메뉴 건너뛰기




Volumn 2, Issue 2, 2010, Pages 885-912

The evolution of biomarkers in thyroid cancer-from mass screening to a personalized biosignature

Author keywords

Biological marker; Biomarker; Epigenetics; Genomics; Molecular marker; Molecular pathways; Proteomics; Serum based biomarkers; Thyroid cancer; Tumor marker

Indexed keywords

CALCITONIN; CARCINOEMBRYONIC ANTIGEN; CELL DNA; MESSENGER RNA; MICRORNA; THYROGLOBULIN; TUMOR MARKER;

EID: 79952262530     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers2020885     Document Type: Review
Times cited : (60)

References (129)
  • 2
    • 0015159160 scopus 로고
    • Early diagnosis of medullary carcinoma of the thyroid gland by means of calcitonin assay
    • Melvin, K.E.; Miller, H.H.; Tashjian, A.H. Early diagnosis of medullary carcinoma of the thyroid gland by means of calcitonin assay. N. Engl. J. Med. 1971, 285, 1115-1120.
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1115-1120
    • Melvin, K.E.1    Miller, H.H.2    Tashjian, A.H.3
  • 3
    • 0035183179 scopus 로고    scopus 로고
    • Trends in biomarker research for cancer detection
    • Srinivas, P.R.; Kramer, B.S.; Srivastava, S. Trends in biomarker research for cancer detection. Lancet Oncol. 2001, 2, 698-704.
    • (2001) Lancet Oncol , vol.2 , pp. 698-704
    • Srinivas, P.R.1    Kramer, B.S.2    Srivastava, S.3
  • 5
    • 33646442046 scopus 로고    scopus 로고
    • Increasing incidence of thyroid cancer in the United States, 1973-2002
    • Davies, L.; Welch, H.G. Increasing incidence of thyroid cancer in the United States, 1973-2002. JAMA 2006, 295, 2164-2167.
    • (2006) JAMA , vol.295 , pp. 2164-2167
    • Davies, L.1    Welch, H.G.2
  • 6
    • 0012420347 scopus 로고    scopus 로고
    • National Cancer Institute. Age-Adjusted SEER Incidence Rates By Cancer Site Ages < 50, All Races, Female 2000 - 2006 (SEER 17), Available on line at, (accessed on 24 February 2010)
    • National Cancer Institute. Age-Adjusted SEER Incidence Rates By Cancer Site Ages < 50, All Races, Female 2000 - 2006 (SEER 17) Surveillance, Epidemiology, and End Results (SEER) Program. Available on line at: http://www.seer.cancer.gov/ (accessed on 24 February 2010).
    • (2010) Surveillance, Epidemiology, and End Results (SEER) Program
  • 7
    • 36549045686 scopus 로고    scopus 로고
    • Recent developments in the clinical application of thyroid cancer biomarkers
    • Shibru, D.; Chung, K.W.; Kebebew, E. Recent developments in the clinical application of thyroid cancer biomarkers. Curr. Opin. Oncol. 2008, 20, 13-18.
    • (2008) Curr. Opin. Oncol. , vol.20 , pp. 13-18
    • Shibru, D.1    Chung, K.W.2    Kebebew, E.3
  • 8
    • 0015634978 scopus 로고
    • Radioimmunoassay for measurement of thyroglobulin in human serum
    • Van Herle, A.J.; Uller, R.P.; Matthews, N.I.; Brown, J. Radioimmunoassay for measurement of thyroglobulin in human serum. J. Clin. Invest. 1973, 52, 1320-1327.
    • (1973) J. Clin. Invest. , vol.52 , pp. 1320-1327
    • van Herle, A.J.1    Uller, R.P.2    Matthews, N.I.3    Brown, J.4
  • 10
    • 51649117327 scopus 로고    scopus 로고
    • The promise and potential pitfalls of serum biomarkers for ischemic stroke and transient ischemic attack
    • Jensen, M.B.; Chacon, M.R.; Sattin, J.A.; Aleu, A.; Lyden, P.D. The promise and potential pitfalls of serum biomarkers for ischemic stroke and transient ischemic attack. Neurologist 2008, 14, 243-246.
    • (2008) Neurologist , vol.14 , pp. 243-246
    • Jensen, M.B.1    Chacon, M.R.2    Sattin, J.A.3    Aleu, A.4    Lyden, P.D.5
  • 11
    • 0017698392 scopus 로고
    • Immunologic tests in diagnosis of cancer
    • R.B. Immunologic tests in diagnosis of cancer. Am. J. Clin. Pathol. 1977, 68, 688-698.
    • (1977) Am. J. Clin. Pathol. , vol.68 , pp. 688-698
  • 15
    • 38349068615 scopus 로고    scopus 로고
    • French Group GTE (Groupe des Tumeurs Endocrines) Reference range of serum calcitonin levels in humans: Influence of calcitonin assays, sex, age, and cigarette smoking
    • d'Herbomez, M.; Caron, P.; Bauters, C.; Cao, C.D.; Schlienger, J.L.; Sapin, R.; Baldet, L.; Carnaille, B.; Wémeau, J.L.; French Group GTE (Groupe des Tumeurs Endocrines) Reference range of serum calcitonin levels in humans: influence of calcitonin assays, sex, age, and cigarette smoking. Eur. J. Endocrinol. 2007, 157, 749-755.
    • (2007) Eur. J. Endocrinol. , vol.157 , pp. 749-755
    • D'Herbomez, M.1    Caron, P.2    Bauters, C.3    Cao, C.D.4    Schlienger, J.L.5    Sapin, R.6    Baldet, L.7    Carnaille, B.8    Wémeau, J.L.9
  • 18
    • 17744381151 scopus 로고    scopus 로고
    • Preoperative calcitonin levels are predictive of tumor size and postoperative calcitonin normalization in medullary thyroid carcinoma. Groupe d'Etudes des Tumeurs a Calcitonine (GETC)
    • Cohen, R.; Campos, J.M.; Salaün, C.; Heshmati, H.M.; Kraimps, J.L.; Proye, C.; Sarfati, E.; Henry, J.F.; Niccoli-Sire, P.; Modigliani, E. Preoperative calcitonin levels are predictive of tumor size and postoperative calcitonin normalization in medullary thyroid carcinoma. Groupe d'Etudes des Tumeurs a Calcitonine (GETC). J. Clin. Endocrinol. Metab. 2000, 85, 919-922.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 919-922
    • Cohen, R.1    Campos, J.M.2    Salaün, C.3    Heshmati, H.M.4    Kraimps, J.L.5    Proye, C.6    Sarfati, E.7    Henry, J.F.8    Niccoli-Sire, P.9    Modigliani, E.10
  • 20
    • 0019979976 scopus 로고
    • The prognostic and biological significance of cellular heterogeneity in medullary thyroid carcinoma: A study of calcitonin, L-dopa decarboxylase, and histaminase
    • Lippman, S.M.; Mendelsohn, G.; Trump, D.L.; Wells, S.A.; Baylin, S.B. The prognostic and biological significance of cellular heterogeneity in medullary thyroid carcinoma: a study of calcitonin, L-dopa decarboxylase, and histaminase. J. Clin. Endocrinol. Metab. 1982, 54, 233-240.
    • (1982) J. Clin. Endocrinol. Metab. , vol.54 , pp. 233-240
    • Lippman, S.M.1    Mendelsohn, G.2    Trump, D.L.3    Wells, S.A.4    Baylin, S.B.5
  • 23
    • 45749136399 scopus 로고    scopus 로고
    • Lessons from a review of thyroglobulin assays in the management of thyroid cancer
    • Wong, J.; Lu, Z.; Doery, J.; Fuller, P. Lessons from a review of thyroglobulin assays in the management of thyroid cancer. Intern. Med. J. 2008, 38, 441-444.
    • (2008) Intern. Med. J. , vol.38 , pp. 441-444
    • Wong, J.1    Lu, Z.2    Doery, J.3    Fuller, P.4
  • 24
    • 2442582438 scopus 로고    scopus 로고
    • Thyroglobulin: A specific serum marker for the management of thyroid carcinoma
    • Whitley, R.J.; Ain, K.B. Thyroglobulin: a specific serum marker for the management of thyroid carcinoma. Clin. Lab. Med. 2004, 24, 29-47.
    • (2004) Clin. Lab. Med. , vol.24 , pp. 29-47
    • Whitley, R.J.1    Ain, K.B.2
  • 26
    • 26244449954 scopus 로고    scopus 로고
    • Clinical impact of thyroglobulin (Tg) and Tg autoantibody method differences on the management of patients with differentiated thyroid carcinomas
    • Spencer, C.A.; Bergoglio, L.M.; Kazarosyan, M.; Fatemi, S.; LoPresti, J.S. Clinical impact of thyroglobulin (Tg) and Tg autoantibody method differences on the management of patients with differentiated thyroid carcinomas. J. Clin. Endocrinol. Metab. 2005, 90, 5566-5575.
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 5566-5575
    • Spencer, C.A.1    Bergoglio, L.M.2    Kazarosyan, M.3    Fatemi, S.4    Lopresti, J.S.5
  • 28
    • 0020508474 scopus 로고
    • The value of serum thyroglobulin measurement in clinical practice
    • Refetoff, S.; Lever, E.G. The value of serum thyroglobulin measurement in clinical practice. JAMA 1983, 250, 2352-2357.
    • (1983) JAMA , vol.250 , pp. 2352-2357
    • Refetoff, S.1    Lever, E.G.2
  • 29
    • 33745188459 scopus 로고    scopus 로고
    • Quantitation of thyroid peroxidase mRNA in peripheral blood for early detection of thyroid papillary carcinoma
    • Ishikawa, T.; Miwa, M.; Uchida, K. Quantitation of thyroid peroxidase mRNA in peripheral blood for early detection of thyroid papillary carcinoma. Thyroid 2006, 16, 435-442.
    • (2006) Thyroid , vol.16 , pp. 435-442
    • Ishikawa, T.1    Miwa, M.2    Uchida, K.3
  • 30
    • 0024520606 scopus 로고
    • Alternative splicing may be responsible for heterogeneity of thyroglobulin structure
    • Mercken, L.; Simons, M.J.; Brocas, H.; Vassart, G. Alternative splicing may be responsible for heterogeneity of thyroglobulin structure. Biochimie 1989, 71, 223-226.
    • (1989) Biochimie , vol.71 , pp. 223-226
    • Mercken, L.1    Simons, M.J.2    Brocas, H.3    Vassart, G.4
  • 31
    • 4043077648 scopus 로고    scopus 로고
    • Detection of thyrotropin-receptor messenger ribonucleic acid (mRNA) and thyroglobulin mRNA transcripts in peripheral blood of patients with thyroid disease: Sensitive and specific markers for thyroid cancer
    • Chinnappa, P.; Taguba, L.; Arciaga, R.; Faiman, C.; Siperstein, A.; Mehta, A.E.; Reddy, S.K.; Nasr, C.; Gupta, M.K. Detection of thyrotropin-receptor messenger ribonucleic acid (mRNA) and thyroglobulin mRNA transcripts in peripheral blood of patients with thyroid disease: sensitive and specific markers for thyroid cancer. J. Clin. Endocrinol. Metab. 2004, 89, 3705-3709.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 3705-3709
    • Chinnappa, P.1    Taguba, L.2    Arciaga, R.3    Faiman, C.4    Siperstein, A.5    Mehta, A.E.6    Reddy, S.K.7    Nasr, C.8    Gupta, M.K.9
  • 35
    • 0026575904 scopus 로고
    • Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland
    • Ito, T.; Seyama, T.; Mizuno, T.; Tsuyama, N.; Hayashi, T.; Hayashi, Y.; Dohi, K.; Nakamura, N.; Akiyama, M. Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland. Cancer Res. 1992, 52, 1369-1371.
    • (1992) Cancer Res , vol.52 , pp. 1369-1371
    • Ito, T.1    Seyama, T.2    Mizuno, T.3    Tsuyama, N.4    Hayashi, T.5    Hayashi, Y.6    Dohi, K.7    Nakamura, N.8    Akiyama, M.9
  • 36
    • 0026600358 scopus 로고
    • TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas
    • Greco, A.; Pierotti, M.A.; Bongarzone, I.; Pagliardini, S.; Lanzi, C.; Della Porta, G. TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. Oncogene 1992, 7, 237-242.
    • (1992) Oncogene , vol.7 , pp. 237-242
    • Greco, A.1    Pierotti, M.A.2    Bongarzone, I.3    Pagliardini, S.4    Lanzi, C.5    della Porta, G.6
  • 38
    • 0037379904 scopus 로고    scopus 로고
    • High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
    • Kimura, E.T.; Nikiforova, M.N.; Zhu, Z.; Knauf, J.A.; Nikiforov, Y.E.; Fagin, J.A. High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res. 2003, 63, 1454-1457.
    • (2003) Cancer Res , vol.63 , pp. 1454-1457
    • Kimura, E.T.1    Nikiforova, M.N.2    Zhu, Z.3    Knauf, J.A.4    Nikiforov, Y.E.5    Fagin, J.A.6
  • 39
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • M. BRAF mutation in thyroid cancer. Endocr. Relat. Cancer 2005, 12, 245-262.
    • (2005) Endocr. Relat. Cancer , vol.12 , pp. 245-262
  • 40
    • 0035986363 scopus 로고    scopus 로고
    • RET/PTC rearrangement in thyroid tumors
    • Nikiforov, Y.E. RET/PTC rearrangement in thyroid tumors. Endocr. Pathol. 2002, 13, 3-16.
    • (2002) Endocr. Pathol. , vol.13 , pp. 3-16
    • Nikiforov, Y.E.1
  • 41
    • 0029907969 scopus 로고    scopus 로고
    • Prevalence of activating ras mutations in morphologically characterized thyroid nodules
    • Ezzat, S.; Zheng, L.; Kolenda, J.; Safarian, A.; Freeman, J.L.; Asa, S.L. Prevalence of activating ras mutations in morphologically characterized thyroid nodules. Thyroid 1996, 6, 409-416.
    • (1996) Thyroid , vol.6 , pp. 409-416
    • Ezzat, S.1    Zheng, L.2    Kolenda, J.3    Safarian, A.4    Freeman, J.L.5    Asa, S.L.6
  • 44
    • 77950939830 scopus 로고    scopus 로고
    • Rearrangements of NTRK1 gene in papillary thyroid carcinoma
    • Greco, A.; Miranda, C.; Pierotti, M.A. Rearrangements of NTRK1 gene in papillary thyroid carcinoma. Mol. Cell Endocrinol. 2009, 321, 44-49.
    • (2009) Mol. Cell Endocrinol. , vol.321 , pp. 44-49
    • Greco, A.1    Miranda, C.2    Pierotti, M.A.3
  • 49
    • 27744512441 scopus 로고    scopus 로고
    • The BRAF mutation is not associated with poor prognostic factors in Korean patients with conventional papillary thyroid microcarcinoma
    • Kim, T.Y.; Kim, W.B.; Song, J.Y.; Rhee, Y.S.; Gong, G.; Cho, Y.M.; Kim, S.Y.; Kim, S.C.; Hong, S.J.; Shong, Y.K. The BRAF mutation is not associated with poor prognostic factors in Korean patients with conventional papillary thyroid microcarcinoma. Clin. Endocrinol. (Oxf.) 2005, 63, 588-593.
    • (2005) Clin. Endocrinol. (Oxf.) , vol.63 , pp. 588-593
    • Kim, T.Y.1    Kim, W.B.2    Song, J.Y.3    Rhee, Y.S.4    Gong, G.5    Cho, Y.M.6    Kim, S.Y.7    Kim, S.C.8    Hong, S.J.9    Shong, Y.K.10
  • 50
    • 34250893789 scopus 로고    scopus 로고
    • Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid: A meta-analysis
    • Lee, J.H.; Lee, E.S.; Kim, Y.S. Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid: a meta-analysis. Cancer 2007, 110, 38-46.
    • (2007) Cancer , vol.110 , pp. 38-46
    • Lee, J.H.1    Lee, E.S.2    Kim, Y.S.3
  • 51
    • 0022330363 scopus 로고
    • Activation of a novel human transforming gene, ret, by DNA rearrangement
    • Takahashi, M.; Ritz, J.; Cooper, G.M. Activation of a novel human transforming gene, ret, by DNA rearrangement. Cell 1985, 42, 581-588.
    • (1985) Cell , vol.42 , pp. 581-588
    • Takahashi, M.1    Ritz, J.2    Cooper, G.M.3
  • 53
    • 0024208663 scopus 로고
    • Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains
    • Takahashi, M.; Buma, Y.; Iwamoto, T.; Inaguma, Y.; Ikeda, H.; Hiai, H. Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene 1988, 3, 571-578.
    • (1988) Oncogene , vol.3 , pp. 571-578
    • Takahashi, M.1    Buma, Y.2    Iwamoto, T.3    Inaguma, Y.4    Ikeda, H.5    Hiai, H.6
  • 56
    • 0027232451 scopus 로고
    • Localisation of the gene for multiple endocrine neoplasia type 2A to a 480 kb region in chromosome band 10q11.2
    • Mole, S.E.; Mulligan, L.M.; Healey, C.S.; Ponder, B.A.; Tunnacliffe, A. Localisation of the gene for multiple endocrine neoplasia type 2A to a 480 kb region in chromosome band 10q11.2. Hum. Mol. Genet. 1993, 2, 247-252.
    • (1993) Hum. Mol. Genet. , vol.2 , pp. 247-252
    • Mole, S.E.1    Mulligan, L.M.2    Healey, C.S.3    Ponder, B.A.4    Tunnacliffe, A.5
  • 60
    • 67749130797 scopus 로고    scopus 로고
    • Medullary thyroid cancer: Management guidelines of the American Thyroid Association
    • American Thyroid Association Guidelines Task Force
    • American Thyroid Association Guidelines Task Force; Kloos, R.T.; Eng, C.; Evans, D.B.; Francis, G.L.; Gagel, R.F.; Gharib, H.; Moley, J.F.; Pacini, F.; Ringel, M.D.; et al. Medullary thyroid cancer: management guidelines of the American Thyroid Association. Thyroid 2009, 19, 565-612.
    • (2009) Thyroid , vol.19 , pp. 565-612
    • Kloos, R.T.1    Eng, C.2    Evans, D.B.3    Francis, G.L.4    Gagel, R.F.5    Gharib, H.6    Moley, J.F.7    Pacini, F.8    Ringel, M.D.9
  • 63
    • 56349145548 scopus 로고    scopus 로고
    • Clinical significance of p53 protein expression in papillary thyroid carcinoma
    • Morita, N.; Ikeda, Y.; Takami, H. Clinical significance of p53 protein expression in papillary thyroid carcinoma. World J. Surg. 2008, 32, 2617-2622.
    • (2008) World J. Surg. , vol.32 , pp. 2617-2622
    • Morita, N.1    Ikeda, Y.2    Takami, H.3
  • 65
    • 0031783481 scopus 로고    scopus 로고
    • Prevalences of Gs alpha, ras, p53 mutations and ret/PTC rearrangement in differentiated thyroid tumours in a Korean population
    • Park, K.Y.; Koh, J.M.; Kim, Y.I.; Park, H.J.; Gong, G.; Hong, S.J.; Ahn, I.M. Prevalences of Gs alpha, ras, p53 mutations and ret/PTC rearrangement in differentiated thyroid tumours in a Korean population. Clin. Endocrinol. (Oxf) 1998, 49, 317-323.
    • (1998) Clin. Endocrinol. (Oxf) , vol.49 , pp. 317-323
    • Park, K.Y.1    Koh, J.M.2    Kim, Y.I.3    Park, H.J.4    Gong, G.5    Hong, S.J.6    Ahn, I.M.7
  • 66
    • 0029671093 scopus 로고    scopus 로고
    • bcl-2, p53 and proliferating cell nuclear antigen expression is related to the degree of differentiation in thyroid carcinomas
    • Pollina, L.; Pacini, F.; Fontanini, G.; Vignati, S.; Bevilacqua, G.; Basolo, F. bcl-2, p53 and proliferating cell nuclear antigen expression is related to the degree of differentiation in thyroid carcinomas. Br. J. Cancer 1996, 73, 139-143.
    • (1996) Br. J. Cancer , vol.73 , pp. 139-143
    • Pollina, L.1    Pacini, F.2    Fontanini, G.3    Vignati, S.4    Bevilacqua, G.5    Basolo, F.6
  • 67
    • 79952268339 scopus 로고    scopus 로고
    • Prognostic significance of RET and NTRK 1 rearrangements in sporadic papillary thyoid carcinoma
    • Musholt, T.J.; Musholt, P.B.; Khaladj, N.; Schulz, D.; Scheumann, G.F.W.; Klempnauer, J. Prognostic significance of RET and NTRK 1 rearrangements in sporadic papillary thyoid carcinoma. Br. J. Surg. 2000, 87, 1256-1278.
    • (2000) Br. J. Surg. , vol.87 , pp. 1256-1278
    • Musholt, T.J.1    Musholt, P.B.2    Khaladj, N.3    Schulz, D.4    Scheumann, G.F.W.5    Klempnauer, J.6
  • 69
    • 0027285475 scopus 로고
    • Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
    • Ionov, Y.; Peinado, M.A.; Malkhosyan, S.; Shibata, D.; Perucho, M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 1993, 363, 558-561.
    • (1993) Nature , vol.363 , pp. 558-561
    • Ionov, Y.1    Peinado, M.A.2    Malkhosyan, S.3    Shibata, D.4    Perucho, M.5
  • 71
    • 0035181352 scopus 로고    scopus 로고
    • Microsatellite instability in thyroid cancer: Hot spots, clinicopathological implications, and prognostic significance
    • Onda, M.; Nakamura, I.; Suzuki, S.; Takenoshita, S.; Brogren, C.H.; Stampanoni, S.; Li, D.; Rampino, N. Microsatellite instability in thyroid cancer: hot spots, clinicopathological implications, and prognostic significance. Clin. Cancer Res. 2001, 7, 3444-3449.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3444-3449
    • Onda, M.1    Nakamura, I.2    Suzuki, S.3    Takenoshita, S.4    Brogren, C.H.5    Stampanoni, S.6    Li, D.7    Rampino, N.8
  • 72
    • 53249088265 scopus 로고    scopus 로고
    • Microsatellite instability in benign and malignant thyroid neoplasms
    • Mitmaker, E.; Alvarado, C.; Bégin, L.R.; Trifiro, M. Microsatellite instability in benign and malignant thyroid neoplasms. J. Surg. Res. 2008, 150, 40-48.
    • (2008) J. Surg. Res. , vol.150 , pp. 40-48
    • Mitmaker, E.1    Alvarado, C.2    Bégin, L.R.3    Trifiro, M.4
  • 74
    • 33847073463 scopus 로고    scopus 로고
    • Gene methylation in thyroid tumorigenesis
    • Xing, M. Gene methylation in thyroid tumorigenesis. Endocrinology 2007, 148, 948-953.
    • (2007) Endocrinology , vol.148 , pp. 948-953
    • Xing, M.1
  • 78
    • 0842278570 scopus 로고    scopus 로고
    • Epigenetic changes in colorectal cancer
    • Kondo, Y.; Issa, J.P.J. Epigenetic changes in colorectal cancer. Cancer Metastasis Rev. 2004, 23, 29-39.
    • (2004) Cancer Metastasis Rev , vol.23 , pp. 29-39
    • Kondo, Y.1    Issa, J.P.J.2
  • 79
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee, R.C.; Feinbaum, R.L.; Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993, 75, 843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 80
    • 65949090276 scopus 로고    scopus 로고
    • MicroRNA Gene Networks in Oncogenesis
    • Drakaki, A.; Iliopoulos, D. MicroRNA Gene Networks in Oncogenesis. Curr. Genomics 2009, 10, 35-41.
    • (2009) Curr. Genomics , vol.10 , pp. 35-41
    • Drakaki, A.1    Iliopoulos, D.2
  • 81
    • 49749150573 scopus 로고    scopus 로고
    • microRNAs and cancer: An overview
    • Medina, P.P.; Slack, F.J. microRNAs and cancer: an overview. Cell Cycle 2008, 7, 2485-2492.
    • (2008) Cell Cycle , vol.7 , pp. 2485-2492
    • Medina, P.P.1    Slack, F.J.2
  • 84
    • 50249103246 scopus 로고    scopus 로고
    • MicroRNA analysis as a potential diagnostic tool for papillary thyroid carcinoma
    • Chen, Y.T.; Kitabayashi, N.; Zhou, X.K.; Fahey, T.J.; Scognamiglio, T. MicroRNA analysis as a potential diagnostic tool for papillary thyroid carcinoma. Mod. Pathol. 2008, 21, 1139-1146.
    • (2008) Mod. Pathol. , vol.21 , pp. 1139-1146
    • Chen, Y.T.1    Kitabayashi, N.2    Zhou, X.K.3    Fahey, T.J.4    Scognamiglio, T.5
  • 85
    • 0003034978 scopus 로고
    • A new discipline, a new name, a new journal
    • McKusick, V.A.; Ruddle, F.H. A new discipline, a new name, a new journal. Genomics 1987, 1, 1-2.
    • (1987) Genomics , vol.1 , pp. 1-2
    • McKusick, V.A.1    Ruddle, F.H.2
  • 86
    • 84934443925 scopus 로고    scopus 로고
    • Technological platforms for microarray gene expression profiling
    • S. Technological platforms for microarray gene expression profiling. Adv. Exp. Med. Biol. 2007, 593, 12-18.
    • (2007) Adv. Exp. Med. Biol. , vol.593 , pp. 12-18
  • 87
    • 34247195104 scopus 로고    scopus 로고
    • Microarrays: An overview
    • Lee, N.H.; Saeed, A.I. Microarrays: an overview. Methods Mol. Biol. 2007, 353, 265-300.
    • (2007) Methods Mol. Biol. , vol.353 , pp. 265-300
    • Lee, N.H.1    Saeed, A.I.2
  • 88
    • 33644844520 scopus 로고    scopus 로고
    • Microarray technology: Beyond transcript profiling and genotype analysis
    • Hoheisel, J.D. Microarray technology: beyond transcript profiling and genotype analysis. Nat. Rev. Genet. 2006, 7, 200-210.
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 200-210
    • Hoheisel, J.D.1
  • 90
    • 27144556185 scopus 로고    scopus 로고
    • Molecular classification of papillary thyroid carcinoma: Distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis
    • Giordano, T.J.; Kuick, R.; Thomas, D.G.; Misek, D.E.; Vinco, M.; Sanders, D.; Zhu, Z.; Ciampi, R.; Roh, M.; Shedden, K.; et al. Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis. Oncogene 2005, 24, 6646-6656.
    • (2005) Oncogene , vol.24 , pp. 6646-6656
    • Giordano, T.J.1    Kuick, R.2    Thomas, D.G.3    Misek, D.E.4    Vinco, M.5    Sanders, D.6    Zhu, Z.7    Ciampi, R.8    Roh, M.9    Shedden, K.10
  • 91
    • 20044391422 scopus 로고    scopus 로고
    • Expression profiling reveals a distinct transcription signature in follicular thyroid carcinomas with a PAX8-PPAR(gamma) fusion oncogene
    • Lui, W.O.; Foukakis, T.; Lidén, J.; Thoppe, S.R.; Dwight, T.; Höög, A.; Zedenius, J.; Wallin, G.; Reimers, M.; Larsson, C. Expression profiling reveals a distinct transcription signature in follicular thyroid carcinomas with a PAX8-PPAR(gamma) fusion oncogene. Oncogene 2005, 24, 1467-1476.
    • (2005) Oncogene , vol.24 , pp. 1467-1476
    • Lui, W.O.1    Foukakis, T.2    Lidén, J.3    Thoppe, S.R.4    Dwight, T.5    Höög, A.6    Zedenius, J.7    Wallin, G.8    Reimers, M.9    Larsson, C.10
  • 93
    • 34548588388 scopus 로고    scopus 로고
    • Genome-wide gene expression profiling suggests distinct radiation susceptibilities in sporadic and post-Chernobyl papillary thyroid cancers
    • Detours, V.; Delys, L.; Libert, F.; Weiss Solís, D.; Bogdanova, T.; Dumont, J.E.; Franc, B.; Thomas, G.; Maenhaut, C. Genome-wide gene expression profiling suggests distinct radiation susceptibilities in sporadic and post-Chernobyl papillary thyroid cancers. Br. J. Cancer 2007, 97, 818-825.
    • (2007) Br. J. Cancer , vol.97 , pp. 818-825
    • Detours, V.1    Delys, L.2    Libert, F.3    Weiss Solís, D.4    Bogdanova, T.5    Dumont, J.E.6    Franc, B.7    Thomas, G.8    Maenhaut, C.9
  • 94
    • 33750943691 scopus 로고    scopus 로고
    • Meta-analysis and meta-review of thyroid cancer gene expression profiling studies identifies important diagnostic biomarkers
    • Griffith, O.L.; Melck, A.; Jones, S.J.; Wiseman, S.M. Meta-analysis and meta-review of thyroid cancer gene expression profiling studies identifies important diagnostic biomarkers. J. Clin. Oncol. 2006, 24, 5043-5051.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 5043-5051
    • Griffith, O.L.1    Melck, A.2    Jones, S.J.3    Wiseman, S.M.4
  • 96
    • 40149103478 scopus 로고    scopus 로고
    • Application of immunohistochemistry to thyroid neoplasms
    • Fischer, S.; Asa, S.L. Application of immunohistochemistry to thyroid neoplasms. Arch. Pathol. Lab. Med. 2008, 132, 359-372.
    • (2008) Arch. Pathol. Lab. Med. , vol.132 , pp. 359-372
    • Fischer, S.1    Asa, S.L.2
  • 98
    • 34548665494 scopus 로고    scopus 로고
    • Galectin-3 is highly expressed in nonencapsulated papillary thyroid carcinoma but weakly expressed in encapsulated type; comparison with Hector Battifora mesothelial cell 1 immunoreactivity
    • Torregrossa, L.; Faviana, P.; Camacci, T.; Materazzi, G.; Berti, P.; Minuto, M.; Elisei, R.; Vitti, P.; Miccoli, P.; Basolo, F. Galectin-3 is highly expressed in nonencapsulated papillary thyroid carcinoma but weakly expressed in encapsulated type; comparison with Hector Battifora mesothelial cell 1 immunoreactivity. Hum. Pathol. 2007, 38, 1482-1488.
    • (2007) Hum. Pathol. , vol.38 , pp. 1482-1488
    • Torregrossa, L.1    Faviana, P.2    Camacci, T.3    Materazzi, G.4    Berti, P.5    Minuto, M.6    Elisei, R.7    Vitti, P.8    Miccoli, P.9    Basolo, F.10
  • 99
    • 55249102910 scopus 로고    scopus 로고
    • Galectin-3 expression in tumor progression and metastasis of papillary thyroid carcinoma
    • Türköz, H.K.; Oksüz, H.; Yurdakul, Z.; Ozcan, D. Galectin-3 expression in tumor progression and metastasis of papillary thyroid carcinoma. Endocr. Pathol. 2008, 19, 92-96.
    • (2008) Endocr. Pathol. , vol.19 , pp. 92-96
    • Türköz, H.K.1    Oksüz, H.2    Yurdakul, Z.3    Ozcan, D.4
  • 101
    • 33744456468 scopus 로고    scopus 로고
    • Simultaneous immunohistochemical expression of HBME-1 and galectin-3 differentiates papillary carcinomas from hyperfunctioning lesions of the thyroid
    • Rossi, E.D.; Raffaelli, M.; Mule', A.; Miraglia, A.; Lombardi, C.P.; Vecchio, F.M.; Fadda, G. Simultaneous immunohistochemical expression of HBME-1 and galectin-3 differentiates papillary carcinomas from hyperfunctioning lesions of the thyroid. Histopathology 2006, 48, 795-800.
    • (2006) Histopathology , vol.48 , pp. 795-800
    • Rossi, E.D.1    Raffaelli, M.2    Mule', A.3    Miraglia, A.4    Lombardi, C.P.5    Vecchio, F.M.6    Fadda, G.7
  • 102
    • 21244455609 scopus 로고    scopus 로고
    • Characterization of thyroid 'follicular neoplasms' in fine-needle aspiration cytological specimens using a panel of immunohistochemical markers: A proposal for clinical application
    • Saggiorato, E.; De Pompa, R.; Volante, M.; Cappia, S.; Arecco, F.; Dei Tos, A.P.; Orlandi, F.; Papotti, M. Characterization of thyroid 'follicular neoplasms' in fine-needle aspiration cytological specimens using a panel of immunohistochemical markers: a proposal for clinical application. Endocr. Relat. Cancer 2005, 12, 305-317.
    • (2005) Endocr. Relat. Cancer , vol.12 , pp. 305-317
    • Saggiorato, E.1    de Pompa, R.2    Volante, M.3    Cappia, S.4    Arecco, F.5    Dei Tos, A.P.6    Orlandi, F.7    Papotti, M.8
  • 103
    • 33750736320 scopus 로고    scopus 로고
    • Diagnostic usefulness of HBME1, galectin-3, CK19, and CITED1 and evaluation of their expression in encapsulated lesions with questionable features of papillary thyroid carcinoma
    • Scognamiglio, T.; Hyjek, E.; Kao, J.; Chen, Y.T. Diagnostic usefulness of HBME1, galectin-3, CK19, and CITED1 and evaluation of their expression in encapsulated lesions with questionable features of papillary thyroid carcinoma. Am. J. Clin. Pathol. 2006, 126, 700-708.
    • (2006) Am. J. Clin. Pathol. , vol.126 , pp. 700-708
    • Scognamiglio, T.1    Hyjek, E.2    Kao, J.3    Chen, Y.T.4
  • 106
    • 22044453230 scopus 로고    scopus 로고
    • Recent advances in biomarkers for cancer diagnosis and treatment
    • Manne, U.; Srivastava, R.G.; Srivastava, S. Recent advances in biomarkers for cancer diagnosis and treatment. Drug Discov. Today 2005, 10, 965-976.
    • (2005) Drug Discov. Today , vol.10 , pp. 965-976
    • Manne, U.1    Srivastava, R.G.2    Srivastava, S.3
  • 107
    • 33749640642 scopus 로고    scopus 로고
    • Application of serum protein fingerprint in diagnosis of papillary thyroid carcinoma
    • Wang, J.X.; Yu, J.K.; Wang, L.; Liu, Q.L.; Zhang, J.; Zheng, S. Application of serum protein fingerprint in diagnosis of papillary thyroid carcinoma. Proteomics 2006, 6, 5344-5349.
    • (2006) Proteomics , vol.6 , pp. 5344-5349
    • Wang, J.X.1    Yu, J.K.2    Wang, L.3    Liu, Q.L.4    Zhang, J.5    Zheng, S.6
  • 108
    • 0038662530 scopus 로고    scopus 로고
    • Proteomic applications for the early detection of cancer
    • Wulfkuhle, J.D.; Liotta, L.A.; Petricoin, E.F. Proteomic applications for the early detection of cancer. Nat. Rev. Cancer 2003, 3, 267-275.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 267-275
    • Wulfkuhle, J.D.1    Liotta, L.A.2    Petricoin, E.F.3
  • 109
    • 23944490671 scopus 로고    scopus 로고
    • Place of pattern in proteomic biomarker discovery
    • Gillette, M.A.; Mani, D.R.; Carr, S.A. Place of pattern in proteomic biomarker discovery. J. Proteome Res. 2005, 4, 1143-1154.
    • (2005) J. Proteome Res. , vol.4 , pp. 1143-1154
    • Gillette, M.A.1    Mani, D.R.2    Carr, S.A.3
  • 110
    • 1242316198 scopus 로고    scopus 로고
    • Ultra-high-efficiency strong cation exchange LC/RPLC/MS/MS for high dynamic range characterization of the human plasma proteome
    • Shen, Y.; Jacobs, J.M.; Camp, D.G.; Fang, R.; Moore, R.J.; Smith, R.D.; Xiao, W.; Davis, R.W.; Tompkins, R.G. Ultra-High-Efficiency Strong Cation Exchange LC/RPLC/MS/MS for High Dynamic Range Characterization of the Human Plasma Proteome. Anal. Chem. 2004, 76, 1134-1144.
    • (2004) Anal. Chem. , vol.76 , pp. 1134-1144
    • Shen, Y.1    Jacobs, J.M.2    Camp, D.G.3    Fang, R.4    Moore, R.J.5    Smith, R.D.6    Xiao, W.7    Davis, R.W.8    Tompkins, R.G.9
  • 114
    • 0033152788 scopus 로고    scopus 로고
    • Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides
    • Nair, S.; Wearsch, P.A.; Mitchell, D.A.; Wassenberg, J.J.; Gilboa, E.; Nicchitta, C.V. Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides. J. Immunol. 1999, 162, 6426-6432.
    • (1999) J. Immunol. , vol.162 , pp. 6426-6432
    • Nair, S.1    Wearsch, P.A.2    Mitchell, D.A.3    Wassenberg, J.J.4    Gilboa, E.5    Nicchitta, C.V.6
  • 121
    • 70449336932 scopus 로고    scopus 로고
    • Discovery and identification of potential biomarkers of papillary thyroid carcinoma
    • Fan, Y.; Shi, L.; Liu, Q.; Dong, R.; Zhang, Q.; Yang, S.; Fan, Y.; Yang, H.; Wu, P.; Yu, J.; et al. Discovery and identification of potential biomarkers of papillary thyroid carcinoma. Mol. Cancer. 2009, 8, 79.
    • (2009) Mol. Cancer , vol.8 , pp. 79
    • Fan, Y.1    Shi, L.2    Liu, Q.3    Dong, R.4    Zhang, Q.5    Yang, S.6    Fan, Y.7    Yang, H.8    Wu, P.9    Yu, J.10
  • 122
    • 33645759443 scopus 로고    scopus 로고
    • Pilot study using SELDI-TOF-MS based proteomic profile for the identification of diagnostic biomarkers of thyroid proliferative diseases
    • Suriano, R.; Lin, Y.; Ashok, B.T.; Schaefer, S.D.; Schantz, S.P.; Geliebter, J.; Tiwari, R.K. Pilot study using SELDI-TOF-MS based proteomic profile for the identification of diagnostic biomarkers of thyroid proliferative diseases. J. Proteome Res. 2006, 5, 856-861.
    • (2006) J. Proteome Res. , vol.5 , pp. 856-861
    • Suriano, R.1    Lin, Y.2    Ashok, B.T.3    Schaefer, S.D.4    Schantz, S.P.5    Geliebter, J.6    Tiwari, R.K.7
  • 124
  • 125
    • 0035812772 scopus 로고    scopus 로고
    • HIF-1, O(2), and the 3 PHDs: How animal cells signal hypoxia to the nucleus
    • Semenza, G.L. HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 2001, 107, 1-3.
    • (2001) Cell , vol.107 , pp. 1-3
    • Semenza, G.L.1
  • 127
    • 68549098240 scopus 로고    scopus 로고
    • Cell surface and secreted protein profiles of human thyroid cancer cell lines reveal distinct glycoprotein patterns
    • Arcinas, A.; Yen, T.Y.; Kebebew, E.; Macher, B.A. Cell surface and secreted protein profiles of human thyroid cancer cell lines reveal distinct glycoprotein patterns. J. Proteome Res. 2009, 8, 3958-3968.
    • (2009) J. Proteome Res. , vol.8 , pp. 3958-3968
    • Arcinas, A.1    Yen, T.Y.2    Kebebew, E.3    Macher, B.A.4
  • 129
    • 33744730025 scopus 로고    scopus 로고
    • Personalized medicine and development of targeted therapies: The upcoming challenge for diagnostic molecular pathology
    • Dietel, M.; Sers, C. Personalized medicine and development of targeted therapies: The upcoming challenge for diagnostic molecular pathology. A review. Virchows Arch. 2006, 448, 744-755.
    • (2006) A review Virchows Arch , vol.448 , pp. 744-755
    • Dietel, M.1    Sers, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.