Role of PI3K/Akt and MEK/ERK in mediating hypoxia-induced expression of HIF-1α and VEGF in laser-induced rat choroidal neovascularization

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 4, 2009, Pages 1873-1879

  Yang, Xiu Mei ^a   Wang, Yu Sheng ^a   Zhang, Jian ^a   Li, Yan ^a   Xu, Jian Feng ^a   Zhu, Jie ^a   Zhao, Wei ^a   Chu, Da Ke ^a   Wiedemann, Peter ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; VASCULOTROPIN; ENZYME INHIBITOR; HIF1A PROTEIN, RAT; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; VASCULAR ENDOTHELIAL GROWTH FACTOR A, RAT; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HYPOXIA; LASER; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SUBRETINAL NEOVASCULARIZATION; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; ANOXIA; BROWN NORWAY RAT; DISEASE MODEL; DRUG ANTAGONISM; ENZYME IMMUNOASSAY; FLUORESCENCE ANGIOGRAPHY; LASER COAGULATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANOXIA; BLOTTING, WESTERN; CHOROIDAL NEOVASCULARIZATION; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLUORESCEIN ANGIOGRAPHY; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOENZYME TECHNIQUES; LASER COAGULATION; MAP KINASE KINASE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, INBRED BN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 64049113588     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2591     Document Type: Article

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