-
1
-
-
0025260531
-
Fatty liver hepatitis (Steatohepatitis) and obesity: An autopsy study with analysis of risk factors
-
Wanless IR, Lentz JS. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology 1990; 12: 1106-10.
-
(1990)
Hepatology
, vol.12
, pp. 1106-1110
-
-
Wanless, I.R.1
Lentz, J.S.2
-
2
-
-
18244385511
-
Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: Further evidence for an etiologic association
-
Pagano G, Pacini G, Musso G, et al. Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association. Hepatology 2002; 35: 367-72.
-
(2002)
Hepatology
, vol.35
, pp. 367-372
-
-
Pagano, G.1
Pacini, G.2
Musso, G.3
-
3
-
-
18244364864
-
NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome
-
Chitturi S, Abeygunasekera S, Farrell GC, et al. NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002; 35: 373-9.
-
(2002)
Hepatology
, vol.35
, pp. 373-379
-
-
Chitturi, S.1
Abeygunasekera, S.2
Farrell, G.C.3
-
4
-
-
33644547706
-
Nonalcoholic fatty liver disease: From steatosis to cirrhosis
-
Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006; 43(2 Suppl 1): S99-S112.
-
(2006)
Hepatology
, vol.43
, Issue.2
, pp. S99-S112
-
-
Farrell, G.C.1
Larter, C.Z.2
-
5
-
-
11144351102
-
The histological course of nonalcoholic fatty liver disease: A longitudinal study of 103 patients with sequential liver biopsies
-
Adams LA, Sanderson S, Lindor KD, Angulo P. The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J Hepatol 2005; 42: 132-8.
-
(2005)
J Hepatol
, vol.42
, pp. 132-138
-
-
Adams, L.A.1
Sanderson, S.2
Lindor, K.D.3
Angulo, P.4
-
6
-
-
0036134022
-
The clinicopathologic spectrum and management of nonalcoholic fatty liver disease
-
Contos MJ, Sanyal AJ. The clinicopathologic spectrum and management of nonalcoholic fatty liver disease. Adv Anat Pathol 2002; 9: 37-51.
-
(2002)
Adv Anat Pathol
, vol.9
, pp. 37-51
-
-
Contos, M.J.1
Sanyal, A.J.2
-
7
-
-
0025178612
-
The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
-
Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 1990; 11: 74-80.
-
(1990)
Hepatology
, vol.11
, pp. 74-80
-
-
Powell, E.E.1
Cooksley, W.G.2
Hanson, R.3
Searle, J.4
Halliday, J.W.5
Powell, L.W.6
-
8
-
-
4644297019
-
Natural history of nonalcoholic steatohepatitis: A longitudinal study of repeat liver biopsies
-
Fassio E, Alvarez E, Dominguez N, Landeira G, Longo C. Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology 2004; 40: 820-6.
-
(2004)
Hepatology
, vol.40
, pp. 820-826
-
-
Fassio, E.1
Alvarez, E.2
Dominguez, N.3
Landeira, G.4
Longo, C.5
-
9
-
-
4644261918
-
Association of non-alcoholic steatohepatitis without significant fibrosis with hepatocellular carcinoma
-
Bullock RE, Zaitoun AM, Aithal GP, Ryder SD, Beckingham IJ, Lobo DN. Association of non-alcoholic steatohepatitis without significant fibrosis with hepatocellular carcinoma. J Hepatol 2004; 41: 685-6.
-
(2004)
J Hepatol
, vol.41
, pp. 685-686
-
-
Bullock, R.E.1
Zaitoun, A.M.2
Aithal, G.P.3
Ryder, S.D.4
Beckingham, I.J.5
Lobo, D.N.6
-
10
-
-
69949099142
-
Nonalcoholic fatty liver disease: Disease and comorbidity--effects on quality of life
-
Marchesini G, Bianchi G. Nonalcoholic fatty liver disease: Disease and comorbidity--effects on quality of life. Nat Rev Gastroenterol Hepatol 2009; 6(9): 504-6.
-
(2009)
Nat Rev Gastroenterol Hepatol
, vol.6
, Issue.9
, pp. 504-506
-
-
Marchesini, G.1
Bianchi, G.2
-
11
-
-
0037382786
-
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
-
Marchesini G, Bugianesi E, Forlani G, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003; 37: 917-23.
-
(2003)
Hepatology
, vol.37
, pp. 917-923
-
-
Marchesini, G.1
Bugianesi, E.2
Forlani, G.3
-
12
-
-
0035084699
-
Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
-
Sanyal AJ, Campbell-Sargent C, Mirshahi F, et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001; 120: 1183-92.
-
(2001)
Gastroenterology
, vol.120
, pp. 1183-1192
-
-
Sanyal, A.J.1
Campbell-Sargent, C.2
Mirshahi, F.3
-
13
-
-
42949178538
-
Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects
-
Korenblat KM, Fabbrini E, Mohammed BS, Klein S. Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology 2008; 134: 1369-75.
-
(2008)
Gastroenterology
, vol.134
, pp. 1369-1375
-
-
Korenblat, K.M.1
Fabbrini, E.2
Mohammed, B.S.3
Klein, S.4
-
14
-
-
6944227798
-
Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults
-
Kim HJ, Lee KE, Kim DJ, et al. Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults. Arch Intern Med 2004; 164: 2169-75.
-
(2004)
Arch Intern Med
, vol.164
, pp. 2169-2175
-
-
Kim, H.J.1
Lee, K.E.2
Kim, D.J.3
-
15
-
-
14644435731
-
Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
-
Petersen KF, Dufour S, Befroy D, Lehrke M, Hendler RE, Shulman GI. Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes 2005; 54: 603-8.
-
(2005)
Diabetes
, vol.54
, pp. 603-608
-
-
Petersen, K.F.1
Dufour, S.2
Befroy, D.3
Lehrke, M.4
Hendler, R.E.5
Shulman, G.I.6
-
16
-
-
57949116523
-
Alterations in fatty acid kinetics in obese adolescents with increased intrahepatic triglyceride content
-
Fabbrini E, deHaseth D, Deivanayagam S, Mohammed BS, Vitola BE, Klein S. Alterations in fatty acid kinetics in obese adolescents with increased intrahepatic triglyceride content. Obesity (Silver Spring) 2009; 17: 25-9.
-
(2009)
Obesity (Silver Spring)
, vol.17
, pp. 25-29
-
-
Fabbrini, E.1
Dehaseth, D.2
Deivanayagam, S.3
Mohammed, B.S.4
Vitola, B.E.5
Klein, S.6
-
17
-
-
18244382304
-
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
-
Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005; 115: 1343-51.
-
(2005)
J Clin Invest
, vol.115
, pp. 1343-1351
-
-
Donnelly, K.L.1
Smith, C.I.2
Schwarzenberg, S.J.3
Jessurun, J.4
Boldt, M.D.5
Parks, E.J.6
-
19
-
-
0033570119
-
Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
-
Shimomura I, Bashmakov Y, Horton JD. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 1999; 274: 30028-32.
-
(1999)
J Biol Chem
, vol.274
, pp. 30028-30032
-
-
Shimomura, I.1
Bashmakov, Y.2
Horton, J.D.3
-
20
-
-
33646403413
-
Hepatic gene regulation by glucose and polyunsaturated fatty acids: A role for ChREBP
-
Dentin R, Denechaud PD, Benhamed F, Girard J, Postic C. Hepatic gene regulation by glucose and polyunsaturated fatty acids: a role for ChREBP. J Nutr 2006; 136: 1145-9.
-
(2006)
J Nutr
, vol.136
, pp. 1145-1149
-
-
Dentin, R.1
Denechaud, P.D.2
Benhamed, F.3
Girard, J.4
Postic, C.5
-
21
-
-
33746536677
-
Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis
-
Uyeda K, Repa JJ. Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. Cell Metab 2006; 4: 107-10.
-
(2006)
Cell Metab
, vol.4
, pp. 107-110
-
-
Uyeda, K.1
Repa, J.J.2
-
22
-
-
33749407193
-
ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver
-
Ma L, Robinson LN, Towle HC. ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver. J Biol Chem 2006; 281: 28721-30.
-
(2006)
J Biol Chem
, vol.281
, pp. 28721-28730
-
-
Ma, L.1
Robinson, L.N.2
Towle, H.C.3
-
23
-
-
0033913213
-
Signaling pathways in insulin action: Molecular targets of insulin resistance
-
Pessin JE, Saltiel AR. Signaling pathways in insulin action: molecular targets of insulin resistance. J Clin Invest 2000; 106: 165-9.
-
(2000)
J Clin Invest
, vol.106
, pp. 165-169
-
-
Pessin, J.E.1
Saltiel, A.R.2
-
24
-
-
37349081571
-
Role of ChREBP in hepatic steatosis and insulin resistance
-
Denechaud PD, Dentin R, Girard J, Postic C. Role of ChREBP in hepatic steatosis and insulin resistance. FEBS Lett 2008; 582: 68-73.
-
(2008)
FEBS Lett
, vol.582
, pp. 68-73
-
-
Denechaud, P.D.1
Dentin, R.2
Girard, J.3
Postic, C.4
-
25
-
-
38649116056
-
Selective versus total insulin resistance: a pathogenic paradox
-
Brown MS, Goldstein JL. Selective versus total insulin resistance: a pathogenic paradox. Cell Metab 2008; 7: 95-6.
-
(2008)
Cell Metab
, vol.7
, pp. 95-96
-
-
Brown, M.S.1
Goldstein, J.L.2
-
26
-
-
40549135297
-
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
-
Postic C, Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 2008; 118: 829-38.
-
(2008)
J Clin Invest
, vol.118
, pp. 829-838
-
-
Postic, C.1
Girard, J.2
-
27
-
-
33645982255
-
From mice to men: Insights into the insulin resistance syndromes
-
Biddinger SB, Kahn CR. From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol 2006; 68: 123-58.
-
(2006)
Annu Rev Physiol
, vol.68
, pp. 123-158
-
-
Biddinger, S.B.1
Kahn, C.R.2
-
28
-
-
0033636523
-
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
-
Michael MD, Kulkarni RN, Postic C, et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 2000; 6: 87-97.
-
(2000)
Mol Cell
, vol.6
, pp. 87-97
-
-
Michael, M.D.1
Kulkarni, R.N.2
Postic, C.3
-
29
-
-
3543029821
-
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
-
Samuel VT, Liu ZX, Qu X, et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 2004; 279: 32345-53.
-
(2004)
J Biol Chem
, vol.279
, pp. 32345-32353
-
-
Samuel, V.T.1
Liu, Z.X.2
Qu, X.3
-
30
-
-
28044446543
-
The metabolic syndrome as a predictor of nonalcoholic fatty liver disease
-
Hamaguchi M, Kojima T, Takeda N, et al. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med 2005; 143: 722-8.
-
(2005)
Ann Intern Med
, vol.143
, pp. 722-728
-
-
Hamaguchi, M.1
Kojima, T.2
Takeda, N.3
-
31
-
-
33644654777
-
Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2
-
Savage DB, Choi CS, Samuel VT, et al. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. J Clin Invest 2006; 116: 817-24.
-
(2006)
J Clin Invest
, vol.116
, pp. 817-824
-
-
Savage, D.B.1
Choi, C.S.2
Samuel, V.T.3
-
32
-
-
33749370739
-
Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice
-
Dentin R, Benhamed F, Hainault I, et al. Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice. Diabetes 2006; 55: 2159-70.
-
(2006)
Diabetes
, vol.55
, pp. 2159-2170
-
-
Dentin, R.1
Benhamed, F.2
Hainault, I.3
-
33
-
-
27244440736
-
Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:Glycerol-sn-3-phosphate acyltransferase 1 knockout mice
-
Neschen S, Morino K, Hammond LE, et al. Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice. Cell Metab 2005; 2: 55-65.
-
(2005)
Cell Metab
, vol.2
, pp. 55-65
-
-
Neschen, S.1
Morino, K.2
Hammond, L.E.3
-
34
-
-
0342314436
-
Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients
-
Ryysy L, Hakkinen AM, Goto T, et al. Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes 2000; 49: 749-58.
-
(2000)
Diabetes
, vol.49
, pp. 749-758
-
-
Ryysy, L.1
Hakkinen, A.M.2
Goto, T.3
-
35
-
-
0036312905
-
Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
-
Seppala-Lindroos A, Vehkavaara S, Hakkinen AM, et al. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 2002; 87: 3023-8.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 3023-3028
-
-
Seppala-Lindroos, A.1
Vehkavaara, S.2
Hakkinen, A.M.3
-
36
-
-
46049089412
-
Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes
-
Kotronen A, Juurinen L, Tiikkainen M, Vehkavaara S, Yki-Jarvinen H. Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. Gastroenterology 2008; 135: 122-30.
-
(2008)
Gastroenterology
, vol.135
, pp. 122-130
-
-
Kotronen, A.1
Juurinen, L.2
Tiikkainen, M.3
Vehkavaara, S.4
Yki-Jarvinen, H.5
-
37
-
-
58149385620
-
Effect of weight loss on liver free fatty acid uptake and hepatic insulin resistance
-
Viljanen AP, Iozzo P, Borra R, et al. Effect of weight loss on liver free fatty acid uptake and hepatic insulin resistance. J Clin Endocrinol Metab 2009; 94: 50-5.
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 50-55
-
-
Viljanen, A.P.1
Iozzo, P.2
Borra, R.3
-
38
-
-
0036114844
-
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
-
Petersen KF, Oral EA, Dufour S, et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J Clin Invest 2002; 109: 1345-50.
-
(2002)
J Clin Invest
, vol.109
, pp. 1345-1350
-
-
Petersen, K.F.1
Oral, E.A.2
Dufour, S.3
-
39
-
-
45149123679
-
Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis
-
Reid BN, Ables GP, Otlivanchik OA, et al. Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis. J Biol Chem 2008; 283: 13087-99.
-
(2008)
J Biol Chem
, vol.283
, pp. 13087-13099
-
-
Reid, B.N.1
Ables, G.P.2
Otlivanchik, O.A.3
-
40
-
-
36749052873
-
Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity
-
Choi CS, Savage DB, Abu-Elheiga L, et al. Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc Natl Acad Sci USA 2007; 104: 16480-5.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 16480-16485
-
-
Choi, C.S.1
Savage, D.B.2
Abu-Elheiga, L.3
-
41
-
-
56749096610
-
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
-
Romeo S, Kozlitina J, Xing C, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008; 40: 1461-5.
-
(2008)
Nat Genet
, vol.40
, pp. 1461-1465
-
-
Romeo, S.1
Kozlitina, J.2
Xing, C.3
-
42
-
-
85047694402
-
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
-
Horie Y, Suzuki A, Kataoka E, et al. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 2004; 113: 1774-83.
-
(2004)
J Clin Invest
, vol.113
, pp. 1774-1783
-
-
Horie, Y.1
Suzuki, A.2
Kataoka, E.3
-
43
-
-
67649304876
-
Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria
-
Nakamura S, Takamura T, Matsuzawa-Nagata N, et al. Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. J Biol Chem 2009; 284: 14809-18.
-
(2009)
J Biol Chem
, vol.284
, pp. 14809-14818
-
-
Nakamura, S.1
Takamura, T.2
Matsuzawa-Nagata, N.3
-
44
-
-
0032905885
-
The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects
-
Chen X, Iqbal N, Boden G. The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects. J Clin Invest 1999; 103: 365-72.
-
(1999)
J Clin Invest
, vol.103
, pp. 365-372
-
-
Chen, X.1
Iqbal, N.2
Boden, G.3
-
45
-
-
55349100928
-
Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling
-
Ruddock MW, Stein A, Landaker E, et al. Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling. J Biochem 2008; 144: 599-607.
-
(2008)
J Biochem
, vol.144
, pp. 599-607
-
-
Ruddock, M.W.1
Stein, A.2
Landaker, E.3
-
46
-
-
0029055746
-
Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: An alteration not due to hyperglycemia
-
Considine RV, Nyce MR, Allen LE, et al. Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia. J Clin Invest 1995; 95: 2938-44.
-
(1995)
J Clin Invest
, vol.95
, pp. 2938-2944
-
-
Considine, R.V.1
Nyce, M.R.2
Allen, L.E.3
-
47
-
-
33847404482
-
Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease
-
Samuel VT, Liu ZX, Wang A, et al. Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease. J Clin Invest 2007; 117: 739-45.
-
(2007)
J Clin Invest
, vol.117
, pp. 739-745
-
-
Samuel, V.T.1
Liu, Z.X.2
Wang, A.3
-
48
-
-
0029800090
-
Zonation of parenchymal and nonparenchymal metabolism in liver
-
Jungermann K, Kietzmann T. Zonation of parenchymal and nonparenchymal metabolism in liver. Annu Rev Nutr 1996; 16: 179-203.
-
(1996)
Annu Rev Nutr
, vol.16
, pp. 179-203
-
-
Jungermann, K.1
Kietzmann, T.2
-
49
-
-
0034903123
-
The biogenesis and functions of lipid bodies in animals, plants and microorganisms
-
Murphy DJ. The biogenesis and functions of lipid bodies in animals, plants and microorganisms. Prog Lipid Res 2001; 40: 325-438.
-
(2001)
Prog Lipid Res
, vol.40
, pp. 325-438
-
-
Murphy, D.J.1
-
50
-
-
0345374579
-
Minireview: Weapons of lean body mass destruction: The role of ectopic lipids in the metabolic syndrome
-
Unger RH. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 2003; 144: 5159-65.
-
(2003)
Endocrinology
, vol.144
, pp. 5159-5165
-
-
Unger, R.H.1
-
51
-
-
0141884326
-
Saturated free fatty acid release and intracellular ceramide generation during apoptosis induction are closely related processes
-
Iturralde M, Gamen S, Pardo J, et al. Saturated free fatty acid release and intracellular ceramide generation during apoptosis induction are closely related processes. Biochim Biophys Acta 2003; 1634: 40-51.
-
(2003)
Biochim Biophys Acta
, vol.1634
, pp. 40-51
-
-
Iturralde, M.1
Gamen, S.2
Pardo, J.3
-
52
-
-
0348134733
-
Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice
-
Feldstein AE, Canbay A, Guicciardi ME, Higuchi H, Bronk SF, Gores GJ. Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice. J Hepatol 2003; 39: 978-83.
-
(2003)
J Hepatol
, vol.39
, pp. 978-983
-
-
Feldstein, A.E.1
Canbay, A.2
Guicciardi, M.E.3
Higuchi, H.4
Bronk, S.F.5
Gores, G.J.6
-
53
-
-
0042165989
-
Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
-
Feldstein AE, Canbay A, Angulo P, et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003; 125: 437-43.
-
(2003)
Gastroenterology
, vol.125
, pp. 437-443
-
-
Feldstein, A.E.1
Canbay, A.2
Angulo, P.3
-
54
-
-
3042824524
-
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
-
Feldstein AE, Werneburg NW, Canbay A, et al. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 2004; 40: 185-94.
-
(2004)
Hepatology
, vol.40
, pp. 185-194
-
-
Feldstein, A.E.1
Werneburg, N.W.2
Canbay, A.3
-
55
-
-
0037143752
-
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
-
Ntambi JM, Miyazaki M, Stoehr JP, et al. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci USA 2002; 99: 11482-6.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11482-11486
-
-
Ntambi, J.M.1
Miyazaki, M.2
Stoehr, J.P.3
-
56
-
-
20144388684
-
Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1
-
Jiang G, Li Z, Liu F, et al. Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. J Clin Invest 2005; 115: 1030-8.
-
(2005)
J Clin Invest
, vol.115
, pp. 1030-1038
-
-
Jiang, G.1
Li, Z.2
Liu, F.3
-
57
-
-
33745212925
-
Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance
-
Gutierrez-Juarez R, Pocai A, Mulas C, et al. Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J Clin Invest 2006; 116: 1686-95.
-
(2006)
J Clin Invest
, vol.116
, pp. 1686-1695
-
-
Gutierrez-Juarez, R.1
Pocai, A.2
Mulas, C.3
-
58
-
-
34250356015
-
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
-
Yamaguchi K, Yang L, McCall S, et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 2007; 45: 1366-74.
-
(2007)
Hepatology
, vol.45
, pp. 1366-1374
-
-
Yamaguchi, K.1
Yang, L.2
McCall, S.3
-
59
-
-
34347235098
-
Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver
-
Monetti M, Levin MC, Watt MJ, et al. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab 2007; 6: 69-78.
-
(2007)
Cell Metab
, vol.6
, pp. 69-78
-
-
Monetti, M.1
Levin, M.C.2
Watt, M.J.3
-
60
-
-
33747079056
-
A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet
-
Raubenheimer PJ, Nyirenda MJ, Walker BR. A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet. Diabetes 2006; 55: 2015-20.
-
(2006)
Diabetes
, vol.55
, pp. 2015-2020
-
-
Raubenheimer, P.J.1
Nyirenda, M.J.2
Walker, B.R.3
-
61
-
-
0037453056
-
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
-
Listenberger LL, Han X, Lewis SE, et al. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci USA 2003; 100: 3077-82.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 3077-3082
-
-
Listenberger, L.L.1
Han, X.2
Lewis, S.E.3
-
62
-
-
34347238724
-
Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance
-
Nagle CA, An J, Shiota M, et al. Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. J Biol Chem 2007; 282: 14807-15.
-
(2007)
J Biol Chem
, vol.282
, pp. 14807-14815
-
-
Nagle, C.A.1
An, J.2
Shiota, M.3
-
63
-
-
41949114990
-
Role of mitochondrial dysfunction in insulin resistance
-
Kim JA, Wei Y, Sowers JR. Role of mitochondrial dysfunction in insulin resistance. Circ Res 2008; 102: 401-14.
-
(2008)
Circ Res
, vol.102
, pp. 401-414
-
-
Kim, J.A.1
Wei, Y.2
Sowers, J.R.3
-
64
-
-
34547123848
-
Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the phosphatidylinositol 3-kinase cell survival pathway
-
Kohli R, Pan X, Malladi P, Wainwright MS, Whitington PF. Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the phosphatidylinositol 3-kinase cell survival pathway. J Biol Chem 2007; 282: 21327-36.
-
(2007)
J Biol Chem
, vol.282
, pp. 21327-21336
-
-
Kohli, R.1
Pan, X.2
Malladi, P.3
Wainwright, M.S.4
Whitington, P.F.5
-
65
-
-
34249792393
-
Role of mitochondria in non-alcoholic fatty liver disease
-
Pessayre D. Role of mitochondria in non-alcoholic fatty liver disease. J Gastroenterol Hepatol 2007; 22 (Suppl 1): S20-7.
-
(2007)
J Gastroenterol Hepatol
, vol.22
, pp. S20-S27
-
-
Pessayre, D.1
|