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Volumn 693, Issue , 2011, Pages 295-308

Generation of Genetically Modified Rodents Using Random ENU Mutagenesis

Author keywords

ENU mutagenesis; Genotype driven screens; Mutant rodent models; Mutation discovery; Phenotype driven screens

Indexed keywords

ETHYLNITROSOUREA;

EID: 79952279695     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-60761-974-1_18     Document Type: Chapter
Times cited : (5)

References (27)
  • 2
    • 0033858522 scopus 로고    scopus 로고
    • The mutagenic action of N-ethyl-N-nitrosourea in the mouse
    • Noveroske, J. K., Weber, J. S., and Justice, M. J. (2000) The mutagenic action of N-ethyl-N-nitrosourea in the mouse, Mamm Genome 11, 478–483.
    • (2000) Mamm Genome , vol.11 , pp. 478-483
    • Noveroske, J.K.1    Weber, J.S.2    Justice, M.J.3
  • 3
    • 0031255352 scopus 로고    scopus 로고
    • Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment
    • Rogers, D. C., Fisher, E. M., Brown, S. D., Peters, J., Hunter, A. J., and Martin, J. E. (1997) Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment, Mamm Genome 8, 711–713.
    • (1997) Mamm Genome , vol.8 , pp. 711-713
    • Rogers, D.C.1    Fisher, E.M.2    Brown, S.D.3    Peters, J.4    Hunter, A.J.5    Martin, J.E.6
  • 5
    • 0346728736 scopus 로고    scopus 로고
    • Target-selected mutagenesis of the rat
    • Smits, B. M., Mudde, J., Plasterk, R. H., and Cuppen, E. (2004) Target-selected mutagenesis of the rat, Genomics 83, 332–334.
    • (2004) Genomics , vol.83 , pp. 332-334
    • Smits, B.M.1    Mudde, J.2    Plasterk, R.H.3    Cuppen, E.4
  • 10
    • 8544219682 scopus 로고    scopus 로고
    • Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice
    • Concepcion, D., Seburn, K. L., Wen, G., Frankel, W. N., and Hamilton, B. A. (2004) Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice, Genetics 168, 953–959.
    • (2004) Genetics , vol.168 , pp. 953-959
    • Concepcion, D.1    Seburn, K.L.2    Wen, G.3    Frankel, W.N.4    Hamilton, B.A.5
  • 14
    • 46949102955 scopus 로고    scopus 로고
    • Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis
    • van Boxtel, R., Toonen, P. W., van Roekel, H. S., Verheul, M., Smits, B. M., Korving, J., de Bruin, A., and Cuppen, E. (2008) Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis, Carcinogenesis 29, 1290–1297.
    • (2008) Carcinogenesis , vol.29 , pp. 1290-1297
    • van Boxtel, R.1    Toonen, P.W.2    van Roekel, H.S.3    Verheul, M.4    Smits, B.M.5    Korving, J.6    de Bruin, A.7    Cuppen, E.8
  • 15
    • 0038405046 scopus 로고    scopus 로고
    • DNA mismatch repair deficiency stimulates N-ethyl-N-nitrosourea-induced mutagenesis and lym-phomagenesis
    • Claij, N., van der Wal, A., Dekker, M., Jansen, L., and te Riele, H. (2003) DNA mismatch repair deficiency stimulates N-ethyl-N-nitrosourea-induced mutagenesis and lym-phomagenesis, Cancer Res 63, 2062–2066.
    • (2003) Cancer Res , vol.63 , pp. 2062-2066
    • Claij, N.1    van der Wal, A.2    Dekker, M.3    Jansen, L.4    Te Riele, H.5
  • 16
    • 54049093244 scopus 로고    scopus 로고
    • Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals
    • van Boxtel, R., Toonen, P. W., Verheul, M., van Roekel, H. S., Nijman, I. J., Guryev, V., and Cuppen, E. (2008) Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals, BMC Genomics 9, 460.
    • (2008) BMC Genomics , vol.9
    • van Boxtel, R.1    Toonen, P.W.2    Verheul, M.3    van Roekel, H.S.4    Nijman, I.J.5    Guryev, V.6    Cuppen, E.7
  • 24
    • 0034813659 scopus 로고    scopus 로고
    • Genome-wide ENU mutagenesis to reveal immune regulators
    • Nelms, K. A. and Goodnow, C. C. (2001) Genome-wide ENU mutagenesis to reveal immune regulators, Immunity 15, 409–418.
    • (2001) Immunity , vol.15 , pp. 409-418
    • Nelms, K.A.1    Goodnow, C.C.2
  • 25
    • 25444525667 scopus 로고    scopus 로고
    • Identification of a rat model for usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward genetics
    • Smits, B. M., Peters, T. A., Mul, J. D., Croes, H. J., Fransen, J. A., Beynon, A. J., Guryev, V., Plasterk, R. H., and Cuppen, E. (2005) Identification of a rat model for usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward genetics, Genetics 170, 1887–1896.
    • (2005) Genetics , vol.170 , pp. 1887-1896
    • Smits, B.M.1    Peters, T.A.2    Mul, J.D.3    Croes, H.J.4    Fransen, J.A.5    Beynon, A.J.6    Guryev, V.7    Plasterk, R.H.8    Cuppen, E.9
  • 26
    • 33644639082 scopus 로고    scopus 로고
    • Estimating the number of coding mutations in genotypic-and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens
    • Keays, D. A., Clark, T. G., and Flint, J. (2006) Estimating the number of coding mutations in genotypic-and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens, Mamm Genome 17, 230–238.
    • (2006) Mamm Genome , vol.17 , pp. 230-238
    • Keays, D.A.1    Clark, T.G.2    Flint, J.3
  • 27
    • 0030872838 scopus 로고    scopus 로고
    • PolyPhred: Automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing
    • Nickerson, D. A., Tobe, V. O., and Taylor, S. L. (1997) PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing, Nucleic Acids Res 25, 2745–2751.
    • (1997) Nucleic Acids Res , vol.25 , pp. 2745-2751
    • Nickerson, D.A.1    Tobe, V.O.2    Taylor, S.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.