Administration of a decoction of sucrose- and polysaccharide-rich radix astragali (Huang Qi) ameliorated insulin resistance and fatty liver but affected beta-cell function in type 2 diabetic rats

Evidence-based Complementary and Alternative Medicine

Volumn 2011, Issue , 2011, Pages

  Liu, Hui Kang ^b   Juan, Yi Chen ^a,b   Kuo, Yao Haur ^b   Chang, Chia Chuan ^b   Zhang, Li Jie ^b   Lin, Yan Yu ^b   Hsu, Chia Yun ^b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CHINESE DRUG; HUANG QI; POLYSACCHARIDE; SUCROSE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTRAGALI MEMBRANACEUS; ASTRAGALUS PLANT; BODY WEIGHT; CELL FUNCTION; CONTROLLED STUDY; DRUG ISOLATION; FATTY LIVER; GLUCOSE BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PLANT ROOT; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; TREATMENT OUTCOME; WEIGHT REDUCTION;

EID: 79952227885     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2011/349807     Document Type: Article

References (31)

1. Mudaliar S., Henry R. R., Effects of incretin hormones on beta-cell mass and function, body weight, and hepatic and myocardial function American Journal of Medicine 2010 123 3 S19 S27
2. Cusi K., Nonalcoholic fatty liver disease in type 2 diabetes mellitus Current Opinion in Endocrinology, Diabetes and Obesity 2009 16 2 141 149
3. Ma X. Q., Shi Q., Duan J. A., Dong T. T. X., Tsim K. W. K., Chemical analysis of Radix Astragali (Huangqi) in China: a comparison with its adulterants and seasonal varia (Pubitemid 34856156)
4. Chen W., Li Y. M., Yu M. H., Astragalus polysaccharides: an effective treatment for diabetes prevention in NOD mice Experimental and Clinical Endocrinology and Diabetes 2008 116 8 468 474
5. Li R. J., Qiu S. D., Chen H. X., Tian H., Wang H. X., The immunotherapeutic effects of Astragalus polysaccharide in type 1 diabetic mice Biological and Pharmaceutical Bulletin 2007 30 3 470 476 (Pubitemid 46355927)
6. Liu M., Wu K., Mao X., Wu Y., Ouyang J., Astragalus polysaccharide improves insulin sensitivity in KKAy mice: regulation of PKB/GLUT4 signaling in skeletal muscle Journal of Ethnopharmacology 2010 127 1 32 37
7. Wang N., Zhang D., Mao X., Zou F., Jin H., Ouyang J., Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes Molecular and Cellular Endocrinology 2009 307 1-2 89 98
8. Chen W., Li Y. M., Yu M. H., Astragalus polysaccharides inhibited diabetic cardiomyopathy in hamsters depending on suppression of heart chymase activation Journal of Diabetes and Its Complications 2010 24 3 199 208
9. Zhang Y. W., Wu C. Y., Cheng J. T., Merit of Astragalus polysaccharide in the improvement of early diabetic nephropathy with an effect on mRNA expressions of NF- B and I B in renal cortex of streptozotoxin-induced diabetic rats Journal of Ethnopharmacology 2007 114 3 387 392
10. Mao X. Q., Wu Y., Wu KE., Liu M., Zhang J. F., Zou F., Ou-Yang J. P., Astragalus polysaccharide reduces hepatic endoplasmic reticulum stress and restores glucose homeostasis in a diabetic KKAy mouse model Acta Pharmacologica Sinica 2007 28 12 1947 1956 (Pubitemid 350198342)
11. Kwon H. J., Kim Y. Y., Choung S. Y., Amelioration effects of traditional Chinese medicine on alcohol-induced fatty liver World Journal of Gastroenterology 2005 11 35 5512 5516
12. Yin X., Zhang Y., Yu J., Zhang P., Shen J., Qiu J., Wu H., Zhu X., The antioxidative effects of Astragalus saponin I protect against development of early diabetic nephropathy Journal of Pharmacological Sciences 2006 101 2 166 173 (Pubitemid 43938768)
13. Motomura K., Fujiwara Y., Kiyota N., Tsurushima K., Takeya M., Nohara T., Nagai R., Ikeda T., Astragalosides isolated from the root of astragalus radix inhibit the formation of advanced glycation end products Journal of Agricultural and Food Chemistry 2009 57 17 7666 7672
14. Juan Y. C., Tsai W. J., Lin Y. L., Wang G. J., Cheng J. J., Yang H. Y., Hsu C. Y., Liu H. K., The novel anti-hyperglycemic effect of Paeoniae radix via the transcriptional suppression of phosphoenopyruvate carboxykinase (PEPCK) Phytomedicine 2010 17 8-9 626 634
15. Srinivasan K., Viswanad B., Asrat L., Kaul C. L., Ramarao P., Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening Pharmacological Research 2005 52 4 313 320 (Pubitemid 41175991)
16. Chen C. C., Hsu C. Y., Chen C. Y., Liu H. K., Fructus Corni suppresses hepatic gluconeogenesis related gene transcription, enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death Journal of Ethnopharmacology 2008 117 3 483 490
17. Liu F. M., Li Z. X., Meng Y. F., Chen Y. Z., Studies on isolation, purification and structure of polysaccharide RHG from Hedysarum polybotrys hand.-mazz Acta Pharmaceutica Sinica 1997 32 8 603 606 (Pubitemid 127464984)
18. CCMP, Information center for the safty of the employment of Chinese herbal medicine: Radix Astragali. 2004, http://tcam.ccmp.gov.tw/meun1content. asp?aaa=20
19. Wang M. S., Li J., Di H. X., Li Z. L., Yang S. L., Hou W., Yan J. Y., Zhao X. M., Clinical study on effect of Astragalus injection and its immuno-regulation action in treating chronic aplastic anemia Chinese Journal of Integrative Medicine 2007 13 2 98 102 (Pubitemid 47047568)
20. Zhou Z. L., Yu P., Lin D., Study on effect of Astragalus injection in treating congestive heart failure Zhongguo Zhong Xi Yi Jie He Za Zhi 2001 21 10 747 749
21. Huang H., The diuretic and the blood pressure lowering effects of Radix Astragali Journal of Pharmacology 1965 12 319
22. Zhang Y., Wang Y., Sheng C., The anti-inflammatory and the hypotensive effects of Astragaloside I Journal of Pharmacology 1984 19 5 333
23. Zou F., Mao X. Q., Wang N., Liu J., Ou-Yang J. P., Astragalus polysaccharides alleviates glucose toxicity and restores glucose homeostasis in diabetic states via activation of AMPK Acta Pharmacologica Sinica 2009 30 12 1607 1615
24. Ferr P., Foufelle F., SREBP-1c transcription factor and lipid homeostasis: clinical perspective Hormone Research 2007 68 2 72 82 (Pubitemid 47026704)
25. Harwood H. J. Jr., Acetyl-CoA carboxylase inhibition for the treatment of metabolic syndrome Current Opinion in Investigational Drugs 2004 5 3 283 289
26. Li R. J., Qiu S. D., Chen H. X., Tian H., Liu G. Q., Effect of Astragalus polysaccharide on pancreatic cell mass in type 1 diabetic mice Zhongguo Zhongyao Zazhi 2007 32 20 2169 2173
27. Stanhope K. L., Havel P. J., Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrup American Journal of Clinical Nutrition 2008 88 6 1733S 1737S
28. Elliott S. S., Keim N. L., Stern J. S., Teff K., Havel P. J., Fructose, weight gain, and the insulin resistance syndrome American Journal of Clinical Nutrition 2002 76 5 911 922 (Pubitemid 35244659)
29. Maiztegui B., Morelli M. I., Raschia M. A., Del Zotto H., Gagliardino J. J., Islet adaptive changes to fructose-induced insulin resistance: -cell mass, glucokinase, glucose metabolism, and insulin secretion Journal of Endocrinology 2009 200 2 139 149
30. Chien T. M., Analysis of crude drug preparations used in Traditional Chinese Medicine in Taiwan National Health Insurance (2002-2003). Chinese Medical University, 2006
31. Jia W., Gao W., Tang L., Antidiabetic herbal drugs officially approved in China Phytotherapy Research 2003 17 10 1127 1134 (Pubitemid 38057166