Sphingosine-1-phosphate decreases melanin synthesis via sustained ERK activation and subsequent MITF degradation

Journal of Cell Science

Volumn 116, Issue 9, 2003, Pages 1699-1706

  Kim, Dong Seok ^a   Hwang, Eui Soo ^b   Lee, Jai Eun ^b   Kim, Sook Young ^b   Kwon, Sun Bang ^b   Park, Kyoung Chan ^b  

^a Seoul National University   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

ERK; Melanogenesis; Microphthamia; MITF; Sphingosine 1 phosphate

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; MELANIN; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MONOPHENOL MONOOXYGENASE; SPHINGOSINE 1 PHOSPHATE; TRANSCRIPTION FACTOR; TYROSINASE RELATED PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL IMMORTALIZATION; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MELANOCYTE; MELANOGENESIS; MOUSE; NONHUMAN; PIGMENTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN SYNTHESIS REGULATION; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; CELL LINE; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; LYSOPHOSPHOLIPIDS; MELANINS; MELANOCYTES; MEMBRANE GLYCOPROTEINS; MICE; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MITOGEN-ACTIVATED PROTEIN KINASES; MONOPHENOL MONOOXYGENASE; OXIDOREDUCTASES; PROTEIN BIOSYNTHESIS; SPHINGOSINE; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0038025417     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00366     Document Type: Article

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