New biological indicators to evaluate and monitor radiation-induced damage: An accident case report

Radiation Research

Volumn 169, Issue 5, 2008, Pages 543-550

  Bertho, J M ^a   Roy, L ^a   Souidi, M ^a   Benderitter, M ^a   Gueguen, Y ^a   Lataillade, J J ^b   Prat, M ^b   Fagot, T ^c   De Revel, T ^c   Gourmelon, P ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

^b Centre de Transfusion Sanguine des Armées   (France)

^c PERCY MILITARY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CITRULLINE; FLT3 LIGAND; OXYSTEROL;

ADULT; ARTICLE; BLOOD SAMPLING; BONE MARROW APLASIA; CARDIOVASCULAR DISEASE; CASE REPORT; CYTOGENETICS; DIGESTIVE SYSTEM INJURY; DOSIMETRY; HEART DISEASE; HEMATOPOIETIC CELL; HUMAN; LIPID METABOLISM; LIVER INJURY; MALE; NAUSEA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RADIATION ACCIDENT; RADIATION EXPOSURE; RADIATION INJURY; RADIATION SICKNESS; THROMBOCYTOPENIA; VOMITING;

ACCIDENTS, RADIATION; BIOLOGICAL MARKERS; BLOOD CELL COUNT; CARDIOVASCULAR SYSTEM; CELL MOVEMENT; CITRULLINE; DIAGNOSIS; FOLLOW-UP STUDIES; GASTROINTESTINAL TRACT; HEMATOPOIESIS; HUMANS; LYMPHOCYTES; RADIOMETRY;

EID: 43449109195     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1259.1     Document Type: Article

References (39)

1. N. Dainiak, P. Berger and J. Albanese, Relevance and feasibility of multi-parameter assessment for management of mass casualties from a radiological event. Exp. Hematol. 35, 17-23 (2007).
2. T. M. Fliedner, D. Graessle, V. Meineke and W. Dörr, Pathophysiological principles underlying the blood cell concentration responses used to assess the severity of effect after accidental whole-body radiation exposure: An essential basis for an evidence-based clinical triage. Exp. Hematol. 35, 8-16 (2007).
3. J. C. Nenot, Radiation accidents: lessons learnt for future radiological protection. Int. J. Radiat. Biol. 73, 435-442 (1998).
4. R. E. Goans, Clinical care of the radiation-accident patient: case presentation, assessment and initial diagnosis. In The Medical Basis For Radiation Accident Preparedness (R. C. Ricks, M. E. Berger and F. M. O'Hara, Eds.), pp. 11-22. Parthenon, Washington, DC, 2002.
5. L. Roy, E. Gregoire, V. Durand, V. Buard, M. Delbos, N. Paillole, I. Sorokine-Durm, P. Gourmelon and P. Voisin, Study of the tools available in biological dosimetry to estimate the dose in cases of accidental complex overexposure to ionizing radiation: The Lilo accident. Int. J. Radiat. Biol. 82, 39-48 (2006).
6. A. Barrett, A. Jacobs, J. Kohn, J. Raymond and R. L. Powles, Changes in serum amylase and its isoenzymes after whole body irradiation. Br. Med. J. 285, 170-171 (1982).
7. D. Junglee, A. Katrak, J. Mohiuddin, H. Blacklock, H. G. Prentice and P. Dnadona, Salivary amylase and pancreatic enzymes in serum after total body irradiation. Clin. Chem. 32, 609-610 (1986).
8. G. Silini and A. Gouskova, Biological dosimetry at Chernobyl. In New Horizons In Biological Dosimetry (B. L. Gledhill and F. Mauro, Eds.), pp 129-144. Wiley-Liss, New York, 1991.
9. T. M. Fliedner, I. Friesecke and K. Beyer, Medical Management of Radiation Accidents: Manual on the Acute Radiation Syndrome. The British Institute of Radiology, London, 2001.
10. A. Huchet, Y. Belkacemi, J. Frick, M. Prat, I. Muresan-Kloos, D. Altan, A. Chapel, N. C. Gorin, P. Gourmelon and J. M. Bertho, Plasma Flt3 ligand concentration correlated with radiation-induced bone marrow damage during local fractionated radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 57, 508-515 (2003).
11. M. Prat, C. Demarquay, J. Frick, N. Dudoignon, D. Thierry and J. M. Bertho, Use of Flt3 ligand to evaluate residual hematopoiesis after heterogeneous irradiation in mice. Radiat. Res. 166, 504-511 (2006).
12. P. Crenn, K. Vahedi, A. Lavergne-Slove, L. Cynober, C. Matuchansky and B. Messing, Plasma citrulline: a marker of enterocyte mass in villous atrophy-associated small bowel disease. Gastroenterology 124, 1210-1219 (2003).
13. L. C. Lutgens, N. Deutz, M. Granzier-Peeters, R. Beets-Tan, D. De Ruysscher, J. Gueulette, J. Cleutjens, M. Berger, B. Wouters and P. Lambin, Plasma citrulline concentration: A surrogate end point for radiation-induced mucosal atrophy of the small bowel. A feasibility study in 23 patients. Int. J. Radiat. Oncol. Biol. Phys. 60, 275-285 (2004).
14. M. Prat, J. Frick, J. P. Laporte, D. Thierry, N. C. Gorin and J. M. Bertho, Kinetics of plasma Flt3 ligand concentration in hematopoietic stem cell transplanted patients. Leuk. Lymph. 47, 77-80 (2006).
15. S. D. Lyman, M. Seaberg, R. Hanna, J. D. Zappone, K. Brasel and J. L. Abkowitz, Plasma/serum levels of Flt3 ligand are low in normal individuals and highly elevated in patients with Fanconi anemia and acquired aplastic anemia. Blood 86, 4091-4096 (1995).
16. I. Björkhem and U. Diczfalusy, Oxysterols: Friends, foes, or just fellow passengers? Arterioscl. Thromb. Vasc. Biol. 22, 734-742 (2002).
17. M. Souidi, S. Dubrac, M. Parquet, D. Volle, J. M. A. Lobaccaro, D. Mathé, O. Combes, P. Scanff, C. Lutton and J. Aigueperse, Oxysterols: metabolism, biological role and associated diseases. Gastroenterol. Clin. Biol. 28, 279-293 (2004).
18. C. Huet, F. Trompier, I. Clairand, F. Queinnec and J. F. Bottollier-Depois, Physical dosimetric reconstruction of a radiological accident at Fleurus (Belgium) on 11 March 2006. Radiat. Meas., in press.
19. T. Fagot, J. F. Bottolier, L. Roy, T. Samson, F. Desangles, J. J. Lataillade, J. M. Bertho, C. Caillot, P. Gourmelon and T. De Revel, A pure hematological syndrome secondary to an accidental radiation exposure treated with G-CSF, EPO and SCF. Exp. Hematol. 34 (Suppl. 1), 76 (2006). [Abstract]
20. IAEA, Cytogenetic Analysis for Dose Assessment: A Manual. Technical reports series No. 405, IAEA, Vienna, 2001.
21. E. Grégoire, I. Sorokine-Durm, J. M. Bertho, N. Jacquet, M. Delbos, C. Demarquay, P. Voisin and L. Roy, Follow-up of stable chromosomal aberrations in gamma-rays irradiated non-human primates. Int. J. Radiat. Biol. 82, 493-502 (2006).
22. P. Voisin, M. Benderitter, M. Claraz, V. Chambrette, I. Sorokine-Durm, M. Delbos, V. Durand, A. Leroy and N. Paillole, The cytogenetic dosimetry of recent radiation overexposure. Cell. Mol. Biol. 47, 557-564 (2001).
23. Y. Gueguen, M. Souidi, C. Baudelin, N. Dudoignon, S. Grison, I. Dublineau, C. Marquette, P. Voisin, P. Gourmelon and J. Aigueperse, Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat. Arch. Toxicol. 80, 187-195 (2005).
24. C. Lindholm, H. Romm, G. Stephan, E. Schmid, J. Moquet and A. Edwards, Intercomparison of translocation and dicentric frequencies between laboratories in a follow-up of the radiological accident in Estonia. Int. J. Radiat. Biol. 78, 883-890 (2002).
25. M. S. Sasaki and H. Miyata, Biological dosimetry in atomic bomb survivors. Nature 220, 1189-1193 (1969).
26. T. Grande and J. A. Bueren, The mobilization of hematopoietic progenitor to peripheral blood is predictive of the hematopoietic syndrome after total or partial body irradiation of mice. Int. J. Radiat. Oncol. Biol. Phys. 64, 612-618 (2006).
27. D. Lütjohann, Cholesterol metabolism in the brain: importance of 24S-hydroxylation. Acta Neurol. Scand. 114 (Suppl. 185), 33-42 (2006).
28. H. Oda, H. Yamashita, K. Kosahara, S. Kuroki and F. Nakayama, Esterified and total 7a-hydroxycholesterol in human serum as an indicator for hepatic bile acid synthesis. J. Lipid Res. 31, 2209-2218 (1990).
29. D. Lütjohann, A. Papassotiropoulos, I. Björkhem, S. Locatelli, M. Bagli, R. D. Oehring, U. Schlegel, F. Jessen, M. L. Rao and R. Heun, Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients. J. Lipid Res. 41, 195-198 (2000).
30. R. Harik-Khan and R. P. Holmes, Estimation of 26-hydroxycholesterol in serum by high-performance liquid chromatography and its measurement in patients with atherosclerosis. J. Steroid Biochem. 36, 351-355 (1990).
31. S. Asano, Multi-organ involvement: Lessons from the experience of one victim of the Tokai-mura criticality accident. In Radiation-Induced Multi-organ Involvement and Failure: A Challenge for Pathogenic, Diagnostic and Therapeutic Approaches and Research (T. M. Fliedner and V. Meineke, Eds.). The British Institute of Radiology, London, 2005.
32. A. E. Baranov, G. D. Selidovkin, A. Butturini and R. P. Gale, Hematopoietic recovery after 10-Gy acute total body irradiation. Blood 83, 596-599 (1994).
33. N. C. Gorin, T. M. Fliedner, P. Gourmelon, A. Ganser, V. Meineke, B. Sirohi, R. Powles and J. Apperley, Consensus conference on European preparedness for haematological and other medical management of mass radiation accidents. Ann. Haematol. 85, 671-679 (2006).
34. J. M. Bertho, C. Demarquay, J. Frick, C. Joubert, S. Arenales, N. Jacquet, I. Sorokine-Durm, Q. Chau, M. Lopez and P. Gourmelon, Level of Flt3 ligand in plasma: a possible new bio-indicator for radiation-induced aplasia. Int. J. Radiat. Biol. 77, 703-712 (2001).
35. S. Kuroki, S. Okamoto, T. Naito, H. Oda, S. Nagase, H. Sakai, H. Nawata, H. Yamashita, K. Chijiiwa and M. Tanaka, Serum 7 alpha-hydroxycholesterol as a new parameter of liver function in patients with chronic liver disease. Hepatology 22, 1182-1187 (1995).
36. M. Rajappa and A. Sharma, Biomarkers of cardiac injury: an update. Angiology 56, 677-691 (2005).
37. T. M. Fliedner, W. Dörr and V. Meineke, Multi-organ involvement as a pathogenic principle of the radiation syndromes: a study involving 110 case histories documented in SEARCH and classified as the bases of haematopoietic indicators of effects. In Radiation-Induced Multi-organ Involvement and Failure: A Challenge for Pathogenic, Diagnostic and Therapeutic Approaches and Research (T. M. Fliedner and V. Meineke, Eds.). The British Institute of Radiology, London, 2005.
38. D. Johnson and I. Mayer, Multiple organ dysfunction syndrome: A narrative review. Can. J. Anesth. 48, 502-509 (2001).
39. W. L. Jackson, C. Gallagher, R. C. Myhand and J. K. Waselenko, Medical management of patients with multiple organ dysfunction syndrome arising from acute radiation syndrome. In Radiation-Induced Multi-organ Involvement and Failure: A Challenge for Pathogenic, Diagnostic and Therapeutic Approaches and Research (T. M. Fliedner and V. Meineke, Eds.). The British Institute of Radiology, London, 2005.