

Volumn 35, Issue 11, 2006, Pages 1005-1010

  Myoung, H ^a   Kim, M J ^a   Lee, J H ^a   Ok, Y J ^a   Paeng, J Y ^a   Yun, P Y ^b  

^a Seoul National University   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

Author keywords

Ki 67; oral squamous cell carcinoma; PCNA; proliferative marker; survival

Indexed keywords

CYCLINE; KI 67 ANTIGEN; TUMOR MARKER;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CANCER PATIENT; CANCER STAGING; CANCER SURVIVAL; CELL PROLIFERATION; CLINICAL STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MOUTH CARCINOMA; MULTIVARIATE ANALYSIS; PREDICTION; PROGNOSIS; SEX DIFFERENCE; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; UNIVARIATE ANALYSIS;

ADOLESCENT; ADULT; AGE FACTORS; AGED; EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; KI-67 ANTIGEN; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; NEOPLASM STAGING; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; SEX FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 33750313394     PISSN: 09015027     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijom.2006.07.016     Document Type: Article

References (21)

1. Franchi A., Gallo O., Boddi V., and Santucci M. Prediction of occult neck metastases in laryngeal carcinoma: role of proliferating cell nuclear antigen, MIB-1, and E-cadherin immunohistochemical determination. Clin Cancer Res 2 (1996) 1801-1808
2. Friedlander P.L. The use of genetic markers in the clinical care of patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 129 (2003) 363-366
3. Gerdes J., Lemke H., Baisch H., Wacker H.H., Schwab U., and Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133 (1984) 1710-1715
4. Helliwell T.R. Molecular markers of metastasis in squamous carcinomas. J Pathol 194 (2001) 289-293
5. Iatropoulos M.J., and Williams G.M. Proliferation markers. Exp Toxicol Pathol 48 (1996) 175-181
6. Jacob R., Welkoborsky H.J., Mann W.J., Hofken F., Dienes H.P., and Freije J.E. Heterogeneity of squamous cell carcinomas of the head and neck - analysis of tumor biologic factors and proliferation rates. Laryngoscope 106 (1996) 1170-1175
7. Kalnins I.K., Leonard A.G., Sako K., Razack M.S., and Shedd D.P. Correlation between prognosis and degree of lymph node involvement in carcinoma of the oral cavity. Am J Surg 134 (1977) 450-454
8. Kelman Z. PCNA: structure, functions and interactions. Oncogene 14 (1997) 629-640
9. Kerns B.J., Jordan P.A., Faerman L.L., Berchuck A., Bast Jr. R.C., and Layfield L.J. Determination of proliferation index with MIB-1 in advanced ovarian cancer using quantitative image analysis. Am J Clin Pathol 101 (1994) 192-197
10. Liu M., Lawson G., Delos M., Jamart J., Chatelain B., Remacle M., and Marbaix E. Prognostic value of cell proliferation markers, tumour suppressor proteins and cell adhesion molecules in primary squamous cell carcinoma of the larynx and hypopharynx. Eur Arch Otorhinolaryngol 260 (2003) 28-34
11. Pisani P., Parkin D.M., Bray F., and Ferlay J. Estimates of the worldwide mortality from 25 cancers in. Int J Cancer 83 (1999) 18-29
12. Scagliotti G.V., Micela M., Gubetta L., Leonardo E., Cappia S., Borasio P., and Pozzi E. Prognostic significance of Ki67 labelling in resected non small cell lung cancer. Eur J Cancer 29 (1993) 363-365
13. Schliephake H. Prognostic relevance of molecular markers of oral cancer - a review. Int J Oral Maxillofac Surg 32 (2003) 233-245
14. Silverman Jr. S., and Gorsky M. Epidemiologic and demographic update in oral cancer: California and national data - 1973 to 1985. J Am Dent Assoc 120 (1990) 495-499
15. Sittel C., Ruiz S., Volling P., Kvasnicka H.M., Jungehulsing M., and Eckel H.E. Prognostic significance of Ki-67 (MIB1), PCNA and p53 in cancer of the oropharynx and oral cavity. Oral Oncol 35 (1999) 583-589
16. Spafford M.F., Koeppe J., Pan Z., Archer P.G., Meyers A.D., and Franklin W.A. Correlation of tumour markers p53, bcl-2, CD34, CD44H, CD44v6, and Ki-67 with survival and metastasis in laryngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 122 (1996) 627-632
17. Takes R.P., Baatenburg de Jong R.J., Schuuring E., Hermans J., Vis A.A., Litvinov S.V., and van Krieken J.H. Markers for assessment of nodal metastasis in laryngeal carcinoma. Arch Otolaryngol Head Neck Surg 123 (1997) 412-419
18. Takes R.P., Baatenburg de Jong R.J., Wijffels K., Schuuring E., Litvinov S.V., Hermans J., and van Krieken J.H. Expression of genetic markers in lymph node metastases compared with their primary tumours in head and neck cancer. J Pathol 194 (2001) 298-302
19. Tannapfel A., and Weber A. Tumour markers in squamous cell carcinoma of the head and neck: clinical effectiveness and prognostic value. Eur Arch Otorhinolaryngol 258 (2001) 83-88
20. Xie X., De Angelis P., Clausen O.P., and Boysen M. Prognostic significance of proliferative and apoptotic markers in oral tongue squamous cell carcinomas. Oral Oncol 35 (1999) 502-509
21. Youssef E.M., Matsuda T., Takada N., Osugi H., Higashino M., Kinoshita H., Watanabe T., Katsura Y., Wanibuchi H., and Fukushima S. Prognostic significance of the MIB-1 proliferation index for patients with squamous cell carcinoma of the esophagus. Cancer 76 (1995) 358-366