Repeated injection of high doses of hemoglobin-encapsulated liposomes (hemoglobin vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model

Drug Metabolism and Disposition

Volumn 39, Issue 3, 2011, Pages 484-489

  Taguchi, Kazuaki ^a   Iwao, Yasunori ^a   Watanabe, Hiroshi ^a   Kadowaki, Daisuke ^a   Sakai, Hiromi ^c   Kobayashi, Koichi ^d   Horinouchi, Hirohisa ^d   Maruyama, Toru ^a   Otagiri, Masaki ^a,b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b SOJO UNIVERSITY   (Japan)

^c WASEDA UNIVERSITY   (Japan)

^d KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN DERIVATIVE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IODINE 125;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VOLUME; DRUG MEGADOSE; HEMORRHAGIC SHOCK; HUMAN; NONHUMAN; PHAGOCYTE; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD SUBSTITUTES; BLOOD VOLUME; COMPLEMENT HEMOLYTIC ACTIVITY ASSAY; DRUG ADMINISTRATION SCHEDULE; HALF-LIFE; HEMOGLOBINS; HUMANS; IMMUNOGLOBULIN M; INJECTIONS, INTRAVENOUS; IODINE RADIOISOTOPES; LIPOSOMES; METABOLIC CLEARANCE RATE; PHAGOCYTOSIS; RATS; RATS, SPRAGUE-DAWLEY; SHOCK, HEMORRHAGIC;

ANIMALIA; RATTUS;

EID: 79951927974     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.036913     Document Type: Article

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