Isoform-specific regulation of cytochrome P450 expression and activity by estradiol in female rats

Biochemical Pharmacology

Volumn 81, Issue 6, 2011, Pages 777-782

  Choi, Su Young ^a   Fischer, Liam ^a   Yang, Kyunghee ^a   Chung, Hyejin ^a   Jeong, Hyunyoung ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Cytochrome P450; Estradiol; Nuclear receptors; p450 oxidoreductase; Pregnancy; Rat

Indexed keywords

BETA NAPHTHOFLAVONE; CYTOCHROME P450 1A2; CYTOCHROME P450 2C; CYTOCHROME P450 2C12; CYTOCHROME P450 2C6; CYTOCHROME P450 2C7; CYTOCHROME P450 3A; CYTOCHROME P450 3A1; CYTOCHROME P450 3A9; CYTOCHROME P450 REDUCTASE; ESTRADIOL; ESTRADIOL BENZOATE; MESSENGER RNA; PHENOBARBITAL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; IMMUNOBLOTTING; IN VIVO STUDY; NONHUMAN; OXIDATION REDUCTION REACTION; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME ACTIVATION; ESTRADIOL; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; ISOENZYMES; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79951956636     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.12.019     Document Type: Article

References (36)

1. Andrade SE, Gurwitz JH, Davis RL, Chan KA, Finkelstein JA, Fortman K, et al. Prescription drug use in pregnancy. Am J Obstet Gynecol 2004;191:398-407. (Pubitemid 39178690)
2. Little BB. Pharmacokinetics during pregnancy: evidence-based maternal dose formulation. Obstet Gynecol 1999;93:858-68. (Pubitemid 29197933)
3. Anderson GD. Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach. Clin Pharmacokinet 2005;44:989-1008. (Pubitemid 41356388)
4. Anderson GD, Carr DB. Effect of pregnancy on the pharmacokinetics of antihypertensive drugs. Clin Pharmacokinet 2009;48:159-68.
5. Hodge LS, Tracy TS. Alterations in drug disposition during pregnancy: implications for drug therapy. Expert Opin Drug Metab Toxicol 2007;3:557-71. (Pubitemid 351324964)
6. Tulchinsky D, Hobel CJ, Yeager E, Marshall JR. Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy. Am J Obstet Gynecol 1972;112:1095-100.
7. Anderson GD. Gender differences in pharmacological response. Int Rev Neurobiol 2008;83:1-10.
8. Martignoni M, Groothuis GM, de Kanter R. Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opin Drug Metab Toxicol 2006;2:875-94. (Pubitemid 44911538)
9. Waxman DJ, Holloway MG. Sex differences in the expression of hepatic drug metabolizing enzymes. Mol Pharmacol 2009;76:215-28.
10. Waxman DJ, Dannan GA, Guengerich FP. Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes. Biochemistry 1985;24:4409-17. (Pubitemid 15228447)
11. Dannan GA, Guengerich FP, Waxman DJ. Hormonal regulation of rat liver microsomal enzymes. Role of gonadal steroids in programming, maintenance, and suppression of delta 4-steroid 5 alpha-reductase, flavin-containing monooxygenase, and sex-specific cytochromes P-450. J Biol Chem 1986;261:10728-35. (Pubitemid 17194858)
12. Jeong H, Chiou WL. Role of P-glycoprotein in the hepatic metabolism of tacrolimus. Xenobiotica 2006;36:1-13.
13. Omura T, Sato R. The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification, and properties. J Biol Chem 1964;239:2379-85.
14. Choi S, Sainz Jr B, Corcoran P, UpRichard S, Jeong H. Characterization of increased drug metabolism activity in DMSO-treated Huh7 hepatoma cells. Xenobiotica 2009;39:205-17.
15. Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000;132:365-86.
16. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008;3:1101-8. (Pubitemid 351818697)
17. Martignoni M, de Kanter R, Grossi P, Mahnke A, Saturno G, Monshouwer M. An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR. Chem Biol Interact 2004;151:1-11. (Pubitemid 39647932)
18. Kobayashi K, Urashima K, Shimada N, Chiba K. Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat. Biochem Pharmacol 2002;63:889-96. (Pubitemid 34243002)
19. Timsit YE, Negishi M. CAR and PXR: the xenobiotic-sensing receptors. Steroids 2007;72:231-46. (Pubitemid 46273513)
20. Shen AL, Kasper CB. Differential contributions of NADPH-cytochrome P450 oxidoreductase FAD binding site residues to flavin binding and catalysis. J Biol Chem 2000;275:41087-91. (Pubitemid 32054937)
21. Rahner C, Stieger B, Landmann L. Structure-function correlation of tight junctional impairment after intrahepatic and extrahepatic cholestasis in rat liver. Gastroenterology 1996;110:1564-78. (Pubitemid 26134091)
22. Shiverick KT, Delorme AM, Scammell JG, Fregly MJ. Effects of chronic treatment with thyroxine and estradiol on estrogen concentration in serum and on hepatic microsomal catechol estrogen formation in female rats. J Pharmacol Exp Ther 1982;221:564-9. (Pubitemid 12085875)
23. Brauze D, Widerak M, Cwykiel J, Szyfter K, Baer-Dubowska W. The effect of aryl hydrocarbon receptor ligands on the expression of AhR, AhRR, ARNT, Hif1alpha, CYP1A1 and NQO1 genes in rat liver. Toxicol Lett 2006;167:212-20. (Pubitemid 44780050)
24. Sarkar S, Jana NR, Yonemoto J, Tohyama C, Sone H. Estrogen enhances induction of cytochrome P-4501A1 by 2,3,7, 8-tetrachlorodibenzo-p-dioxin in liver of female Long-Evans rats. Int J Oncol 2000;16:141-7.
25. Murray IA, Reen RK, Leathery N, Ramadoss P, Bonati L, Gonzalez FJ, et al. Evidence that ligand binding is a key determinant of Ah receptor-mediated transcriptional activity. Arch Biochem Biophys 2005;442:59-71. (Pubitemid 41330994)
26. Bandiera S, Dworschak C. Effects of testosterone and estrogen on hepatic levels of cytochromes P450 2C7 and P450 2C11 in the rat. Arch Biochem Biophys 1992;296:286-95.
27. Endoh A, Natsume H, Igarashi Y. Dual regulation of 21-hydroxylase activity by sex steroid hormones in rat hepatocytes. J Steroid Biochem Mol Biol 1995;54:163-5.
28. Natsume H, Endoh A, Nakagawa Y, Igarashi Y. Regulation of steroid 21-hydroxylation by 17 beta-estradiol in rat liver: in vivo and in vitro study. Endocr J 1993;40:197-206. (Pubitemid 23257673)
29. Dickmann LJ, Tay S, Senn TD, Zhang H, Visone A, Unadkat JD, et al. Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy. Biochem Pharmacol 2008;75:1677-87.
30. Kaminsky LS, Guengerich FP. Cytochrome P-450 isozyme/isozyme functional interactions and NADPH-cytochrome P-450 reductase concentrations as factors in microsomal metabolism of warfarin. Eur J Biochem 1985;149:479-89. (Pubitemid 15068152)
31. Jager W, Correia MA, Bornheim LM, Mahnke A, Hanstein WG, Xue L, et al. Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism. Drug Metab Dispos 1999;27:1505-11.
32. Hartley DP, Dai X, He YD, Carlini EJ, Wang B, Huskey SE, et al. Activators of the rat pregnane X receptor differentially modulate hepatic and intestinal gene expression. Mol Pharmacol 2004;65:1159-71. (Pubitemid 38543487)
33. Mahnke A, Strotkamp D, Roos PH, Hanstein WG, Chabot GG, Nef P. Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver. Arch Biochem Biophys 1997;337:62-8. (Pubitemid 27198055)
34. Wang H, Strobel HW. Regulation of CYP3A9 gene expression by estrogen and catalytic studies using cytochrome P450 3A9 expressed in Escherichia coli. Arch Biochem Biophys 1997;344:365-72. (Pubitemid 27344074)
35. Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, et al. The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol Endocrinol 2000;14:27-39. (Pubitemid 32260325)
36. Jeong H, Choi S, Song JW, Chen H, Fischer JH. Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination. Xenobiotica 2008;38:62-75.