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Volumn 40, Issue 3, 2011, Pages 218-226

Expression of DNA repair proteins, MSH2, MLH1 and MGMT in mobile tongue squamous cell carcinoma: Associations with clinicopathological parameters and patients' survival

Author keywords

Clinicopathological parameters; DNA repair; Immunohistochemistry; Mobile tongue squamous cell carcinoma; Prognosis

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN MLH1; PROTEIN MSH2;

EID: 79951877583     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2010.00945.x     Document Type: Article
Times cited : (21)

References (54)
  • 1
    • 0036024553 scopus 로고    scopus 로고
    • Oral cavity and pharynx cancer incidence in the United States, 1975-1988
    • Canto MT, Devesa SS. Oral cavity and pharynx cancer incidence in the United States, 1975-1988. Oral Oncol 2002; 38: 610-7.
    • (2002) Oral Oncol , vol.38 , pp. 610-7
    • Canto, M.T.1    Devesa, S.S.2
  • 3
    • 0037068957 scopus 로고    scopus 로고
    • Long-term survival rates of cancer patients achieved by the end of the 20th century: a period analysis
    • Brenner H. Long-term survival rates of cancer patients achieved by the end of the 20th century: a period analysis. Lancet 2002; 360: 1131-5.
    • (2002) Lancet , vol.360 , pp. 1131-5
    • Brenner, H.1
  • 4
    • 17644420688 scopus 로고    scopus 로고
    • Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44years
    • Shiboski CH, Schmidt BL, Jordan RC. Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44years. Cancer 2005; 103: 1843-9.
    • (2005) Cancer , vol.103 , pp. 1843-9
    • Shiboski, C.H.1    Schmidt, B.L.2    Jordan, R.C.3
  • 5
    • 36148960076 scopus 로고    scopus 로고
    • Metastasis of squamous cell carcinoma of the oral tongue
    • Sano D, Myers JN. Metastasis of squamous cell carcinoma of the oral tongue. Cancer Metastasis Rev 2007; 26: 645-62.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 645-62
    • Sano, D.1    Myers, J.N.2
  • 6
    • 0033883429 scopus 로고    scopus 로고
    • Prognostic factors in tongue cancer-relative importance of demographic, clinical and histopathological factors
    • Kantola S, Parikka M, Jokinen K, et al. Prognostic factors in tongue cancer-relative importance of demographic, clinical and histopathological factors. Br J Cancer 2000; 83: 614-9.
    • (2000) Br J Cancer , vol.83 , pp. 614-9
    • Kantola, S.1    Parikka, M.2    Jokinen, K.3
  • 7
    • 53049092877 scopus 로고    scopus 로고
    • Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma
    • Wangsa D, Ryott M, Avall-Lundquist E, et al. Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma. Br J Cancer 2008; 99: 1121-8.
    • (2008) Br J Cancer , vol.99 , pp. 1121-8
    • Wangsa, D.1    Ryott, M.2    Avall-Lundquist, E.3
  • 8
    • 0036264024 scopus 로고    scopus 로고
    • Prognostic factors clinically stage I and II oral tongue carcinoma: a comparative study of stage, thickness, shape, growth pattern, invasive front malignancy grading, Martinez-Gimeno score and pathologic features
    • Po Wing Yen A, Lam KY, Lam LK, et al. Prognostic factors clinically stage I and II oral tongue carcinoma: a comparative study of stage, thickness, shape, growth pattern, invasive front malignancy grading, Martinez-Gimeno score and pathologic features. Head Neck 2002; 24: 513-20.
    • (2002) Head Neck , vol.24 , pp. 513-20
    • Po Wing Yen, A.1    Lam, K.Y.2    Lam, L.K.3
  • 9
    • 59149085884 scopus 로고    scopus 로고
    • Prognostic factors in the surgical treatment of patients with oral carcinoma
    • Patel RS, Clark JR, Dirven R, Wyten R, Gao K, O'Brien CJ. Prognostic factors in the surgical treatment of patients with oral carcinoma. ANZ J Surg 2009; 79: 19-22.
    • (2009) ANZ J Surg , vol.79 , pp. 19-22
    • Patel, R.S.1    Clark, J.R.2    Dirven, R.3    Wyten, R.4    Gao, K.5    O'Brien, C.J.6
  • 10
    • 33846363943 scopus 로고    scopus 로고
    • Tongue cancer: is there a difference in survival compared with other subsites in the oral cavity
    • Bell RB, Kademani D, Homer L, Dierks EJ, Potter BE. Tongue cancer: is there a difference in survival compared with other subsites in the oral cavity. J Oral Maxillofac Surg 2007; 65: 229-36.
    • (2007) J Oral Maxillofac Surg , vol.65 , pp. 229-36
    • Bell, R.B.1    Kademani, D.2    Homer, L.3    Dierks, E.J.4    Potter, B.E.5
  • 11
  • 13
    • 11144357255 scopus 로고    scopus 로고
    • Cellular machineries for chromosomal DNA repair
    • Peterson CL, Côté J. Cellular machineries for chromosomal DNA repair. Genes Dev 2004; 18: 602-16.
    • (2004) Genes Dev , vol.18 , pp. 602-16
    • Peterson, C.L.1    Côté, J.2
  • 15
    • 38149071013 scopus 로고    scopus 로고
    • Low hMLH1 expression prior to definitive chemoradiotherapy predicts poor prognosis in esophageal squamous cell carcinoma
    • Nam TK, Lee JH, Cho SH, et al. Low hMLH1 expression prior to definitive chemoradiotherapy predicts poor prognosis in esophageal squamous cell carcinoma. Cancer Lett 2008; 260: 109-17.
    • (2008) Cancer Lett , vol.260 , pp. 109-17
    • Nam, T.K.1    Lee, J.H.2    Cho, S.H.3
  • 16
    • 34748877623 scopus 로고    scopus 로고
    • Significance and mechanism of microsatellite instability in laryngeal squamous cell carcinoma
    • Zhigang H, Demin H, Han G, Erzhong F, Xiaohong C, Hongbo X. Significance and mechanism of microsatellite instability in laryngeal squamous cell carcinoma. J Otolaryngol 2007; 36: 168-74.
    • (2007) J Otolaryngol , vol.36 , pp. 168-74
    • Zhigang, H.1    Demin, H.2    Han, G.3    Erzhong, F.4    Xiaohong, C.5    Hongbo, X.6
  • 17
    • 33846938335 scopus 로고    scopus 로고
    • Inactivation of human mutL homolog 1 and mutS homolog 2 genes in head and neck squamous cell carcinoma tumors and leukoplakia samples by promoter hypermethylation and its relation with microsatellite instability phenotype
    • Sengupta S, Chakrabarti S, Roy A, Panda CK, Roychoudhury S. Inactivation of human mutL homolog 1 and mutS homolog 2 genes in head and neck squamous cell carcinoma tumors and leukoplakia samples by promoter hypermethylation and its relation with microsatellite instability phenotype. Cancer 2007; 109: 703-12.
    • (2007) Cancer , vol.109 , pp. 703-12
    • Sengupta, S.1    Chakrabarti, S.2    Roy, A.3    Panda, C.K.4    Roychoudhury, S.5
  • 18
    • 33646872606 scopus 로고    scopus 로고
    • Microsatellite instability and methylation of the DNA mismatch repair genes in head and neck cancer
    • Demokan S, Suoglu Y, Demir D, Gozeler M, Dalay N. Microsatellite instability and methylation of the DNA mismatch repair genes in head and neck cancer. Ann Oncol 2006; 17: 995-9.
    • (2006) Ann Oncol , vol.17 , pp. 995-9
    • Demokan, S.1    Suoglu, Y.2    Demir, D.3    Gozeler, M.4    Dalay, N.5
  • 19
    • 27644547870 scopus 로고    scopus 로고
    • Deficiency of hMLH1 and hMSH2 expression is a poor prognostic factor in esophageal squamous cell carcinoma
    • Uehara H, Miyamoto M, Kato K, et al. Deficiency of hMLH1 and hMSH2 expression is a poor prognostic factor in esophageal squamous cell carcinoma. J Surg Oncol 2005; 92: 109-15.
    • (2005) J Surg Oncol , vol.92 , pp. 109-15
    • Uehara, H.1    Miyamoto, M.2    Kato, K.3
  • 20
    • 27544500524 scopus 로고    scopus 로고
    • Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma
    • Tzao C, Hsu HS, Sun GH, et al. Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma. J Thorac Cardiovasc Surg 2005; 130: 1371.
    • (2005) J Thorac Cardiovasc Surg , vol.130 , pp. 1371
    • Tzao, C.1    Hsu, H.S.2    Sun, G.H.3
  • 21
    • 12244283694 scopus 로고    scopus 로고
    • Allelic imbalance at the DNA mismatch repair loci, hMSH2, hMLH1, hPMS1, hPMS2 and hMSH3, in squamous cell carcinoma of the head and neck
    • Nunn J, Nagini S, Risk JM, et al. Allelic imbalance at the DNA mismatch repair loci, hMSH2, hMLH1, hPMS1, hPMS2 and hMSH3, in squamous cell carcinoma of the head and neck. Oral Oncol 2003; 39: 115-29.
    • (2003) Oral Oncol , vol.39 , pp. 115-29
    • Nunn, J.1    Nagini, S.2    Risk, J.M.3
  • 22
    • 0345269743 scopus 로고    scopus 로고
    • Promoter hypermethylation profile of tumor-associated genes p16, p15, hMLH1, MGMT and E-cadherin in oral squamous cell carcinoma
    • Viswanathan M, Tsuchida N, Shanmugam G. Promoter hypermethylation profile of tumor-associated genes p16, p15, hMLH1, MGMT and E-cadherin in oral squamous cell carcinoma. Int J Cancer 2003; 105: 41-6.
    • (2003) Int J Cancer , vol.105 , pp. 41-6
    • Viswanathan, M.1    Tsuchida, N.2    Shanmugam, G.3
  • 23
    • 0032561163 scopus 로고    scopus 로고
    • Expression of hMSH2 correlates with in vitro chemosensitivity to CDDP cytotoxicity in oral and oropharyngeal carcinoma
    • Fujieda S, Tanaka N, Sunaga H, et al. Expression of hMSH2 correlates with in vitro chemosensitivity to CDDP cytotoxicity in oral and oropharyngeal carcinoma. Cancer Lett 1998; 132: 37-44.
    • (1998) Cancer Lett , vol.132 , pp. 37-44
    • Fujieda, S.1    Tanaka, N.2    Sunaga, H.3
  • 24
    • 0032996262 scopus 로고    scopus 로고
    • Immunocytochemical detection of hMSH2 and hMLH1 expression in oral SCC
    • Lo Muzio L, Nocini P, Mignogna MD, et al. Immunocytochemical detection of hMSH2 and hMLH1 expression in oral SCC. Anticancer Res 1999; 19: 933-40.
    • (1999) Anticancer Res , vol.19 , pp. 933-40
    • Lo Muzio, L.1    Nocini, P.2    Mignogna, M.D.3
  • 25
  • 26
    • 0035850251 scopus 로고    scopus 로고
    • Molecular mechanisms of DNA mismatch repair
    • Hsieh P. Molecular mechanisms of DNA mismatch repair. Mut Res 2001; 486: 71-87.
    • (2001) Mut Res , vol.486 , pp. 71-87
    • Hsieh, P.1
  • 27
    • 0036198664 scopus 로고    scopus 로고
    • DNA mismatch repair and mutation avoidance pathways
    • Marti TM, Kunz C, Fleck O. DNA mismatch repair and mutation avoidance pathways. J Cell Physiol 2002; 191: 28-41.
    • (2002) J Cell Physiol , vol.191 , pp. 28-41
    • Marti, T.M.1    Kunz, C.2    Fleck, O.3
  • 28
    • 0036175062 scopus 로고    scopus 로고
    • Emerging pathways in colorectal cancer development
    • Haydon AM, Jass JA. Emerging pathways in colorectal cancer development. Lancet Oncol 2002; 3: 83-8.
    • (2002) Lancet Oncol , vol.3 , pp. 83-8
    • Haydon, A.M.1    Jass, J.A.2
  • 29
    • 38849089235 scopus 로고    scopus 로고
    • Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism in esophageal squamous cell carcinoma
    • Wang J, Sasco AJ, Fu C, et al. Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism in esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 2008; 17: 118-25.
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 118-25
    • Wang, J.1    Sasco, A.J.2    Fu, C.3
  • 30
    • 34147106521 scopus 로고    scopus 로고
    • MGMT expression in oral precancerous and cancerous lesions: correlation with progression, nodal metastasis and poor prognosis
    • Sawhney M, Rohatgi N, Kaur J, et al. MGMT expression in oral precancerous and cancerous lesions: correlation with progression, nodal metastasis and poor prognosis. Oral Oncol 2007; 43: 515-22.
    • (2007) Oral Oncol , vol.43 , pp. 515-22
    • Sawhney, M.1    Rohatgi, N.2    Kaur, J.3
  • 31
    • 33845607550 scopus 로고    scopus 로고
    • Loss of expression of DNA repair enzyme MGMT in oral leukoplakia and early oral squamous cell carcinoma. A prognostic tool?
    • Rodríguez MJ, Acha A, Ruesga MT, Rodríguez C, Rivera JM, Aguirre JM. Loss of expression of DNA repair enzyme MGMT in oral leukoplakia and early oral squamous cell carcinoma. A prognostic tool? Cancer Lett 2007; 245: 263-8.
    • (2007) Cancer Lett , vol.245 , pp. 263-8
    • Rodríguez, M.J.1    Acha, A.2    Ruesga, M.T.3    Rodríguez, C.4    Rivera, J.M.5    Aguirre, J.M.6
  • 32
    • 34247844346 scopus 로고    scopus 로고
    • Reduced expression of human DNA repair genes in esophageal squamous-cell carcinoma in china
    • Liu R, Yin LH, Pu YP. Reduced expression of human DNA repair genes in esophageal squamous-cell carcinoma in china. J Toxicol Environ Health A 2007; 70: 956-63.
    • (2007) J Toxicol Environ Health A , vol.70 , pp. 956-63
    • Liu, R.1    Yin, L.H.2    Pu, Y.P.3
  • 33
    • 33748365200 scopus 로고    scopus 로고
    • Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa
    • Kato K, Hara A, Kuno T, et al. Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa. Cancer Res Clin Oncol 2006; 132: 735-43.
    • (2006) Cancer Res Clin Oncol , vol.132 , pp. 735-43
    • Kato, K.1    Hara, A.2    Kuno, T.3
  • 34
    • 20344382068 scopus 로고    scopus 로고
    • Promoter hypermethylation and inactivation of O(6)-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell lines
    • Fang MZ, Jin Z, Wang Y, et al. Promoter hypermethylation and inactivation of O(6)-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell lines. Int J Oncol 2005; 26: 615-22.
    • (2005) Int J Oncol , vol.26 , pp. 615-22
    • Fang, M.Z.1    Jin, Z.2    Wang, Y.3
  • 35
    • 0038687773 scopus 로고    scopus 로고
    • Inactivation of DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relation to p53 mutations in esophageal squamous cell carcinoma
    • Zhang L, Lu W, Miao X, Xing D, Tan W, Lin D. Inactivation of DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relation to p53 mutations in esophageal squamous cell carcinoma. Carcinogenesis 2003; 24: 1039-44.
    • (2003) Carcinogenesis , vol.24 , pp. 1039-44
    • Zhang, L.1    Lu, W.2    Miao, X.3    Xing, D.4    Tan, W.5    Lin, D.6
  • 36
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers JH. Genome maintenance mechanisms for preventing cancer. Nature 2001; 411: 366-74.
    • (2001) Nature , vol.411 , pp. 366-74
    • Hoeijmakers, J.H.1
  • 37
    • 0036256948 scopus 로고    scopus 로고
    • Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma
    • Kohya N, Miyazaki K, Matsukura S, et al. Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma. Ann Surg Oncol 2002; 9: 371-9.
    • (2002) Ann Surg Oncol , vol.9 , pp. 371-9
    • Kohya, N.1    Miyazaki, K.2    Matsukura, S.3
  • 38
    • 0035665415 scopus 로고    scopus 로고
    • Expression and prognostic significance of O6-methylguanine-DNA methyltransferase in hepatocellular, gastric, and breast cancers
    • Matsukura S, Miyazaki K, Yakushiji H, et al. Expression and prognostic significance of O6-methylguanine-DNA methyltransferase in hepatocellular, gastric, and breast cancers. Ann Surg Oncol 2001; 8: 807-16.
    • (2001) Ann Surg Oncol , vol.8 , pp. 807-16
    • Matsukura, S.1    Miyazaki, K.2    Yakushiji, H.3
  • 39
    • 0037374586 scopus 로고    scopus 로고
    • Combined loss of expression of O6-methylguanine-DNA methyltransferase and hMLH1 accelerates progression of hepatocellular carcinoma
    • Matsukura S, Miyazaki K, Yakushiji H, Ogawa A, Chen Y, Sekiguchi M. Combined loss of expression of O6-methylguanine-DNA methyltransferase and hMLH1 accelerates progression of hepatocellular carcinoma. J Surg Oncol 2003; 82: 194-200.
    • (2003) J Surg Oncol , vol.82 , pp. 194-200
    • Matsukura, S.1    Miyazaki, K.2    Yakushiji, H.3    Ogawa, A.4    Chen, Y.5    Sekiguchi, M.6
  • 40
    • 41149130073 scopus 로고    scopus 로고
    • Prognostic significance of DNA repair proteins MLH1, MSH2 and MGMT expression in non-small-cell lung cancer and precursor lesions
    • Cooper WA, Kohonen-Corish MRJ, Chan C, et al. Prognostic significance of DNA repair proteins MLH1, MSH2 and MGMT expression in non-small-cell lung cancer and precursor lesions. Histopathology 2008; 52: 613-22.
    • (2008) Histopathology , vol.52 , pp. 613-22
    • Cooper, W.A.1    Kohonen-Corish, M.R.J.2    Chan, C.3
  • 41
    • 12844278687 scopus 로고    scopus 로고
    • Oral squamous cell carcinoma: histological risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival
    • Brandwein-Gensler M, Teixeira MS, Lewis CM, et al. Oral squamous cell carcinoma: histological risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival. Am J Surg Pathol 2005; 29: 167-78.
    • (2005) Am J Surg Pathol , vol.29 , pp. 167-78
    • Brandwein-Gensler, M.1    Teixeira, M.S.2    Lewis, C.M.3
  • 42
    • 0030730322 scopus 로고    scopus 로고
    • The relationship of shape of tumor invasion to depth of invasion and cervical lymph node metastasis in squamous cell carcinoma of the tongue
    • Shintani S, Matsuura H, Hasegawa Y, Nakayama B, Fujimoto Y. The relationship of shape of tumor invasion to depth of invasion and cervical lymph node metastasis in squamous cell carcinoma of the tongue. Oncology 1997; 54: 463-7.
    • (1997) Oncology , vol.54 , pp. 463-7
    • Shintani, S.1    Matsuura, H.2    Hasegawa, Y.3    Nakayama, B.4    Fujimoto, Y.5
  • 43
    • 30944460555 scopus 로고    scopus 로고
    • World Health Organization classifications tumours. Pathology and genetics of head and neck tumours
    • Lyon: IARC Press,
    • Barnes L, Eveson JW, Reichert P, Sidransky D. World Health Organization classifications tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press, 2005.
    • (2005)
    • Barnes, L.1    Eveson, J.W.2    Reichert, P.3    Sidransky, D.4
  • 44
    • 0033810944 scopus 로고    scopus 로고
    • A comparison of prognostic significance of tumor diameter, length, width, thickness area, volume and clinicopathological features of oral tongue carcinoma
    • Po Wing Yen A, Lam KY, Wei WI, et al. A comparison of prognostic significance of tumor diameter, length, width, thickness area, volume and clinicopathological features of oral tongue carcinoma. Am J Surg 2000; 180: 139-43.
    • (2000) Am J Surg , vol.180 , pp. 139-43
    • Po Wing Yen, A.1    Lam, K.Y.2    Wei, W.I.3
  • 46
    • 61349167824 scopus 로고    scopus 로고
    • Heat shock protein-27, -60 and -90 expression in gastric cancer: association with clinicopathological variables and patient survival
    • Giaginis C, Daskalopoulou S, Vgenopoulou S, Sfiniadakis I, Kouraklis G, Theocharis S. Heat shock protein-27, -60 and -90 expression in gastric cancer: association with clinicopathological variables and patient survival. BMC Gastroenterol 2009; 9: 14.
    • (2009) BMC Gastroenterol , vol.9 , pp. 14
    • Giaginis, C.1    Daskalopoulou, S.2    Vgenopoulou, S.3    Sfiniadakis, I.4    Kouraklis, G.5    Theocharis, S.6
  • 47
    • 77955713537 scopus 로고    scopus 로고
    • Clinical significance of ephrin (Eph)-A1, -A2, -A4, -A5 and -A7 receptors in pancreatic ductal adenocarcinoma
    • Giaginis C, Tsourouflis G, Zizi-Serbetzoglou A, et al. Clinical significance of ephrin (Eph)-A1, -A2, -A4, -A5 and -A7 receptors in pancreatic ductal adenocarcinoma. Pathol Oncol 2010; 16: 267-76.
    • (2010) Pathol Oncol , vol.16 , pp. 267-76
    • Giaginis, C.1    Tsourouflis, G.2    Zizi-Serbetzoglou, A.3
  • 48
    • 17844382964 scopus 로고    scopus 로고
    • Epidemiology of head and neck cancer: magnitude of the problem
    • Döbrossy L. Epidemiology of head and neck cancer: magnitude of the problem. Cancer Metastasis Rev 2005; 24: 9-17.
    • (2005) Cancer Metastasis Rev , vol.24 , pp. 9-17
    • Döbrossy, L.1
  • 50
    • 77952103745 scopus 로고    scopus 로고
    • Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer
    • Zhang Z, Wang L, Wei S, et al. Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer. DNA Repair (Amst) 2010; 9: 558-66.
    • (2010) DNA Repair (Amst) , vol.9 , pp. 558-66
    • Zhang, Z.1    Wang, L.2    Wei, S.3
  • 51
    • 11144316623 scopus 로고    scopus 로고
    • Aberrant promoter hypermethylation of multiple genes in head and neck squamous cell carcinoma
    • Puri SK, Si L, Fan CY, Hanna E. Aberrant promoter hypermethylation of multiple genes in head and neck squamous cell carcinoma. Am J Otolaryngol 2005; 26: 12-7.
    • (2005) Am J Otolaryngol , vol.26 , pp. 12-7
    • Puri, S.K.1    Si, L.2    Fan, C.Y.3    Hanna, E.4
  • 52
    • 34548853713 scopus 로고    scopus 로고
    • Association between hypermethylated tumor and paired surgical margins in head and neck squamous cell carcinomas
    • Martone T, Gillio-Tos A, De Marco L, et al. Association between hypermethylated tumor and paired surgical margins in head and neck squamous cell carcinomas. Clin Cancer Res 2007; 13: 5089-94.
    • (2007) Clin Cancer Res , vol.13 , pp. 5089-94
    • Martone, T.1    Gillio-Tos, A.2    De Marco, L.3
  • 53
    • 2942620221 scopus 로고    scopus 로고
    • O6-methylguanine-DNA methyltransferase gene: epigenetic silencing and prognostic value in head and neck squamous cell carcinoma
    • Zuo C, Ai L, Ratliff P, et al. O6-methylguanine-DNA methyltransferase gene: epigenetic silencing and prognostic value in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 2004; 13: 967-75.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 967-75
    • Zuo, C.1    Ai, L.2    Ratliff, P.3
  • 54
    • 0038270068 scopus 로고    scopus 로고
    • Loss of expression of DNA repair enzymes MGMT, hMLH1 and hMSH2 during tumor progression in gastric cancer
    • Kitajima Y, Miyazaki K, Matsukura S, Tanaka M, Sekiguchi M. Loss of expression of DNA repair enzymes MGMT, hMLH1 and hMSH2 during tumor progression in gastric cancer. Gastric Cancer 2003; 6: 86-95.
    • (2003) Gastric Cancer , vol.6 , pp. 86-95
    • Kitajima, Y.1    Miyazaki, K.2    Matsukura, S.3    Tanaka, M.4    Sekiguchi, M.5


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