Saturated free fatty acid release and intracellular ceramide generation during apoptosis induction are closely related processes

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1634, Issue 1-2, 2003, Pages 40-51

  Iturralde, María ^a   Gamen, Susana ^a   Pardo, Julián ^a   Bosque, Alberto ^a   Piñeiro, Andrés ^a   Alava, María Angeles ^a   Naval, Javier ^a   Anel, Alberto ^a  

^a UNIVERSITY OF ZARAGOZA   (Spain)

Author keywords

Apoptosis; Ceramide; Cytotoxic T lymphocyte; Fas CD95; Free fatty acid; Perforin granzyme

Indexed keywords

CERAMIDE; FATTY ACID; FATTY ACID RELEASE; SPHINGOMYELIN PHOSPHODIESTERASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SECRETION;

EID: 0141884326     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2003.08.005     Document Type: Article

References (38)

1. 2 activation in tumour cell killing by tumour necrosis factor. Immunology. 64:1988;81-85.
2. Koren H.S., Ferber E., Fischer H. Changes in phospholipid metabolism of a tumor target cell during a cell-mediated cytotoxic reaction. Biochim. Biophys. Acta. 231:1971;520-526.
3. Richieri G.V., Kleinfeld A.M. Free fatty acids are produced in and secreted from target cells very early in cytotoxic T lymphocyte-mediated killing. J. Immunol. 147:1991;2809-2815.
4. Kägi D., Vignaux F., Ledermann B., Bürki K., Depraetere V., Nagata S., Hengartner H., Golstein P. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science. 265:1994;528-530.
5. 2 is crucial in the cytotoxic action of tumor necrosis factor. J. Biol. Chem. 268:1993;11290-11298.
6. 2 is necessary for tumor necrosis factor ?-induced ceramide generation in L929 cells. J. Biol. Chem. 272:1997;17196-17203.
7. 2. Nat. Immunol. 4:2003;387-393.
8. Brekke O.L., Sagen E., Bjerve K.S. Specificity of endogenous fatty acid release during TNF-induced apoptosis in WEHI 164 fibrosarcoma cells. J. Lipid Res. 40:1999;2223-2233.
9. Foghsgaard L., Lademann U., Wissing D., Poulsen B., Jäätela M. Cathepsin B mediates TNF-induced arachidonic acid release in tumor cells. J. Biol. Chem. 277:2002;39499-39506.
10. 2 is not involved in Fas-mediated apoptosis. Eur. J. Biochem. 236:1996;533-538.
11. Cifone M.G., De Maria R., Roncaioli P., Rippo M.R., Azuma M., Lanier L.L., Santoni A., Testi R. Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J. Exp. Med. 177:1993;1547-1552.
12. Kim M.Y., Linardic C., Obeid L., Hannun Y. Identification of sphingomyelin turnover as an effector mechanism for the action of TNF-α and IFN-γ. Specific role in cell differentiation. J. Biol. Chem. 266:1991;484-492.
13. Wiegmann K., Schütze S., Machleidt T., Witte D., Krönke M. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell. 78:1994;1005-1015.
14. Obeid L.M., Linardic C.M., Karolak L.A., Hannun Y.A. Programmed cell death induced by ceramide. Science. 259:1993;1769-1771.
15. Kolesnick R., Golde D.W. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell. 77:1994;325-328.
16. Nicholson D.W., Thornberry N.A. Caspases: killer proteases. Trends Biochem. Sci. 22:1997;299-306.
17. Gamen S., Marzo I., Anel A., Piñeiro A., Naval J. CPP32 inhibition prevents Fas-induced ceramide generation and apoptosis in human cells. FEBS Lett. 390:1996;233-237.
18. Dbaibo G.S., Perry D.K., Gamard C.J., Platt R., Poirier G.G., Obeid L.M., Hannun Y.A. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumour necrosis factor (TNF)-α: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J. Exp. Med. 185:1997;481-490.
19. Pronk G.J., Ramer K., Amiri P., Williams L.T. Requirement of an ICE-like protease for induction of apoptosis and ceramide generation by REAPER. Science. 271:1996;808-810.
20. Anel A., Gamen S., Alava M.A., Schmitt-Verhulst A.M., Piñeiro A., Naval J. Inhibition of CPP32-like proteases prevents granzyme B- and Fas-, but not granzyme A-based cytotoxicity exerted by CTL clones. J. Immunol. 158:1997;1999-2006.
21. Gamen S., Anel A., Piñeiro A., Naval J. Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signaling pathway. Cell Death Differ. 5:1998;241-249.
22. Hofmann K., Dixit V.M. Ceramide in apoptosis - does it really matter? Trends Biochem. Sci. 23:1998;374-377.
23. Tepper A.D., Ruurs P., Wiedmer T., Sims P.J., Borst J., van Blitterswijk W.J. Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology. J. Cell Biol. 150:2000;155-164.
24. Anel A., Buferne M., Boyer C., Schmitt-Verhulst A.M., Golstein P. T cell receptor-induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A. Eur. J. Immunol. 24:1994;2469-2476.
25. 2+-independent T cell-mediated cytotoxicity. J. Exp. Med. 177:1993;195-200.
26. Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D., Abbot B.J., Mayo J.G., Shoemaker R.H., Boyd M.R. Sensibility of drug screening with panels of human tumor cell lines using microculture tetrazolium assay. Cancer Res. 46:1988;589-601.
27. Anel A., Naval J., González B., Torres J.M., Mishal Z., Uriel J., Piñeiro A. Fatty acid metabolism in human lymphocytes. I. Time-course changes in fatty acid composition and membrane fluidity during blastic transformation of peripheral blood lymphocytes. Biochim. Biophys. Acta. 1044:1990;323-331.
28. Marzo I., Martínez-Lorenzo M.J., Anel A., Desportes P., Alava M.A., Naval J., Piñeiro A. Biosynthesis of unsaturated fatty acids in the main cell lineages of human leukemia and lymphoma. Biochim. Biophys. Acta. 1257:1995;140-148.
29. Zhang J., Driscoll T.A., Hannun Y.A., Obeid L.M. Regulation of membrane release in apoptosis. Biochem. J. 334:1998;479-485.
30. Anel A., Richieri G.V., Kleinfeld A.M. A tyrosine phosphorylation requirement for cytotoxic T-lymphocyte degranulation. J. Biol. Chem. 269:1994;9506-9513.
31. Tepper A.D., Boesen-de Cock J.G.R., de Vries E., Borst J., van Blitterswijk W.J. CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32 inhibition. J. Biol. Chem. 272:1997;24308-24312.
32. Tepper A.D., de Vries E., van Blitterswijk W.J., Borst J. Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis. J. Clin. Invest. 103:1999;971-978.
33. Simon M.M., Waring P., Lobigs M., Nil A., Tran T., Hla R.T., Chin S., Müllbacher A. CTL specifically induce Fas on target cells, thereby facilitating exocytosis-independent induction of apoptosis. J. Immunol. 165:2000;3663-3672.
34. 2 activity by either FcγRIIA or FcγRIIIB in human neutrophils. J. Biol. Chem. 275:2000;12416-12423.
35. Paumen M.B., Ishida Y., Muramatsu M., Yamamoto M., Honjo T. Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J. Biol. Chem. 272:1997;3324-3329.
36. Savill J., Fadok V. Corpse clearance defines the meaning of cell death. Nature. 407:2000;784-788.
37. Ren Y., Silverstein R.L., Allen J., Savill J. CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis. J. Exp. Med. 181:1995;1857-1862.
38. Ibrahimi A., Sfeir Z., Magahrie H., Amri E.Z., Frimaldi P., Abumrad N.A. Expression of the CD36 homolog fatty acid translocase (FAT) in fibroblast cells: effect on fatty acid transport. Proc. Natl. Acad. Sci. U. S. A. 93:1996;2646-2651.