Mechanistic insights into cyclooxygenase irreversible inactivation by aspirin

ChemMedChem

Volumn 4, Issue 6, 2009, Pages 939-945

  Tosco, Paolo ^a   Lazzarato, Loretta ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Acylation; Aspirin; Cyclooxygenases; Enzyme catalysis; Quantum chemistry

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INDOMETACIN; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; SERINE; TYROSINE;

ANALGESIA; ARTICLE; DRUG ACETYLATION; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME INACTIVATION; GASTROINTESTINAL HEMORRHAGE; HUMAN; HYDROLYSIS; MATHEMATICAL COMPUTING; MOLECULAR MODEL; NONHUMAN; OXIDATION REDUCTION REACTION; PEPTIC ULCER; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STOMACH INJURY; STOMACH PROTECTION; STRUCTURE ACTIVITY RELATION; THEORETICAL MODEL; TRANSESTERIFICATION;

ACETYLATION; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; MODELS, CHEMICAL; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67049167364     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800438     Document Type: Article

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