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Volumn 266, Issue 1, 2009, Pages 126-140

Medullary thyroid carcinoma and biomarkers: Past, present and future

Author keywords

Biomarker; Doubling time; Imaging; Prognosis; RET; Targeted therapy

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; 4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; 6 FLUORODOPA F 18; ANTIBODY CONJUGATE; AXITINIB; CALCITONIN; CARCINOEMBRYONIC ANTIBODY; CARCINOEMBRYONIC ANTIBODY I 131; CARCINOEMBRYONIC ANTIGEN; CEP 751; CHOLECYSTOKININ B RECEPTOR; DOTATOC Y 90; FLUORODEOXYGLUCOSE F 18; GASTRIN RECEPTOR; GELATINASE A; IMATINIB; LABETUZUMAB; LESTAURTINIB; MOTESANIB; OCTREOTIDE; PENTETREOTIDE; PENTETREOTIDE IN 111; PROTEIN TYROSINE KINASE INHIBITOR; RPI 1; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR 2; SORAFENIB; SUNITINIB; TUMOR MARKER; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB;

EID: 66849087637     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2009.02106.x     Document Type: Conference Paper
Times cited : (53)

References (136)
  • 1
    • 85047682409 scopus 로고    scopus 로고
    • Guidelines for diagnosis and therapy of MEN type 1 and type 2
    • Brandi ML, Gagel RF, Angeli A et al. Guidelines for diagnosis and therapy of MEN type 1 and type 2. J Clin Endocrinol Metab 2001 86 : 5658 71.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5658-71
    • Brandi, M.L.1    Gagel, R.F.2    Angeli, A.3
  • 2
    • 33747080744 scopus 로고    scopus 로고
    • RET as a diagnostic and therapeutic target in sporadic and hereditary endocrine tumors
    • de Groot JW, Links TP, Plukker JT, Lips CJ, Hofstra RM. RET as a diagnostic and therapeutic target in sporadic and hereditary endocrine tumors. Endocr Rev 2006 27 : 535 60.
    • (2006) Endocr Rev , vol.27 , pp. 535-60
    • De Groot, J.W.1    Links, T.P.2    Plukker, J.T.3    Lips, C.J.4    Hofstra, R.M.5
  • 3
    • 18344380647 scopus 로고    scopus 로고
    • Molecular genetics of multiple endocrine neoplasia types 1 and 2
    • Marx SJ. Molecular genetics of multiple endocrine neoplasia types 1 and 2. Nat Rev Cancer 2005 5 : 367 75.
    • (2005) Nat Rev Cancer , vol.5 , pp. 367-75
    • Marx, S.J.1
  • 4
    • 24044463845 scopus 로고    scopus 로고
    • Medullary thyroid cancer: Medical management and follow-up
    • Traugott A, Moley JF. Medullary thyroid cancer: medical management and follow-up. Curr Treat Options Oncol 2005 6 : 339 46.
    • (2005) Curr Treat Options Oncol , vol.6 , pp. 339-46
    • Traugott, A.1    Moley, J.F.2
  • 5
    • 0038360113 scopus 로고    scopus 로고
    • Greene FLP, D.L. Fleming, I.D. Fritz, A. Balch, C.M. Haller, D.G. Morrow, M. eds.). Philadelphia. Lippincott Raven Publishers
    • Greene FLP DL, Fleming ID, Fritz A, Balch CM, Haller DG, Morrow M (eds.). AJCC Cancer Staging Manual. Thyroid Gland. Philadelphia : Lippincott Raven Publishers, 1997.
    • (1997) AJCC Cancer Staging Manual. Thyroid Gland.
  • 6
    • 0034163301 scopus 로고    scopus 로고
    • Medullary thyroid carcinoma: Clinical characteristics, treatment, prognostic factors, and a comparison of staging systems
    • Kebebew E, Ituarte PH, Siperstein AE, Duh QY, Clark OH. Medullary thyroid carcinoma: clinical characteristics, treatment, prognostic factors, and a comparison of staging systems. Cancer 2000 88 : 1139 48.
    • (2000) Cancer , vol.88 , pp. 1139-48
    • Kebebew, E.1    Ituarte, P.H.2    Siperstein, A.E.3    Duh, Q.Y.4    Clark, O.H.5
  • 7
    • 14444272505 scopus 로고    scopus 로고
    • Prognostic factors for survival and for biochemical cure in medullary thyroid carcinoma: Results in 899 patients. the GETC Study Group. Groupe d'etude des tumeurs a calcitonine
    • Modigliani E, Cohen R, Campos JM et al. Prognostic factors for survival and for biochemical cure in medullary thyroid carcinoma: results in 899 patients. The GETC Study Group. Groupe d'etude des tumeurs a calcitonine. Clin Endocrinol (Oxf) 1998 48 : 265 73.
    • (1998) Clin Endocrinol (Oxf) , vol.48 , pp. 265-73
    • Modigliani, E.1    Cohen, R.2    Campos, J.M.3
  • 8
    • 34247142774 scopus 로고    scopus 로고
    • Natural history, diagnosis, treatment and outcome of medullary thyroid cancer: 37 years experience on 157 patients
    • Pelizzo MR, Boschin IM, Bernante P et al. Natural history, diagnosis, treatment and outcome of medullary thyroid cancer: 37 years experience on 157 patients. Eur J Surg Oncol 2007 33 : 493 7.
    • (2007) Eur J Surg Oncol , vol.33 , pp. 493-7
    • Pelizzo, M.R.1    Boschin, I.M.2    Bernante, P.3
  • 9
    • 33750509391 scopus 로고    scopus 로고
    • Prognosis of medullary thyroid carcinoma: Demographic, clinical, and pathologic predictors of survival in 1252 cases
    • Roman S, Lin R, Sosa JA. Prognosis of medullary thyroid carcinoma: demographic, clinical, and pathologic predictors of survival in 1252 cases. Cancer 2006 107 : 2134 42.
    • (2006) Cancer , vol.107 , pp. 2134-42
    • Roman, S.1    Lin, R.2    Sosa, J.A.3
  • 10
    • 35648968625 scopus 로고    scopus 로고
    • Long-term clinical and biochemical follow-up in medullary thyroid carcinoma: A single institution's experience over 20 years
    • Cupisti K, Wolf A, Raffel A et al. Long-term clinical and biochemical follow-up in medullary thyroid carcinoma: a single institution's experience over 20 years. Ann Surg 2007 246 : 815 21.
    • (2007) Ann Surg , vol.246 , pp. 815-21
    • Cupisti, K.1    Wolf, A.2    Raffel, A.3
  • 12
    • 34248158281 scopus 로고    scopus 로고
    • Evidence-based approach to the management of sporadic medullary thyroid carcinoma
    • Moley JF, Fialkowski EA. Evidence-based approach to the management of sporadic medullary thyroid carcinoma. World J Surg 2007 31 : 946 56.
    • (2007) World J Surg , vol.31 , pp. 946-56
    • Moley, J.F.1    Fialkowski, E.A.2
  • 13
    • 0028205885 scopus 로고
    • Disappearance rate of serum calcitonin after total thyroidectomy for medullary thyroid carcinoma
    • Fugazzola L, Pinchera A, Luchetti F et al. Disappearance rate of serum calcitonin after total thyroidectomy for medullary thyroid carcinoma. Int J Biol Markers 1994 9 : 21 4.
    • (1994) Int J Biol Markers , vol.9 , pp. 21-4
    • Fugazzola, L.1    Pinchera, A.2    Luchetti, F.3
  • 14
    • 0037779093 scopus 로고    scopus 로고
    • Long-term outcome of medullary thyroid carcinoma in patients with normal postoperative medical imaging
    • Pellegriti G, Leboulleux S, Baudin E et al. Long-term outcome of medullary thyroid carcinoma in patients with normal postoperative medical imaging. Br J Cancer 2003 88 : 1537 42.
    • (2003) Br J Cancer , vol.88 , pp. 1537-42
    • Pellegriti, G.1    Leboulleux, S.2    Baudin, E.3
  • 15
    • 0038369070 scopus 로고    scopus 로고
    • Rationale for central and bilateral lymph node dissection in sporadic and hereditary medullary thyroid cancer
    • Scollo C, Baudin E, Travagli JP et al. Rationale for central and bilateral lymph node dissection in sporadic and hereditary medullary thyroid cancer. J Clin Endocrinol Metab 2003 88 : 2070 5.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2070-5
    • Scollo, C.1    Baudin, E.2    Travagli, J.P.3
  • 16
    • 0034851702 scopus 로고    scopus 로고
    • Complete surgical lymph node resection does not prevent authentic recurrences of medullary thyroid carcinoma
    • Franc S, Niccoli-Sire P, Cohen R et al. Complete surgical lymph node resection does not prevent authentic recurrences of medullary thyroid carcinoma. Clin Endocrinol (Oxf) 2001 55 : 403 9.
    • (2001) Clin Endocrinol (Oxf) , vol.55 , pp. 403-9
    • Franc, S.1    Niccoli-Sire, P.2    Cohen, R.3
  • 17
    • 35748947727 scopus 로고    scopus 로고
    • Challenges of cancer biomarker profiling
    • Bensalah K, Montorsi F, Shariat SF. Challenges of cancer biomarker profiling. Eur Urol 2007 52 : 1601 9.
    • (2007) Eur Urol , vol.52 , pp. 1601-9
    • Bensalah, K.1    Montorsi, F.2    Shariat, S.F.3
  • 18
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group.
    • Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001 69 : 89 95.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
  • 19
    • 10244261646 scopus 로고    scopus 로고
    • Tumor marker utility grading system: A framework to evaluate clinical utility of tumor markers
    • Hayes DF, Bast RC, Desch CE et al. Tumor marker utility grading system: a framework to evaluate clinical utility of tumor markers. J Natl Cancer Inst 1996 88 : 1456 66.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1456-66
    • Hayes, D.F.1    Bast, R.C.2    Desch, C.E.3
  • 20
    • 50649083690 scopus 로고    scopus 로고
    • Medullary thyroid carcinoma without marked elevation of calcitonin: A diagnostic and surveillance dilemma
    • Wang TS, Ocal IT, Sosa JA, Cox H, Roman S. Medullary thyroid carcinoma without marked elevation of calcitonin: a diagnostic and surveillance dilemma. Thyroid 2008 18 : 889 94.
    • (2008) Thyroid , vol.18 , pp. 889-94
    • Wang, T.S.1    Ocal, I.T.2    Sosa, J.A.3    Cox, H.4    Roman, S.5
  • 21
    • 50649100154 scopus 로고    scopus 로고
    • Normal perioperative serum calcitonin levels in patients with advanced medullary thyroid carcinoma: Case report and review of the literature
    • Dora JM, Canalli MH, Capp C, Punales MK, Vieira JG, Maia AL. Normal perioperative serum calcitonin levels in patients with advanced medullary thyroid carcinoma: case report and review of the literature. Thyroid 2008 18 : 895 9.
    • (2008) Thyroid , vol.18 , pp. 895-9
    • Dora, J.M.1    Canalli, M.H.2    Capp, C.3    Punales, M.K.4    Vieira, J.G.5    Maia, A.L.6
  • 22
    • 33846964878 scopus 로고    scopus 로고
    • Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules
    • Costante G, Meringolo D, Durante C et al. Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules. J Clin Endocrinol Metab 2007 92 : 450 5.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 450-5
    • Costante, G.1    Meringolo, D.2    Durante, C.3
  • 23
    • 10744223544 scopus 로고    scopus 로고
    • Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: Experience in 10,864 patients with nodular thyroid disorders
    • Elisei R, Bottici V, Luchetti F et al. Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: experience in 10,864 patients with nodular thyroid disorders. J Clin Endocrinol Metab 2004 89 : 163 8.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 163-8
    • Elisei, R.1    Bottici, V.2    Luchetti, F.3
  • 24
    • 0035125612 scopus 로고    scopus 로고
    • Routine measurement of serum calcitonin is useful for early detection of medullary thyroid carcinoma in patients with nodular thyroid diseases
    • Hahm JR, Lee MS, Min YK et al. Routine measurement of serum calcitonin is useful for early detection of medullary thyroid carcinoma in patients with nodular thyroid diseases. Thyroid 2001 11 : 73 80. (Pubitemid 32140448)
    • (2001) Thyroid , vol.11 , Issue.1 , pp. 73-80
    • Hahm, J.R.1    Lee, M.-S.2    Min, Y.-K.3    Lee, M.-K.4    Kim, K.-W.5    Seok Jin Nam6    Yang, J.-H.7    Jae Hoon Chung8
  • 25
    • 33745912492 scopus 로고    scopus 로고
    • Value of routine measurement of serum calcitonin concentrations in patients with nodular thyroid disease: A multicenter study
    • Papi G, Corsello SM, Cioni K et al. Value of routine measurement of serum calcitonin concentrations in patients with nodular thyroid disease: a multicenter study. J Endocrinol Invest 2006 29 : 427 37.
    • (2006) J Endocrinol Invest , vol.29 , pp. 427-37
    • Papi, G.1    Corsello, S.M.2    Cioni, K.3
  • 26
    • 1442352328 scopus 로고    scopus 로고
    • Frequency and relevance of elevated calcitonin levels in patients with neoplastic and nonneoplastic thyroid disease and in healthy subjects
    • Karanikas G, Moameni A, Poetzi C et al. Frequency and relevance of elevated calcitonin levels in patients with neoplastic and nonneoplastic thyroid disease and in healthy subjects. J Clin Endocrinol Metab 2004 89 : 515 9.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 515-9
    • Karanikas, G.1    Moameni, A.2    Poetzi, C.3
  • 27
    • 38349068615 scopus 로고    scopus 로고
    • Reference range of serum calcitonin levels in humans: Influence of calcitonin assays, sex, age, and cigarette smoking
    • d'Herbomez M, Caron P, Bauters C et al. Reference range of serum calcitonin levels in humans: influence of calcitonin assays, sex, age, and cigarette smoking. Eur J Endocrinol 2007 157 : 749 55.
    • (2007) Eur J Endocrinol , vol.157 , pp. 749-55
    • D'Herbomez, M.1    Caron, P.2    Bauters, C.3
  • 28
    • 0037925438 scopus 로고    scopus 로고
    • Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease
    • Baloch Z, Carayon P, Conte-Devolx B et al. Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid 2003 13 : 3 126.
    • (2003) Thyroid , vol.13 , pp. 3-126
    • Baloch, Z.1    Carayon, P.2    Conte-Devolx, B.3
  • 29
    • 0037318895 scopus 로고    scopus 로고
    • Laboratory medicine practice guidelines: Laboratory support for the diagnosis and monitoring of thyroid disease
    • Demers LM, Spencer CA. Laboratory medicine practice guidelines: laboratory support for the diagnosis and monitoring of thyroid disease. Clin Endocrinol (Oxf) 2003 58 : 138 40.
    • (2003) Clin Endocrinol (Oxf) , vol.58 , pp. 138-40
    • Demers, L.M.1    Spencer, C.A.2
  • 30
    • 0037091109 scopus 로고    scopus 로고
    • Screening for medullary thyroid carcinoma: Experience with different immunoassays for human calcitonin
    • Bieglmayer C, Scheuba C, Niederle B, Flores J, Vierhapper H. Screening for medullary thyroid carcinoma: experience with different immunoassays for human calcitonin. Wien Klin Wochenschr 2002 114 : 267 73.
    • (2002) Wien Klin Wochenschr , vol.114 , pp. 267-73
    • Bieglmayer, C.1    Scheuba, C.2    Niederle, B.3    Flores, J.4    Vierhapper, H.5
  • 32
    • 17744381151 scopus 로고    scopus 로고
    • Preoperative calcitonin levels are predictive of tumor size and postoperative calcitonin normalization in medullary thyroid carcinoma. Groupe d'Etudes des Tumeurs a Calcitonine (GETC)
    • Cohen R, Campos JM, Salaun C et al. Preoperative calcitonin levels are predictive of tumor size and postoperative calcitonin normalization in medullary thyroid carcinoma. Groupe d'Etudes des Tumeurs a Calcitonine (GETC). J Clin Endocrinol Metab 2000 85 : 919 22.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 919-22
    • Cohen, R.1    Campos, J.M.2    Salaun, C.3
  • 33
    • 0036842406 scopus 로고    scopus 로고
    • Presurgical assessment of the tumor burden of familial medullary thyroid carcinoma by calcitonin testing
    • Pomares FJ, Rodriguez JM, Nicolas F et al. Presurgical assessment of the tumor burden of familial medullary thyroid carcinoma by calcitonin testing. J Am Coll Surg 2002 195 : 630 4.
    • (2002) J Am Coll Surg , vol.195 , pp. 630-4
    • Pomares, F.J.1    Rodriguez, J.M.2    Nicolas, F.3
  • 34
    • 0032756813 scopus 로고    scopus 로고
    • Is medullary thyroid cancer predictable? A prospective study of 86 patients with abnormal pentagastrin tests
    • discussion 96.
    • Scheuba C, Kaserer K, Weinhausl A et al. Is medullary thyroid cancer predictable? A prospective study of 86 patients with abnormal pentagastrin tests. Surgery 1999 126 : 1089 95 discussion 96.
    • (1999) Surgery , vol.126 , pp. 1089-95
    • Scheuba, C.1    Kaserer, K.2    Weinhausl, A.3
  • 35
    • 45149095297 scopus 로고    scopus 로고
    • Medullary thyroid cancer responsiveness to pentagastrin stimulation: An early surrogate parameter of tumor dissemination?
    • Machens A, Hauptmann S, Dralle H. Medullary thyroid cancer responsiveness to pentagastrin stimulation: an early surrogate parameter of tumor dissemination? J Clin Endocrinol Metab 2008 93 : 2234 8.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2234-8
    • MacHens, A.1    Hauptmann, S.2    Dralle, H.3
  • 36
    • 0021368579 scopus 로고
    • Relation of doubling time of plasma calcitonin levels to prognosis and recurrence of medullary thyroid carcinoma
    • Miyauchi A, Onishi T, Morimoto S et al. Relation of doubling time of plasma calcitonin levels to prognosis and recurrence of medullary thyroid carcinoma. Ann Surg 1984 199 : 461 6.
    • (1984) Ann Surg , vol.199 , pp. 461-6
    • Miyauchi, A.1    Onishi, T.2    Morimoto, S.3
  • 37
    • 27744485886 scopus 로고    scopus 로고
    • Prognostic impact of serum calcitonin and carcinoembryonic antigen doubling-times in patients with medullary thyroid carcinoma
    • Barbet J, Campion L, Kraeber-Bodere F, Chatal JF. Prognostic impact of serum calcitonin and carcinoembryonic antigen doubling-times in patients with medullary thyroid carcinoma. J Clin Endocrinol Metab 2005 90 : 6077 84.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6077-84
    • Barbet, J.1    Campion, L.2    Kraeber-Bodere, F.3    Chatal, J.F.4
  • 38
    • 38949129191 scopus 로고    scopus 로고
    • Progression of medullary thyroid carcinoma: Assessment with calcitonin and carcinoembryonic antigen doubling times
    • Laure Giraudet A, Al Ghulzan A, Auperin A et al. Progression of medullary thyroid carcinoma: assessment with calcitonin and carcinoembryonic antigen doubling times. Eur J Endocrinol 2008 158 : 239 46.
    • (2008) Eur J Endocrinol , vol.158 , pp. 239-46
    • Laure Giraudet, A.1    Al Ghulzan, A.2    Auperin, A.3
  • 39
    • 0021902411 scopus 로고
    • CEA-related antigens: Molecular biology and clinical significance
    • Shively JE, Beatty JD. CEA-related antigens: molecular biology and clinical significance. Crit Rev Oncol Hematol 1985 2 : 355 99.
    • (1985) Crit Rev Oncol Hematol , vol.2 , pp. 355-99
    • Shively, J.E.1    Beatty, J.D.2
  • 41
    • 0018084532 scopus 로고
    • The detection of elevated plasma levels of carcinoembryonic antigen in patients with suspected or established medullary thyroid carcinoma
    • Wells SA Jr., Haagensen DE Jr., Linehan WM, Farrell RE, Dilley WG. The detection of elevated plasma levels of carcinoembryonic antigen in patients with suspected or established medullary thyroid carcinoma. Cancer 1978 42 : 1498 503.
    • (1978) Cancer , vol.42 , pp. 1498-503
    • Wells, Jr.S.A.1    Haagensen, Jr.D.E.2    Linehan, W.M.3    Farrell, R.E.4    Dilley, W.G.5
  • 42
    • 0020663356 scopus 로고
    • The values of calcitonin and carcinoembryonic antigen in the treatment and management of nonfamilial medullary thyroid carcinoma
    • Rougier P, Calmettes C, Laplanche A et al. The values of calcitonin and carcinoembryonic antigen in the treatment and management of nonfamilial medullary thyroid carcinoma. Cancer 1983 51 : 855 62.
    • (1983) Cancer , vol.51 , pp. 855-62
    • Rougier, P.1    Calmettes, C.2    Laplanche, A.3
  • 43
    • 33947371271 scopus 로고    scopus 로고
    • Abnormal carcinoembryonic antigen levels and medullary thyroid cancer progression: A multivariate analysis
    • discussion 94.
    • Machens A, Ukkat J, Hauptmann S, Dralle H. Abnormal carcinoembryonic antigen levels and medullary thyroid cancer progression: a multivariate analysis. Arch Surg 2007 142 : 289 93 discussion 94.
    • (2007) Arch Surg , vol.142 , pp. 289-93
    • MacHens, A.1    Ukkat, J.2    Hauptmann, S.3    Dralle, H.4
  • 44
    • 0026609674 scopus 로고
    • Immunoscintigraphy using 111In-labeled F(ab')2 fragments of anticarcinoembryonic antigen monoclonal antibody for detecting recurrences of medullary thyroid carcinoma
    • Vuillez JP, Peltier P, Caravel JP, Chetanneau A, Saccavini JC, Chatal JF. Immunoscintigraphy using 111In-labeled F(ab')2 fragments of anticarcinoembryonic antigen monoclonal antibody for detecting recurrences of medullary thyroid carcinoma. J Clin Endocrinol Metab 1992 74 : 157 63.
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 157-63
    • Vuillez, J.P.1    Peltier, P.2    Caravel, J.P.3    Chetanneau, A.4    Saccavini, J.C.5    Chatal, J.F.6
  • 45
    • 0027166186 scopus 로고
    • Radioimmunodetection of medullary thyroid cancer using a bispecific anti-CEA/anti-indium-DTPA antibody and an indium-111-labeled DTPA dimer
    • Peltier P, Curtet C, Chatal JF et al. Radioimmunodetection of medullary thyroid cancer using a bispecific anti-CEA/anti-indium-DTPA antibody and an indium-111-labeled DTPA dimer. J Nucl Med 1993 34 : 1267 73.
    • (1993) J Nucl Med , vol.34 , pp. 1267-73
    • Peltier, P.1    Curtet, C.2    Chatal, J.F.3
  • 46
    • 0031459447 scopus 로고    scopus 로고
    • Anti-carcinoembryonic antigen antibodies versus somatostatin analogs in the detection of metastatic medullary thyroid carcinoma: Are carcinoembryonic antigen and somatostatin receptor expression prognostic factors?
    • Behr TM, Gratz S, Markus PM et al. Anti-carcinoembryonic antigen antibodies versus somatostatin analogs in the detection of metastatic medullary thyroid carcinoma: are carcinoembryonic antigen and somatostatin receptor expression prognostic factors? Cancer 1997 80 : 2436 57.
    • (1997) Cancer , vol.80 , pp. 2436-57
    • Behr, T.M.1    Gratz, S.2    Markus, P.M.3
  • 47
    • 0031869630 scopus 로고    scopus 로고
    • Radioimmunodetection of medullary thyroid carcinoma using indium-111 bivalent hapten and anti-CEA x anti-DTPA-indium bispecific antibody
    • Barbet J, Peltier P, Bardet S et al. Radioimmunodetection of medullary thyroid carcinoma using indium-111 bivalent hapten and anti-CEA x anti-DTPA-indium bispecific antibody. J Nucl Med 1998 39 : 1172 8.
    • (1998) J Nucl Med , vol.39 , pp. 1172-8
    • Barbet, J.1    Peltier, P.2    Bardet, S.3
  • 48
    • 0028088256 scopus 로고
    • Clinical screening as compared with DNA analysis in families with multiple endocrine neoplasia type 2A
    • Lips CJ, Landsvater RM, Hoppener JW et al. Clinical screening as compared with DNA analysis in families with multiple endocrine neoplasia type 2A. N Engl J Med 1994 331 : 828 35.
    • (1994) N Engl J Med , vol.331 , pp. 828-35
    • Lips, C.J.1    Landsvater, R.M.2    Hoppener, J.W.3
  • 49
    • 0035022302 scopus 로고    scopus 로고
    • Medullary thyroid carcinoma: Role of genetic testing and calcitonin measurement
    • Lips CJ, Hoppener JW, Thijssen JH. Medullary thyroid carcinoma: role of genetic testing and calcitonin measurement. Ann Clin Biochem 2001 38 : 168 79.
    • (2001) Ann Clin Biochem , vol.38 , pp. 168-79
    • Lips, C.J.1    Hoppener, J.W.2    Thijssen, J.H.3
  • 50
    • 0028019769 scopus 로고
    • Parent-of-origin effects in multiple endocrine neoplasia type 2B
    • Carlson KM, Bracamontes J, Jackson CE et al. Parent-of-origin effects in multiple endocrine neoplasia type 2B. Am J Hum Genet 1994 55 : 1076 82.
    • (1994) Am J Hum Genet , vol.55 , pp. 1076-82
    • Carlson, K.M.1    Bracamontes, J.2    Jackson, C.E.3
  • 51
    • 0028953446 scopus 로고
    • Detection of a germline mutation at codon 918 of the RET proto-oncogene in French MEN 2B families
    • Rossel M, Schuffenecker I, Schlumberger M et al. Detection of a germline mutation at codon 918 of the RET proto-oncogene in French MEN 2B families. Hum Genet 1995 95 : 403 6.
    • (1995) Hum Genet , vol.95 , pp. 403-6
    • Rossel, M.1    Schuffenecker, I.2    Schlumberger, M.3
  • 52
    • 0028206298 scopus 로고
    • A de novo mutation of the RET proto-oncogene in a patient with MEN 2A
    • Mulligan LM, Eng C, Healey CS et al. A de novo mutation of the RET proto-oncogene in a patient with MEN 2A. Hum Mol Genet 1994 3 : 1007 8.
    • (1994) Hum Mol Genet , vol.3 , pp. 1007-8
    • Mulligan, L.M.1    Eng, C.2    Healey, C.S.3
  • 53
    • 0031018680 scopus 로고    scopus 로고
    • Prevalence and parental origin of de novo RET mutations in multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma. le Groupe d'Etude des Tumeurs a Calcitonine
    • Schuffenecker I, Ginet N, Goldgar D et al. Prevalence and parental origin of de novo RET mutations in multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma. Le Groupe d'Etude des Tumeurs a Calcitonine. Am J Hum Genet 1997 60 : 233 7.
    • (1997) Am J Hum Genet , vol.60 , pp. 233-7
    • Schuffenecker, I.1    Ginet, N.2    Goldgar, D.3
  • 54
    • 0028101170 scopus 로고
    • Somatic and MEN 2A de novo mutations identified in the RET proto-oncogene by screening of sporadic MTC:s
    • Zedenius J, Wallin G, Hamberger B, Nordenskjold M, Weber G, Larsson C. Somatic and MEN 2A de novo mutations identified in the RET proto-oncogene by screening of sporadic MTC:s. Hum Mol Genet 1994 3 : 1259 62.
    • (1994) Hum Mol Genet , vol.3 , pp. 1259-62
    • Zedenius, J.1    Wallin, G.2    Hamberger, B.3    Nordenskjold, M.4    Weber, G.5    Larsson, C.6
  • 55
    • 36849056630 scopus 로고    scopus 로고
    • Ret Genetic screening in patients with medullary thyroid cancer and their relatives: Experience with 807 individuals at one center
    • Elisei R, Romei C, Cosci B et al. Ret Genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one center. J Clin Endocrinol Metab 2007 92 : 4725 9.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4725-9
    • Elisei, R.1    Romei, C.2    Cosci, B.3
  • 56
    • 0035281583 scopus 로고    scopus 로고
    • Estimation of risk of inherited medullary thyroid carcinoma in apparent sporadic patients
    • Wiench M, Wygoda Z, Gubala E et al. Estimation of risk of inherited medullary thyroid carcinoma in apparent sporadic patients. J Clin Oncol 2001 19 : 1374 80.
    • (2001) J Clin Oncol , vol.19 , pp. 1374-80
    • Wiench, M.1    Wygoda, Z.2    Gubala, E.3
  • 57
    • 10244245097 scopus 로고    scopus 로고
    • Relevance of RET proto-oncogene mutations in sporadic medullary thyroid carcinoma
    • Wohllk N, Cote GJ, Bugalho MM et al. Relevance of RET proto-oncogene mutations in sporadic medullary thyroid carcinoma. J Clin Endocrinol Metab 1996 81 : 3740 5.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3740-5
    • Wohllk, N.1    Cote, G.J.2    Bugalho, M.M.3
  • 58
    • 0141940150 scopus 로고    scopus 로고
    • Early malignant progression of hereditary medullary thyroid cancer
    • Machens A, Niccoli-Sire P, Hoegel J et al. Early malignant progression of hereditary medullary thyroid cancer. N Engl J Med 2003 349 : 1517 25.
    • (2003) N Engl J Med , vol.349 , pp. 1517-25
    • MacHens, A.1    Niccoli-Sire, P.2    Hoegel, J.3
  • 59
    • 0344716605 scopus 로고    scopus 로고
    • Multiple endocrine neoplasia type 2: Evaluation of the genotype-phenotype relationship
    • discussion 16.
    • Yip L, Cote GJ, Shapiro SE et al. Multiple endocrine neoplasia type 2: evaluation of the genotype-phenotype relationship. Arch Surg 2003 138 : 409 16 discussion 16.
    • (2003) Arch Surg , vol.138 , pp. 409-16
    • Yip, L.1    Cote, G.J.2    Shapiro, S.E.3
  • 60
    • 22244480355 scopus 로고    scopus 로고
    • RET proto-oncogene: A review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors
    • Kouvaraki MA, Shapiro SE, Perrier ND et al. RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors. Thyroid 2005 15 : 531 44.
    • (2005) Thyroid , vol.15 , pp. 531-44
    • Kouvaraki, M.A.1    Shapiro, S.E.2    Perrier, N.D.3
  • 61
    • 33645015594 scopus 로고    scopus 로고
    • DNA-based window of opportunity for curative pre-emptive therapy of hereditary medullary thyroid cancer
    • Machens A, Dralle H. DNA-based window of opportunity for curative pre-emptive therapy of hereditary medullary thyroid cancer. Surgery 2006 139 : 279 82.
    • (2006) Surgery , vol.139 , pp. 279-82
    • MacHens, A.1    Dralle, H.2
  • 62
    • 34248170296 scopus 로고    scopus 로고
    • Genotype-phenotype based surgical concept of hereditary medullary thyroid carcinoma
    • Machens A, Dralle H. Genotype-phenotype based surgical concept of hereditary medullary thyroid carcinoma. World J Surg 2007 31 : 957 68.
    • (2007) World J Surg , vol.31 , pp. 957-68
    • MacHens, A.1    Dralle, H.2
  • 63
    • 0030896418 scopus 로고    scopus 로고
    • Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumours, and Hirschsprung disease
    • DOI 10.1002/(SICI)1098-1004(1997)9:2<97::AID-HUMU1>3.0.CO;2-M
    • Eng C, Mulligan LM. Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumours, and hirschsprung disease. Hum Mutat 1997 9 : 97 109. (Pubitemid 27133173)
    • (1997) Human Mutation , vol.9 , Issue.2 , pp. 97-109
    • Eng, C.1    Mulligan, L.M.2
  • 64
    • 40849094269 scopus 로고    scopus 로고
    • Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: A 10 years follow up study
    • Elisei R, Cosci B, Romei C et al. Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10 years follow up study. J Clin Endocrinol Metab 2007 93 : 682 7.
    • (2007) J Clin Endocrinol Metab , vol.93 , pp. 682-7
    • Elisei, R.1    Cosci, B.2    Romei, C.3
  • 65
    • 0029986851 scopus 로고    scopus 로고
    • Somatic mutations of the ret protooncogene in sporadic medullary thyroid carcinoma are not restricted to exon 16 and are associated with tumor recurrence
    • Romei C, Elisei R, Pinchera A et al. Somatic mutations of the ret protooncogene in sporadic medullary thyroid carcinoma are not restricted to exon 16 and are associated with tumor recurrence. J Clin Endocrinol Metab 1996 81 : 1619 22.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1619-22
    • Romei, C.1    Elisei, R.2    Pinchera, A.3
  • 66
    • 18044404622 scopus 로고    scopus 로고
    • Prognostic value of codon 918 (ATG→ACG) RET proto-oncogene mutations in sporadic medullary thyroid carcinoma
    • Schilling T, Burck J, Sinn HP et al. Prognostic value of codon 918 (ATG→ACG) RET proto-oncogene mutations in sporadic medullary thyroid carcinoma. Int J Cancer 2001 95 : 62 6.
    • (2001) Int J Cancer , vol.95 , pp. 62-6
    • Schilling, T.1    Burck, J.2    Sinn, H.P.3
  • 67
    • 39649096941 scopus 로고    scopus 로고
    • Somatic mutations in the RET proto-oncogene in sporadic medullary thyroid carcinomas
    • Dvorakova S, Vaclavikova E, Sykorova V et al. Somatic mutations in the RET proto-oncogene in sporadic medullary thyroid carcinomas. Mol Cell Endocrinol 2008 284 : 21 7.
    • (2008) Mol Cell Endocrinol , vol.284 , pp. 21-7
    • Dvorakova, S.1    Vaclavikova, E.2    Sykorova, V.3
  • 68
    • 47949100651 scopus 로고    scopus 로고
    • Is somatic RET mutation a prognostic factor for sporadic medullary thyroid carcinoma?
    • Zedenius J. Is somatic RET mutation a prognostic factor for sporadic medullary thyroid carcinoma? Nat Clin Pract Endocrinol Metab 2008 4 : 432 3.
    • (2008) Nat Clin Pract Endocrinol Metab , vol.4 , pp. 432-3
    • Zedenius, J.1
  • 69
    • 0034815430 scopus 로고    scopus 로고
    • Sporadic versus familial medullary thyroid microcarcinoma: A histopathologic study of 50 consecutive patients
    • Kaserer K, Scheuba C, Neuhold N et al. Sporadic versus familial medullary thyroid microcarcinoma: a histopathologic study of 50 consecutive patients. Am J Surg Pathol 2001 25 : 1245 51.
    • (2001) Am J Surg Pathol , vol.25 , pp. 1245-51
    • Kaserer, K.1    Scheuba, C.2    Neuhold, N.3
  • 70
    • 33646584477 scopus 로고    scopus 로고
    • Desmoplastic stromal reaction in medullary thyroid cancer-an intraoperative "marker" for lymph node metastases
    • Scheuba C, Kaserer K, Kaczirek K, Asari R, Niederle B. Desmoplastic stromal reaction in medullary thyroid cancer-an intraoperative "marker" for lymph node metastases. World J Surg 2006 30 : 853 9.
    • (2006) World J Surg , vol.30 , pp. 853-9
    • Scheuba, C.1    Kaserer, K.2    Kaczirek, K.3    Asari, R.4    Niederle, B.5
  • 71
    • 41149155222 scopus 로고    scopus 로고
    • Desmoplasia in medullary thyroid carcinoma: A reliable indicator of metastatic potential
    • Koperek O, Scheuba C, Cherenko M et al. Desmoplasia in medullary thyroid carcinoma: a reliable indicator of metastatic potential. Histopathology 2008 52 : 623 30.
    • (2008) Histopathology , vol.52 , pp. 623-30
    • Koperek, O.1    Scheuba, C.2    Cherenko, M.3
  • 72
    • 0034807066 scopus 로고    scopus 로고
    • Matrix metalloproteinases: A multifunctional group of molecules
    • Murray GI. Matrix metalloproteinases: a multifunctional group of molecules. J Pathol 2001 195 : 135 7.
    • (2001) J Pathol , vol.195 , pp. 135-7
    • Murray, G.I.1
  • 73
    • 0037903231 scopus 로고    scopus 로고
    • Roles of matrix metalloproteinases in tumor metastasis and angiogenesis
    • Yoon SO, Park SJ, Yun CH, Chung AS. Roles of matrix metalloproteinases in tumor metastasis and angiogenesis. J Biochem Mol Biol 2003 36 : 128 37.
    • (2003) J Biochem Mol Biol , vol.36 , pp. 128-37
    • Yoon, S.O.1    Park, S.J.2    Yun, C.H.3    Chung, A.S.4
  • 74
    • 50649112589 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in medullary thyroid carcinoma: Prognostic implications
    • Cavalheiro BG, Junqueira CR, Brandao LG. Expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in medullary thyroid carcinoma: prognostic implications. Thyroid 2008 18 : 865 71.
    • (2008) Thyroid , vol.18 , pp. 865-71
    • Cavalheiro, B.G.1    Junqueira, C.R.2    Brandao, L.G.3
  • 75
    • 35948994121 scopus 로고    scopus 로고
    • Imaging medullary thyroid carcinoma with persistent elevated calcitonin levels
    • Giraudet AL, Vanel D, Leboulleux S et al. Imaging medullary thyroid carcinoma with persistent elevated calcitonin levels. J Clin Endocrinol Metab 2007 92 : 4185 90.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4185-90
    • Giraudet, A.L.1    Vanel, D.2    Leboulleux, S.3
  • 76
    • 33747841242 scopus 로고    scopus 로고
    • Staging of carcinoid tumours with 18F-DOPA PET: A prospective, diagnostic accuracy study
    • Koopmans KP, de Vries EG, Kema IP et al. Staging of carcinoid tumours with 18F-DOPA PET: a prospective, diagnostic accuracy study. Lancet Oncol 2006 7 : 728 34.
    • (2006) Lancet Oncol , vol.7 , pp. 728-34
    • Koopmans, K.P.1    De Vries, E.G.2    Kema, I.P.3
  • 78
    • 6944231270 scopus 로고    scopus 로고
    • Impact of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in patients with biochemical evidence of recurrent or residual medullary thyroid cancer
    • de Groot JW, Links TP, Jager PL, Kahraman T, Plukker JT. Impact of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in patients with biochemical evidence of recurrent or residual medullary thyroid cancer. Ann Surg Oncol 2004 11 : 786 94.
    • (2004) Ann Surg Oncol , vol.11 , pp. 786-94
    • De Groot, J.W.1    Links, T.P.2    Jager, P.L.3    Kahraman, T.4    Plukker, J.T.5
  • 79
    • 0034756055 scopus 로고    scopus 로고
    • Fluorine-18 fluorodeoxyglucose positron emission tomography in medullary thyroid cancer: Results of a multicentre study
    • Diehl M, Risse JH, Brandt-Mainz K et al. Fluorine-18 fluorodeoxyglucose positron emission tomography in medullary thyroid cancer: results of a multicentre study. Eur J Nucl Med 2001 28 : 1671 6.
    • (2001) Eur J Nucl Med , vol.28 , pp. 1671-6
    • Diehl, M.1    Risse, J.H.2    Brandt-Mainz, K.3
  • 81
    • 33847411464 scopus 로고    scopus 로고
    • Detection of occult medullary thyroid cancer recurrence with 2-deoxy-2-[F-18]fluoro-D-glucose-PET and PET/CT
    • Iagaru A, Masamed R, Singer PA, Conti PS. Detection of occult medullary thyroid cancer recurrence with 2-deoxy-2-[F-18]fluoro-D-glucose-PET and PET/CT. Mol Imaging Biol 2007 9 : 72 7.
    • (2007) Mol Imaging Biol , vol.9 , pp. 72-7
    • Iagaru, A.1    Masamed, R.2    Singer, P.A.3    Conti, P.S.4
  • 82
    • 36849090954 scopus 로고    scopus 로고
    • Sensitivity and prognostic value of positron emission tomography with f-18-fluorodeoxyglucose and sensitivity of immunoscintigraphy in patients with medullary thyroid carcinoma treated with anticarcinoembryonic antigen-targeted radioimmunotherapy
    • Oudoux A, Salaun PY, Bournaud C et al. Sensitivity and prognostic value of positron emission tomography with f-18-fluorodeoxyglucose and sensitivity of immunoscintigraphy in patients with medullary thyroid carcinoma treated with anticarcinoembryonic antigen-targeted radioimmunotherapy. J Clin Endocrinol Metab 2007 92 : 4590 7.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4590-7
    • Oudoux, A.1    Salaun, P.Y.2    Bournaud, C.3
  • 83
    • 39049177934 scopus 로고    scopus 로고
    • Positron emission tomography (18FDG-PET) in the detection of medullary thyroid carcinoma metastases
    • Mucha SA, Kunert-Radek J, Pomorski L. Positron emission tomography (18FDG-PET) in the detection of medullary thyroid carcinoma metastases. Endokrynol Pol 2006 57 : 452 5.
    • (2006) Endokrynol Pol , vol.57 , pp. 452-5
    • Mucha, S.A.1    Kunert-Radek, J.2    Pomorski, L.3
  • 84
    • 42049120081 scopus 로고    scopus 로고
    • 6-L-18F-fluorodihydroxyphenylalanine PET in neuroendocrine tumors: Basic aspects and emerging clinical applications
    • Jager PL, Chirakal R, Marriott CJ, Brouwers AH, Koopmans KP, Gulenchyn KY. 6-L-18F-fluorodihydroxyphenylalanine PET in neuroendocrine tumors: basic aspects and emerging clinical applications. J Nucl Med 2008 49 : 573 86.
    • (2008) J Nucl Med , vol.49 , pp. 573-86
    • Jager, P.L.1    Chirakal, R.2    Marriott, C.J.3    Brouwers, A.H.4    Koopmans, K.P.5    Gulenchyn, K.Y.6
  • 85
    • 0034746433 scopus 로고    scopus 로고
    • 18F-DOPA positron emission tomography for tumour detection in patients with medullary thyroid carcinoma and elevated calcitonin levels
    • DOI 10.1007/s002590000404
    • Hoegerle S, Altehoefer C, Ghanem N, Brink I, Moser E, Nitzsche E. 18F-DOPA positron emission tomography for tumour detection in patients with medullary thyroid carcinoma and elevated calcitonin levels. Eur J Nucl Med 2001 28 : 64 71. (Pubitemid 32120808)
    • (2001) European Journal of Nuclear Medicine , vol.28 , Issue.1 , pp. 64-71
    • Hoegerle, S.1    Altehoefer, C.2    Ghanem, N.3    Brink, I.4    Moser, E.5    Nitzsche, E.6
  • 86
    • 34748868457 scopus 로고    scopus 로고
    • Diagnostic impact of PET with 18F-FDG, 18F-DOPA and 3-O-methyl-6-[18F] fluoro-DOPA in recurrent or metastatic medullary thyroid carcinoma
    • Beuthien-Baumann B, Strumpf A, Zessin J, Bredow J, Kotzerke J. Diagnostic impact of PET with 18F-FDG, 18F-DOPA and 3-O-methyl-6-[18F]fluoro-DOPA in recurrent or metastatic medullary thyroid carcinoma. Eur J Nucl Med Mol Imaging 2007 34 : 1604 9.
    • (2007) Eur J Nucl Med Mol Imaging , vol.34 , pp. 1604-9
    • Beuthien-Baumann, B.1    Strumpf, A.2    Zessin, J.3    Bredow, J.4    Kotzerke, J.5
  • 87
    • 42049103697 scopus 로고    scopus 로고
    • 18F-Dihydroxyphenylalanine PET in patients with biochemical evidence of medullary thyroid cancer: Relation to tumor differentiation
    • Koopmans KP, de Groot JW, Plukker JT et al. 18F-Dihydroxyphenylalanine PET in patients with biochemical evidence of medullary thyroid cancer: relation to tumor differentiation. J Nucl Med 2008 49 : 524 31.
    • (2008) J Nucl Med , vol.49 , pp. 524-31
    • Koopmans, K.P.1    De Groot, J.W.2    Plukker, J.T.3
  • 88
    • 34250159501 scopus 로고    scopus 로고
    • Superiority of fluorodeoxyglucose positron emission tomography to other functional imaging techniques in the evaluation of metastatic SDHB-associated pheochromocytoma and paraganglioma
    • Timmers HJ, Kozupa A, Chen CC et al. Superiority of fluorodeoxyglucose positron emission tomography to other functional imaging techniques in the evaluation of metastatic SDHB-associated pheochromocytoma and paraganglioma. J Clin Oncol 2007 25 : 2262 9.
    • (2007) J Clin Oncol , vol.25 , pp. 2262-9
    • Timmers, H.J.1    Kozupa, A.2    Chen, C.C.3
  • 90
    • 0031849777 scopus 로고    scopus 로고
    • Metabolic (PET) and receptor (SPET) imaging of well- and less well-differentiated tumours: Comparison with the expression of the Ki-67 antigen
    • Adams S, Baum RP, Hertel A, Schumm-Drager PM, Usadel KH, Hor G. Metabolic (PET) and receptor (SPET) imaging of well- and less well-differentiated tumours: comparison with the expression of the Ki-67 antigen. Nucl Med Commun 1998 19 : 641 7.
    • (1998) Nucl Med Commun , vol.19 , pp. 641-7
    • Adams, S.1    Baum, R.P.2    Hertel, A.3    Schumm-Drager, P.M.4    Usadel, K.H.5    Hor, G.6
  • 91
    • 34248594179 scopus 로고    scopus 로고
    • Diagnostic accuracy of 18F-FDG PET in restaging patients with medullary thyroid carcinoma and elevated calcitonin levels
    • Ong SC, Schoder H, Patel SG et al. Diagnostic accuracy of 18F-FDG PET in restaging patients with medullary thyroid carcinoma and elevated calcitonin levels. J Nucl Med 2007 48 : 501 7.
    • (2007) J Nucl Med , vol.48 , pp. 501-7
    • Ong, S.C.1    Schoder, H.2    Patel, S.G.3
  • 92
    • 0035726431 scopus 로고    scopus 로고
    • Immunohistochemical detection of somatostatin receptor types 1-5 in medullary carcinoma of the thyroid
    • Papotti M, Kumar U, Volante M, Pecchioni C, Patel YC. Immunohistochemical detection of somatostatin receptor types 1-5 in medullary carcinoma of the thyroid. Clin Endocrinol (Oxf) 2001 54 : 641 9.
    • (2001) Clin Endocrinol (Oxf) , vol.54 , pp. 641-9
    • Papotti, M.1    Kumar, U.2    Volante, M.3    Pecchioni, C.4    Patel, Y.C.5
  • 93
    • 0031784575 scopus 로고    scopus 로고
    • Somatostatin and somatostatin receptor subtype gene expression in medullary thyroid carcinoma
    • Mato E, Matias-Guiu X, Chico A et al. Somatostatin and somatostatin receptor subtype gene expression in medullary thyroid carcinoma. J Clin Endocrinol Metab 1998 83 : 2417 20.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2417-20
    • Mato, E.1    Matias-Guiu, X.2    Chico, A.3
  • 94
    • 0029770675 scopus 로고    scopus 로고
    • Unexpected high incidence of cholecystokinin-B/gastrin receptors in human medullary thyroid carcinomas
    • Reubi JC, Waser B. Unexpected high incidence of cholecystokinin-B/gastrin receptors in human medullary thyroid carcinomas. Int J Cancer 1996 67 : 644 7.
    • (1996) Int J Cancer , vol.67 , pp. 644-7
    • Reubi, J.C.1    Waser, B.2
  • 95
    • 0032791105 scopus 로고    scopus 로고
    • Expression of cholecystokinin-B/gastrin receptors in medullary thyroid cancer
    • Amiri-Mosavi A, Ahlman H, Tisell LE et al. Expression of cholecystokinin-B/gastrin receptors in medullary thyroid cancer. Eur J Surg 1999 165 : 628 31.
    • (1999) Eur J Surg , vol.165 , pp. 628-31
    • Amiri-Mosavi, A.1    Ahlman, H.2    Tisell, L.E.3
  • 97
    • 0842281596 scopus 로고    scopus 로고
    • The cholecystokinin2-receptor mediates calcitonin secretion, gene expression, and proliferation in the human medullary thyroid carcinoma cell line, TT
    • Blaker M, Arrenberg P, Stange I et al. The cholecystokinin2-receptor mediates calcitonin secretion, gene expression, and proliferation in the human medullary thyroid carcinoma cell line, TT. Regul Pept 2004 118 : 111 7.
    • (2004) Regul Pept , vol.118 , pp. 111-7
    • Blaker, M.1    Arrenberg, P.2    Stange, I.3
  • 98
    • 0030162739 scopus 로고    scopus 로고
    • Comparison of octreotide scintigraphy and conventional imaging in medullary thyroid carcinoma
    • Baudin E, Lumbroso J, Schlumberger M et al. Comparison of octreotide scintigraphy and conventional imaging in medullary thyroid carcinoma. J Nucl Med 1996 37 : 912 6.
    • (1996) J Nucl Med , vol.37 , pp. 912-6
    • Baudin, E.1    Lumbroso, J.2    Schlumberger, M.3
  • 100
    • 8644273965 scopus 로고    scopus 로고
    • The role of combined imaging in metastatic medullary thyroid carcinoma: 111In-DTPA-octreotide and 131I/123I-MIBG as predictors for radionuclide therapy
    • Gao Z, Biersack HJ, Ezziddin S, Logvinski T, An R. The role of combined imaging in metastatic medullary thyroid carcinoma: 111In-DTPA-octreotide and 131I/123I-MIBG as predictors for radionuclide therapy. J Cancer Res Clin Oncol 2004 130 : 649 56.
    • (2004) J Cancer Res Clin Oncol , vol.130 , pp. 649-56
    • Gao, Z.1    Biersack, H.J.2    Ezziddin, S.3    Logvinski, T.4    An, R.5
  • 101
    • 34748865440 scopus 로고    scopus 로고
    • Somatostatin receptor scintigraphy using 99mTc-EDDA/HYNIC-TOC in patients with medullary thyroid carcinoma
    • Czepczynski R, Parisella MG, Kosowicz J et al. Somatostatin receptor scintigraphy using 99mTc-EDDA/HYNIC-TOC in patients with medullary thyroid carcinoma. Eur J Nucl Med Mol Imaging 2007 34 : 1635 45.
    • (2007) Eur J Nucl Med Mol Imaging , vol.34 , pp. 1635-45
    • Czepczynski, R.1    Parisella, M.G.2    Kosowicz, J.3
  • 102
    • 0031945355 scopus 로고    scopus 로고
    • Targeting of cholecystokinin-B/gastrin receptors in vivo: Preclinical and initial clinical evaluation of the diagnostic and therapeutic potential of radiolabelled gastrin
    • Behr TM, Jenner N, Radetzky S et al. Targeting of cholecystokinin-B/ gastrin receptors in vivo: preclinical and initial clinical evaluation of the diagnostic and therapeutic potential of radiolabelled gastrin. Eur J Nucl Med 1998 25 : 424 30.
    • (1998) Eur J Nucl Med , vol.25 , pp. 424-30
    • Behr, T.M.1    Jenner, N.2    Radetzky, S.3
  • 103
    • 0036231110 scopus 로고    scopus 로고
    • Cholecystokinin-B/gastrin receptor-targeting peptides for staging and therapy of medullary thyroid cancer and other cholecystokinin-B receptor-expressing malignancies
    • Behr TM, Behe MP. Cholecystokinin-B/gastrin receptor-targeting peptides for staging and therapy of medullary thyroid cancer and other cholecystokinin-B receptor-expressing malignancies. Semin Nucl Med 2002 32 : 97 109. (Pubitemid 34311076)
    • (2002) Seminars in Nuclear Medicine , vol.32 , Issue.2 , pp. 97-109
    • Behr, T.M.1    Behe, M.P.2
  • 104
    • 33750310034 scopus 로고    scopus 로고
    • Improved tumour detection by gastrin receptor scintigraphy in patients with metastasised medullary thyroid carcinoma
    • Gotthardt M, Behe MP, Beuter D et al. Improved tumour detection by gastrin receptor scintigraphy in patients with metastasised medullary thyroid carcinoma. Eur J Nucl Med Mol Imaging 2006 33 : 1273 9.
    • (2006) Eur J Nucl Med Mol Imaging , vol.33 , pp. 1273-9
    • Gotthardt, M.1    Behe, M.P.2    Beuter, D.3
  • 105
    • 0345240929 scopus 로고    scopus 로고
    • Cholecystokinin-B/gastrin receptor binding peptides: Preclinical development and evaluation of their diagnostic and therapeutic potential
    • Behr TM, Behe M, Angerstein C et al. Cholecystokinin-B/gastrin receptor binding peptides: preclinical development and evaluation of their diagnostic and therapeutic potential. Clin Cancer Res 1999 5 : 3124s 38s.
    • (1999) Clin Cancer Res , vol.5
    • Behr, T.M.1    Behe, M.2    Angerstein, C.3
  • 106
    • 0033001991 scopus 로고    scopus 로고
    • Radiolabeled peptides for targeting cholecystokinin-B/gastrin receptor-expressing tumors
    • Behr TM, Jenner N, Behe M et al. Radiolabeled peptides for targeting cholecystokinin-B/gastrin receptor-expressing tumors. J Nucl Med 1999 40 : 1029 44.
    • (1999) J Nucl Med , vol.40 , pp. 1029-44
    • Behr, T.M.1    Jenner, N.2    Behe, M.3
  • 107
    • 0242668666 scopus 로고    scopus 로고
    • Cholecystokinin-B (CCK-B)/gastrin receptor targeting peptides for staging and therapy of medullary thyroid cancer and other CCK-B receptor expressing malignancies
    • Behe M, Behr TM. Cholecystokinin-B (CCK-B)/gastrin receptor targeting peptides for staging and therapy of medullary thyroid cancer and other CCK-B receptor expressing malignancies. Biopolymers 2002 66 : 399 418.
    • (2002) Biopolymers , vol.66 , pp. 399-418
    • Behe, M.1    Behr, T.M.2
  • 108
    • 0033856992 scopus 로고    scopus 로고
    • Cholecystokinin receptor imaging using an octapeptide DTPA-CCK analogue in patients with medullary thyroid carcinoma
    • Kwekkeboom DJ, Bakker WH, Kooij PP et al. Cholecystokinin receptor imaging using an octapeptide DTPA-CCK analogue in patients with medullary thyroid carcinoma. Eur J Nucl Med 2000 27 : 1312 7.
    • (2000) Eur J Nucl Med , vol.27 , pp. 1312-7
    • Kwekkeboom, D.J.1    Bakker, W.H.2    Kooij, P.P.3
  • 109
    • 15844365303 scopus 로고    scopus 로고
    • GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF
    • Jing S, Wen D, Yu Y et al. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Cell 1996 85 : 1113 24.
    • (1996) Cell , vol.85 , pp. 1113-24
    • Jing, S.1    Wen, D.2    Yu, Y.3
  • 110
    • 15844418441 scopus 로고    scopus 로고
    • Characterization of a multicomponent receptor for GDNF
    • Treanor JJ, Goodman L, de Sauvage F et al. Characterization of a multicomponent receptor for GDNF. Nature 1996 382 : 80 3.
    • (1996) Nature , vol.382 , pp. 80-3
    • Treanor, J.J.1    Goodman, L.2    De Sauvage, F.3
  • 111
    • 0035937727 scopus 로고    scopus 로고
    • Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells
    • Lindahl M, Poteryaev D, Yu L et al. Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells. J Biol Chem 2001 276 : 9344 51.
    • (2001) J Biol Chem , vol.276 , pp. 9344-51
    • Lindahl, M.1    Poteryaev, D.2    Yu, L.3
  • 112
    • 0032504961 scopus 로고    scopus 로고
    • GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin
    • Enokido Y, de Sauvage F, Hongo JA et al. GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. Curr Biol 1998 8 : 1019 22.
    • (1998) Curr Biol , vol.8 , pp. 1019-22
    • Enokido, Y.1    De Sauvage, F.2    Hongo, J.A.3
  • 113
    • 0031053848 scopus 로고    scopus 로고
    • Immunoelectron microscopic demonstration of regulated pathway for calcitonin and constitutive pathway for carcinoembryonic antigen in the same cells of human medullary carcinomas of thyroid glands
    • Osamura RY, Yasuda O, Kawakami T, Itoh Y, Inada K, Kakudo K. Immunoelectron microscopic demonstration of regulated pathway for calcitonin and constitutive pathway for carcinoembryonic antigen in the same cells of human medullary carcinomas of thyroid glands. Mod Pathol 1997 10 : 7 11. (Pubitemid 27090769)
    • (1997) Modern Pathology , vol.10 , Issue.1 , pp. 7-11
    • Osamura, R.Y.1    Yasuda, O.2    Kawakami, T.3    Itoh, Y.4    Inada, K.5    Kakudo, K.6
  • 114
    • 0031440647 scopus 로고    scopus 로고
    • Improved selection of patients for reoperation for medullary thyroid cancer by imaging with radiolabeled anticarcinoembryonic antigen antibodies
    • Juweid M, Sharkey RM, Swayne LC, Goldenberg DM. Improved selection of patients for reoperation for medullary thyroid cancer by imaging with radiolabeled anticarcinoembryonic antigen antibodies. Surgery 1997 122 : 1156 65.
    • (1997) Surgery , vol.122 , pp. 1156-65
    • Juweid, M.1    Sharkey, R.M.2    Swayne, L.C.3    Goldenberg, D.M.4
  • 115
    • 18344399584 scopus 로고    scopus 로고
    • Successful surgical removal of occult metastases of medullary thyroid carcinoma recurrences with the help of immunoscintigraphy and radioimmunoguided surgery
    • de Labriolle-Vaylet C, Cattan P, Sarfati E et al. Successful surgical removal of occult metastases of medullary thyroid carcinoma recurrences with the help of immunoscintigraphy and radioimmunoguided surgery. Clin Cancer Res 2000 6 : 363 71.
    • (2000) Clin Cancer Res , vol.6 , pp. 363-71
    • De Labriolle-Vaylet, C.1    Cattan, P.2    Sarfati, E.3
  • 116
    • 0021325077 scopus 로고
    • Nonparallel patterns of calcitonin and carcinoembryonic antigen levels in the follow-up of medullary thyroid carcinoma
    • Busnardo B, Girelli ME, Simioni N, Nacamulli D, Busetto E. Nonparallel patterns of calcitonin and carcinoembryonic antigen levels in the follow-up of medullary thyroid carcinoma. Cancer 1984 53 : 278 85.
    • (1984) Cancer , vol.53 , pp. 278-85
    • Busnardo, B.1    Girelli, M.E.2    Simioni, N.3    Nacamulli, D.4    Busetto, E.5
  • 117
  • 118
    • 33845420535 scopus 로고    scopus 로고
    • Current approaches to medullary thyroid carcinoma, sporadic and familial
    • Fialkowski EA, Moley JF. Current approaches to medullary thyroid carcinoma, sporadic and familial. J Surg Oncol 2006 94 : 737 47.
    • (2006) J Surg Oncol , vol.94 , pp. 737-47
    • Fialkowski, E.A.1    Moley, J.F.2
  • 120
    • 33845356681 scopus 로고    scopus 로고
    • Medullary thyroid cancer: Therapeutic targets and molecular markers
    • DOI 10.1097/CCO.0b013e32801173ea, PII 0000162220070100000005
    • Ball DW. Medullary thyroid cancer: therapeutic targets and molecular markers. Curr Opin Oncol 2007 19 : 18 23. (Pubitemid 44885595)
    • (2007) Current Opinion in Oncology , vol.19 , Issue.1 , pp. 18-23
    • Ball, D.W.1
  • 121
    • 11244327801 scopus 로고    scopus 로고
    • Identification of RET kinase inhibitors as potential new treatment for sporadic and inherited thyroid cancer
    • Carlomagno F, Santoro M. Identification of RET kinase inhibitors as potential new treatment for sporadic and inherited thyroid cancer. J Chemother 2004 16 (Suppl 4 49 51. (Pubitemid 40065281)
    • (2004) Journal of Chemotherapy , vol.16 , Issue.SUPPL. 4 , pp. 49-51
    • Carlomagno, F.1    Santoro, M.2
  • 122
    • 17744373695 scopus 로고    scopus 로고
    • The RET proto-oncogene: A molecular therapeutic target in thyroid cancer
    • Kodama Y, Asai N, Kawai K et al. The RET proto-oncogene: a molecular therapeutic target in thyroid cancer. Cancer Sci 2005 96 : 143 8.
    • (2005) Cancer Sci , vol.96 , pp. 143-8
    • Kodama, Y.1    Asai, N.2    Kawai, K.3
  • 123
    • 3042749217 scopus 로고    scopus 로고
    • The RET proto-oncogene: A potential target for molecular cancer therapy
    • Putzer BM, Drosten M. The RET proto-oncogene: a potential target for molecular cancer therapy. Trends Mol Med 2004 10 : 351 7.
    • (2004) Trends Mol Med , vol.10 , pp. 351-7
    • Putzer, B.M.1    Drosten, M.2
  • 124
    • 50649095250 scopus 로고    scopus 로고
    • Phase II trial of Sorafenib in advanced thyroid cancer
    • Gupta-Abramson V, Troxel AB, Nellore A et al. Phase II trial of Sorafenib in advanced thyroid cancer. J Clin Oncol 2008 26 : 4714 9.
    • (2008) J Clin Oncol , vol.26 , pp. 4714-9
    • Gupta-Abramson, V.1    Troxel, A.B.2    Nellore, A.3
  • 125
    • 50649095801 scopus 로고    scopus 로고
    • Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: Results from a phase II study
    • Cohen EE, Rosen LS, Vokes EE et al. Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study. J Clin Oncol 2008 26 : 4708 13.
    • (2008) J Clin Oncol , vol.26 , pp. 4708-13
    • Cohen, E.E.1    Rosen, L.S.2    Vokes, E.E.3
  • 126
    • 0037115405 scopus 로고    scopus 로고
    • ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases
    • Carlomagno F, Vitagliano D, Guida T et al. ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res 2002 62 : 7284 90.
    • (2002) Cancer Res , vol.62 , pp. 7284-90
    • Carlomagno, F.1    Vitagliano, D.2    Guida, T.3
  • 127
    • 33746337869 scopus 로고    scopus 로고
    • A phase II trial of ZD6474 in patients with hereditary metastatic medullary thyroid cancer
    • Wells S, You YN, Lakhani V et al. A phase II trial of ZD6474 in patients with hereditary metastatic medullary thyroid cancer. J Clin Oncol (Meeting Abstracts) 2006 24 : 5553.
    • (2006) J Clin Oncol (Meeting Abstracts) , vol.24 , pp. 5553
    • Wells, S.1    You, Y.N.2    Lakhani, V.3
  • 128
    • 4444273158 scopus 로고    scopus 로고
    • Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors
    • Carlomagno F, Guida T, Anaganti S et al. Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors. Oncogene 2004 23 : 6056 63.
    • (2004) Oncogene , vol.23 , pp. 6056-63
    • Carlomagno, F.1    Guida, T.2    Anaganti, S.3
  • 129
    • 35748958721 scopus 로고    scopus 로고
    • Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting
    • Plaza-Menacho I, Mologni L, Sala E et al. Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting. J Biol Chem 2007 282 : 29230 40.
    • (2007) J Biol Chem , vol.282 , pp. 29230-40
    • Plaza-Menacho, I.1    Mologni, L.2    Sala, E.3
  • 130
    • 33644747449 scopus 로고    scopus 로고
    • BAY 43-9006 inhibition of oncogenic RET mutants
    • Carlomagno F, Anaganti S, Guida T et al. BAY 43-9006 inhibition of oncogenic RET mutants. J Natl Cancer Inst 2006 98 : 326 34.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 326-34
    • Carlomagno, F.1    Anaganti, S.2    Guida, T.3
  • 131
    • 0030163020 scopus 로고    scopus 로고
    • Radioimmunotherapy of medullary thyroid cancer with iodine-131-labeled anti-CEA antibodies
    • Juweid M, Sharkey RM, Behr T et al. Radioimmunotherapy of medullary thyroid cancer with iodine-131-labeled anti-CEA antibodies. J Nucl Med 1996 37 : 905 11.
    • (1996) J Nucl Med , vol.37 , pp. 905-11
    • Juweid, M.1    Sharkey, R.M.2    Behr, T.3
  • 132
    • 12344315241 scopus 로고
    • Targeting and initial radioimmunotherapy of medullary thyroid carcinoma with 131I-labeled monoclonal antibodies to carcinoembryonic antigen
    • Juweid M, Sharkey RM, Behr T et al. Targeting and initial radioimmunotherapy of medullary thyroid carcinoma with 131I-labeled monoclonal antibodies to carcinoembryonic antigen. Cancer Res 1995 55 : 5946s 51s.
    • (1995) Cancer Res , vol.55
    • Juweid, M.1    Sharkey, R.M.2    Behr, T.3
  • 133
    • 0033561012 scopus 로고    scopus 로고
    • Phase I/II trial of (131)I-MN-14F(ab)2 anti-carcinoembryonic antigen monoclonal antibody in the treatment of patients with metastatic medullary thyroid carcinoma
    • Juweid ME, Hajjar G, Swayne LC et al. Phase I/II trial of (131)I-MN-14F(ab)2 anti-carcinoembryonic antigen monoclonal antibody in the treatment of patients with metastatic medullary thyroid carcinoma. Cancer 1999 85 : 1828 42.
    • (1999) Cancer , vol.85 , pp. 1828-42
    • Juweid, M.E.1    Hajjar, G.2    Swayne, L.C.3
  • 134
    • 33645834287 scopus 로고    scopus 로고
    • Survival improvement in patients with medullary thyroid carcinoma who undergo pretargeted anti-carcinoembryonic-antigen radioimmunotherapy: A collaborative study with the French Endocrine Tumor Group
    • Chatal JF, Campion L, Kraeber-Bodere F et al. Survival improvement in patients with medullary thyroid carcinoma who undergo pretargeted anti-carcinoembryonic-antigen radioimmunotherapy: a collaborative study with the French Endocrine Tumor Group. J Clin Oncol 2006 24 : 1705 11.
    • (2006) J Clin Oncol , vol.24 , pp. 1705-11
    • Chatal, J.F.1    Campion, L.2    Kraeber-Bodere, F.3
  • 135
    • 12544255778 scopus 로고    scopus 로고
    • Somatostatin receptor expression in vivo and response to somatostatin analog therapy with or without other antineoplastic treatments in advanced medullary thyroid carcinoma
    • Vainas I, Koussis C, Pazaitou-Panayiotou K et al. Somatostatin receptor expression in vivo and response to somatostatin analog therapy with or without other antineoplastic treatments in advanced medullary thyroid carcinoma. J Exp Clin Cancer Res 2004 23 : 549 59.
    • (2004) J Exp Clin Cancer Res , vol.23 , pp. 549-59
    • Vainas, I.1    Koussis, C.2    Pazaitou-Panayiotou, K.3


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