메뉴 건너뛰기




Volumn 9, Issue 9, 2008, Pages 1009-1019

Hemospan: A hemoglobin-based oxygen carrier for potential use as a blood substitute and for the potential treatment of critical limb ischemia

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD SUBSTITUTE; HEMOSPAN; POLYMERIZED HEMOGLOBIN; UNCLASSIFIED DRUG;

EID: 50249150337     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (16)

References (62)
  • 1
    • 0031858604 scopus 로고    scopus 로고
    • 309897 The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery. Gould SA, Moore EE, Hoyt DB, Burch JM, Haenel JB, Garcia J, DeWoskin R, Moss GS J AM COLL SURG 1998 187 2 113-122
    • 309897 The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery. Gould SA, Moore EE, Hoyt DB, Burch JM, Haenel JB, Garcia J, DeWoskin R, Moss GS J AM COLL SURG 1998 187 2 113-122
  • 2
    • 0033079841 scopus 로고    scopus 로고
    • 392703 Future prospects for artificial blood. Chang TMS TRENDS BIOTECHNOL 1999 17 2 61-67
    • 392703 Future prospects for artificial blood. Chang TMS TRENDS BIOTECHNOL 1999 17 2 61-67
  • 3
    • 50249130935 scopus 로고    scopus 로고
    • 504280 Sangart and Gambro enter into strategic partnership. Sangart Inc PRESS RELEASE 2001 July 27
    • 504280 Sangart and Gambro enter into strategic partnership. Sangart Inc PRESS RELEASE 2001 July 27
  • 4
    • 0037390385 scopus 로고    scopus 로고
    • 504292 MP4, a new non-vasoactive PEG-Hb conjugate. Vandegriff KD, Malavalli A, Wooldridge J, Lohman J, Winslow RM TRANSFUSION 2003 43 4 509-516
    • 504292 MP4, a new non-vasoactive PEG-Hb conjugate. Vandegriff KD, Malavalli A, Wooldridge J, Lohman J, Winslow RM TRANSFUSION 2003 43 4 509-516
  • 5
    • 0038170347 scopus 로고    scopus 로고
    • 504294 Resuscitation with polyethylene glycol-modified human hemoglobin improves microcirculatory blood flow and tissue oxygenation after hemorrhagic shock in awake hamsters. Wettstein R, Tsai AG, Erni D, Winslow RM, Intaglietta M CRIT CARE MED 2003 31 6 1824-1830
    • 504294 Resuscitation with polyethylene glycol-modified human hemoglobin improves microcirculatory blood flow and tissue oxygenation after hemorrhagic shock in awake hamsters. Wettstein R, Tsai AG, Erni D, Winslow RM, Intaglietta M CRIT CARE MED 2003 31 6 1824-1830
  • 6
    • 50249183120 scopus 로고    scopus 로고
    • 612991 Sangart starts US blood substitute phase II trial. Sangart Inc PRESS RELEASE 2005 July 19
    • 612991 Sangart starts US blood substitute phase II trial. Sangart Inc PRESS RELEASE 2005 July 19
  • 7
    • 50249144870 scopus 로고    scopus 로고
    • 647478 Biopure launches Hemopure blood substitute in South Africa. Biopure Corp PRESS RELEASE 2006 January 30
    • 647478 Biopure launches Hemopure blood substitute in South Africa. Biopure Corp PRESS RELEASE 2006 January 30
  • 8
    • 50249157149 scopus 로고    scopus 로고
    • 738742 MalPEG-hemoglobin (p50 about 7 mmHg) lower the minimal permissive (critical) hematocrit in rats. Winslow RM, Lohman J, Malavalli A, Vandegriff KD BLOOD 2003 102 11 Pt 2 137b-138b
    • 50 about 7 mmHg) lower the minimal permissive (critical) hematocrit in rats. Winslow RM, Lohman J, Malavalli A, Vandegriff KD BLOOD 2003 102 11 Pt 2 137b-138b
  • 9
    • 0141453887 scopus 로고    scopus 로고
    • 738744 Targeted O2 delivery by low p50 hemoglobin: A new basis for O2 therapeutics. Tsai AG, Vandegriff KD, Intaglietta M, Winslow RM AM J PHYSIOL 2003 285 4 Pt 2 H1411-H1419
    • 2 therapeutics. Tsai AG, Vandegriff KD, Intaglietta M, Winslow RM AM J PHYSIOL 2003 285 4 Pt 2 H1411-H1419
  • 10
    • 50249109218 scopus 로고    scopus 로고
    • 738746 Resuscitation with the human hemoglobin-based oxygen carrier MP4, Equivalence to autologous blood following hemorrhage in rats. Young M, Lohman J, Gottschalk L, Vandegriff K, Winslow R FASEB J 2003 17 5 Pt 2 A1239
    • 738746 Resuscitation with the human hemoglobin-based oxygen carrier (MP4): Equivalence to autologous blood following hemorrhage in rats. Young M, Lohman J, Gottschalk L, Vandegriff K, Winslow R FASEB J 2003 17 5 Pt 2 A1239
  • 11
    • 23844531886 scopus 로고    scopus 로고
    • 738751 MalPEG-hemoglobin (MP4) improves hemodynamics, acid-base status, and survival after uncontrolled hemorrhage in anesthetized swine. Young MA, Riddez L, Kjellstrom BT, Bursell J, Winslow F, Lohman J, Winslow RM CRIT CARE MED 2005 33 8 1794-1804
    • 738751 MalPEG-hemoglobin (MP4) improves hemodynamics, acid-base status, and survival after uncontrolled hemorrhage in anesthetized swine. Young MA, Riddez L, Kjellstrom BT, Bursell J, Winslow F, Lohman J, Winslow RM CRIT CARE MED 2005 33 8 1794-1804
  • 12
    • 17844411218 scopus 로고    scopus 로고
    • 738752 A phase I single blind clinical trial of a new oxygen transport agent MP4, human hemoglobin modified with maleimide-activated polyethylene glycol. Bjorkholm M, Fagrell B, Przybelski R, Winslow N, Young M, Winslow RM HAEMATOLOGICA 2005 90 4 505-515
    • 738752 A phase I single blind clinical trial of a new oxygen transport agent (MP4), human hemoglobin modified with maleimide-activated polyethylene glycol. Bjorkholm M, Fagrell B, Przybelski R, Winslow N, Young M, Winslow RM HAEMATOLOGICA 2005 90 4 505-515
  • 13
    • 50249126874 scopus 로고    scopus 로고
    • 738755 Targeted O2 delivery by low-p50 hemoglobin: A new basis for hemoglobin-based oxygen carriers. Winslow RM ARTIF CELS BLOD SUBST BIOTECHNOL 2005 33 1 1-12
    • 50 hemoglobin: A new basis for hemoglobin-based oxygen carriers. Winslow RM ARTIF CELS BLOD SUBST BIOTECHNOL 2005 33 1 1-12
  • 14
    • 2342576923 scopus 로고    scopus 로고
    • 738756 Hemodynamic response and oxygen transport in pigs resuscitated with maleimide-polyethylene glycol-modified hemoglobin MP4, Drobin D, Kjellstrom BT, Malm E, Malavalli A, Lohman J, Vandegriff KD, Young MA, Winslow RM J APPL PHYSIOL 2004 96 5 1843-1853
    • 738756 Hemodynamic response and oxygen transport in pigs resuscitated with maleimide-polyethylene glycol-modified hemoglobin (MP4). Drobin D, Kjellstrom BT, Malm E, Malavalli A, Lohman J, Vandegriff KD, Young MA, Winslow RM J APPL PHYSIOL 2004 96 5 1843-1853
  • 15
    • 4644234884 scopus 로고    scopus 로고
    • 738757 Comparison of PEG-modified albumin and hemoglobin in extreme hemodilution in the rat. Winslow RM, Lohman J, Malavalli A, Vandegriff KD J APPL PHYSIOL 1985 97 4 1527-1534
    • 738757 Comparison of PEG-modified albumin and hemoglobin in extreme hemodilution in the rat. Winslow RM, Lohman J, Malavalli A, Vandegriff KD J APPL PHYSIOL 1985 97 4 1527-1534
  • 16
    • 85121095592 scopus 로고    scopus 로고
    • 738758 MP4, a new nonvasoactive polyethylene glycol-hemoglobin conjugate. Winslow RM ARTIF ORGANS 2004 28 9 800-806
    • 738758 MP4, a new nonvasoactive polyethylene glycol-hemoglobin conjugate. Winslow RM ARTIF ORGANS 2004 28 9 800-806
  • 17
    • 4344704521 scopus 로고    scopus 로고
    • 738759 Kinetics of NO and O2 binding to a maleimide poly(ethylene glycol)-conjugated human haemoglobin. Vandegriff KD, Bellelli A, Samaja M, Malavalli A, Brunori M, Winslow RM BIOCHEM J 2004 382 1 183-189
    • 2 binding to a maleimide poly(ethylene glycol)-conjugated human haemoglobin. Vandegriff KD, Bellelli A, Samaja M, Malavalli A, Brunori M, Winslow RM BIOCHEM J 2004 382 1 183-189
  • 18
    • 33751338255 scopus 로고    scopus 로고
    • 752804 A multicenter clinical study of the safety and activity of maleimide-polyethylene glycol-modified hemoglobin (Hemospan) in patients undergoing major orthopedic surgery. Olofsson C, Ahl T, Johansson T, Larsson S, Nellgard P, Ponzer S, Fagrell B, Przybelski R, Keipert P, Winslow N, Winslow RM ANESTHESIOLOGY 2006 105 6 1153-1163
    • 752804 A multicenter clinical study of the safety and activity of maleimide-polyethylene glycol-modified hemoglobin (Hemospan) in patients undergoing major orthopedic surgery. Olofsson C, Ahl T, Johansson T, Larsson S, Nellgard P, Ponzer S, Fagrell B, Przybelski R, Keipert P, Winslow N, Winslow RM ANESTHESIOLOGY 2006 105 6 1153-1163
  • 19
    • 50249151068 scopus 로고    scopus 로고
    • 758747 HHS announces $175 million in grant opportunities for states to assist health care providers in the Gulf coast region. U.S. Department of Health and Human Services PRESS RELEASE 2007 January 18
    • 758747 HHS announces $175 million in grant opportunities for states to assist health care providers in the Gulf coast region. U.S. Department of Health and Human Services PRESS RELEASE 2007 January 18
  • 20
    • 50249154525 scopus 로고    scopus 로고
    • 765752 Sangart starts European phase III Hemospan trials. Sangart Inc PRESS RELEASE 2007 February 13
    • 765752 Sangart starts European phase III Hemospan trials. Sangart Inc PRESS RELEASE 2007 February 13
  • 21
    • 50249094801 scopus 로고    scopus 로고
    • 765944 NCT00420277: Phase III efficacy and safety study of Hemospan for treating hypotension in hip arthroplasty. CLINICALTRIALS.GOV 2007 January 18
    • 765944 NCT00420277: Phase III efficacy and safety study of Hemospan for treating hypotension in hip arthroplasty. CLINICALTRIALS.GOV 2007 January 18
  • 22
    • 50249179397 scopus 로고    scopus 로고
    • 765946 NCT00421200: Phase III efficacy and safety study of Hemospan to prevent hypotension in hip arthroplasty. CLINICALTRIALS.GOV 2007 January 18
    • 765946 NCT00421200: Phase III efficacy and safety study of Hemospan to prevent hypotension in hip arthroplasty. CLINICALTRIALS.GOV 2007 January 18
  • 23
    • 50249176187 scopus 로고    scopus 로고
    • 824526 Biopure applies for compassionate use of Hemopure for anemia in US. Biopure Corp PRESS RELEASE 2007 August 23
    • 824526 Biopure applies for compassionate use of Hemopure for anemia in US. Biopure Corp PRESS RELEASE 2007 August 23
  • 24
    • 50249132194 scopus 로고    scopus 로고
    • 865552 Sangart begins phase II limb ischemia trial of Hemospan. Sangart Inc PRESS RELEASE 2008 January 07
    • 865552 Sangart begins phase II limb ischemia trial of Hemospan. Sangart Inc PRESS RELEASE 2008 January 07
  • 25
    • 50249157728 scopus 로고    scopus 로고
    • 888572 Sangart completes enrollment in phase III study of its novel blood substitute Hemospan. Sangart Inc PRESS RELEASE 2008 March 24
    • 888572 Sangart completes enrollment in phase III study of its novel blood substitute Hemospan. Sangart Inc PRESS RELEASE 2008 March 24
  • 26
    • 39049134910 scopus 로고    scopus 로고
    • 897006 A randomized, single-blind, increasing dose safety trial of an oxygen-carrying plasma expander (Hemospan) administered to orthopaedic surgery patients with spinal anaesthesia. Olofsson C, Nygards EB, Ponzer S, Fagrell B, Przybelski R, Keipert PE, Winslow N, Winslow RM TRANSFUS MED 2008 18 1 28-39
    • 897006 A randomized, single-blind, increasing dose safety trial of an oxygen-carrying plasma expander (Hemospan) administered to orthopaedic surgery patients with spinal anaesthesia. Olofsson C, Nygards EB, Ponzer S, Fagrell B, Przybelski R, Keipert PE, Winslow N, Winslow RM TRANSFUS MED 2008 18 1 28-39
  • 27
    • 38949119470 scopus 로고    scopus 로고
    • 897007 Effect of maleimide-polyethylene glycol hemoglobin (MP4) on hemodynamics and acid-base status after uncontrolled hemorrhage in anesthetized swine: Comparison with crystalloid and blood. Young MA, Riddez L, Kjellstrom BT, Winslow RM J TRAUMA 2007 63 6 1234-1244
    • 897007 Effect of maleimide-polyethylene glycol hemoglobin (MP4) on hemodynamics and acid-base status after uncontrolled hemorrhage in anesthetized swine: Comparison with crystalloid and blood. Young MA, Riddez L, Kjellstrom BT, Winslow RM J TRAUMA 2007 63 6 1234-1244
  • 28
    • 37748998773 scopus 로고    scopus 로고
    • 897010 Solution structure of poly(ethylene) glycol-conjugated hemoglobin revealed by small-angle X-ray scattering: Implications for a new oxygen therapeutic. Svergun DI, Ekstrom F, Vandegriff KD, Malavalli A, Baker DA, Nilsson C, Winslow RM BIOPHYS J 2008 94 1 173-181
    • 897010 Solution structure of poly(ethylene) glycol-conjugated hemoglobin revealed by small-angle X-ray scattering: Implications for a new oxygen therapeutic. Svergun DI, Ekstrom F, Vandegriff KD, Malavalli A, Baker DA, Nilsson C, Winslow RM BIOPHYS J 2008 94 1 173-181
  • 29
    • 34249317587 scopus 로고    scopus 로고
    • 897014 Toxicity and hemodynamic effects after single dose administration of MalPEG-hemoglobin (MP4) in rhesus monkeys. Young MA, Malavalli A, Winslow N, Vandegriff KD, Winslow RM TRANSLATIONAL RES 2008 149 6 333-342
    • 897014 Toxicity and hemodynamic effects after single dose administration of MalPEG-hemoglobin (MP4) in rhesus monkeys. Young MA, Malavalli A, Winslow N, Vandegriff KD, Winslow RM TRANSLATIONAL RES 2008 149 6 333-342
  • 30
    • 33750546863 scopus 로고    scopus 로고
    • 897016 Oxidation and haem loss kinetics of poly(ethylene glycol)-conjugated hemoglobin MP4, Dissociation between in vitro and in vivo oxidation rates. Vandegriff KD, Malavalli A, Minn C, Jiang E, Lohman J, Young MA, Winslow RM BIOCHEM J 2006 399 3 463-471
    • 897016 Oxidation and haem loss kinetics of poly(ethylene glycol)-conjugated hemoglobin (MP4): Dissociation between in vitro and in vivo oxidation rates. Vandegriff KD, Malavalli A, Minn C, Jiang E, Lohman J, Young MA, Winslow RM BIOCHEM J 2006 399 3 463-471
  • 31
    • 50249157729 scopus 로고    scopus 로고
    • 907516 Sangart, Inc. completes enrollment in second phase III study of Hemospan, a novel oxygen transport agent. Sangart Inc PRESS RELEASE 2008 May 19
    • 907516 Sangart, Inc. completes enrollment in second phase III study of Hemospan, a novel oxygen transport agent. Sangart Inc PRESS RELEASE 2008 May 19
  • 32
    • 57149093993 scopus 로고    scopus 로고
    • 915381 HBOC-201 as an alternative to blood transfusion: Efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery. Jahr S, Mackenzie C, Pearce LB, Pitman A, Greenburg AG J TRAUMA 2008 64 6 1484-1497
    • 915381 HBOC-201 as an alternative to blood transfusion: Efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery. Jahr S, Mackenzie C, Pearce LB, Pitman A, Greenburg AG J TRAUMA 2008 64 6 1484-1497
  • 33
    • 0015506081 scopus 로고    scopus 로고
    • 925000 Predisposition to atherosclerosis in the head, heart and legs. The Framingham study. Gordon T, Kannel WB J AM MED ASSOC 1972 221 7 661-666
    • 925000 Predisposition to atherosclerosis in the head, heart and legs. The Framingham study. Gordon T, Kannel WB J AM MED ASSOC 1972 221 7 661-666
  • 34
    • 0000901991 scopus 로고    scopus 로고
    • 925002 Occlusive disease of the lower extremities in patients 16 to 37 years of age. DeBakey ME, Crawford ES, Garrett E, Cooley DA, Morris GC Jr, Abbott JP Ann Surg 1964 159 6 873-890
    • 925002 Occlusive disease of the lower extremities in patients 16 to 37 years of age. DeBakey ME, Crawford ES, Garrett E, Cooley DA, Morris GC Jr, Abbott JP Ann Surg 1964 159 6 873-890
  • 35
    • 50249164005 scopus 로고    scopus 로고
    • 925008 Blood substitutes based on modified hemoglobin prepared by encapsulation crosslinking. Chang TMS ARTIF CELS BLOD SUBST BIOTECHNOL 1992 20 2-4 154-174
    • 925008 Blood substitutes based on modified hemoglobin prepared by encapsulation crosslinking. Chang TMS ARTIF CELS BLOD SUBST BIOTECHNOL 1992 20 2-4 154-174
  • 36
    • 0017840440 scopus 로고    scopus 로고
    • 925009 A clinical safety trial of stroma-free hemoglobin. Savitsky JP, Doczi J, Black J, Arnold JD CLIN PHARM THER 1978 23 1 73-80
    • 925009 A clinical safety trial of stroma-free hemoglobin. Savitsky JP, Doczi J, Black J, Arnold JD CLIN PHARM THER 1978 23 1 73-80
  • 37
    • 0027251288 scopus 로고    scopus 로고
    • 925010 Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. Hess JR, MacDonald VW, Brinkley WW J APPL PHYSIOL 1993 74 4 1769-1778
    • 925010 Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. Hess JR, MacDonald VW, Brinkley WW J APPL PHYSIOL 1993 74 4 1769-1778
  • 38
    • 0024794744 scopus 로고    scopus 로고
    • 925011 Efficacy of a new blood substitute based on ultrapure polymerized bovine hemoglobin. Vlahakes GJ, Lee R, Jacobs EE, Austen WG EUR J CARDIOTHORAC SURG 1989 3 4 353-354
    • 925011 Efficacy of a new blood substitute based on ultrapure polymerized bovine hemoglobin. Vlahakes GJ, Lee R, Jacobs EE, Austen WG EUR J CARDIOTHORAC SURG 1989 3 4 353-354
  • 39
    • 0032524907 scopus 로고    scopus 로고
    • 925012 Arterial blood pressure response to cell-free hemoglobin solutions and the reaction with nitric oxide. Rohlfs RJ, Bruner E, Chiu A, Gonzales A, Gonzales ML, Magde D, Magde MD, Vandegriff KD, Winslow RM J BIOL CHEM 1998 273 20 12128-12134
    • 925012 Arterial blood pressure response to cell-free hemoglobin solutions and the reaction with nitric oxide. Rohlfs RJ, Bruner E, Chiu A, Gonzales A, Gonzales ML, Magde D, Magde MD, Vandegriff KD, Winslow RM J BIOL CHEM 1998 273 20 12128-12134
  • 40
    • 33846849275 scopus 로고    scopus 로고
    • 925013 Pharmacological and physicochemical factors in the pressor effects of conjugated hemoglobin-based oxygen carriers in vivo. Smani Y, Fifre A, Labrude P, Vigneron C, Faivre B J HYPERT 2007 25 3 599-608
    • 925013 Pharmacological and physicochemical factors in the pressor effects of conjugated hemoglobin-based oxygen carriers in vivo. Smani Y, Fifre A, Labrude P, Vigneron C, Faivre B J HYPERT 2007 25 3 599-608
  • 41
    • 4844221727 scopus 로고    scopus 로고
    • 925014 Toxicities of hemoglobin solutions: In search of in vitro and in vivo model systems. Buehler PW, Alayash AI TRANSFUSION 2004 44 10 1516-1530
    • 925014 Toxicities of hemoglobin solutions: In search of in vitro and in vivo model systems. Buehler PW, Alayash AI TRANSFUSION 2004 44 10 1516-1530
  • 42
    • 50249185849 scopus 로고    scopus 로고
    • 925017 Blood product from cattle wins approval for use in humans. Lok C NATURE 2001 410 6831 855
    • 925017 Blood product from cattle wins approval for use in humans. Lok C NATURE 2001 410 6831 855
  • 43
    • 33745926240 scopus 로고    scopus 로고
    • 925018 Blood substitutes based on nanobiotechnology. Chang TMS TRENDS BIOTECHNOL 2006 24 8 372-377
    • 925018 Blood substitutes based on nanobiotechnology. Chang TMS TRENDS BIOTECHNOL 2006 24 8 372-377
  • 44
    • 20444383839 scopus 로고    scopus 로고
    • 925019 The European network of transfusion medicine societies EuroNet-TMS, The White Book 2005. Rouger P TRANS CLIN BIOL 2005 12 2 83-92
    • 925019 The European network of transfusion medicine societies (EuroNet-TMS): The White Book 2005. Rouger P TRANS CLIN BIOL 2005 12 2 83-92
  • 45
    • 21344440823 scopus 로고    scopus 로고
    • 925020 Artificial O2 carriers: Status in 2005. Spahn DR, Kocian R CURR PHARM DES 2005 11 31 4099-4114
    • 2 carriers: Status in 2005. Spahn DR, Kocian R CURR PHARM DES 2005 11 31 4099-4114
  • 46
    • 18044363491 scopus 로고    scopus 로고
    • 925024 Effects of extreme hemodilution with hemoglobin based O 2 carriers on microvascular pressure. Cabrales P, Tsai AG, Winslow RM, Intaglietta M AM J PHYSIOL, HEART CIRCULAT PHYSIOL 2005 288 5 H2146-H2153
    • 2 carriers on microvascular pressure. Cabrales P, Tsai AG, Winslow RM, Intaglietta M AM J PHYSIOL - HEART CIRCULAT PHYSIOL 2005 288 5 H2146-H2153
  • 47
    • 0036209470 scopus 로고    scopus 로고
    • 925025 The use of bovine hemoglobin glutamer-250 (Hemopure) in surgical patients: Results of a multicenter, randomized single-blind study. Sprung J, Kindscher JD, Wahr JA, Levy JH, Monk TG, Moritz MW, O'Hara PJ ANESTH ANALG 2002 94 4 799-808
    • 925025 The use of bovine hemoglobin glutamer-250 (Hemopure) in surgical patients: Results of a multicenter, randomized single-blind study. Sprung J, Kindscher JD, Wahr JA, Levy JH, Monk TG, Moritz MW, O'Hara PJ ANESTH ANALG 2002 94 4 799-808
  • 48
    • 0036789874 scopus 로고    scopus 로고
    • 925026 The life-sustaining capacity of human polymerized hemoglobin when red cells might be unavailable. Gould S, Moore EE, Hoyt DB, Ness PM, Norris EJ, Carson JL, Hides GA, Freeman IH, DeWoskin R, Moss GS J AM COLL SURG 2002 195 4 445-455
    • 925026 The life-sustaining capacity of human polymerized hemoglobin when red cells might be unavailable. Gould S, Moore EE, Hoyt DB, Ness PM, Norris EJ, Carson JL, Hides GA, Freeman IH, DeWoskin R, Moss GS J AM COLL SURG 2002 195 4 445-455
  • 49
    • 24644443128 scopus 로고    scopus 로고
    • 925027 Insights from studies of blood substitutes in trauma. Moore EE, Johnson JL, Cheng AM, Masuno T, Banerjee A SHOCK 2005 24 3 197-205
    • 925027 Insights from studies of blood substitutes in trauma. Moore EE, Johnson JL, Cheng AM, Masuno T, Banerjee A SHOCK 2005 24 3 197-205
  • 50
    • 50249147105 scopus 로고    scopus 로고
    • 925993 NCT00494949: A clinical safety increasing dose study of hemospan in orthopedic surgery patients, 2008 July 17
    • 925993 NCT00494949: A clinical safety increasing dose study of hemospan in orthopedic surgery patients. WWW.CLINICALTRIALS.GOV 2008 July 17
  • 51
    • 50249156157 scopus 로고    scopus 로고
    • 926009 NCT00425334: A safety study of Hemospan in total prostatectomy patients, 2008 July 17
    • 926009 NCT00425334: A safety study of Hemospan in total prostatectomy patients. WWW.CLINICALTRIALS.GOV 2008 July 17
  • 52
    • 50249097492 scopus 로고    scopus 로고
    • 926010 NCT00633659: Pilot study of Hemospan in patients with chronic critical limb ischemia, 2008 July 17
    • 926010 NCT00633659: Pilot study of Hemospan in patients with chronic critical limb ischemia. WWW.CLINICALTRIALS.GOV 2008 July 17
  • 53
    • 50249099459 scopus 로고    scopus 로고
    • 926787 Arteriosclerosis and atherosclerosis. Brown AL, Juergens JL In: PERIPHER AL VASCULAR DISEASE Allen E (Ed) Saunders (WB) Co Ltd, London, UK 1972 57-66
    • 926787 Arteriosclerosis and atherosclerosis. Brown AL, Juergens JL In: PERIPHER AL VASCULAR DISEASE Allen E (Ed) Saunders (WB) Co Ltd, London, UK 1972 57-66
  • 54
    • 50249133929 scopus 로고    scopus 로고
    • 926789 Endovascular treatment of intermittent claudication and critical limb ischemia. Arain S, White CJ In: PERIPHERAL ARTERIAL DISEASE Shammas NW Ed, American College of Physicians, Philadelphia, PA, USA 2008 85-113
    • 926789 Endovascular treatment of intermittent claudication and critical limb ischemia. Arain S, White CJ In: PERIPHERAL ARTERIAL DISEASE Shammas NW (Ed), American College of Physicians, Philadelphia, PA, USA 2008 85-113
  • 55
    • 41049088349 scopus 로고    scopus 로고
    • 926790 Hemoglobin, oxygen carriers and perioperative organ perfusion. Kocian R, Spahn DR BEST PRACT RES CLIN ANAESTHESIOL 2008 22 1 63-80
    • 926790 Hemoglobin, oxygen carriers and perioperative organ perfusion. Kocian R, Spahn DR BEST PRACT RES CLIN ANAESTHESIOL 2008 22 1 63-80
  • 56
    • 85120276211 scopus 로고    scopus 로고
    • 928853 Hemoglobin-based oxygen carriers and trials to substitute red blood cells. Smani Y, Labrude P, Vigneron C, Faivre B TRANSFUS CLIN BIOL 2007 14 5 464-473
    • 928853 Hemoglobin-based oxygen carriers and trials to substitute red blood cells. Smani Y, Labrude P, Vigneron C, Faivre B TRANSFUS CLIN BIOL 2007 14 5 464-473
  • 57
    • 41149086655 scopus 로고    scopus 로고
    • 928988 Blood substitutes, the polyheme trials Apte SS MCGIL J MED 2008 11 1 59-65
    • 928988 Blood substitutes - the polyheme trials Apte SS MCGIL J MED 2008 11 1 59-65
  • 58
    • 34447325354 scopus 로고    scopus 로고
    • 929221 Blood substitutes as pharmacotherapies in clinical practice. Jahr JS, Walker V, Manoochehri K CUR OPIN ANAESTHESIOL 2007 20 4 325-330
    • 929221 Blood substitutes as pharmacotherapies in clinical practice. Jahr JS, Walker V, Manoochehri K CUR OPIN ANAESTHESIOL 2007 20 4 325-330
  • 59
    • 0035856220 scopus 로고    scopus 로고
    • 929222 Peripheral arterial disease. Ouriel K LANCET 2001 358 9289 1257-1264
    • 929222 Peripheral arterial disease. Ouriel K LANCET 2001 358 9289 1257-1264
  • 60
    • 14544279858 scopus 로고    scopus 로고
    • 929223 Management of peripheral vascular disease. Baumgartner I, Schainfeld R, Graziani L ANNU REV MED 2005 56 249-272
    • 929223 Management of peripheral vascular disease. Baumgartner I, Schainfeld R, Graziani L ANNU REV MED 2005 56 249-272
  • 61
    • 1242353138 scopus 로고    scopus 로고
    • 929224 Oxygen therapeutics: Can we tame hemoglobin? Alayash AI NAT REV DRUG DISCOV 2005 3 2 152-159
    • 929224 Oxygen therapeutics: Can we tame hemoglobin? Alayash AI NAT REV DRUG DISCOV 2005 3 2 152-159
  • 62
    • 33750862670 scopus 로고    scopus 로고
    • 929225 Perfluorocarbon-based oxygen delivery. Riess JG ARTIF CELS BLOD SUBST BIOTECHNOL 2006 34 6 567-580
    • 929225 Perfluorocarbon-based oxygen delivery. Riess JG ARTIF CELS BLOD SUBST BIOTECHNOL 2006 34 6 567-580


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.