Cyanidin-3-O-glucoside protection against TNF-α-induced endothelial dysfunction: Involvement of nuclear factor-κB signaling

Journal of Agricultural and Food Chemistry

Volumn 58, Issue 22, 2010, Pages 12048-12054

  Speciale, Antonio ^a   Canali, Raffaella ^b   Chirafisi, Joselita ^a   Saija, Antonella ^a   Virgili, Fabio ^b   Cimino, Francesco ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

Author keywords

Anthocyanins; Atherosclerosis; Cyanidin 3 O glusoside; Endothelial dysfunction; Nf b;

Indexed keywords

ADHESION MOLECULES; ATHEROSCLEROSIS; CELLULAR REDOX; CYANIDIN; DIETARY PLANTS; ENDOTHELIAL DYSFUNCTION; FREE RADICAL SCAVENGERS; GENE REGULATIONS; HUMAN ENDOTHELIAL CELLS; INTRACELLULAR ACCUMULATION; LEUKOCYTE ADHESION; LIPID PEROXIDATION; NUCLEAR FACTORS; PHYTOCHEMICALS; POTENT ANTIOXIDANTS; SIGNAL TRANSDUCTION PATHWAYS; TRIGGERING ACTIVATION;

ADHESION; BYPRODUCTS; DISEASES; ENDOTHELIAL CELLS; FREE RADICALS; GENES; OXIDATIVE STRESS; PATHOLOGY; PHENOLS; SELF ASSEMBLY; SIGNAL TRANSDUCTION; TRANSCRIPTION; TRANSCRIPTION FACTORS;

ANTHOCYANINS;

ANTHOCYANIN; ANTIOXIDANT; CYANIDIN 3 O GLUCOSIDE; CYANIDIN 3-O-GLUCOSIDE; GLUCOSIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTECTIVE AGENT; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL CULTURE; DRUG EFFECT; ENDOTHELIUM CELL; GENETICS; HUMAN; METABOLISM; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

ANTHOCYANINS; ANTIOXIDANTS; CELLS, CULTURED; ENDOTHELIAL CELLS; GLUCOSIDES; HUMANS; NF-KAPPA B; OXIDATIVE STRESS; PROTECTIVE AGENTS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79952277621     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf1029515     Document Type: Article

References (43)

1. Glass, C. K.; Witztum, J. L. Atherosclerosis: the road ahead. Cell 2001, 104 (4), 503-516.
2. Libby, P. Inflammation in atherosclerosis. Nature 2002, 420 (6917), 868-874. (Pubitemid 36019640)
3. Willerson, J. T.; Ridker, P. M. Inflammation as a cardiovascular risk factor. Circulation 2004, 109, II2-II10.
4. Virgili, F.; Marino, M. Regulation of cellular signals from nutritional molecules: a specific role for phytochemicals, beyond antioxidant activity. Free Radical Biol. Med. 2008, 45 (9), 1205-1216.
5. Na, H. K.; Surh, Y. J. Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection. Mol. Carcinog. 2006, 45 (6), 368-380.
6. Oliveira-Marques, V.; Marinho, H. S.; Cyrne, L.; Antunes, F. Role of hydrogen peroxide in NF-κB activation: from inducer to modulator. Antioxid. Redox Signal. 2009, 11 (9), 2223-2243.
7. Kay, C. D.; Kris-Etherton, P. M.; West, S. G. Effects of antioxidant-rich foods on vascular reactivity: review of the clinical evidence. Curr. Atheroscler. Rep. 2006, 8 (6), 510-522. (Pubitemid 44697805)
8. Andreadi, C. K.; Howells, L. M.; Atherfold, P. A.; Manson, M. M. Involvement of Nrf2, p38, B-Raf, and nuclear factor-κB but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols. Mol. Pharmacol. 2006, 69, 1033-1040. (Pubitemid 43363879)
9. Chen, C. Y.; Jang, J. H.; Li, M. H.; Surh, Y. J. Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells. Biochem. Biophys. Res. Commun. 2005, 331, 993-1000.
10. Cimino, F.; Ambra, R.; Canali, R.; Saija, A.; Virgili, F. Effect of cyanidin-3-O-glucoside on UVB-induced response in human keratinocytes. J. Agric. Food Chem. 2006, 54 (11), 4041-4047. (Pubitemid 44030588)
11. Bonina, F. P.; Leotta, C.; Scalia, G.; Puglia, C.; Trombetta, D.; Tringali, G.; Roccazzello, A. M.; Rapisarda, P.; Saija, A. Evaluation of oxidative stress in diabetic patients after supplementation with a standardised red orange extract. Diabetes Nutr. Metab. 2002, 15 (1), 14-19. (Pubitemid 34228939)
12. Galvano, F.; La Fauci, L.; Lazzarino, G.; Fogliano, V.; Ritieni, A.; Ciappellano, S.; Battistini, N. C.; Tavazzi, B.; Galvano, G. Cyanidins: metabolism and biological properties. J. Nutr. Biochem. 2004, /5(1), 2-11.
13. Kong, J. M.; Chia, L. S.; Goh, N. K.; Chia, T. F.; Brouillard, R. Analysis and biological activities of anthocyanins. Phytochemistry 2003, 64, 923-933.
14. de Pascual-Teresa, S.; Moreno, D. A.; Garcia-Viguera, C. Flavanols and anthocyanins in cardiovascular health: a review of current evidence. Int. J. Mol. Sci. 2010, 11 (4), 1679-1703.
15. Trombetta, D.; Cimino, F.; Cristani, M.; Mandalari, G.; Saija, A.; Ginestra, G.; Speciale, A.; Chirafisi, J.; Bisignano, G.; Waldron, K.; Narbad, A.; Faulds, C. B. In vitro protective effects of two extracts from bergamot peels on human endothelial cells exposed to tumor necrosis factor-α (TNF-α). J. Agric. Food Chem. 2010, 58, 8430-8436.
16. Jaffe, E.; Nachmann, R. L.; Becker, C. G.; Minick, C. R. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 1973, 52 (11), 2745-2756.
17. Canali, R.; Comitato, R.; Ambra, R.; Virgili, F. Red wine metabolites modulate NF-κB, activator protein-1 and cAMP response element-binding proteins in human endothelial cells. Br. J. Nutr. 2010, 103 (6), 807-814.
18. Mo, S. J.; Son, E. W.; Lee, S. R.; Lee, S. M.; Shin, D. H.; Pyo, S. CML-1 inhibits TNF-α-induced NF-κB activation and adhesion molecule expression in endothelial cells through inhibition of IαBα kinase. J. Ethnopharmacol. 2007, 109 (1), 78-86. (Pubitemid 44883186)
19. Canali, R.; Ambra, R.; Stelitano, C.; Mattivi, F.; Scaccini, C.; Virgili, F. A novel model to study the biological effects of red wine at the molecular level. Br. J. Nutr. 2007, 97, 1053-1058. (Pubitemid 46925356)
20. Cassie, S.; Masterson, M. F.; Polukoshko, A.; Viskovic, M. M.; Tibbies, L. A. Ischemia/reperfusion induces the recruitment of leukocytes from whole blood under flow conditions. Free Radical Biol. Med. 2004, 36(9), 1102-1111.
21. Livak, K. J.; Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method. Methods 2001, 25 (4), 402-408. (Pubitemid 34164012)
22. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.
23. Korolyuk, A. M.; Ivanova, I. L.; Maiorova, G. I.; Tokarev, E. B. A method for measuring catalase activity. Lab. Delo 1988, 1, 16-18.
24. Lazzè, M. C.; Savio, M.; Pizzala, R.; Cazzalini, O.; Perucca, P.; Scovassi, A. I.; Stivala, L. A.; Bianchi, L. Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines. Carcinogenesis 2004, 25 (8), 1427-1433. (Pubitemid 39162708)
25. Russo, A.; La Fauci, L.; Acquaviva, R.; Campisi, A.; Raciti, G.; Scifo, C.; Renis, M.; Galvano, G.; Vanella, A.; Galvano, F. Ochratoxin A-induced DNA damage in human fibroblast: protective effect of cyanidin-3-O-β-D- glucoside. J. Nutr. Biochem. 2005, 16, 31-33.
26. Lazzé, M. C.; Pizzala, R.; Savio, M.; Stivala, L. A.; Prosperi, E.; Bianchi, L. Anthocyanins protect against DNA damage induced by tert-butyl-hydroperoxide in rat smooth muscle and hepatoma cells. Mutat. Res. 2003, 535 (1), 103-115. (Pubitemid 36124018)
27. Denk, A.; Goebeler, M.; Schmid, S.; Berberich, I.; Ritz, O.; Lindeniann, D.; Ludwig, S.; Wirth, T. Activation of NF-κB via the IκB kinase complex is both essential and sufficient for proinflammatory gene expression in primary endothelial cells. J. Biol. Chem. 2001, 276 (30), 28451-28458.
28. Lee, J. H.; Zhou, H. Y.; Cho, S. Y.; Kim, Y. S.; Lee, Y. S.; Jeong, C. S. Anti-inflammatory mechanisms of apigenin: inhibition of cyclooxygenase-2 expression, adhesion of monocytes to human umbilical vein endothelial cells, and expression of cellular adhesion molecules. Arch. Pharm. Res. 2007, 30 (10), 1318-1327.
29. Fearon, I. M.; Faux, S. P. Oxidative stress and cardiovascular disease: novel tools give (free) radical insight. J. Mol. Cell Cardiol. 2009, 47 (3), 372-381.
30. Minuz, P.; Fava, C.; Cominacini, L. Oxidative stress, antioxidants, and vascular damage. Br. J. Clin. Pharmacol. 2006, 61 (6), 774-777. (Pubitemid 43794809)
31. Cagnin, S.; Biscuola, M.; Patuzzo, C.; Trabetti, E.; Pasquali, A.; Laveder, P.; Faggian, G.; Iafrancesco, M.; Mazzucco, A.; Pignatti, P. F.; Lanfranchi, G. Reconstruction and functional analysis of altered molecular pathways in human atherosclerotic arteries. BMC Genomics 2009, 10, 13.
32. Esper, R. J.; Nordaby, R. A.; Vilariño, J. O.; Paragano, A.; Cacharrón, J. L.; Machado, R. A. Endothelial dysfunction: a comprehensive appraisal. Cardiovasc. Diabetol. 2006, 5, 4.
33. de Winther, M. P.; Kanters, E.; Kraal, T.; Hofker, M. H. Nuclear factor κB signaling in atherogenesis. Arterioscler. Thromb. Vasc. Biol. 2005, 25, 904-914.
34. Cai, H.; Harrison, D. G. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ. Res. 2000, 87 (10), 840-844.
35. Sakon, S.; Xue, X.; Takekawa, M.; Sasazuki, T.; Okazaki, T.; Kojima, Y.; Piao, J. H.; Yagita, H.; Okumura, K.; Doi, T.; Nakano, H. NF-κB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J. 2003, 22(15), 3898-3909. (Pubitemid 36975716)
36. Surh, Y. J.; Na, H. K. NF-κB and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals. Genes Nutr. 2008, 2 (4), 313-317.
37. Galvano, F.; La Fauci, L.; Vitaglione, P.; Fogliano, V.; Vanella, L.; Felgines, C. Bioavailability, antioxidant and biological properties of the natural free-radical scavengers cyanidin and related glycosides. Ann. 1st. Super. Sanita 2007, 43 (4), 382-393.
38. Stintzing, F. C.; Stintzing, A. S.; Carle, R.; Frei, B.; Wrolstad, R. E. Color and antioxidant properties of cyanidin-based anthocyanin pigments. J. Agric. Food Chem. 2002, 50 (21), 6172-6181.
39. Zhou, Z.; Connell, M. C.; MacEwan, D. J. TNFR1-induced NF-κB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells. Cell Signal. 2007, 19 (6), 1238-1248.
40. Xiao, W. Advances in NF-αB signaling transduction and transcription. Cell Mol. Immunol. 2004, 1 (6), 425-435.
41. Xia, M.; Ling, W.; Zhu, H.; Ma, J.; Wang, Q.; Hou, M.; Tang, Z.; Guo, H.; Liu, C.; Ye, Q. Anthocyanin attenuates CD40-mediated endothelial cell activation and apoptosis by inhibiting CD40-induced MAPK activation. Atherosclerosis 2009, 202 (1), 41-47.
42. Csiszar, A.; Wang, M; Lakatta, E.G.; Ungvari, Z. Inflammation and endothelial dysfunction during aging: role of NF-κB. J. Appl. Physiol. 2008, 105 (4), 1333-1341.
43. Tuñón, M. J.; García-Mediavilla, M. V.; Sánchez-Campos, S.; González-Gallego, J. Potential of flavonoids as anti-inflammatory agents: modulation of pro-inflammatory gene expression and signal transduction pathways. Curr. Drug Metab. 2009, 10, 256-271.