Intrathecal increase of sphingosine 1-phosphate at early stage multiple sclerosis

Neuroscience Letters

Volumn 477, Issue 3, 2010, Pages 149-152

  Kułakowska, Alina ^a   Zendzian Piotrowska, Małgorzata ^a   Baranowski, Marcin ^a   Konończuk, Tomasz ^a   Drozdowski, Wiesław ^a   Górski, Jan ^a   Bucki, Robert ^b  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Blood; Cerebrospinal fluid; Sphingosine 1 phosphate

Indexed keywords

SPHINGOSINE 1 PHOSPHATE;

ADULT; ARTICLE; BELL PALSY; BLOOD LEVEL; CEREBROSPINAL FLUID LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE SEVERITY; HEADACHE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MULTIPLE SCLEROSIS; NEUROPATHOLOGY; PRIORITY JOURNAL;

ADULT; FEMALE; HUMANS; LYSOPHOSPHOLIPIDS; MALE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; SPHINGOSINE;

EID: 77953361436     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.04.052     Document Type: Article

References (24)

1. Brinkmann V. FTY720 (fingolimod) in multiple sclerosis: therapeutic effects in the immune and the central nervous system. Br. J. Pharmacol. 2009, 158:1173-1182.
2. Brinkmann V. Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol. Ther. 2007, 115:84-105.
3. Gardell S.E., Dubin A.E., Chun J. Emerging medicinal roles for lysophospholipid signaling. Trends Mol. Med. 2006, 12:65-75.
4. Hla T., Venkataraman K., Michaud J. The vascular S1P gradient-cellular sources and biological significance. Biochim. Biophys. Acta 2008, 1781:477-482.
5. Kappos L., Radue E.W., O'Connor P., Polman C., Hohlfeld R., Calabresi P., Selmaj K., Agoropoulou C., Leyk M., Zhang-Auberson L., Burtin P. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl. J. Med. 2010, 362:387-401.
6. Kulakowska A., Drozdowski W., Sadzynski A., Bucki R., Janmey P.A. Gelsolin concentration in cerebrospinal fluid from patients with multiple sclerosis and other neurological disorders. Eur. J. Neurol. 2008, 15:584-588.
7. Mehta D., Konstantoulaki M., Ahmmed G.U., Malik A.B. Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cells. J. Biol. Chem. 2005, 280:17320-17328.
8. Min J.K., Yoo H.S., Lee E.Y., Lee W.J., Ym L. Simultaneous quantitative analysis of sphingoid base 1-phosphates in biological samples by o-phthalaldehyde precolumn derivatization after dephosphorylation with alkaline phosphatase. Anal. Biochem. 2002, 303:167-175.
9. O'Brien N., Jones S.T., Williams D.G., Cunningham H.B., Moreno K., Visentin B., Gentile A., Vekich J., Shestowsky W., Hiraiwa M., Matteo R., Cavalli A., Grotjahn D., Grant M., Hansen G., Campbell M.A., Sabbadini R. Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies. J. Lipid Res. 2009.
10. Pebay A., Toutant M., Premont J., Calvo C.F., Venance L., Cordier J., Glowinski J., Tence M. Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades. Eur. J. Neurosci. 2001, 13:2067-2076.
11. Peng X., Hassoun P.M., Sammani S., McVerry B.J., Burne M.J., Rabb H., Pearse D., Tuder R.M., Garcia J.G. Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. Am. J. Respir. Crit. Care Med. 2004, 169:1245-1251.
12. Rouach N., Pebay A., Meme W., Cordier J., Ezan P., Etienne E., Giaume C., Tence M. S1P inhibits gap junctions in astrocytes: involvement of G and Rho GTPase/ROCK. Eur. J. Neurosci. 2006, 23:1453-1464.
13. Sato K., Malchinkhuu E., Horiuchi Y., Mogi C., Tomura H., Tosaka M., Yoshimoto Y., Kuwabara A., Okajima F. HDL-like lipoproteins in cerebrospinal fluid affect neural cell activity through lipoprotein-associated sphingosine 1-phosphate. Biochem. Biophys. Res. Commun. 2007, 359:649-654.
14. Scanu A.M., Edelstein C. HDL: bridging past and present with a look at the future. Faseb J. 2008, 22:4044-4054.
15. Schubert R. Sphingosine-1-phosphate in the circulatory system: Cause and therapeutic target for vascular dysfunction?. Cardiovasc. Res. 2006, 70:9-11.
16. Sorensen S.D., Nicole O., Peavy R.D., Montoya L.M., Lee C.J., Murphy T.J., Traynelis S.F., Hepler J.R. Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes. Mol. Pharmacol. 2003, 64:1199-1209.
17. Spiegel S., Milstien S. Sphingosine 1-phosphate, a key cell signaling molecule. J. Biol. Chem. 2002, 277:25851-25854.
18. Takabe K., Paugh S.W., Milstien S., Spiegel S. " Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol. Rev. 2008, 60:181-195.
19. Tosaka M., Okajima F., Hashiba Y., Saito N., Nagano T., Watanabe T., Kimura T., Sasaki T. Sphingosine 1-phosphate contracts canine basilar arteries in vitro and in vivo: possible role in pathogenesis of cerebral vasospasm. Stroke 2001, 32:2913-2919.
20. Tumani H., Hartung H.P., Hemmer B., Teunissen C., Deisenhammer F., Giovannoni G., Zettl U.K. Cerebrospinal fluid biomarkers in multiple sclerosis. Neurobiol. Dis. 2009, 35:117-127.
21. Venkataraman K., Lee Y.M., Michaud J., Thangada S., Ai Y., Bonkovsky H.L., Parikh N.S., Habrukowich C., Hla T. Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. Circ. Res. 2008, 102:669-676.
22. Wu Y.P., Mizugishi K., Bektas M., Sandhoff R., Proia R.L. Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease. Hum. Mol. Genet. 2008, 17:2257-2264.
23. Yatomi Y., Igarashi Y., Yang L., Hisano N., Qi R., Asazuma N., Satoh K., Ozaki Y., Kume S. Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum. J. Biochem. 1997, 121:969-973.
24. Yatomi Y., Yamamura S., Ruan F., Igarashi Y. Sphingosine 1-phosphate induces platelet activation through an extracellular action and shares a platelet surface receptor with lysophosphatidic acid. J. Biol. Chem. 1997, 272:5291-5297.