Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 4, 2008, Pages 1948-1956

  Chowdhury, Morshed Alam ^a   Dong, Ying ^a   Chen, Qiao Hong ^a   Abdellatif, Khaled R A ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Anti inflammatory activity; Cyclooxygenase 1 and 2 inhibitors; Linear acetylenes; MeSO2 and H2NSO2 COX 2 pharmacophores; Sonogashira cross coupling reaction

Indexed keywords

1 (3 METHANESULFONYLPHENYL) 2 (2 PYRIDYL)ACETYLENE; 1 (3 METHANESULFONYLPHENYL) 2 (4 PYRIDYL)ACETYLENE; 1 (4 AMINOSULFONYLPHENYL) 2 (3 METHY 2 PYRIDYL)ACETYLENE; 1 (4 METHANESULFONYLPHENYL) 2 (2 PYRIDYL)ACETYLENE; 1 (4 METHANESULFONYLPHENYL) 2 (3 PYRIDYL)ACETYLENE; ACETYLENE DERIVATIVE; ACETYLSALICYLIC ACID; CELECOXIB; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; SONOGASHIRA REACTION; STRUCTURE ACTIVITY RELATION;

ALKYNES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 38949128016     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.003     Document Type: Article

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