Surface modification of hemoglobin vesicles with poly(ethylene glycol) and effects on aggregation, viscosity, and blood flow during 90% exchange transfusion in anesthetized rats

Bioconjugate Chemistry

Volumn 8, Issue 1, 1997, Pages 23-30

  Sakai, Hiromi ^a   Takeoka, Shinji ^a   Park, Sung Ick ^a   Kose, Takehiro ^a   Nishide, Hiroyuki ^a   Izumi, Yotaro ^b   Yoshizu, Akira ^b   Kobayashi, Koichi ^b   Tsuchida, Eishun ^a  

^a WASEDA UNIVERSITY   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATES; BLOOD; BLOOD VESSELS; ENDOTHELIAL CELLS; ETHYLENE GLYCOL; HEMODYNAMICS; HEMOGLOBIN; LIPOSOMES; PHOSPHOLIPIDS; POLYOLS; PORE SIZE; RATS; SHEAR DEFORMATION; SURFACE TREATMENT; SUSPENSIONS (FLUIDS); VISCOSITY;

BLOOD FLOW; FLOW PROFILE; HAEMODYNAMICS; HEMOGLOBIN VESICLES; HUMAN BLOODS; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID VESICLES; SHEAR-RATE; STERIC HINDRANCES; SURFACE-MODIFICATION;

POLYETHYLENE GLYCOLS;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0031055298     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc960069p     Document Type: Article

References (54)

1. Allen, T. M., and Cohn A. (1987) Large Unilamellar Liposomes with Low Uptake into the Reticuloendothelial System. FEBS Lett. 223, 42-46.
2. Chang, T. M. S. (1991) Blood Substitutes Based on Modified Hemoglobin Prepared by Encapsulation or Crosslinking: An Overview. Biomater. Artif. Cell Immobilization Biotechnol. 20, 159-182.
3. Chonn, A., Semple, S. C., and Cullis, P. R. (1991) Separation of Large Unilameller Liposomes from Blood Components by a Spin Column Procedure: towards Identifying Plasma Proteins which Mediate Liposome Clearance in Vivo. Biochim. Biophys. Acta 1070, 215-222.
4. Chung, J. E., Hamada, K., Sakai, H., Takeoka, S., and Tsuchida, E. (1995) Ligand Exchange Reaction of Carbonylhemoglobin to Oxyhemoglobin in a Hemoglobin Liquid Membrane. Nihon Kagaku Kaishi 2, 123-127.
5. Djordjevich, L., and Miller, I. F. (1980) Synthetic Erythrocytes from Lipid Encapsulated Hemoglobin. Exp. Hematol. 8, 584-592.
6. Fähraeus, R., and Lindqvist, T. (1931) The Viscosity of Blood in Narrow Capillary Tubes. Am. J. Physiol. 96, 562-568.
7. Gabizon, A., and Papahadjopoulos, D. (1988) Liposome Formulations with Prolonged Circulation Time in Blood and Enhanced Uptake by Tumors. Proc. Natl. Acad. Sci. U.S.A. 85, 6949-6953.
8. Gardiner, S. M., Compton, A. M., Bennett, T., and Hartley, C. J. (1990) Can Pulsed Doppler Technique Measure Changes in Aortic Blood Flow in Conscious Rats? Am. J. Physiol. 259, H448-H456.
9. Hamada, K., Kose, T., Ohgushi, T., Sakai, H., Takeoka, S., Nishide, H., and Tsuchida, E. (1995) Assay Systems for the Components of Red Cell Substitutes (NRC). Artif. Blood 3, 96-101.
10. Harasym, T. O., Tardi, P., Longman, S. A., Ansell, S. M., Bally, M. B., Cullis, P. R., and Choi, L. S. (1995) Poly(ethylene glycol)-modified Phospholipid Prevent Aggregation during Covalent Conjugation of Proteins to Liposomes. Bioconjugate Chem. 6, 1043-1802.
11. Haywood, J. R., Shaffer, R. A., Fastenow, C., Fink, G. D., and Brody, M. J. (1981) Regional Blood Flow Measurement with Pulsed Doppler Flowmeter in Conscious Rat. Am. J. Physiol. 24, H273-H278.
12. Hristova, K., and Needham, D. (1995) Phase Behavior of a Lipid/ Polymer-Mixture in Aqueous Medium. Macromolecules 28, 991-1002.
13. Hunt, C. A., Burnette, R. R., MacGregor, R. D., Strubbe, A. E., Lau, D. T., Taylor N., and Kawada, H. (1985) Synthesis and Evaluation of a Prototypal Artificial Red Cell. Science 30, 1165-1168.
14. Izumi, Y., Sakai, H., Hamada, K., Takeoka, S., Yamahata, K., Katoh, H., Nishide, H., Tsuchida, E., and Kobayashi, K. (1996) Physiological Responses to Exchange Transfusion with Hemoglobin Vesicles as an Artificial Oxygen Carrier in Anesthetized Rats: Changes in Mean Arterial Pressure and Renal Cortical Tissue Oxygen Tension. Crit. Care Med. 24, 1869-1873.
15. Izumi, Y., Sakai, H., Takeoka, S., Kose, T., Hamada, K., Yoshizu, A., Nishide, H., Tsuchida, E., and Kobayashi, K. (1997) Evaluation of the Capabilitites of Hemoglobin Vesicles as an Artificial Oxygen Carriers in a Rat Exchange Transfusion Model. ASAIO J. (in press).
16. Kaca, W., Roth, R. I., Vandegriff, K. D., Chen, G. C., Kuypers, F. A., Winslow, R. M., and Levin, J. (1995) Effects of Bacterial Endotoxin on Human Cross-Linked and Native Hemoglobins. Biochemistry 34, 11186-11185.
17. Kandel, G., and Aberman, A. (1983) Mixed Venous Oxygen Saturation. Its Role in the Assessment of the Critically Ill Patient. Arch. Intern. Med. 143, 1400-1402.
18. Kikuchi, Y., and Koyama, T. (1984) Red Blood Cell Deformability and Protein Adsorption on Red Blood Cell Surface. Am. J. Physiol. 247, H739-H747.
19. Kilbanov, A., Maruyama, K., Torchilin V. P., and Huang L. (1990) Amphipatic Polyoxyethylenes Effectively Prolong the Circulation Time of Liposomes. FEBS Lett. 268, 235-237.
20. King, R. G., and Copley, A. L. (1975) Some New Accessories to the Weissenberg Rheoginometer: An Exhibit. Biorheology 16, 355-360.
21. Kobayashi, K., Tsuchida, E., and Nishide, H. (1995) Totally Synthetic Hemes: Their Characteristics and Oxygen-carrying Capacity in Dogs. Artificial Red Cells (E. Tsuchida, Ed.) pp 35-64, Wiley, New York.
22. Loughley, H. C., Bally, M. B., Reihish, L. W., and Cullis, P. R. (1990) The Binding of Phosphatidylglycerol Liposomes to Rat Platelets is Mediated by Complement. Thromb. Haemostasis 64, 172-176.
23. Malek, A. M., and Izumo, S. (1995) Control of Endothelial Cell Gene Expression by Flow. J. Biomech. 28, 1515-1528.
24. Miyamoto, K., Schultz, E., Heath, T., Mitchell, M. D., Albertine, K. H., and Staub, N. C. (1988) Pulmonary Intravascular Macrophages and Hemodynamic Effects of Liposomes in Sheep. J. Appl. Physiol. 64, 1143-1152.
25. Needham, D., McIntosh, T. J., and Lasic, D. D. (1992) Repulsive Interactions and Mechanical Stability of Polymer-grafted Lipid Membranes. Biochim Biophys. Acta 1108, 40-48.
26. Nelimarkka, O., Halkola, L., and Niinikoski, J. (1982) Distribution of Renal Cortical and Medullary Tissue Oxygenation in Hemorrhagic Shock. Acta Chir Scand. 148, 213-219.
27. Oka, S. (1971) An Approach to a Unified Theory of the Flow Behavior of Time-Independent Non-Newtonian Suspensions. Jpn. J. Appl. Phys. 10, 287-291.
28. Oka, S. (1984) Biorheology, Shokabo Publisher, Tokyo.
29. Olsen, S. B., Tang, D. B., Jackson, M. R., Gomez, E. R., Ayala, B., and Alving, B. M. (1996) Enhancement of Platelet Deposition by Cross-linked Hemoglobin in a Rat Carotid Endarterectomy Model. Circulation 93, 327-332.
30. Peterson, G. L. (1983) Determination of total protein. Methods Enzymol. 91, 95-119.
31. Pries, A. R., Neuhaus, D., and Gaehtgens, P. (1992) Blood Viscosity in Tube Flow: Dependence on Diameter and Hematocrit. Am. J. Physiol. 263, H1770-H1778.
32. Prime, K. L., and Whiteslides, G. M. (1993) Adsorption of Proteins onto the Surface Containing End-attached Oligo-(ethylene Oxide): A Model System Using Self-Assembled Monolayers. J. Am. Chem. Soc. 115, 10714-10721.
33. Rudolph, A. S. (1995) Encapsulation of Hemoglobin in Liposomes. Blood Substitutes: Physiological Basis of Efficacy (R. M. Winslow, K. D. Vandegriff, and M. Intaglietta, Eds.) pp 90-104, Birkhauser, Boston.
34. Sakai, H., Takeoka, S.. Yokohama, H., Seino, Y., Nishide, H., and Tsuchida, E. (1993) Purification of Concentrated Hemoglobin Using Organic Solvent and Heat Treatment. Protein Expression Purif. 4, 563-569.
35. Sakai, H., Hamada, K., Takeoka, S., Nishide, H., and Tsuchida, E. (1996) Physical Characteristics of Hemoglobin Vesicles as Red Cell Substitutes. Biotechnol. Prog. 12, 119-125.
36. Schneditz, D., Ribitsch V., and Kenner, T. (1985) Rheological Discrimination between Native, Rigid, and Aggregated Red Blood Cells in Oscillatory Flow. Biorheology 22, 209-219.
37. Takeoka, S., Sakai, H., Takisada, M., and Tsuchida, E. (1992) Inhibition of Intervesicular Aggregation of Phospholipid Vesicles by Incorporation of Dialkyl Oligosaccharide Glycerol. Chem. Lett., 1877-1880.
38. Takeoka, S., Ohgushi, T., Ohmori, T., Terase, K., Nishide, H., and Tsuchida, E. (1996) Layer Controlled Hemoglobin Vesicles by Interaction of Hemoglobin with Phospholipid Assembly. Langmuir 12, 1755-1759.
39. Torchilin, V. P., Omelyaneko, V. G., Papisov, M. I., Bogdanov, Jr., A. A., Trubetskoy, V. S., Herron, J. N., and Gentry, C. A. (1994) Poly(ethylene glycol) on the Liposome Surface: on the Mechanism of Polymer-coated Liposome Longevity. Biochim. Biophys. Acta 1195, 11-20.
40. Tsai, A. G., Kerger, H., and Intaglietta, M. (1995) Microcirculatory Consequences of Blood Substitution with αα-Hemoglobin. Blood Substitutes: Physiological Basis of Efficacy (R. M. Winslow, K. D. Vandegriff, and M. Intaglietta, Eds.) pp 155-174, Birkhauser, Boston.
41. Tsai, A. G., Kerger, H., and Intaglietta, M. (1996) Microvascular Oxygen Distribution: Effects due to Free Hemoglobin in Plasma. Blood Substitutes: New Challenges (R. M. Winslow, K. D. Vandegriff, and M. Intaglietta, Eds.) pp 124-131, Birkhauser, Boston.
42. Tsuchida, E. (1995) Introduction: Overview and Perspective. Artificial Red Cells (E. Tsuchida, Ed.) pp 1-20, Wiley, New York.
43. Tsuchida, E., and Takeoka, S. (1995) Stabilized Hemoglobin Vesicles. Artificial Red Cells (E. Tsuchida, Ed.) pp 35-64, Wiley, New York.
44. Usuba, A., Miyazawa M., Motoki, R., Sakaguchi, K., Suzuki, K., Kamitani, T., and Takahashi, A. (1993) Oxygen Transport Capacity and Hemodynamic Effect of Newly Developed Artificial Blood "Neo Red Cells (NRC)". Int. J. Artif. Organs 16, 551-556.
45. Vandegriff, K. D., and Winslow, R. M. (1995) The Theoretical Analysis of Oxygen Transport: A New Strategy for the Design of Hemoglobin-based Red Cell Substitutes. Blood Substitutes: Physiological Basis of Efficacy (R. M. Winslow, K. D. Vandegriff, and M. Intaglietta, Eds.) pp 143-154, Birkhauser, Boston.
46. Vertut-Do, A., Ishiwata, H., and Miyajima, K. (1996) Binding and Uptake of Liposomes Containing a Poly(ethyleneglycol) Derivative of Cholesterol (Stealth Liposomes) by the Macrophage Cell Line J774: Influence of PEG Content and its Molecular Weight. Biochim. Biophys. Acta 1278, 19-28.
47. Watanabe, M., Ohyanagi, H., and Saitoh, Y. (1988) Experimental Study on Anaphylactic Effects by Fluosol DA as an Oxygen Carrier. Jpn J. Artif. Organs 17, 1513-1522.
48. Winslow, R. M. (1995) Blood Substitutes: A Moving Target. Nature Med. 1, 1212-1215.
49. Woodle, M. C., and Lasic, D. D. (1992) Sterically Stabilized Liposomes. Biochim. Biophys. Acta 1113, 171-199.
50. Woodle, M. C., Engbers, C. M., and Zalipsky, S. (1994) New Amphiphatic Polymer-Lipid Conjugates Forming Long Circulating Reticuloendothelial System-Evading Liposomes. Bioconjugate Chem. 5, 493-496.
51. Wu, P.-S., Tin, G. W., Baldeschwieler, J. D., Shen, T. Y., and Ponpipom, M. M. (1981) Effect of Surface Modification on Aggregation of Phospholipid Vesicles. Proc. Natl. Acad. Sci. U.S.A. 78, 6211-6215.
52. Yoshioka, H. (1991) Surface Modification of Haemoglobin-containing Liposomes with Polyethylene Glycol Prevents Liposome Aggregation in Blood Plasma. Biomaterials 12, 861-864.
53. Zalipsly, S., Puntambeker, B., Boulikas, P., Engbers, P. B., and Woodle, M. C. (1995) Peptide Attachment to Extremities of Liposomal Surface Grafted PEG Chains: Preparation of the Long-Circulating Form of Laminin Pentapeptide, YIGSR. Bioconjugate Chem. 6, 705-708.
54. Zheng, S., Beissinger, R., Sherwood, R. L., McCormick, D. L., Lasic D. D., and Martin, F. J. (1993) Liposome-encapsulated Hemoglobin: A Red Blood Cell Substitute. J. Liposome Res. 3, 575-588.