Sphingosine-1-phosphate decreases melanin synthesis via microphthalmia-associated transcription factor phosphorylation through the S1P3 receptor subtype

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 3, 2011, Pages 409-416

  Kim, Dong Seok ^a   Park, Seo Hyoung ^b   Jeong, Yun Mi ^a   Kwon, Sun Bang ^b   Miller, Arlo J ^c   Fisher, David E ^c   Park, Kyoung Chan ^b  

^a Chung Ang University   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Extracellular signal regulated kinase; Melanogenesis; Microphthalmia associated transcription factor; S1P receptor; Sphingosine 1 phosphate

Indexed keywords

MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PERTUSSIS TOXIN; PROTEIN S6; SPHINGOSINE 1 PHOSPHATE RECEPTOR;

ANIMAL CELL; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ELECTRON MICROSCOPY; HYPOPIGMENTATION; MELANOCYTE; MELANOGENESIS; MOUSE; MUTANT; NONHUMAN; PHOSPHORYLATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LYSOPHOSPHOLIPIDS; MELANINS; MELANOCYTES; MICE; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MICROSCOPY, CONFOCAL; PHOSPHORYLATION; RECEPTORS, LYSOSPHINGOLIPID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPHINGOSINE; TRANSFECTION;

EID: 79952226197     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2010.01223.x     Document Type: Article

References (43)

1. Spiegel S, Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol 2003; 4: 397-407. (Pubitemid 36565571)
2. Maceyka M et al. Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling. J Lipid Res 2009; 50 (Suppl.): S272-S276.
3. Leong WI, Saba JD. S1P metabolism in cancer and other pathological conditions. Biochimie 2010; 92: 716-723.
4. Pyne NJ, Pyne S. Sphingosine 1-phosphate and cancer. Nat Rev Cancer 2010; 10: 489-503.
5. Verzijl D et al. Sphingosine-1-phosphate receptors: zooming in on ligand-induced intracellular trafficking and its functional implications. Mol Cells 2010; 29: 99-104.
6. Vogler R et al. Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. J Invest Dermatol 2003; 120: 693-700. (Pubitemid 36344015)
7. Kim DS et al. Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation. Cell Signal 2004; 16: 89-95.
8. Kim DS et al. Sphingosine-1-phosphate decreases melanin synthesis via sustained ERK activation and subsequent MITF degradation. J Cell Sci 2003; 116: 1699-1706.
9. Lin JY, Fisher DE. Melanocyte biology and skin pigmentation. Nature 2007; 445: 843-850.
10. Widlund HR, Fisher DE. Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival. Oncogene 2003; 22: 3035-3041. (Pubitemid 36713753)
11. Vachtenheim J, Borovansky J. "Transcription physiology" of pigment formation in melanocytes: central role of MITF. Exp Dermatol 2010; 19: 617-627.
12. Bentley NJ et al. Melanocyte-specific expression of the human tyrosinase promoter: activation by the microphthalmia gene product and role of the initiator. Mol Cell Biol 1994; 14: 7996-8006. (Pubitemid 24373548)
13. Bertolotto C et al. Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia. Mol Cell Biol 1998; 18: 694-702. (Pubitemid 28063402)
14. Yasumoto K et al. Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes. J Biol Chem 1997; 272: 503-509. (Pubitemid 27021187)
15. Steingrimsson E et al. Melanocytes and the microphthalmia transcription factor network. Annu Rev Genet 2004; 38: 365-411. (Pubitemid 40013733)
16. Hughes AE et al. Agene for Waardenburg syndrome type 2 maps close to the human homologue of the microphthalmia gene at chromosome 3p12-p14.1. Nat Genet 1994; 7: 509-512. (Pubitemid 24308338)
17. Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1995; 80: 179-185.
18. Mebratu Y, Tesfaigzi Y. How ERK1/2 activation controls cell proliferation and cell death is subcellular localization the answer? Cell Cycle 2009; 8: 1168-1175.
19. Hunter T. Oncoprotein networks. Cell 1997; 88: 333-346. (Pubitemid 27131375)
20. Cowley S et al. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 1994; 77: 841-852. (Pubitemid 24187682)
21. Sale EM et al. Requirement of MAP kinase for differentiation of fibroblasts to adipocytes, for insulin activation of p90 S6 kinase and for insulin or serum stimulation of DNA synthesis. EMBO J 1995; 14: 674-684.
22. Englaro W et al. Inhibition of the mitogen-activated protein kinase pathway triggers B16 melanoma cell differentiation. J Biol Chem 1998; 273: 9966-9970. (Pubitemid 28183097)
23. Kim DS et al. Sphingosylphosphorylcholine inhibits melanin synthesis via pertussis toxin-sensitive MITF degradation. J Pharm Pharmacol 2010; 62: 181-187.
24. Hemesath TJ et al. MAP kinase links the transcription factor microphthalmia to c-Kit signalling in melanocytes. Nature 1998; 391: 298-301. (Pubitemid 28099019)
25. Xu W et al. Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9. Exp Cell Res 2000; 255: 135-143. (Pubitemid 30143848)
26. Wu M et al. c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. Genes Dev 2000; 14: 301-312. (Pubitemid 30106485)
27. Olivera A, Spiegel S. Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature 1993; 365: 557-560. (Pubitemid 23317779)
28. Spiegel S. Sphingosine 1-phosphate: a prototype of a new class of second messengers. J Leukoc Biol 1999; 65: 341-344. (Pubitemid 29109706)
29. Lee MJ et al. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science 1998; 279: 1552-1555.
30. Hla T et al. Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors. Ann NY Acad Sci 2000; 905: 16-24. (Pubitemid 30255402)
31. Cuvillier O et al. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 1996; 381: 800-803. (Pubitemid 26243122)
32. Van Brocklyn JR et al. Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. Blood 2000; 95: 2624-2629. (Pubitemid 30210542)
33. Kim DS et al. Sphingosylphosphorylcholine-induced ERK activation inhibits melanin synthesis in human melanocytes. Pigment Cell Res 2006; 19: 146-153.
34. Dooley TP et al. Development of an in vitro primary screen for skin depigmentation and antimelanoma agents. Skin Pharmacol 1994; 7: 188-200. (Pubitemid 24116810)
35. Choo SJ et al. Silymarin inhibits melanin synthesis in melanocyte cells. J Pharm Pharmacol 2009; 61: 663-667.
36. Tsuboi T et al. Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma. Pigment Cell Res 1998; 11: 275-282. (Pubitemid 128533540)
37. Tachibana M. MITF: a stream flowing for pigment cells. Pigment Cell Res 2000; 13: 230-240. (Pubitemid 30610799)
38. Grabacka M et al. PPAR gamma regulates MITF and beta-catenin expression and promotes a differentiated phenotype in mouse melanoma S91. Pigment Cell Melanoma Res 2008; 21: 388-396. (Pubitemid 351678081)
39. Grabacka M et al. Peroxisome proliferator-activated receptor alpha activation decreases metastatic potential of melanoma cells in vitro via down-regulation of Akt. Clin Cancer Res 2006; 12: 3028-3036. (Pubitemid 43837347)
40. Jimenez-Cervantes C et al. Inhibition of melanogenesis in response to oxidative stress: transient downregulation of melanocyte differentiation markers and possible involvement of microphthalmia transcription factor. J Cell Sci 2001; 114: 2335-2344. (Pubitemid 32633704)
41. Lee EH et al. Inhibitory effects of 5-chloroacetyl-2-piperidino-1,3- selenazole, a novel selenium-containing compound, on skin melanin biosynthesis. J Pharm Pharmacol 2010; 62: 352-359.
42. Kim DS et al. Effects of lysophosphatidic acid on melanogenesis. Chem Phys Lipids 2004; 127: 199-206.
43. Davis MD et al. Sphingosine 1-phosphate analogs as receptor antagonists. J Biol Chem 2005; 280: 9833-9841. (Pubitemid 40395829)