Pharmacokinetic study of enclosed hemoglobin and outer lipid component after the administration of hemoglobin vesicles as an artificial oxygen carrier

Drug Metabolism and Disposition

Volumn 37, Issue 7, 2009, Pages 1456-1463

  Taguchi, Kazuaki ^a   Urata, Yukino ^a   Anraku, Makoto ^a   Maruyama, Toru ^a   Watanabe, Hiroshi ^a   Sakai, Hiromi ^b   Horinouchi, Hirohisa ^c   Kobayashi, Koichi ^c   Tsuchida, Eishun ^b   Kai, Toshiya ^a,d   Otagiri, Masaki ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b WASEDA UNIVERSITY   (Japan)

^c KEIO UNIVERSITY   (Japan)

^d Nipro Corporation   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIPALMITOYLGLYCERO 3 PHOSPHATIDYLCHOLINE; 1,2 DISTEAROYLGLYCERO 3 PHOSPHATIDYLETHANOLAMINE N MACROGOL; 1,5 BIS O HEXADECYL N SUCCINYLGLUTAMATE; CHOLESTEROL; GLUTAMIC ACID DERIVATIVE; HEMOGLOBIN; LIPOSOME; PHOSPHOLIPID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BILIARY EXCRETION; CIRCULATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG FECES LEVEL; DRUG HALF LIFE; DRUG UPTAKE; DRUG URINE LEVEL; ENCAPSULATION; ENDOTHELIUM CELL; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBIN VESICLE; ISOTOPE LABELING; KIDNEY; LIPID BILAYER; LIPID VESICLE; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN;

ANIMALS; BLOOD SUBSTITUTES; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; HALF-LIFE; HEMOGLOBINS; LIPID METABOLISM; LIPIDS; MALE; MICE; OXYGEN; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN;

MUS; RATTUS;

EID: 67649415048     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.027094     Document Type: Article

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