Sp1 mediate hypoxia induced ephrinB2 expression via a hypoxia-inducible factor independent mechanism

Biochemical and Biophysical Research Communications

Volumn 391, Issue 1, 2010, Pages 24-27

  Sohl, Marcus ^a   Lanner, Fredrik ^a   Farnebo, Filip ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Arteriogenesis; EphrinB2; Gene expression; Hypoxia; Promoter; Sp1; Transcription factor

Indexed keywords

EPHRIN B2; HYPOXIA INDUCIBLE FACTOR; MYC PROTEIN; OXYGEN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SP1; ZINC FINGER PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ARTERY; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; COMPARATIVE STUDY; CONTROLLED STUDY; ENDOTHELIUM CELL; HYPOXIA; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; TRANSACTIVATION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL HYPOXIA; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; DNA-BINDING PROTEINS; EPHRIN-B2; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; OXYGEN; RESPONSE ELEMENTS; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 72949090149     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.10.146     Document Type: Article

References (16)

1. Moyon D., Pardanaud L., Yuan L., Bréant C., and Eichman A. Plasticity of endothelial cells during arterial-venous differentiation in the avian embryo. Development 128 (2001) 3359-3370
2. Othman-Hassan K., Patel K., Papoutsi M., Rodrigues-Niedelfuhr M., Christ B., and Wilting J. Arterial identity of endothelial cells is controlled by local cues. Dev. Biol. 237 (2001) 398-409
3. Wang H., Chen C., and Anderson D. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell 93 (1998) 741-753
4. Adams R.H., Wilkinson G.A., Weiss C., Diella F., Gale N.W., Deutch U., Risau W., and Klein R. Roles of EphrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 13 (1999) 295-306
5. Gerety S.S., Wang H.U., Chen Z.F., and Anderson D.J. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol. Cell 4 1999 (1999) 403-414
6. Sohl M., Lanner F., and Farnebo F. Characterization of the murine Ephrin-B2 promoter. Gene 437 (2009) 54-59
7. Parks C.L., and Shenk T. The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. J. Biol. Chem. 271 (1996) 4417-4430
8. Song J., Ugai H., Ogawa K., Wang Y., Sarai A., Obata Y., Kanazawa I., Sun K., Itakura K., and Yokoyama K.K. Two consecutive zinc fingers in Sp1 and in MAZ are essential for interactions with cis-elements. J. Biol. Chem. 276 (2001) 30429-30434
9. Song J., Ugai H., Nakata-Tsutsui H., Kishikawa S., Suzuki E., Murata T., and Yokoyama K.K. Transcriptional regulation by zinc-finger proteins Sp1 and MAZ involves interactions with the same cis-elements. Int. J. Mol. Med. 11 (2003) 547-553
10. Obi S., Yamamoto K., Shimizu N., Kumagaya S., Masumura T., Sokabe T., Asahara T., and Ando J. Fluid shear stress induces arterial differentiation of endothelial progenitor cells. J. Appl. Physiol. 106 (2009) 203-211
11. Vihanto M.M., Plock J., Erni D., Frey B.M., Frey F.J., and Huynh-Do U. Hypoxia up-regulates expression of Eph receptors and ephrins in mouse skin. FASEB J. 12 (2005) 1689-1691
12. Eltzschig H.K., Köhler D., Eckle T., Kong T., Robson S.C., and Colgan S.P. Central role of Sp1-regulated CD39 in hypoxia/ischemia protection. Blood 113 (2009) 224-232
13. Kato A., Endo T., Abiko S., Ariga H., and Matsumoto K. Induction of truncated form of tenascin-X (XB-S) through dissociation of HDAC1 from SP-1/HDAC1 complex in response to hypoxic conditions. Exp. Cell Res. 314 (2008) 2661-2673
14. Hänze J., Weissmann N., Grimminger F., Seeger W., and Rose F. Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling. Thromb. Haemost. 97 (2007) 774-787
15. Shibuya M. Vascular endothelial growth factor-dependent and -independent regulation of angiogenesis. BMB Rep. 41 (2008) 278-286
16. Mukhopadhyay A., and Peterson R.T. Deciphering arterial identity through gene expression, genetics, and chemical biology. Curr. Opin. Hematol. 15 (2008) 221-227