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Volumn 32, Issue 7, 2011, Pages 1236-1248

The apolipoprotein E ε4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase

Author keywords

Alzheimer's disease; Apolipoprotein E; Beta amyloid; Butyrylcholinesterase; Fibrillization; Proinflammatory cytokine (IL 1 ); Risk factors

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E4; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; ISOPROTEIN; TAU PROTEIN;

EID: 79952231145     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2009.07.015     Document Type: Article
Times cited : (43)

References (63)
  • 1
    • 0023629312 scopus 로고
    • Cholinesterase activities in cerebrospinal fluid of patients with senile dementia of Alzheimer type
    • Appleyard M.E., Smith A.D., Berman P., Wilcock G.K., Esiri M.M., Neary D., Bowen D.M. Cholinesterase activities in cerebrospinal fluid of patients with senile dementia of Alzheimer type. Brain 1987, 110:1309-1322.
    • (1987) Brain , vol.110 , pp. 1309-1322
    • Appleyard, M.E.1    Smith, A.D.2    Berman, P.3    Wilcock, G.K.4    Esiri, M.M.5    Neary, D.6    Bowen, D.M.7
  • 2
    • 0026794041 scopus 로고
    • Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development-a study of molecular forms
    • Arendt T., Bruckner M.K., Lange M., Bigl V. Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development-a study of molecular forms. Neurochem. Int. 1992, 21:381-396.
    • (1992) Neurochem. Int. , vol.21 , pp. 381-396
    • Arendt, T.1    Bruckner, M.K.2    Lange, M.3    Bigl, V.4
  • 3
    • 1542409285 scopus 로고    scopus 로고
    • Functions of lipoprotein receptors in neurons
    • Beffert U., Stolt P.C., Herz J. Functions of lipoprotein receptors in neurons. J. Lipid. Res. 2004, 45:403-409.
    • (2004) J. Lipid. Res. , vol.45 , pp. 403-409
    • Beffert, U.1    Stolt, P.C.2    Herz, J.3
  • 4
  • 6
    • 33750005095 scopus 로고    scopus 로고
    • Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE epsilon4 allele, in relation to cognitive function and cerebral glucose metabolism
    • Darreh-Shori T., Brimijoin S., Kadir A., Almkvist O., Nordberg A. Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE epsilon4 allele, in relation to cognitive function and cerebral glucose metabolism. Neurobiol. Dis. 2006, 24:326-333.
    • (2006) Neurobiol. Dis. , vol.24 , pp. 326-333
    • Darreh-Shori, T.1    Brimijoin, S.2    Kadir, A.3    Almkvist, O.4    Nordberg, A.5
  • 8
    • 79958765597 scopus 로고    scopus 로고
    • Apolipoprotein E and butyrylcholinesterase synergistically promote amyloid-beta peptides oligomerization
    • Alzheimers Dement, Abstract P1-163
    • Darreh-Shori T., Modiri N., Lahaut P., Nordberg A. Apolipoprotein E and butyrylcholinesterase synergistically promote amyloid-beta peptides oligomerization. ICAD 2009, Alzheimers Dement, Abstract P1-163.
    • (2009) ICAD
    • Darreh-Shori, T.1    Modiri, N.2    Lahaut, P.3    Nordberg, A.4
  • 9
    • 79958771618 scopus 로고    scopus 로고
    • ApoE and amyloid beta deflate the cholinergic neurotransmission by boosting the activity and stability of cholinesterases in the brain
    • Alzheimers Dement, Abstract P2-151
    • Darreh-Shori T., Modiri N., Nordberg A. ApoE and amyloid beta deflate the cholinergic neurotransmission by boosting the activity and stability of cholinesterases in the brain. ICAD 2009, Alzheimers Dement, Abstract P2-151.
    • (2009) ICAD
    • Darreh-Shori, T.1    Modiri, N.2    Nordberg, A.3
  • 10
    • 0011162190 scopus 로고
    • Selective loss of central cholinergic neurons in Alzheimer's disease
    • Davies P., Maloney A.J. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 1976, 2:1403.
    • (1976) Lancet , vol.2 , pp. 1403
    • Davies, P.1    Maloney, A.J.2
  • 11
    • 0034181473 scopus 로고    scopus 로고
    • Association of apolipoprotein E polymorphism with plasma lipids and Alzheimer's disease in a Southern Brazilian population
    • de-Andrade F.M., Larrandaburu M., Callegari-Jacques S.M., Gastaldo G., Hutz M.H. Association of apolipoprotein E polymorphism with plasma lipids and Alzheimer's disease in a Southern Brazilian population. Braz. J. Med. Biol. Res. 2000, 33:529-537.
    • (2000) Braz. J. Med. Biol. Res. , vol.33 , pp. 529-537
    • de-Andrade, F.M.1    Larrandaburu, M.2    Callegari-Jacques, S.M.3    Gastaldo, G.4    Hutz, M.H.5
  • 13
    • 0030823158 scopus 로고    scopus 로고
    • Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
    • Farrer L.A., Cupples L.A., Haines J.L., Hyman B., Kukull W.A., Mayeux R., Myers R.H., Pericak-Vance M.A., Risch N., van Duijn C.M. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 1997, 278:1349-1356.
    • (1997) JAMA , vol.278 , pp. 1349-1356
    • Farrer, L.A.1    Cupples, L.A.2    Haines, J.L.3    Hyman, B.4    Kukull, W.A.5    Mayeux, R.6    Myers, R.H.7    Pericak-Vance, M.A.8    Risch, N.9    van Duijn, C.M.10
  • 16
    • 0036315026 scopus 로고    scopus 로고
    • Inhibition of acetyl- and butyryl-cholinesterase in the cerebrospinal fluid of patients with Alzheimer's disease by rivastigmine: correlation with cognitive benefit
    • Giacobini E., Spiegel R., Enz A., Veroff A.E., Cutler N.R. Inhibition of acetyl- and butyryl-cholinesterase in the cerebrospinal fluid of patients with Alzheimer's disease by rivastigmine: correlation with cognitive benefit. J. Neural. Transm. 2002, 109:1053-1065.
    • (2002) J. Neural. Transm. , vol.109 , pp. 1053-1065
    • Giacobini, E.1    Spiegel, R.2    Enz, A.3    Veroff, A.E.4    Cutler, N.R.5
  • 17
    • 0037119427 scopus 로고    scopus 로고
    • Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice
    • Gong J.S., Kobayashi M., Hayashi H., Zou K., Sawamura N., Fujita S.C., Yanagisawa K., Michikawa M. Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice. J. Biol. Chem. 2002, 277:29919-29926.
    • (2002) J. Biol. Chem. , vol.277 , pp. 29919-29926
    • Gong, J.S.1    Kobayashi, M.2    Hayashi, H.3    Zou, K.4    Sawamura, N.5    Fujita, S.C.6    Yanagisawa, K.7    Michikawa, M.8
  • 18
    • 34248153778 scopus 로고    scopus 로고
    • Influence of apolipoprotein E polymorphism on serum lipid and lipoprotein changes: a 21-year follow-up study from childhood to adulthood. The Cardiovascular Risk in Young Finns Study
    • Gronroos P., Raitakari O.T., Kahonen M., Hutri-Kahonen N., Marniemi J., Viikari J., Lehtimaki T. Influence of apolipoprotein E polymorphism on serum lipid and lipoprotein changes: a 21-year follow-up study from childhood to adulthood. The Cardiovascular Risk in Young Finns Study. Clin. Chem. Lab. Med. 2007, 45:592-598.
    • (2007) Clin. Chem. Lab. Med. , vol.45 , pp. 592-598
    • Gronroos, P.1    Raitakari, O.T.2    Kahonen, M.3    Hutri-Kahonen, N.4    Marniemi, J.5    Viikari, J.6    Lehtimaki, T.7
  • 19
  • 21
    • 33847240080 scopus 로고    scopus 로고
    • Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1
    • Hayashi H., Campenot R.B., Vance D.E., Vance J.E. Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1. J. Neurosci. 2007, 27:1933-1941.
    • (2007) J. Neurosci. , vol.27 , pp. 1933-1941
    • Hayashi, H.1    Campenot, R.B.2    Vance, D.E.3    Vance, J.E.4
  • 22
    • 0034305790 scopus 로고    scopus 로고
    • Apolipoprotein E receptors: linking brain development and Alzheimer's disease
    • Herz J., Beffert U. Apolipoprotein E receptors: linking brain development and Alzheimer's disease. Nat. Rev. Neurosci. 2000, 1:51-58.
    • (2000) Nat. Rev. Neurosci. , vol.1 , pp. 51-58
    • Herz, J.1    Beffert, U.2
  • 23
    • 0030276257 scopus 로고    scopus 로고
    • Acetylcholinesterase is a senile plaque component that promotes assembly of amyloid beta-peptide into Alzheimer's filaments
    • Inestrosa N.C., Alvarez A., Calderon F. Acetylcholinesterase is a senile plaque component that promotes assembly of amyloid beta-peptide into Alzheimer's filaments. Mol. Psychiatry 1996, 1:359-361.
    • (1996) Mol. Psychiatry , vol.1 , pp. 359-361
    • Inestrosa, N.C.1    Alvarez, A.2    Calderon, F.3
  • 26
    • 0033574377 scopus 로고    scopus 로고
    • No association between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset Alzheimer's disease
    • Ki C.S., Na D.L., Kim J.W., Kim H.J., Kim D.K., Yoon B.K. No association between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset Alzheimer's disease. Am. J. Med. Genet. 1999, 88:113-115.
    • (1999) Am. J. Med. Genet. , vol.88 , pp. 113-115
    • Ki, C.S.1    Na, D.L.2    Kim, J.W.3    Kim, H.J.4    Kim, D.K.5    Yoon, B.K.6
  • 28
    • 29944441736 scopus 로고    scopus 로고
    • In vivo butyrylcholinesterase activity is not increased in Alzheimer's disease synapses
    • Kuhl D.E., Koeppe R.A., Snyder S.E., Minoshima S., Frey K.A., Kilbourn M.R. In vivo butyrylcholinesterase activity is not increased in Alzheimer's disease synapses. Ann. Neurol. 2006, 59(1):13-20.
    • (2006) Ann. Neurol. , vol.59 , Issue.1 , pp. 13-20
    • Kuhl, D.E.1    Koeppe, R.A.2    Snyder, S.E.3    Minoshima, S.4    Frey, K.A.5    Kilbourn, M.R.6
  • 30
    • 0034599501 scopus 로고    scopus 로고
    • No association between butyrylcholinesterase K-variant and Alzheimer disease in Chinese
    • Lee D.W., Liu H.C., Liu T.Y., Chi C.W., Hong C.J. No association between butyrylcholinesterase K-variant and Alzheimer disease in Chinese. Am. J. Med. Genet. 2000, 96:167-169.
    • (2000) Am. J. Med. Genet. , vol.96 , pp. 167-169
    • Lee, D.W.1    Liu, H.C.2    Liu, T.Y.3    Chi, C.W.4    Hong, C.J.5
  • 31
    • 0030731562 scopus 로고    scopus 로고
    • Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease
    • Lehmann D.J., Johnston C., Smith A.D. Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease. Hum. Mol. Genet. 1997, 6:1933-1936.
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 1933-1936
    • Lehmann, D.J.1    Johnston, C.2    Smith, A.D.3
  • 32
    • 0034018129 scopus 로고    scopus 로고
    • Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer's disease
    • Lehmann D.J., Nagy Z., Litchfield S., Borja M.C., Smith A.D. Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer's disease. Hum. Genet. 2000, 106:447-452.
    • (2000) Hum. Genet. , vol.106 , pp. 447-452
    • Lehmann, D.J.1    Nagy, Z.2    Litchfield, S.3    Borja, M.C.4    Smith, A.D.5
  • 33
    • 34748897213 scopus 로고    scopus 로고
    • Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1
    • Liu Q., Zerbinatti C.V., Zhang J., Hoe H.S., Wang B., Cole S.L., Herz J., Muglia L., Bu G. Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 2007, 56:66-78.
    • (2007) Neuron , vol.56 , pp. 66-78
    • Liu, Q.1    Zerbinatti, C.V.2    Zhang, J.3    Hoe, H.S.4    Wang, B.5    Cole, S.L.6    Herz, J.7    Muglia, L.8    Bu, G.9
  • 34
    • 0034575124 scopus 로고    scopus 로고
    • Apolipoprotein E: far more than a lipid transport protein
    • Mahley R.W., Rall S.C. Apolipoprotein E: far more than a lipid transport protein. Annu. Rev. Genomics Hum. Genet. 2000, 1:507-537.
    • (2000) Annu. Rev. Genomics Hum. Genet. , vol.1 , pp. 507-537
    • Mahley, R.W.1    Rall, S.C.2
  • 35
    • 33746565284 scopus 로고    scopus 로고
    • Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease
    • Martins I.J., Hone E., Foster J.K., Sunram-Lea S.I., Gnjec A., Fuller S.J., Nolan D., Gandy S.E., Martins R.N. Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease. Mol. Psychiatry 2006, 11:721-736.
    • (2006) Mol. Psychiatry , vol.11 , pp. 721-736
    • Martins, I.J.1    Hone, E.2    Foster, J.K.3    Sunram-Lea, S.I.4    Gnjec, A.5    Fuller, S.J.6    Nolan, D.7    Gandy, S.E.8    Martins, R.N.9
  • 37
    • 22144456107 scopus 로고    scopus 로고
    • Butyrylcholinesterase and dementia with Lewy bodies: involvement in symptom progression and treatment response
    • Martin Dunitz, London, E. Giacobini (Ed.)
    • McKeith I.G., O'Brien K.K., Morris C.M., Perry E.K. Butyrylcholinesterase and dementia with Lewy bodies: involvement in symptom progression and treatment response. Butyrylcholinesterase: Its Function and Inhibitors 2003, 149-162. Martin Dunitz, London. E. Giacobini (Ed.).
    • (2003) Butyrylcholinesterase: Its Function and Inhibitors , pp. 149-162
    • McKeith, I.G.1    O'Brien, K.K.2    Morris, C.M.3    Perry, E.K.4
  • 38
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984, 34:939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 39
    • 0027973241 scopus 로고
    • Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia
    • Mesulam M.M., Geula C. Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia. Ann. Neurol. 1994, 36:722-727.
    • (1994) Ann. Neurol. , vol.36 , pp. 722-727
    • Mesulam, M.M.1    Geula, C.2
  • 40
    • 0037012468 scopus 로고    scopus 로고
    • Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine
    • Mesulam M.M., Guillozet A., Shaw P., Levey A., Duysen E.G., Lockridge O. Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine. Neuroscience 2002, 110:627-639.
    • (2002) Neuroscience , vol.110 , pp. 627-639
    • Mesulam, M.M.1    Guillozet, A.2    Shaw, P.3    Levey, A.4    Duysen, E.G.5    Lockridge, O.6
  • 41
    • 0033281948 scopus 로고    scopus 로고
    • Mood and cognitive disorders in cancer patients receiving cytokine therapy
    • Meyers C.A. Mood and cognitive disorders in cancer patients receiving cytokine therapy. Adv. Exp. Med. Biol. 1999, 461:75-81.
    • (1999) Adv. Exp. Med. Biol. , vol.461 , pp. 75-81
    • Meyers, C.A.1
  • 42
    • 0033968648 scopus 로고    scopus 로고
    • Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture
    • Michikawa M., Fan Q.W., Isobe I., Yanagisawa K. Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture. J. Neurochem. 2000, 74:1008-1016.
    • (2000) J. Neurochem. , vol.74 , pp. 1008-1016
    • Michikawa, M.1    Fan, Q.W.2    Isobe, I.3    Yanagisawa, K.4
  • 43
    • 55449097874 scopus 로고    scopus 로고
    • Pharmacogenetics of apolipoprotein E gene during lipid-lowering therapy: lipid levels and prevention of coronary heart disease
    • Nieminen T., Kahonen M., Viiri L.E., Gronroos P., Lehtimaki T. Pharmacogenetics of apolipoprotein E gene during lipid-lowering therapy: lipid levels and prevention of coronary heart disease. Pharmacogenomics 2008, 9:1475-1486.
    • (2008) Pharmacogenomics , vol.9 , pp. 1475-1486
    • Nieminen, T.1    Kahonen, M.2    Viiri, L.E.3    Gronroos, P.4    Lehtimaki, T.5
  • 45
    • 0038792258 scopus 로고    scopus 로고
    • Butyrylcholinesterase and progression of cognitive deficits in dementia with Lewy bodies
    • Perry E., McKeith I., Ballard C. Butyrylcholinesterase and progression of cognitive deficits in dementia with Lewy bodies. Neurology 2003, 60:1852-1853.
    • (2003) Neurology , vol.60 , pp. 1852-1853
    • Perry, E.1    McKeith, I.2    Ballard, C.3
  • 47
    • 40449118768 scopus 로고    scopus 로고
    • Human recombinant butyrylcholinesterase purified from the milk of transgenic goats interacts with beta-amyloid fibrils and suppresses their formation in vitro
    • Podoly E., Bruck T., Diamant S., Melamed-Book N., Weiss A., Huang Y., Livnah O., Langermann S., Wilgus H., Soreq H. Human recombinant butyrylcholinesterase purified from the milk of transgenic goats interacts with beta-amyloid fibrils and suppresses their formation in vitro. Neurodegener. Dis. 2008, 5:232-236.
    • (2008) Neurodegener. Dis. , vol.5 , pp. 232-236
    • Podoly, E.1    Bruck, T.2    Diamant, S.3    Melamed-Book, N.4    Weiss, A.5    Huang, Y.6    Livnah, O.7    Langermann, S.8    Wilgus, H.9    Soreq, H.10
  • 48
    • 11444251445 scopus 로고    scopus 로고
    • Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease
    • Poirier J. Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease. Neurobiol. Aging 2005, 26:355-361.
    • (2005) Neurobiol. Aging , vol.26 , pp. 355-361
    • Poirier, J.1
  • 49
    • 0242570611 scopus 로고    scopus 로고
    • ApoE isoforms affect neuronal N-methyl-d-aspartate calcium responses and toxicity via receptor-mediated processes
    • Qiu Z., Crutcher K.A., Hyman B.T., Rebeck G.W. ApoE isoforms affect neuronal N-methyl-d-aspartate calcium responses and toxicity via receptor-mediated processes. Neuroscience 2003, 122:291-303.
    • (2003) Neuroscience , vol.122 , pp. 291-303
    • Qiu, Z.1    Crutcher, K.A.2    Hyman, B.T.3    Rebeck, G.W.4
  • 50
    • 33744991531 scopus 로고    scopus 로고
    • Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes
    • Rapp A., Gmeiner B., Huttinger M. Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes. Biochimie 2006, 88:473-483.
    • (2006) Biochimie , vol.88 , pp. 473-483
    • Rapp, A.1    Gmeiner, B.2    Huttinger, M.3
  • 51
    • 33749066121 scopus 로고    scopus 로고
    • Association between apolipoprotein E polymorphism and serum lipid and apolipoprotein levels with Alzheimer's disease
    • Raygani A.V., Rahimi Z., Kharazi H., Tavilani H., Pourmotabbed T. Association between apolipoprotein E polymorphism and serum lipid and apolipoprotein levels with Alzheimer's disease. Neurosci. Lett. 2006, 408:68-72.
    • (2006) Neurosci. Lett. , vol.408 , pp. 68-72
    • Raygani, A.V.1    Rahimi, Z.2    Kharazi, H.3    Tavilani, H.4    Pourmotabbed, T.5
  • 53
    • 7444260921 scopus 로고    scopus 로고
    • Analysis of association between butyrylcholinesterase K variant and apolipoprotein E genotypes in Alzheimer's disease
    • Raygani A.V., Zahrai M., Soltanzadeh A., Doosti M., Javadi E., Pourmotabbed T. Analysis of association between butyrylcholinesterase K variant and apolipoprotein E genotypes in Alzheimer's disease. Neurosci. Lett. 2004, 371:142-146.
    • (2004) Neurosci. Lett. , vol.371 , pp. 142-146
    • Raygani, A.V.1    Zahrai, M.2    Soltanzadeh, A.3    Doosti, M.4    Javadi, E.5    Pourmotabbed, T.6
  • 54
    • 0027374047 scopus 로고
    • Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions
    • Rebeck G.W., Reiter J.S., Strickland D.K., Hyman B.T. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron 1993, 11:575-580.
    • (1993) Neuron , vol.11 , pp. 575-580
    • Rebeck, G.W.1    Reiter, J.S.2    Strickland, D.K.3    Hyman, B.T.4
  • 58
    • 18144385517 scopus 로고    scopus 로고
    • Similar promotion of Abeta1-42 fibrillogenesis by native apolipoprotein E epsilon3 and epsilon4 isoforms
    • Sweeney D., Martins R., LeVine H., Smith J.D., Gandy S. Similar promotion of Abeta1-42 fibrillogenesis by native apolipoprotein E epsilon3 and epsilon4 isoforms. J. Neuroinflammation 2004, 1:15.
    • (2004) J. Neuroinflammation , vol.1 , pp. 15
    • Sweeney, D.1    Martins, R.2    LeVine, H.3    Smith, J.D.4    Gandy, S.5
  • 60
    • 0033020325 scopus 로고    scopus 로고
    • Further evidence for a synergistic association between APOE epsilon4 and BCHE-K in confirmed Alzheimer's disease
    • Wiebusch H., Poirier J., Sevigny P., Schappert K. Further evidence for a synergistic association between APOE epsilon4 and BCHE-K in confirmed Alzheimer's disease. Hum. Genet. 1999, 104:158-163.
    • (1999) Hum. Genet. , vol.104 , pp. 158-163
    • Wiebusch, H.1    Poirier, J.2    Sevigny, P.3    Schappert, K.4
  • 61
    • 48649094017 scopus 로고    scopus 로고
    • Interactions between hepatic lipase and apolipoprotein E gene polymorphisms affect serum lipid profiles of healthy Canadian adults
    • Wood K.C., Fullerton M.D., El-Sohemy A., Bakovic M. Interactions between hepatic lipase and apolipoprotein E gene polymorphisms affect serum lipid profiles of healthy Canadian adults. Appl. Physiol. Nutr. Metab. 2008, 33:761-768.
    • (2008) Appl. Physiol. Nutr. Metab. , vol.33 , pp. 761-768
    • Wood, K.C.1    Fullerton, M.D.2    El-Sohemy, A.3    Bakovic, M.4


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