Advances in mitigation of injuries from radiological terrorism or nuclear accidents

Defence Science Journal

Volumn 61, Issue 2, 2011, Pages 99-104

  Moulder, John E ^a   Medhora, Meetha ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Acute radiation syndrome; Biodosimetry; Countermeasures; Nuclear accident; Radiological terrorism

Indexed keywords

NUCLEAR REACTOR ACCIDENTS; RADIATION;

ACUTE RADIATION SYNDROME; BIODOSIMETRY; CHRONIC RADIATIONS; COUNTERMEASURE; LABORATORY STUDIES; NUCLEAR ACCIDENTS; NUMBER OF PEOPLES; PRINCIPAL COMPONENTS; RADIATION INJURY; RADIOLOGICAL TERRORISM;

TERRORISM;

EID: 79952254259     PISSN: 0011748X     EISSN: None     Source Type: Journal    
DOI: 10.14429/dsj.61.828     Document Type: Review

References (55)

1. United States-India Nuclear Cooperation Approval and Nonproliferation Enhancement Act (Public Law No. 110-369). 8 October 2008.
2. Moulder, J. E. Report on an interagency workshop on the radiobiology of nuclear terrorism. Radiation Research, 2002, 158(1), 118-24.
3. Moulder, J. Medical countermeasures against radiological terrorism: What do we need and what do we have? Health Phys. News, 2010, 38(7), 16-18.
4. Ramakrishnan, N.; Norman, M. K.; DiCarlo, A.; Kaminski, J.; Maidment, B.; Cassett, D.; Benjamin, J. & Hatchett, R. Research and development of medical countermeasures for radiation injury. Ind. J. Radiat. Res., 2009, 6(1-2), 3-4.
5. Bhardwaj, J.R. Medical countermeasures for radiation injury: Indian perspectives. Ind. J. Radiat. Res., 2009, 6(1-2), 1-2.
6. Mould, R.F. Chernobyl: The real story. Pergamon Press, Oxford, UK, 1988.
7. van Dyk, J.; Keane, T.J.; Kan, S.; Rider, W.D. & Fryer, C.J.H. Radiation pneumonitis following large single dose irradiation: A re-evaluation based on absolute dose to the lung. Int. J. Radiât. Oncol. Biol. Phys., 1981, 7(4), 461-67.
8. Rola, R.; Raber, J.; Rizk, A.; Otsuka, S.; VandenBerg, S. R.; Morhardt, D. R. & Fike, J. R. Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Experimental Neurology, 2004, 188(2), 316-30. (Pubitemid 38891593)
9. Raber, J.; Rola, R.; LeFevour, A.; Morhardt, D.; Curley, J.; Mizumatsu, S.; VandenBerg, S.R. & Fike, J. R. Radiationinduced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiation Research, 2004, 162(1), 39-47. (Pubitemid 39044717)
10. Tatsukawa, Y.; Nakashima, E.; Yamada, M.; Funamoto, S.; Hida, A.; Akahoshi, M.; Sakata, R.; Ross, N. P.; Kasagi, F.; Fujiwara, S. & Shore, R. E. Cardiovascular disease risk among atomic bomb survivours exposed in utero, 1978-2003. Radiation Research, 2008, 170(3), 269-74.
11. Baker, J. E.; Fish, B. L.; Su, J.; Haworth, S. T.; Strande, J. L.; Komorowski, R. A.; Migrino, R. Q.; Doppalapudi, A.; Harmann, L.; Li, X. A.; Hopewell, J. W. & Moulder, J.E. 10 Gy total body irradiation increases risk of coronary sclerosis, degeneration of heart structure and function in a rat model. Int. J. Radiat. Biol., 2009, 85(12), 1089-100.
12. Otterson, M.F.; Sarna, S.K. & Moulder, J.E. The effects of radiation on gastro-intestinal motility and potential therapies. In Advances in the treatment of radiation injuries, edited by T.J. MacVittie, J.F. Weiss & D. Browne. Elsevier, New York, U.S.A., 1996. pp. 207-16.
13. Anno, G. H.; McClellan, G. E. & Dore, M. A. Protracted radiation-induced performance decrement. Volume 1 : Model development Pacific-Sierra Research Corporation, Santa Monica, United States, 1995.
14. Moulder, J.E. & Cohen, E.P. Radiation-induced multiorgan involvement and failure: The contribution of radiation effects on the renal system. Br. J. Radiol. Suppl, 2005, 27, 82-88.
15. Lawton, C.A.; Cohen, E.P. & Moulder, J.E. Kidney and adrenal toxicity. In Human radiation injury, edited by D.C. Shrieve & J.S. Loeffler Lippincott. Williams & Wilkins, Philadelphia, Pennsylvania, USA, 2010, pp 328-339.
16. Stone, H.B.; Moulder, J.E.; Coleman, C. N.; Ang, K.K.; Anscher, M.S.; Barcellos-Hoff, M.H.; Dynan, W.S.; Fike, J.R.; Grdina, D.J.; Greenberger, J.S.; Hauer-Jensen, M.; Hill, R.P.; Kolesnick, R. N.; Macvittie, T. J.; Marks, C.; McBride, W.H.; Metting, N.; Pellmar, T.; Purucker, M.; Robbins, M.E.; Schiestl, R.H.; Seed, T.M.; Tomaszewski, J. E.; Travis, E.L.; Wallner, P. E.; Wolpert, M. & Zaharevitz, D. Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI workshop, December 3-4, 2003. Radiation Research, 2004, 162(6), 711-28. (Pubitemid 39552901)
17. Greenberger, J.S. Radioprotection. in vivo, 2009, 23(2), 323-26.
18. Weiss, J.F. & Landauer, M.R. History and development of radiation-protective agents. Int. J. Radiat. Biol., 2009, 85(7), 539-73.
19. Uma Devi, P. Development of an herbal radioprotector from the Indian holy basil: bench to bed progress. Ind. J. Radiat. Res., 2009, 6(1-2), 31-33.
20. Arora, R.; Kumar, R.; Sharma, A.; Prasad, J.; Singh, S.; Gupta, D.; Sharma, R.K. & Tripathi, R. P. Radiation countermeasure agents from novel high-altitude Himalayan herbs: Promise and prospects. Ind. J. Radiat. Res., 2009, 6(1-2), 34-36.
21. Cohen, E.P.; Fish, B.L. & Moulder, J.E. Mitigation of radiation injuries via suppression of the renin-angiotensin system: Emphasis on radiation nephropathy. Cur. Drug Targets, 2010, 11( 11): 1423-1429.
22. Cohen, E.P.; Joines, M.M. & Moulder, J.E. Prevention and treatment of radiation injuries - The role of the renin-angiotensin system. In Late effects of cancer treatment on normal tissues, edited by P. Rubin, L.S. Constine, L.B. Mark & P. Okunieff. Springer-Verlag, Heidelberg, Germany, 2008. pp. 69-76.
23. Zhao, W.; Diz, D.I. & Robbins, M.E. Oxidative damage pathways in relation to normal tissue injury. Br. J. Radiol, 2007, 80(1), S23-S31. (Pubitemid 47517796)
24. Moulder, J.E. & Cohen, E.P. Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury. Sem. Rad. One, 2007, 17(2), 141-48. (Pubitemid 46467384)
25. Langan, A.R.; Kahn, M.A.; Yeung, I. W.T.; VanDyk, J. & Hill, R.P. Partial volume rat lung irradiation: The protective/mitigating effects of Eukarion-189, a superoxide dismutase-catalase mimetic. Radiother. Oncol., 2006, 92(2), 231-38. (Pubitemid 43884942)
26. Delanian, S.; Porcher, R.; Rudant, J. & Lefaix, J.L. Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis. J. Clin. Oncol., 2005, 23(34), 8570-79. (Pubitemid 46211498)
27. Boerma, M.; Roberto, K.A. & Hauer-Jensen, M. Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alphatocopherol. Int. J. Radiat. Oncol. Biol. Phys., 2008, 71(1), 170-77.
28. Dainiak, N. Rationale and recommendations for treatment of radiation injury with cytokines. Health Physics, 2010, 98(6), 838-42.
29. MacVittie, T.J.; Farese, A. M. & Jackson, W. Defining the full therapeutic potential of recombinant growth factors in the post radiation-accident environment: the effect of supportive care plus administration of G-CSF. Health Physics, 2005, 89(5), 546-55. (Pubitemid 41463888)
30. Dwarakanath, B. S.; Bhatt, A.N.; Adhikari, J. S.; Soni, R.; Farooque, A.; Verma, A. & Singh, S. Metabolic and cell signaling approaches for obviating acute and late effects of ionizing radiation. Ind. J. Radiât. Res., 2009, 6(1-2), 40-42.
31. Sarin, R. Human clinical model systems for testing novel radiation protectors. Ind. J. Radiât. Res., 2009, 6(1-2), 21-23.
32. Pellmar, T.C. & Rockwell, S. Priority list of research areas for radiological nuclear threat countermeasures. Radiation Research, 2005, 163(1), 115-23. (Pubitemid 40039952)
33. Rojas-Palma, C.; Liland, A.; Jerstad, A.N.; Etherington, G.; del Rosario Pérez, M.; Rahola, T. & Smith, K. TMT Handbook - Triage, monitoring and treatment - handbook for management of the public in the event of malevolent use of radiation. Norwegian Radiation Protection Agency, Østeras, Norway 2009.
34. Bertho, J. M.; Roy, L.; Souidi, M.; Benderitter, M.; Gueguen, Y.; Lataillade, J. J.; Prat, M.; Fagot, T.; De Revel, T. & Gourmelon, P. New biological indicators to evaluate and monitor radiation-induced damage: an accident case report. Radiation Research, 2008, 169(5), 543-50. (Pubitemid 351671520)
35. Prasanna, P.G.S.; Blakely, W.F.; Bertho, J.M.; Chute, J.P.; Cohen, E.P.; Goans, R. E.; Grace, M.B.; LillisHearne, P.K.; Lloyd, D.C.; Lutgens, L.C.; Meineke, V.; Ossetrova, N.I.; Romanyukha, A.; Saba, J.D.; Weisdorf, D.J.; Wojcik, A.; Yukihara, E.G. & Pellmar, T.C. Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop. Radiation Research, 2010, 173(2), 245-53.
36. Swartz, H.M.; Flood, A.B.; Gougelet, R.M.; Rea, M.E.; Nicolalde, R.J. & Williams, B. B. A critical assessment of biodosimetry methods for large-scale incidents. Health Physics, 2010, 98(2), 95-108.
37. Goans, R.E. & Waselenko, J.K. Medical management of radiological casualties. Health Physics, 2005, 89(5), 505-12. (Pubitemid 41463884)
38. Demidenko, E.; Williams, B.B. & Swartz, H.M. Radiation dose prediction using data on time to emesis in the case of nuclear terrorism. Radiation Research, 2009, 171(3), 310-19.
39. Wilcox, D.E.; He, X.; Gui, J.; Ruuge, A.E.; Li, H.; Williams, B.B. & Swartz, H.M. Dosimetry based on EPR spectral analysis of fingernail clippings. Health Physics, 2010, 98(2), 309-17.
40. Williams, B.B.; Dong, R.; Kmiec, M.; Burke, G.; Demidenko, E.; Gladstone, D.; Nicolalde, R.J.; Sucheta, A.; Lesniewski, P. & Swartz, H.M. Development of in vivo tooth EPR for individual radiation dose estimation and screening. Health Physics, 2010, 98(2), 327-38.
41. Garty,' G.; Chen, Y.; Salerno, A.; Turner, H.; Zhang, J.; Lyulko, O.; Bertucci, A.; Xu, Y.; Wang, H.; Simaan, N.; Randers-Pehrson, G.; Yao, Y.L.; Amundson, S.A. & Brenner, D.J. The RABIT: a rapid automated biodosimetry tool for radiological triage. Health Physics, 2010, 98(2), 209-17.
42. Brown, S.L.; Kolozsvary, A.; Liu, J.; Jenrow, K.A.; Ryu, S. & Kim, J.H. Antioxidant diet supplementation starting 24 hours after exposure reduces radiation lethality. Radiation Research, 2010, 173(4), 462-68.
43. Epperly, M.l.; Jin, S.Q.; Nie, S.; Cao, S.; Zhang, X.N.; Franicola, D.; Wang, H.; Fink, M.P. & Greenberger, J. S. Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation. Radiation Research, 2007, 168(5), 552-59.
44. Burdelya, L.G.; Krivokrysenko, V.I.; Tallant, T.C; Strom, E.; Gleiberman, A.S.; Gupta, D.; Kurnasov, O.V; Fort, F.L.; Osterman, A.L.; Didonato, J. A.; Feinstein, E. & Gudkov, A. V. An agonist of Toll-like receptor 5 has radioprotective activity in mouse and primate models. Science, 2008, 320(5873), 226-30. (Pubitemid 351521417)
45. Georges, G.; Lesnikov, V.; Jordan, R.; Lesnikova, M.; Yang, J.Y.L. & Aragon, A. Hematopoietic stem cells (HSC) survive and reconstitute hematopoiesis after 8 Gy total body irradiation (TBI) in dogs given intensive supportive care and cytokine treatment. In Annual Meeting of the Radiation Research Society, Savannah, Georgia, U.S.A., October, 2009. pp. 30-31.
46. Moulder, J.E.; Cohen, E.P. & Fish, B.L. Captopril and losartan for mitigation of renal injury caused by singledose total body irradiation. Radiation Research, 2011, 175(1), 29-36.
47. Ghosh, S.N.; Zhang, R.; Fish, B.L.; Semenenko, V.A.; Li, X. A.; Moulder, J.E.; Jacobs, E.R. & Medhora, M. Renin-angiotensin system suppression mitigates experimental radiation pneumonitis Int. J. Radiat. Oncol. Biol. Phys., 2009, 75(5), 1528-36.
48. Jenrow, K.A.; Brown, S. L.; Liu, J.; Kolozsvary, A. & Kim, J.H. Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus. Radiation Oncology, 2010, 5(1), Article 6.
49. Baker, J.E.; Moulder, J.E. & Hopewell, J.W. Radiation as a risk factor for cardiovascular disease. Antioxid. Redox Signal, (online 21 November 2010).
50. Cohen, E.R; Irving, A. A.; Drobyski, W.R.; Klein, J.P.; Passweg, J.; Talano, J.; Juçkett, M. & Moulder, J.E. Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: A randomised controlled trial. Int. J. Radiat. Oncol. Biol. Phys., 2008, 70(5), 1546-51. (Pubitemid 351417757)
51. Moulder, J.E.; Robbins, M.E.C; Cohen, E.R; Hopewell, J.W. & Ward, W.F. Pharmacologic modification of radiation-induced late normal tissue injury. Cancer Treat. Res., 1998, 93, 129-51.
52. Jourdan, M.M.; Olasz, E.B.; Moulder, J.E.; Fish, B.L.; Mäder, M.; Schock, A.; Morrow, N.; Semenenko, V.A.; Doctrow, S.R. & Lazarova, Z. Mitigation of combined radiation and skin wound injury by SOD/catalase mimetic EUK-207. In Annual Meeting of the Radiation Research Society, Savannah, Georgia, U.S.A., October 2009. pp. 64-65.
53. 5+ in mitigation and treatment of radiation-induced lung damage. Free Radie. Biol. Med., 2010, 48(8), 1034-43.
54. Vorotnikova, E.; Rosenthal, R.A.; Tries, M.; Doctrow, S.R. & Braunhut, S. Novel synthetic SOD/catalase mimetics can mitigate capillary endothelial cell apoptosis caused by ionizing radiation. Radiation Research, 2010, 173(6), 748-59.
55. Food and Drug Administration. New drug and biological drug products: Evidence needed to demonstrate effectiveness of new drugs when human efficacy studies are not ethical or feasible. Federal Register, 2002, 67, 37988-98.