Antioxidant diet supplementation starting 24 hours after exposure reduces radiation lethality

Radiation Research

Volumn 173, Issue 4, 2010, Pages 462-468

  Brown, Stephen L ^a   Kolozsvary, Andrew ^a   Liu, Jianguo ^a   Jenrow, Kenneth A ^a   Ryu, Samuel ^a   Kim, Jae Ho ^a  

^a HENRY FORD HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL SUCCINATE; ANTIOXIDANT; ASCORBIC ACID; SELENOMETHIONINE; THIOCTIC ACID; UBIDECARENONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD CELL; BONE MARROW CELL; CELL SURVIVAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; LETHALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIATION PROTECTION; SPLEEN CELL; SURVIVAL; WHOLE BODY RADIATION;

ANIMALS; ANTIOXIDANTS; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, RADIATION; MICE; MICE, INBRED C57BL; PREVALENCE; RADIATION INJURIES; RADIATION PROTECTION; SURVIVAL ANALYSIS; SURVIVAL RATE; WHOLE-BODY IRRADIATION;

MUS;

EID: 77950255849     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1716.1     Document Type: Article

References (21)

1. C. Wambi, J. Sanzari, X. S. Wan, M. Nuth, J. Davis, Y-H. Ko, C. M. Sayers, M. Baran, J. H. Ware and A. R. Kennedy, Dietary antioxidants protect hematopoietic cells and improve animal survival after total-body irradiation. Radiat. Res. 169, 384-396 (2008).
2. A. M. Farese, F. Herodin, J. P. McKearn, C. Baum, E. Burton and T. J. MacVittie, Acceleration of hematopoietic reconstitution with a synthetic cytokine (SC-55494) after radiation-induced bone marrow aplasia. Blood 87, 581-591 (1996).
3. F. Herodin, P. Bourin, J. F. Mayol, J. J. Lataillade and M. Drouet, Short-term injection of antiapoptotic cytokine combinations soon after lethal gamma-irradiation promotes survival. Blood 101, 2609-2616 (2003).
4. F. Herodin and M. Drouet, Cytokine-based treatment of accidentally irradiated victims and new approaches. Exp. Hematol. 33, 1071-1080 (2005).
5. J. Guan, J. Stewart, J. H. Ware, Z. Zhou, J. J. Donahue and A. R. Kennedy, Effects of dietary supplements on space radiation-induced induction in total antioxidant status in CBA mice. Radiat. Res. 165, 373-378 (2006).
6. S. L. Brown, A. Kolozsvary, J. Liu, S. Ryu and J. H. Kim, Histone deacetylase inhibitors protect against and mitigate the lethality of total-body irradiation in mice. Radiat. Res. 169, 474-478 (2008).
7. K. L. Quick and L. L. Dugan, Superoxide stress identifies neurons at risk in a model of ataxia-telangiectasia. Ann. Neurol. 49, 627-635 (2001).
8. W. Zhao, D. I. Diz and M. E. Robbins, Oxidative damage pathways in relation to normal tissue injury. Br. J. Radiol. 80, S23-S31 (2007).
9. K. N. Prasad, W. Cole and P. Hovland, Cancer prevention studies: past, present and future direction. Nutrition 14, 197-210 (1998).
10. K. S. Kumar, V. Srinivasan, R. Toles, L. Jobe and T. M. Seed, Nutritional approaches to radioprotection: Vitamin E. Mil. Med. 167, 57-59 (2002).
11. Q. Guo and L. Parker, Ascorbate-dependent recycling of the vitamin E homologue Trolox by dihyrolipoate and glutathione in murine skin homogenates. Free Radic. Biol. Med. 29, 368-374 (2000).
12. J. Haendeler, A. M. Zeiher and S. Dimmler, Vitamin C and vitamin E prevent lipopolysaccharide-induced apoptosis in human endothelial cells by modulating Bcl-2 and Bax. Eur. J. Pharmacol. 17, 407-411 (1996).
13. K. N. Prasad, B. Kumar, X. D. Yan, A. J. Hanson and W. C. Cole, Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review. J. Am. Coll. Nutr. 22, 108-117 (2003).
14. J. A. Rotolo, R. Kolesnick and Z. Fuks, Timing of lethality from gastointestinal syndrome in mice revisited. Int. J. Radiat. Oncol. Biol. Phys. 73, 6-8 (2009).
15. M. Sattler, T. Winkler, S. Verma, C. H. Byrne, G. Shrikhande, R. Salgia and J. D. Griffin, Hematopoietic growth factors signal through the formation of reactive oxygen species. Blood 93, 2928-2935 (1999).
16. M. Iiyama, K. Kakihana, T. Kurosu and O. Miura, Reactive oxygen species generated by hematopoietic cytokines play roles in activation of receptor-mediated signaling and in cell cycle progression. Cell Signal. 18, 174-182 (2006).
17. S. Yousefi, D. R. Green, K. Blaser and H. U. Simon, Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proc. Natl. Acad. Sci. USA 91, 10868-10872 (1994).
18. C. G. Havens, A. Ho, N. Yoshioka and S. F. Dowdy, Regulation of late G1/S phase transition and APC Cdh1 by reactive oxygen species. Mol. Cell Biol. 26, 4701-4711 (2006).
19. W. K. Sinclair, Cyclic X-ray responses in mammalian cells in vitro. Radiat. Res. 33, 620-643 (1968).
20. H. D. Thames, Jr., H. R. Withers and L. J. Peters, Tissue repair capacity and repair kinetics deduced from multifractionated or continuous irradiation regimens with incomplete repair. Br. J. Cancer Suppl. 6, 263-269 (1984).
21. W. T. Millar and J. H. Hendry, Haemopoietic injury after irradiation: analysis of dose responses and repair using a target-cell model. Int. J. Radiat. Biol. 72, 561-573 (1997).