Translational control gone awry: A new mechanism of tumorigenesis and novel targets of cancer treatments

Bioscience Reports

Volumn 31, Issue 1, 2011, Pages 1-15

  Yin, Ji Ye ^a,b   Dong, Zizheng ^a   Liu, Zhao Qian ^b   Zhang, Jian Ting ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Cancer therapy; Eukaryotic initiation factor (eIF); Prognosis; Translational control; Tumorigenesis

Indexed keywords

ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; COMPLEMENTARY RNA; GANCICLOVIR; INITIATION FACTOR; INITIATION FACTOR 2; INITIATION FACTOR 2ALPHA; INITIATION FACTOR 3; INITIATION FACTOR 3A; INITIATION FACTOR 3C; INITIATION FACTOR 3E; INITIATION FACTOR 3F; INITIATION FACTOR 3H; INITIATION FACTOR 3I; INITIATION FACTOR 4A; INITIATION FACTOR 4E; INITIATION FACTOR 4F; INITIATION FACTOR 4G; INITIATION FACTOR 4G1; INITIATION FACTOR 4G2; INITIATION FACTOR 6; MESSENGER RNA; NSC 119889; ORNITHINE DECARBOXYLASE; PATEANMINE; PHOSPHONIC ACID DERIVATIVE; RIBAVIRIN; SALUBRINAL; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS VECTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; CANCER CHEMOTHERAPY; CANCER RISK; CANCER SURVIVAL; CANCER SUSCEPTIBILITY; CARCINOGENESIS; DISEASE ACTIVITY; DRUG EFFICACY; DRUG TARGETING; EUKARYOTE; GENE CONTROL; GENE EXPRESSION REGULATION; GENETIC SUSCEPTIBILITY; HUMAN; MALIGNANT TRANSFORMATION; MULTIPLE CYCLE TREATMENT; NONHUMAN; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; SUICIDE GENE THERAPY; TRANSLATION INITIATION; TRANSLATION REGULATION; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; EUKARYOTIC INITIATION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; PROTEIN BIOSYNTHESIS;

EUKARYOTA;

EID: 79952221509     PISSN: 01448463     EISSN: None     Source Type: Journal    
DOI: 10.1042/BSR20100077     Document Type: Review

References (159)

1. Hershey, J. W. B. (2000) in Translational Control of Gene Expression (Sonenberg, N., ed.), pp. 33-88, Cold Spring Harbor Laboratory Press, Plainview, NY
2. Dong, Z. and Zhang, J. T. (2006) Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer. Crit. Rev. Oncol. Hematol. 59, 169-180
3. De Benedetti, A. and Graff, J. R. (2004) eIF-4E expression and its role in malignancies and metastases. Oncogene 23, 3189-3199
4. Hinnebusch, A. G. (1991) in Translation in Eukaryotes (Trachsel, H., ed.), pp. 243-272, CRC Press, Boca Raton, FL
5. Donze, O., Jagus, R., Koromilas, A. E., Hershey, J. W. and Sonenberg, N. (1995) Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. EMBO J. 14, 3828-3834
6. Wang, S., Rosenwald, I. B., Hutzler, M. J., Pihan, G. A., Savas, L., Chen, J. J. and Woda, B. A. (1999) Expression of the eukaryotic translation initiation factors 4E and 2alpha in non-Hodgkin's lymphomas. Am. J. Pathol. 155, 247-255
7. Rosenwald, I. B., Koifman, L., Savas, L., Chen, J. J., Woda, B. A. and Kadin, M. E. (2008) Expression of the translation initiation factors eIF-4E and eIF-2* is frequently increased in neoplastic cells of Hodgkin lymphoma. Hum. Pathol. 39, 910-916
8. Lobo, M. V., Martin, M. E., Perez, M. I., Alonso, F. J., Redondo, C., Alvarez, M. I. and Salinas, M. (2000) Levels, phosphorylation status and cellular localization of translational factor eIF2 in gastrointestinal carcinomas. Histochem. J. 32, 139-150 (Pubitemid 30312790)
9. Rosenwald, I. B., Hutzler, M. J., Wang, S., Savas, L. and Fraire, A. E. (2001) Expression of eukaryotic translation initiation factors 4E and 2alpha is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung. Cancer 92, 2164-2171
10. Wang, S., Lloyd, R. V., Hutzler, M. J., Rosenwald, I. B., Safran, M. S., Patwardhan, N. A. and Khan, A. (2001) Expression of eukaryotic translation initiation factors 4E and 2alpha correlates with the progression of thyroid carcinoma. Thyroid 11, 1101-1107 (Pubitemid 34041889)
11. Rosenwald, I. B., Wang, S., Savas, L., Woda, B. and Pullman, J. (2003) Expression of translation initiation factor eIF-2alpha is increased in benign and malignant melanocyte and colonic epithelial neoplasms. Cancer 98, 1080-1088 (Pubitemid 37022111)
12. Tejada, S., Lobo, M. V., Garcia-Villanueva, M., Sacristan, S., Perez-Morgado, M. I., Salinas, M. and Martin, M. E. (2009) Eukaryotic initiation factors (eIF) 2alpha and 4E expression, localization, and phosphorylation in brain tumors. J. Histochem. Cytochem. 57, 503-512
13. Pestova, T. V. and Hellen, C. U. (2000) The structure and function of initiation factors in eukaryotic protein synthesis. Cell. Mol. Life. Sci. 57, 651-674
14. Browning, K. S., Gallie, D. R., Hershey, J. W., Hinnebusch, A. G., Maitra, U., Merrick, W. C. and Norbury, C. (2001) Unified nomenclature for the subunits of eukaryotic initiation factor 3. Trends Biochem. Sci. 26, 284
15. Bachmann, F., Banziger, R. and Burger, M. M. (1997) Cloning of a novel protein overexpressed in human mammary carcinoma. Cancer Res. 57, 988-994
16. Dellas, A., Torhorst, J., Bachmann, F., Banziger, R., Schultheiss, E. and Burger, M. M. (1998) Expression of p150 in cervical neoplasia and its potential value in predicting survival. Cancer 83, 1376-1383
17. Chen, G. and Burger, M. M. (1999) p150 expression and its prognostic value in squamous-cell carcinoma of the esophagus. Int. J. Cancer 84, 95-100
18. Chen, G. and Burger, M. M. (2004) p150 overexpression in gastric carcinoma: the association with p53, apoptosis and cell proliferation. Int. J. Cancer 112, 393-398
19. Pincheira, R., Chen, Q. and Zhang, J. T. (2001) Identification of a 170-kDa protein over-expressed in lung cancers. Br. J. Cancer 84, 1520-1527
20. Dong, Z., Liu, L. H., Han, B., Pincheira, R. and Zhang, J. T. (2004) Role of eIF3 p170 in controlling synthesis of ribonucleotide reductase M2 and cell growth. Oncogene 23, 3790-3801
21. Zhang, L., Pan, X. and Hershey, J. W. (2007) Individual overexpression of five subunits of human translation initiation factor eIF3 promotes malignant transformation of immortal fibroblast cells. J. Biol. Chem. 282, 5790-5800
22. Olson, J. E., Wang, X., Goode, E. L., Pankratz, V. S., Fredericksen, Z. S., Vierkant, R. A., Pharoah, P. D., Cerhan, J. R. and Couch, F. J. (2010) Variation in genes required for normal mitosis and risk of breast cancer. Breast Cancer Res. Treat. 119, 423-430
23. Rothe, M., Ko, Y., Albers, P and Wernert, N. (2000) Eukaryotic initiation factor 3 p110 mRNA is overexpressed in testicular seminomas. Am. J. Pathol. 157, 1597-1604
24. Baldi, A., Battista, T., De Luca, A., Santini, D., Rossiello, L., Baldi, F., Natali, P. G., Lombardi, D., Picardo, M., Felsani, A. and Paggi, M. G. (2003) Identification of genes down-regulated during melanoma progression: a cDNA array study. Exp. Dermatol. 12, 213-218
25. Scoles, D. R., Yong, W. H., Qin, Y., Wawrowsky, K. and Pulst, S. M. (2006) Schwannomin inhibits tumorigenesis through direct interaction with the eukaryotic initiation factor subunit c (eIF3c). Hum. Mol. Genet. 15, 1059-1070
26. Loftus, B. J., Kim, U. J., Sneddon, V. P., Kalush, F., Brandon, R., Fuhrmann, J., Mason, T., Crosby, M. L., Barnstead, M., Cronin, L. et al. (1999) Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Genomics 60, 295-308 (Pubitemid 29471497)
27. Marchetti, A., Buttitta, F., Miyazaki, S., Gallahan, D., Smith, G. H. and Callahan, R. (1995) Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasia. J. Virol. 69, 1932-1938
28. Rasmussen, S. B., Kordon, E., Callahan, R. and Smith, G. H. (2001) Evidence for the transforming activity of a truncated Int6 gene, in vitro. Oncogene 20, 5291-5301
29. Mack, D. L., Boulanger, C. A., Callahan, R. and Smith, G. H. (2007) Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis. Breast Cancer Res. 9, R42
30. Mayeur, G. L. and Hershey, J. W. (2002) Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e). FEBS Lett. 514, 49-54
31. Marchetti, A., Buttitta, F., Pellegrini, S., Bertacca, G. and Callahan, R. (2001) Reduced expression of INT-6/eIF3-p48 in human tumors. Int. J. Oncol. 18, 175-179
32. Miyazaki, S., Imatani, A., Ballard, L., Marchetti, A., Buttitta, F., Albertsen, H., Nevanlinna, H. A., Gallahan, D. and Callahan, R. (1997) The chromosome location of the human homolog of the mouse mammary tumor-associated gene INT6 and its status in human breast carcinomas. Genomics 46, 155-158 (Pubitemid 27527706)
33. Traicoff, J. L., Chung, J. Y., Braunschweig, T., Mazo, I., Shu, Y., Ramesh, A., D'Amico, M. W., Galperin, M. M., Knezevic, V. and Hewitt, S. M. (2007) Expression of EIF3-p48/INT6, TID1 and Patched in cancer, a profiling of multiple tumor types and correlation of expression. J. Biomed. Sci. 14, 395-405
34. Buttitta, F., Martella, C., Barassi, F., Felicioni, L., Salvatore, S., Rosini, S., D'Antuono, T., Chella, A., Mucilli, F., Sacco, R. et al. (2005) Int6 expression can predict survival in early-stage non-small cell lung cancer patients. Clin. Cancer Res. 11, 3198-3204
35. Doldan, A., Chandramouli, A., Shanas, R., Bhattacharyya, A., Leong, S. P., Nelson, M. A. and Shi, J. (2008) Loss of the eukaryotic initiation factor 3f in melanoma. Mol. Carcinog. 47, 806-813
36. Shi, J., Kahle, A., Hershey, J. W., Honchak, B. M., Warneke, J. A., Leong, S. P. and Nelson, M. A. (2006) Decreased expression of eukaryotic initiation factor 3f deregulates translation and apoptosis in tumor cells. Oncogene 25, 4923-4936
37. Doldan, A., Chandramouli, A., Shanas, R., Bhattacharyya, A., Cunningham, J. T., Nelson, M. A. and Shi, J. (2008) Loss of the eukaryotic initiation factor 3f in pancreatic cancer. Mol. Carcinog. 47, 235-244
38. Nupponen, N. N., Isola, J. and Visakorpi, T. (2000) Mapping the amplification of EIF3S3 in breast and prostate cancer. Genes Chromosomes Cancer 28, 203-210 (Pubitemid 30246998)
39. Savinainen, K. J., Linja, M. J., Saramaki, O. R., Tammela, T. L., Chang, G. T., Brinkmann, A. O. and Visakorpi, T. (2004) Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer. Br. J. Cancer 90, 1041-1046
40. Nupponen, N. N., Porkka, K., Kakkola, L., Tanner, M., Persson, K., Borg, A., Isola, J. and Visakorpi, T. (1999) Amplification and overexpression of p40 subunit of eukaryotic translation initiation factor 3 in breast and prostate cancer. Am. J. Pathol. 154, 1777-1783
41. Saramaki, O., Willi, N., Bratt, O., Gasser, T. C., Koivisto, P., Nupponen, N. N., Bubendorf, L. and Visakorpi, T. (2001) Amplification of EIF3S3 gene is associated with advanced stage in prostate cancer. Am. J. Pathol. 159, 2089-2094
42. Saramaki, O. and Visakorpi, T. (2007) Chromosomal aberrations in prostate cancer. Front. Biosci. 12, 3287-3301
43. Okamoto, H., Yasui, K., Zhao, C., Aril, S. and Inazawa, J. (2003) PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas. Hepatology 38, 1242-1249 (Pubitemid 37314833)
44. Cappuzzo, F., Varella-Garcia, M., Rossi, E., Gajapathy, S., Valente, M., Drabkin, H. and Gemmill, R. (2009) MYC and EIF3H coamplification significantly improve response and survival of non-small cell lung cancer patients (NSCLC) treated with gefitinib. J. Thorac. Oncol. 4, 472-478
45. Zhang, L., Smit-McBride, Z., Pan, X., Rheinhardt, J. and Hershey, J. W. (2008) An oncogenic role for the phosphorylated h-subunit of human translation initiation factor eIF3. J. Biol. Chem. 283, 24047-24060
46. Tomlinson, I. P., Webb, E., Carvajal-Carmona, L., Broderick, P., Howarth, K., Pittman, A. M., Spain, S., Lubbe, S., Walther, A., Sullivan, K., Jaeger, E. et al. (2008) A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23. 3. Nat. Genet. 40, 623-630
47. Wijnen, J. T., Brohet, R. M., van Eijk, R., Jagmohan-Changur, S., Middeldorp, A., Tops, C. M., van Puijenbroek, M., Ausems, M. G., Gomez Garcia, E., Hes, F. J. et al. (2009) Chromosome 8q23. 3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome. Gastroenterology 136, 131-137
48. Middeldorp, A., Jagmohan-Changur, S., van Eijk, R., Tops, C., Devilee, P., Vasen, H. F., Hes, F. J., Houlston, R., Tomlinson, I., Houwing-Duistermaat, J. J. et al. (2009) Enrichment of low penetrance susceptibility loci in a Dutch familial colorectal cancer cohort. Cancer Epidemiol. Biomarkers Prev. 18, 3062-3067
49. Asano, K., Kinzy, T. G., Merrick, W. C. and Hershey, J. W. (1997) Conservation and diversity of eukaryotic translation initiation factor eIF3. J. Biol. Chem. 272, 1101-1109
50. Chen, R. H., Miettinen, P. J., Maruoka, E. M., Choy, L. and Derynck, R. (1995) A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor. Nature 377, 548-552
51. Choy, L. and Derynck, R. (1998) The type II transforming growth factor (TGF)beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response. J. Biol. Chem. 273, 31455-31462
52. Huang, J. S., Chao, C. C., Su, T. L., Yeh, S. H., Chen, D. S., Chen, C. T., Chen, P. J. and Jou, Y. S. (2004) Diverse cellular transformation capability of overexpressed genes in human hepatocellular carcinoma. Biochem. Biophys. Res. Commun. 315, 950-958
53. Rauch, J., Ahlemann, M., Schaffrik, M., Mack, B., Ertongur, S., Andratschke, M., Zeidler, R., Lang, S. and Gires, O. (2004) Allogenic antibody-mediated identification of head and neck cancer antigens. Biochem. Biophys. Res. Commun. 323, 156-162
54. Joseph, P., Lei, Y. X., Whong, W. Z. and Ong, T. M. (2002) Molecular cloning and functional analysis of a novel cadmium-responsive proto-oncogene. Cancer Res. 62, 703-707
55. Joseph, P., Lei, Y. X. and Ong, T. M. (2004) Up-regulation of expression of translation factors - a novel molecular mechanism for cadmium carcinogenesis. Mol. Cell. Biochem. 255, 93-101
56. Dong, Z. and Zhang, J. T. (2003) EIF3 p170, a mediator of mimosine effect on protein synthesis and cell cycle progression. Mol. Biol. Cell. 14, 3942-3951
57. Nielsen, P. J. and Trachsel, H. (1988) The mouse protein synthesis initiation factor 4A gene family includes two related functional genes which are differentially expressed. EMBO J. 7, 2097-2105
58. Yoder-Hill, J., Pause, A., Sonenberg, N. and Merrick, W. C. (1993) The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A. J. Biol. Chem. 268, 5566-5573
59. Eberle, J., Krasagakis, K. and Orfanos, C. E. (1997) Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro. Int. J. Cancer 71, 396-401
60. Shuda, M., Kondoh, N., Tanaka, K., Ryo, A., Wakatsuki, T., Hada, A., Goseki, N., Igari, T., Hatsuse, K., Aihara, T. et al. (2000) Enhanced expression of translation factor mRNAs in hepatocellular carcinoma. Anticancer Res. 20, 2489-2494 (Pubitemid 30614457)
61. Franklin, S., Pho, T., Abreo, F. W., Nassar, R., De Benedetti, A., Stucker, F. J. and Nathan, C. O. (1999) Detection of the proto-oncogene eIF4E in larynx and hypopharynx cancers. Arch. Otolaryngol. Head Neck Surg. 125, 177-182
62. Liang, Z., Lei, T., LuYing, Z. and YuPing, G. (2003) The expression of proto-oncogene eIF4E in laryngeal squamous cell carcinoma. Laryngoscope 113, 1238-1243 (Pubitemid 36835573)
63. Coleman, L. J., Peter, M. B., Teall, T. J., Brannan, R. A., Hanby, A. M., Honarpisheh, H., Shaaban, A. M., Smith, L., Speirs, V., Verghese, E. T., McElwaine, J. N. and Hughes, T. A. (2009) Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity. Br. J. Cancer 100, 1393-1399
64. DeFatta, R. J., Turbat-Herrera, E. A., Li, B. D., Anderson, W. and De Benedetti, A. (1999) Elevated expression of eIF4E in confined early breast cancer lesions: possible role of hypoxia. Int. J. Cancer 80, 516-522 (Pubitemid 29047514)
65. Li, B. D., McDonald, J. C., Nassar, R. and De Benedetti, A. (1998) Clinical outcome in stage I to III breast carcinoma and eIF4E overexpression. Ann. Surg. 227, 756-763
66. Lee, J. W., Choi, J. J., Lee, K. M., Choi, C. H., Kim, T. J., Lee, J. H., Kim, B. G., Ahn, G., Song, S. Y. and Bae, D. S. (2005) eIF4E expression is associated with histopathologic grades in cervical neoplasia. Hum. Pathol. 36, 1197-1203
67. Van Trappen, P. O., Ryan, A., Carroll, M., Lecoeur, C., Goff, L., Gyselman, V. G., Young, B. D., Lowe, D. G., Pepper, M. S., Shepherd, J. H. and Jacobs, I. J. (2002) A model for co-expression pattern analysis of genes implicated in angiogenesis and tumour cell invasion in cervical cancer. Br. J. Cancer 87, 537-544
68. Berkel, H. J., Turbat-Herrera, E. A., Shi, R. and de Benedetti, A. (2001) Expression of the translation initiation factor eIF4E in the polyp-cancer sequence in the colon. Cancer Epidemiol. Biomarkers Prev. 10, 663-666
69. Yang, Y. J., Zhang, Y. L., Li, X., Dan, H. L., Lai, Z. S., Wang, J. D., Wang, Q. Y., Cui, H. H., Sun, Y. and Wang, Y. D. (2003) Contribution of eIF4E inhibition to the expression and activity of heparanase in human colon adenocarcinoma cell line: LS-174T. World J. Gastroenterol. 9, 1707-1712
70. Salehi, Z. and Mashayekhi, F. (2006) Expression of the eukaryotic translation initiation factor 4E (eIF4E) and 4E-BP1 in esophageal cancer. Clin. Biochem. 39, 404-409
71. Chen, C. N., Hsieh, F. J., Cheng, Y. M., Lee, P. H. and Chang, K. J. (2004) Expression of eukaryotic initiation factor 4E in gastric adenocarcinoma and its association with clinical outcome. J. Surg. Oncol. 86, 22-27
72. Graff, J. R., Konicek, B. W., Lynch, R. L., Dumstorf, C. A., Dowless, M. S., McNulty, A. M., Parsons, S. H., Brail, L. H., Colligan, B. M., Koop, J. et al. (2009) eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival. Cancer Res. 69, 3866-3873
73. Salehi, Z., Mashayekhi, F. and Shahosseini, F. (2007) Significance of eIF4E expression in skin squamous cell carcinoma. Cell Biol. Int. 31, 1400-1404
74. Wang, R., Geng, J., Wang, J. H., Chu, X. Y., Geng, H. C. and Chen, L. B. (2009) Overexpression of eukaryotic initiation factor 4E (eIF4E) and its clinical significance in lung adenocarcinoma. Lung Cancer 66, 237-244
75. Seki, N., Takasu, T., Mandai, K., Nakata, M., Saeki, H., Heike, Y., Takata, I., Segawa, Y., Hanafusa, T. and Eguchi, K. (2002) Expression of eukaryotic initiation factor 4E in atypical adenomatous hyperplasia and adenocarcinoma of the human peripheral lung. Clin. Cancer Res. 8, 3046-3053
76. Nathan, C. O., Amirghahri, N., Rice, C., Abreo, F. W., Shi, R. and Stucker, F. J. (2002) Molecular analysis of surgical margins in head and neck squamous cell carcinoma patients. Laryngoscope 112, 2129-2140 (Pubitemid 35417033)
77. Sorrells, D. L., Ghali, G. E., Meschonat, C., DeFatta, R. J., Black, D., Liu, L., De Benedetti, A., Nathan, C. O. and Li, B. D. (1999) Competitive PCR to detect eIF4E gene amplification in head and neck cancer. Head Neck 21, 60-65
78. Assouline, S., Culjkovic, B., Cocolakis, E., Rousseau, C., Beslu, N., Amri, A., Caplan, S., Leber, B., Roy, D. C., Miller, Jr, W. H. and Borden, K. L. (2009) Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin. Blood 114, 257-260
79. Lazaris-Karatzas, A., Montine, K. S. and Sonenberg, N. (1990) Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap. Nature 345, 544-547
80. Kevil, C. G., De Benedetti, A., Payne, D. K., Coe, L. L., Laroux, F. S. and Alexander, J. S. (1996) Translational regulation of vascular permeability factor by eukaryotic initiation factor 4E: implications for tumor angiogenesis. Int. J. Cancer 65, 785-790 (Pubitemid 26127753)
81. DeBenedetti, A., Joshi, B. and Graff, J. R. (1994) CHO cells transformed by the initiation factor eIF4E display increased c-myc expression but require overexpression of ax for tumorigenicity. Mol. Cell. Differ. 347-371
82. Graff, J. R., De Benedetti, A., Olson, J. W., Tamez, P., Casero, Jr, R. A. and Zimmer, S. G. (1997) Translation of ODC mRNA and polyamine transport are suppressed in Ras-transformed CREF cells by depleting translation initiation factor 4E. Biochem. Biophys. Res. Commun. 240, 15-20
83. Barve, S. S., Cohen, D. A., De Benedetti, A., Rhoads, R. E. and Kaplan, A. M. (1994) Mechanism of differential regulation of IL-2 in murine Th1 and Th2 T cell subsets. 1. Induction of IL-2 transcription in Th2 cells by up-regulation of transcription factors with the protein synthesis initiation factor 4E. J. Immunol. 152, 1171-1181
84. De Benedetti, A. and Rhoads, R. E. (1990) Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology. Proc. Natl. Acad. Sci. U.S.A. 87, 8212-8216
85. Graff, J. R., Boghaert, E. R., De Benedetti, A., Tudor, D. L., Zimmer, C. C., Chan, S. K. and Zimmer, S. G. (1995) Reduction of translation initiation factor 4E decreases the malignancy of Ras-transformed cloned rat embryo fibroblasts. Int. J. Cancer 60, 255-263
86. Keiper, B. D., Gan, W. and Rhoads, R. E. (1999) Protein synthesis initiation factor 4G. Int. J. Biochem. Cell Biol. 31, 37-41
87. Imataka, H., Olsen, H. S. and Sonenberg, N. (1997) A new translational regulator with homology to eukaryotic translation initiation factor 4G. EMBO J. 16, 817-825 (Pubitemid 27089528)
88. Yamanaka, S., Poksay, K. S., Arnold, K. S. and Innerarity, T. L. (1997) A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme. Genes Dev. 11, 321-333
89. Henis-Korenblit, S., Shani, G., Sines, T., Marash, L., Shohat, G. and Kimchi, A. (2002) The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins. Proc. Natl. Acad. Sci. U.S.A. 99, 5400-5405
90. Han, B., Dong, Z., Liu, Y., Chen, Q., Hashimoto, K. and Zhang, J. T. (2003) Regulation of constitutive expression of mouse PTEN by the 5′-untranslated region. Oncogene 22, 5325-5337
91. Han, B., Dong, Z. and Zhang, J. T. (2003) Tight control of platelet-derived growth factor B/c-sis expression by interplay between the 5′-untranslated region sequence and the major upstream promoter. J. Biol. Chem. 278, 46983-46993
92. Han, B. and Zhang, J. T. (2002) Regulation of gene expression by internal ribosome entry sites or cryptic promoters: the eIF4G story. Mol. Cell. Biol. 22, 7372-7384
93. Liu, Z., Dong, Z., Han, B., Yang, Y., Liu, Y. and Zhang, J. T. (2005) Regulation of expression by promoters versus internal ribosome entry site in the 5′-untranslated sequence of the human cyclin-dependent kinase inhibitor p27kip1. Nucleic Acids Res. 33, 3763-3771
94. Brass, N., Ukena, I., Remberger, K., Mack, U., Sybrecht, G. W. and Meese, E. U. (1996) DNA amplification on chromosome 3q26. 1-q26. 3 in squamous cell carcinoma of the lung detected by reverse chromosome painting. Eur. J. Cancer 32A, 1205-1208
95. Sattler, H. P., Lensch, R., Rohde, V., Zimmer, E., Meese, E., Bonkhoff, H., Retz, M., Zwergel, T., Bex, A., Stoeckle, M. and Wullich, B. (2000) Novel amplification unit at chromosome 3q25-q27 in human prostate cancer. Prostate 45, 207-215
96. Rao, R H., Arias-Pulido, H., Lu, X. Y., Harris, C. P., Vargas, H., Zhang, F. F., Narayan, G., Schneider, A., Terry, M. B. and Murty, V. V. (2004) Chromosomal amplifications, 3q gain and deletions of 2q33-q37 are the frequent genetic changes in cervical carcinoma. BMC Cancer 4, 5
97. Bockmuhl, U., Schluns, K., Kuchler, I., Petersen, S. and Petersen, I. (2000) Genetic imbalances with impact on survival in head and neck cancer patients. Am. J. Pathol. 157, 369-375
98. Bauer, C., Diesinger, I., Brass, N., Steinhart, H., Iro, H. and Meese, E. U. (2001) Translation initiation factor eIF-4G is immunogenic, overexpressed, and amplified in patients with squamous cell lung carcinoma. Cancer 92, 822-829
99. Silvera, D., Arju, R., Darvishian, F., Levine, P. H., Zolfaghari, L., Goldberg, J., Hochman, T., Formenti, S. C. and Schneider, R. J. (2009) Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer. Nat. Cell Biol. 11, 903-908
100. Fukuchi-Shimogori, T., Ishii, I., Kashiwagi, K., Mashiba, H., Ekimoto, H. and Igarashi, K. (1997) Malignant transformation by overproduction of translation initiation factor eIF4G. Cancer Res. 57, 5041-5044 (Pubitemid 27498117)
101. Levy-Strumpf, N., Deiss, L. P., Berissi, H. and Kimchi, A. (1997) DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death. Mol. Cell. Biol. 17, 1615-1625
102. Obermann, E. C., Junker, K., Stoehr, R., Dietmaier, W., Zaak, D., Schubert, J., Hofstaedter, F., Knuechel, R. and Hartmann, A. (2003) Frequent genetic alterations in flat urothelial hyperplasias and concomitant papillary bladder cancer as detected by CGH, LOH, and FISH analyses. J. Pathol. 199, 50-57
103. Zhang, J., Zheng, S., Gao, Y., Rotolo, J. A., Xiao, Z., Li, C. and Cheng, S. (2004) A partial allelotyping of urothelial carcinoma of bladder in the Chinese. Carcinogenesis 25, 343-347 (Pubitemid 38344400)
104. Buim, M. E., Soares, F. A., Sarkis, A. S. and Nagai, M. A. (2005) The transcripts of SFRP1,CEP63 and EIF4G2 genes are frequently downregulated in transitional cell carcinomas of the bladder. Oncology 69, 445-454
105. Li, B. D., Liu, L., Dawson, M. and De Benedetti, A. (1997) Overexpression of eukaryotic initiation factor 4E (eIF4E) in breast carcinoma. Cancer 79, 2385-2390 (Pubitemid 27251022)
106. Li, B. D., Gruner, J. S., Abreo, F., Johnson, L. W., Yu, H., Nawas, S., McDonald, J. C. and DeBenedetti, A. (2002) Prospective study of eukaryotic initiation factor 4E protein elevation and breast cancer outcome. Ann. Surg. 235, 732-738
107. Holm, N., Byrnes, K., Johnson, L., Abreo, F., Sehon, K., Alley, J., Meschonat, C., Md, Q. C. and Li, B. D. (2008) A prospective trial on initiation factor 4E (eIF4E) overexpression and cancer recurrence in node-negative breast cancer. Ann. Surg. Oncol. 15, 3207-3215
108. Khoury, T., Alrawi, S., Ramnath, N., Li, Q., Grimm, M., Black, J. and Tan, D. (2009) Eukaryotic initiation factor4E and cyclin D1 expression associated with patient survival in lung cancer. Clin. Lung Cancer 10, 58-66
109. Nathan, C. O., Franklin, S., Abreo, F. W., Nassar, R., De Benedetti, A. and Glass, J. (1999) Analysis of surgical margins with the molecular marker eIF4E: a prognostic factor in patients with head and neck cancer. J. Clin. Oncol. 17, 2909-2914
110. Nathan, C. O., Liu, L., Li, B. D., Abreo, F. W., Nandy, I. and De Benedetti, A. (1997) Detection of the proto-oncogene eIF4E in surgical margins may predict recurrence in head and neck cancer. Oncogene 15, 579-584 (Pubitemid 27384735)
111. Ceci, M., Gaviraghi, C., Gorrini, C., Sala, L. A., Offenhauser, N., Marchisio, P. C. and Biffo, S. (2003) Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly. Nature 426, 579-584 (Pubitemid 37522646)
112. Flavin, R. J., Smyth, P. C., Finn, S. P., Laios, A., O'Toole, S. A., Barrett, C., Ring, M., Denning, K. M., Li, J., Aherne, S. T. et al. (2008) Altered eIF6 and Dicer expression is associated with clinicopathological features in ovarian serous carcinoma patients. Mod. Pathol. 21, 676-684
113. Hershey, J. W. B. (2000) in Translational Control of Gene Expression (Sonenberg, N., ed.), pp. 637-654, Cold Spring Harbor Laboratory Press, Plainview, NY
114. Auvinen, M., Laine, A., Paasinen-Sohns, A., Kangas, A., Kangas, L., Saksela, O., Andersson, L. C. and Holtta, E. (1997) Human Ornithine decarboxylase-overproducing NIH3T3 cells induce rapidly growing, highly vascularized tumors in nude mice. Cancer Res. 57, 3016-3025 (Pubitemid 27315055)
115. Grens, A. and Scheffler, I. E. (1990) The 5′- and 3′-untranslated regions of ornithine decarboxylase mRNA affect the translational efficiency. J. Biol. Chem. 265, 11810-11816
116. Shantz, L. M., Hu, R. H. and Pegg, A. E. (1996) Regulation of ornithine decarboxylase in a transformed cell line that overexpresses translation initiation factor eIF-4E. Cancer Res. 56, 3265-3269
117. Kleiner, H. E., Krishnan, P., Tubbs, J., Smith, M., Meschonat, C., Shi, R., Lowery-Nordberg, M., Adegboyega, P., Unger, M., Cardelli, J. et al. (2009) Tissue microarray analysis of eIF4E and its downstream effector proteins in human breast cancer. J. Exp. Clin. Cancer Res. 28, 5
118. Schmidt, E. V. (2004) The role of c-myc in regulation of translation initiation. Oncogene 23, 3217-3221
119. Lin, C. J., Cencic, R., Mills, J. R., Robert, F. and Pelletier, J. (2008) c-Myc and eIF4F are components of a feedforward loop that links transcription and translation. Cancer Res. 68, 5326-5334
120. Fan, H., Villegas, C. and Wright, J. A. (1996) Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential. Proc. Natl. Acad. Sci. U.S.A. 93, 14036-14040
121. Lee, Y., Vassilakos, A., Feng, N., Lam, V., Xie, H., Wang, M., Jin, H., Xiong, K., Liu, C., Wright, J. and Young, A. (2003) GTI-2040, an antisense agent targeting the small subunit component (R2) of human ribonucleotide reductase, shows potent antitumor activity against a variety of tumors. Cancer Res. 63, 2802-2811
122. Ahlemann, M., Zeidler, R., Lang, S., Mack, B., Munz, M. and Gires, O. (2006) Carcinoma-associated eIF3i overexpression facilitates mTOR-dependent growth transformation. Mol. Carcinog. 45, 957-967
123. Rinker-Schaeffer, C. W., Graff, J. R., De Benedetti, A., Zimmer, S. G. and Rhoads, R. E. (1993) Decreasing the level of translation initiation factor 4E with antisense RNA causes reversal of Ras-mediated transformation and tumorigenesis of cloned rat embryo fibroblasts. Int. J. Cancer 55, 841-847
124. DeFatta, R. J., Nathan, C. O. and De Benedetti, A. (2000) Antisense RNA to eIF4E suppresses oncogenic properties of a head and neck squamous cell carcinoma cell line. Laryngoscope 110, 928-933 (Pubitemid 30368633)
125. De Benedetti, A., Joshi-Barve, S., Rinker-Schaeffer, C. and Rhoads, R. E. (1991) Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times, diminished translation rates, and reduced levels of both eIF-4E and the p220 component of eIF-4E Mol. Cell. Biol. 11, 5435-5445
126. Graff, J. R., Konicek, B. W., Vincent, T. M., Lynch, R. L., Monteith, D., Weir, S. N., Schwier, P., Capen, A., Goode, R. L., Dowless, M. S. et al. (2007) Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity. J. Clin. Invest. 117, 2638-2648
127. DeFatta, R. J., Li, Y. and De Benedetti, A. (2002) Selective killing of cancer cells based on translational control of a suicide gene. Cancer Gene Ther. 9, 573-578 (Pubitemid 34734421)
128. Yu, D., Scott, C., Jia, W. W., De Benedetti, A., Williams, B. J., Fazli, L., Wen, Y., Gleave, M., Nelson, C. and Rennie, P. S. (2006) Targeting and killing of prostate cancer cells using lentiviral constructs containing a sequence recognized by translation factor eIF4E and a prostate-specific promoter. Cancer Gene Ther. 13, 32-43 (Pubitemid 41816347)
129. Mathis, J. M., Williams, B. J., Sibley, D. A., Carroll, J. L., Li, J., Odaka, Y., Barlow, S., Nathan, C. O., Li, B. D. and DeBenedetti, A. (2006) Cancer-specific targeting of an adenovirus-delivered herpes simplex virus thymidine kinase suicide gene using translational control. J. Gene Med. 8, 1105-1120 (Pubitemid 44480403)
130. Marcotrigiano, J., Gingras, A. C., Sonenberg, N. and Burley, S. K. (1997) Cocrystal structure of the messenger RNA 5′ cap-binding protein (eIF4E) bound to 7-methyl-GDR Cell 89, 951-961
131. Ghosh, P., Park, C., Peterson, M. S., Bitterman, P. B., Polunovsky, V. A. and Wagner, C. R. (2005) Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP. Bioorg. Med. Chem. Lett. 15, 2177-2180
132. Moerke, N. J., Aktas, H., Chen, H., Cartel, S., Reibarkh, M. Y., Fahmy, A., Gross, J. D., Degterev, A., Yuan, J., Chorev, M., Halperin, J. A. and Wagner, G. (2007) Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell 128, 257-267 (Pubitemid 46137991)
133. Smith, R. A. (1984) in Clinical Applications of Ribavirin (Smith, R. A., ed.), pp. 1-18, Academic Press, Orlando, FL
134. Kentsis, A., Topisirovic, I., Culjkovic, B., Shao, L. and Borden, K. L. (2004) Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proc. Natl. Acad. Sci. U.S.A. 101, 18105-18110
135. Kentsis, A., Volpon, L., Topisirovic, I., Soll, C. E., Culjkovic, B., Shao, L. and Borden, K. L. (2005) Further evidence that ribavirin interacts with eIF4E. RNA 11, 1762-1766
136. Tan, K., Culjkovic, B., Amri, A. and Borden, K. L. (2008) Ribavirin targets eIF4E dependent Akt survival signaling. Biochem. Biophys. Res. Commun. 375, 341-345
137. Novac, O., Guenier, A. S. and Pelletier, J. (2004) Inhibitors of protein synthesis identified by a high throughput multiplexed translation screen. Nucleic Acids Res. 32, 902-915 (Pubitemid 38854693)
138. Bordeleau, M. E., Matthews, J., Wojnar, J. M., Lindqvist, L., Novac, O., Jankowsky, E., Sonenberg, N., Northcote, P., Teesdale-Spittle, P. and Pelletier, J. (2005) Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proc. Natl. Acad. Sci. U.S.A. 102, 10460-10465
139. Low, W. K., Dang, Y., Schneider-Poetsch, T., Shi, Z., Choi, N. S., Merrick, W. C., Romo, D. and Liu, J. O. (2005) Inhibition of eukaryotic translation initiation by the marine natural product pateamine A. Mol. Cell 20, 709-722
140. Huang, S. and Houghton, P. J. (2002) Inhibitors of mammalian target of rapamycin as novel antitumor agents: from bench to clinic. Curr. Opin. Invest ig. Drugs 3, 295-304
141. Meric-Bernstam, F. and Gonzalez-Angulo, A. M. (2009) Targeting the mTOR signaling network for cancer therapy. J. Clin. Oncol. 27, 2278-2287
142. Dowling, R. J., Pollak, M. and Sonenberg, N. (2009) Current status and challenges associated with targeting mTOR for cancer therapy. BioDrugs 23, 77-91
143. Jefferies, H. B., Reinhard, C., Kozma, S. C. and Thomas, G. (1994) Rapamycin selectively represses translation of the 'polypyrimidine tract' mRNA family. Proc. Natl. Acad. Sci. U.S.A. 91, 4441-4445
144. Terada, N., Patel, H. R., Takase, K., Kohno, K., Nairn, A. C. and Gelfand, E. W. (1994) Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc. Natl. Acad. Sci. U.S.A. 91, 11477-11481
145. Jefferies, H. B., Fumagalli, S., Dennis, P. B., Reinhard, C., Pearson, R. B. and Thomas, G. (1997) Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k. EMBO J. 16, 3693-3704
146. Boyce, M., Bryant, K. F., Jousse, C., Long, K., Harding, H. P., Scheuner, D., Kaufman, R. J., Ma, D., Coen, D. M., Ron, D. and Yuan, J. (2005) A
147. Sanvito, F., Vivoli, F., Gambini, S., Santambrogio, G., Catena, M., Viale, E., Veglia, F., Donadini, A., Biffo, S. and Marchisio, P. C. (2000) Expression of a highly conserved protein, p27BBR during the progression of human colorectal cancer. Cancer Res. 60, 510-516
148. Harris, M. N., Ozpolat, B., Abdi, F., Gu, S., Legier, A., Mawuenyega, K. G., Tirade-Gomez, M., Lopez-Berestein, G. and Chen, X. (2004) Comparative proteomic analysis of all-trans-retinoic acid treatment reveals systematic posttranscriptional control mechanisms in acute promyelocytic leukemia. Blood 104, 1314-1323 (Pubitemid 39166505)
149. Rosso, P., Cortesina, G., Sanvito, F., Donadini, A., Di Benedetto, B., Biffo, S. and Marchisio, P. C. (2004) Overexpression of p27BBP in head and neck carcinomas and their lymph node metastases. Head Neck 26, 408-417
150. Hinnebusch, A. G. (2005) Translational regulation of GCN4 and the general amino acid control of yeast. Annu. Rev. Microbiol. 59, 407-450
151. Vattem, K. M. and Wek, R. C. (2004) Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 101, 11269-11274
152. Rosenwald, I. B., Lazaris-Karatzas, A., Sonenberg, N. and Schmidt, E. V. (1993) Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E. Mol. Cell. Biol. 13, 7358-7363
153. Rosenwald, I. B., Kaspar, R., Rousseau, D., Gehrke, L., Leboulch, P., Chen, J. J., Schmidt, E. V., Sonenberg, N. and London, I. M. (1995) Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels. J. Biol. Chem. 270, 21176-21180
154. Nathan, C. A., Carter, P., Liu, L., Li, B. D., Abreo, F., Tudor, A., Zimmer, S. G. and De Benedetti, A. (1997) Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas. Oncogene 15, 1087-1094 (Pubitemid 27401963)
155. Li, Y., DeFatta, R., Anthony, C., Sunavala, G. and De Benedetti, A. (2001) A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed. Oncogene 20, 726-738 (Pubitemid 32179341)
156. Wolfort, R., de Benedetti, A., Nuthalapaty, S., Yu, H., Chu, Q. D. and Li, B. D. (2006) Up-regulation of TLK1B by eIF4E overexpression predicts cancer recurrence in irradiated patients with breast cancer. Surgery 140, 161-169
157. Graff, J. R. and Zimmer, S. G. (2003) Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs. Clin. Exp. Metastasis 20, 265-273
158. Abid, M. R., Li, Y., Anthony, C. and De Benedetti, A. (1999) Translational regulation of ribonucleotide reductase by eukaryotic initiation factor 4E links protein synthesis to the control of DNA replication. J. Biol. Chem. 274, 35991-35998
159. Wang, H., Vardy, L. A., Tan, C. P., Loo, J. M., Guo, K., Li, J., Lim, S. G., Zhou, J., Chng, W. J., Ng, S. B., Li, H. X. and Zeng, Q. PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase. Cancer Cell 18, 52-62