Reduced TIMP-2 in hypoxia enhances angiogenesis

American Journal of Physiology - Cell Physiology

Volumn 300, Issue 3, 2011, Pages

  Lahat, Nitza ^a   Bitterman, Haim ^a   Engelmayer Goren, Miri ^a   Rosenzweig, Doron ^a   Weiss Cerem, Lea ^a   Rahat, Michal A ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Human; Inflammation; Low oxygen tension; Monocytes

Indexed keywords

GELATINASE A; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP 1; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CELL STRAIN THP 1; CELL STRAIN U937; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENDOTHELIUM CELL; EXTRAVASATION; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; HYPOXIA; INFLAMMATION; MONOCYTE; PRIORITY JOURNAL; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANIMALS; ANOXIA; BASE SEQUENCE; CELL LINE; CELL MIGRATION INHIBITION; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DOWN-REGULATION; ENDOTHELIAL CELLS; HUMANS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MONOCYTES; NEOVASCULARIZATION, PHYSIOLOGIC; SP1 TRANSCRIPTION FACTOR; TISSUE INHIBITOR OF METALLOPROTEINASE-2; U937 CELLS; UP-REGULATION;

EID: 79952121696     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00177.2010     Document Type: Article

References (50)

1. Aranda E, Owen GI. A semi-quantitative assay to screen for angiogenic compounds and compounds with angiogenic potential using the EA.hy926 endothelial cell line. Biol Res 42: 377-389, 2009.
2. Bernhagen J. Macrophage migration and function: from recruitment in vascular disease to redox regulation in the immune and neuroendocrine networks. Antioxid Redox Signal 7: 1182-1188, 2005. (Pubitemid 41232513)
3. Bjorklund M, Koivunen E. Gelatinase-mediated migration and invasion of cancer cells. Biochim Biophys Acta 1755: 37-69, 2005. (Pubitemid 40720240)
4. Bosco MC, Puppo M, Blengio F, Fraone T, Cappello P, Giovarelli M, Varesio L. Monocytes and dendritic cells in a hypoxic environment: spotlights on chemotaxis and migration. Immunobiology 213: 733-749, 2008.
5. Bosco MC, Puppo M, Santangelo C, Anfosso L, Pfeffer U, Fardin P, Battaglia F, Varesio L. Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene. J Immunol 177: 1941-1955, 2006.
6. Chakraborti S, Mandal M, Das S, Mandal A, Chakraborti T. Regulation of matrix metalloproteinases: an overview. Mol Cell Biochem 253: 269-285, 2003.
7. Chang C, Werb Z. The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol 11: S37-S43, 2001.
8. Charles S, Ammosova T, Cardenas J, Foster A, Rotimi J, Jerebtsova M, Ayodeji AA, Niu X, Ray PE, Gordeuk VR, Kashanchi F, Nekhai S. Regulation of HIV-1 transcription at 3% versus 21% oxygen concentration. J Cell Physiol 221: 469-479, 2009.
9. Chirco R, Liu XW, Jung KK, Kim HR. Novel functions of TIMPs in cell signaling. Cancer Metastasis Rev 25: 99-113, 2006. (Pubitemid 43723986)
10. Fassina G, Ferrari N, Brigati C, Benelli R, Santi L, Noonan DM, Albini A. Tissue inhibitors of metalloproteases: regulation and biological activities. Clin Exp Metastasis 18: 111-120, 2000. (Pubitemid 32165244)
11. Galm O, Suzuki H, Akiyama Y, Esteller M, Brock MV, Osieka R, Baylin SB, Herman JG. Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies. Oncogene 24: 4799-4805, 2005. (Pubitemid 41076297)
12. Grimshaw MJ, Balkwill FR. Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation - a potential mechanism. Eur J Immunol 31: 480-489, 2001. (Pubitemid 32166603)
13. Hammani K, Blakis A, Morsette D, Bowcock AM, Schmutte C, Henriet P, DeClerck YA. Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene. J Biol Chem 271: 25498-25505, 1996. (Pubitemid 26337925)
14. Hernandez-Barrantes S, Shimura Y, Soloway PD, Sang QA, Fridman R. Differential roles of TIMP-4 and TIMP-2 in pro-MMP-2 activation by MT1-MMP. Biochem Biophys Res Commun 281: 126-130, 2001. (Pubitemid 32924409)
15. Kohro T, Tanaka T, Murakami T, Wada Y, Aburatani H, Hamakubo T, Kodama T. A comparison of differences in the gene expression profiles of phorbol 12-myristate 13-acetate differentiated THP-1 cells and human monocyte-derived macrophage. J Atheroscler Thromb 11: 88-97, 2004.
16. Lamagna C, Aurrand-Lions M, Imhof BA. Dual role of macrophages in tumor growth and angiogenesis. J Leukoc Biol 80: 705-713, 2006. (Pubitemid 44835885)
17. Lewis C, Murdoch C. Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am J Pathol 167: 627-635, 2005. (Pubitemid 41216349)
18. Lewis CE, Pollard JW. Distinct role of macrophages in different tumor microenvironments. Cancer Res 66: 605-612, 2006. (Pubitemid 43165918)
19. Lewis JS, Lee JA, Underwood JC, Harris AL, Lewis CE. Macrophage responses to hypoxia: relevance to disease mechanisms. J Leukoc Biol 66: 889-900, 1999. (Pubitemid 30010512)
20. Martinez FO, Sica A, Mantovani A, Locati M. Macrophage activation and polarization. Front Biosci 13: 453-461, 2008. (Pubitemid 351599757)
21. Murdoch C, Giannoudis A, Lewis CE. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 104: 2224-2234, 2004. (Pubitemid 39331817)
22. Murdoch C, Muthana M, Lewis CE. Hypoxia regulates macrophage functions in inflammation. J Immunol 175: 6257-6263, 2005. (Pubitemid 41598863)
23. Nagase H, Visse R, Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 69: 562-573, 2006. (Pubitemid 43139720)
24. Nagase H, Woessner JF Jr. Matrix metalloproteinases. J Biol Chem 274: 21491-21494, 1999. (Pubitemid 129519680)
25. Nuttall RK, Sampieri CL, Pennington CJ, Gill SE, Schultz GA, Edwards DR. Expression analysis of the entire MMP and TIMP gene families during mouse tissue development. FEBS Lett 563: 129-134, 2004. (Pubitemid 38471586)
26. Olofsson BA, Kelly CM, Kim J, Hornsby SM, Azizkhan-Clifford J. Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia- mutated kinase. Mol Cancer Res 5: 1319-1330, 2007.
27. Page-McCaw A, Ewald AJ, Werb Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol 8: 221-233, 2007.
28. Perri SR, Annabi B, Galipeau J. Angiostatin inhibits monocyte/macrophage migration via disruption of actin cytoskeleton. FASEB J 21: 3928-3936, 2007. (Pubitemid 350232350)
29. Philipsen S, Suske G. A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res 27: 2991-3000, 1999. (Pubitemid 29355710)
30. Pulukuri SM, Patibandla S, Patel J, Estes N, Rao JS. Epigenetic inactivation of the tissue inhibitor of metalloproteinase-2 (TIMP-2) gene in human prostate tumors. Oncogene 26: 5229-5237, 2007. (Pubitemid 47237624)
31. Rahat MA, Chernichovski I, Lahat N. Increased binding of IFN regulating factor 1 mediates the synergistic induction of CIITA by IFN-gamma and tumor necrosis factor-alpha in human thyroid carcinoma cells. Int Immunol 13: 1423-1432, 2001. (Pubitemid 33049126)
32. Rahat MA, Marom B, Bitterman H, Weiss-Cerem L, Kinarty A, Lahat N. Hypoxia reduces the output of matrix metalloproteinase-9 (MMP-9) in monocytes by inhibiting its secretion and elevating membranal association. J Leukoc Biol 79: 706-718, 2006. (Pubitemid 44835603)
33. Reith W, Mach B. The bare lymphocyte syndrome and the regulation of MHC expression. Annu Rev Immunol 19: 331-373, 2001. (Pubitemid 32368039)
34. Roy B, Li WW, Lee AS. Calcium-sensitive transcriptional activation of the proximal CCAAT regulatory element of the grp78/BiP promoter by the human nuclear factor CBF/NF-Y. J Biol Chem 271: 28995-29002, 1996. (Pubitemid 26382603)
35. Samson SL, Wong NC. Role of Sp1 in insulin regulation of gene expression. J Mol Endocrinol 29: 265-279, 2002. (Pubitemid 36024543)
36. Seo DW, Li H, Qu CK, Oh J, Kim YS, Diaz T, Wei B, Han JW, Stetler-Stevenson WG. Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells. J Biol Chem 281: 3711-3721, 2006. (Pubitemid 43845989)
37. Shapiro S, Khodalev O, Bitterman H, Auslender R, Lahat N. Different activation forms of MMP-2 oppositely affect the fate of endothelial cells. Am J Physiol Cell Physiol 298: C942-C951, 2010.
38. Sohl M, Lanner F, Farnebo F. Sp1 mediate hypoxia induced ephrinB2 expression via a hypoxia-inducible factor independent mechanism. Biochem Biophys Res Commun 391: 24-27, 2010.
39. Stetler-Stevenson WG. Tissue inhibitors of metalloproteinases in cell signaling: metalloproteinase-independent biological activities. Sci Signal 1: re6, 2008.
40. Stetler-Stevenson WG. The tumor microenvironment: regulation by MMP-independent effects of tissue inhibitor of metalloproteinases-2. Cancer Metastasis Rev 27: 57-66, 2008.
41. Stetler-Stevenson WG, Seo DW. TIMP-2: an endogenous inhibitor of angiogenesis. Trends Mol Med 11: 97-103, 2005. (Pubitemid 40348986)
42. Tan NY, Khachigian LM. Sp1 phosphorylation and its regulation of gene transcription. Mol Cell Biol 29: 2483-2488, 2009.
43. 2+ increases. Cell Calcium 36: 187-199, 2004.
44. Turpeenniemi-Hujanen T. Gelatinases (MMP-2 and -9) and their natural inhibitors as prognostic indicators in solid cancers. Biochimie 87: 287-297, 2005. (Pubitemid 40387607)
45. Verhoeckx KC, Bijlsma S, de Groene EM, Witkamp RF, van der Greef J, Rodenburg RJ. A combination of proteomics, principal component analysis and transcriptomics is a powerful tool for the identification of biomarkers for macrophage maturation in the U937 cell line. Proteomics 4: 1014-1028, 2004. (Pubitemid 38450707)
46. Vicart A, Lefebvre T, Imbert J, Fernandez A, Kahn-Perles B. Increased chromatin association of Sp1 in interphase cells by PP2A-mediated dephosphorylations. J Mol Biol 364: 897-908, 2006. (Pubitemid 44765037)
47. Villard J, Peretti M, Masternak K, Barras E, Caretti G, Mantovani R, Reith W. A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y. Mol Cell Biol 20: 3364-3376, 2000. (Pubitemid 30243882)
48. White JR, Harris RA, Lee SR, Craigon MH, Binley K, Price T, Beard GL, Mundy CR, Naylor S. Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis. Genomics 83: 1-8, 2004. (Pubitemid 37518254)
49. Zhong H, Simons JW. Direct comparison of GAPDH, beta-actin, cyclophilin, and 28S rRNA as internal standards for quantifying RNA levels under hypoxia. Biochem Biophys Res Commun 259: 523-526, 1999. (Pubitemid 29335566)
50. Zhong ZD, Hammani K, Bae WS, DeClerck YA. NF-Y and Sp1 cooperate for the transcriptional activation and cAMP response of human tissue inhibitor of metalloproteinases-2. J Biol Chem 275: 18602-18610, 2000. (Pubitemid 30414824)