Oral squamous cell carcinoma: Histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival

American Journal of Surgical Pathology

Volumn 29, Issue 2, 2005, Pages 167-178

  Brandwein Gensler, Margaret ^a,e   Teixeira, Miriam S ^a   Lewis, Carol Ming ^c   Lee, Bryant ^a   Rolnitzky, Linda ^b   Hille, Johannes J ^d   Genden, Eric ^a   Urken, Mark L ^a   Wang, Beverly Yiyao ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF THE WESTERN CAPE   (South Africa)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Diagnosis; Margins; Oral squamous carcinoma; Pathology; Prognosis; Radiotherapy; Risk

Indexed keywords

ADULT; AGED; ARTICLE; BONE METASTASIS; CANCER ADJUVANT THERAPY; CANCER INVASION; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CANCER SURGERY; CHEEK MUCOSA; FEMALE; FROZEN SECTION; HIGH RISK POPULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MOUTH CARCINOMA; OROPHARYNX; RISK ASSESSMENT; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; TONGUE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; FEMALE; HUMANS; MIDDLE AGED; MOUTH NEOPLASMS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RADIOTHERAPY, ADJUVANT; RISK ASSESSMENT; SURVIVAL ANALYSIS;

EID: 12844278687     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pas.0000149687.90710.21     Document Type: Article

References (25)

1. Anneroth G, Batsakis J, Luna M. Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinoma. Scan J Dent Res. 1987;95:229-249.
2. Bundegaard T, Rossen K, Henriksen SD, et al. Histologic parameters in the evaluation of T1 squamous cell carcinomas of the oral cavity. Head Neck. 2002;24:656-660.
3. Bryne M, Koppang HS, Lilleng R, et al. New malignancy grading is a better prognostic indicator than Broders' grading in oral squamous cell carcinomas. J Oral Pathol Med. 1989;18:432-437.
4. Bryne M, Koppang HS, Lilleng R, et al. Malignancy grading of the deep invasive margins of oral squamous cell carcinomas has high prognostic value. J Pathol. 1992;166:375-381.
5. Bryne M, Jenssen N, Boysen M. Histologic grading in the deep invasive front of T1 and T2 glottic squamous cell carcinomas has high prognostic value. Virchows Arch. 1995;427:277-281.
6. Byers RM, Bland KI, Borlase B, et al. The prognostic and therapeutic value of frozen section determination in the surgical treatment of squamous cell carcinoma of the head and neck. Am J Surg. 1978;136:525-528.
7. Chen TY, Edmrich LJ, Driscoll DL. The clinical significance of pathological findings in surgically resected margins of the primary tumor in head and neck carcinoma. Int J Radiat Oncol Biol Phys. 1987;13:833-837.
8. Pagan JJ, Collins B, Barnes L, et al. Perineural invasion in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg. 1998;124:637-640.
9. Hiratsuka H, Miyakawa A, Nakamori K, et al. Multivariate analysis of occult lymph node metastasis as a prognostic indicator for patients with squamous cell carcinoma of the oral cavity. Cancer. 1997;80:351-356.
10. Hosal AS, Unal OF, Ayhan A. Possible prognostic value of histopathologic parameters in patients with carcinoma of the oral tongue. Eur Arch Otolaryngol. 1998;225:216-219.
11. Jacobs JR, Ahmad K, Casiano R, et al. Implications of positive surgical margins. Laryngoscope. 1993;103:64-68.
12. Jones AS. Prognosis in mouth cancer: tumor factors. Oral Oncol Eur J Cancer. 1994;30B:8-15.
13. Kim HC, Kusukawa J, Kameyama T. Clinicopathologic parameters in predicting cervical nodal metastasis in early squamous cell carcinoma of the oral cavity. Kurume Med J. 1993;40:183-192.
14. Kurokawa H, Yamashita Y, Murata T, et al. Histologic grading of malignancy correlates with regional lymph node metastasis and survival of patients with oral squamous cell carcinoma. Fukuoka Acta Med. 1998;89:225-231.
15. Looser KG, Shah JP, Strong EW. The significance of 'positive' margins in surgically resected epidermoid carcinomas. Head Neck Surg. 1978;1:107-111.
16. Loree TR, Strong EW. Significance of positive margins in oral cavity squamous carcinoma. Am J Surg. 1990;160:410-414.
17. Martinez-Gimeno C, Rodriguez EM, Vila CN, et al. Squamous cell carcinoma of the oral cavity: a clinicopathologic scoring system for evaluating risk of cervical lymph node metastasis. Laryngoscope. 1995;105:728-733.
18. Odell EW, Jani P, Sherriff M, et al. The prognostic value of individual histology grading parameters in small lingual squamous cell carcinomas. Cancer. 1994;74:789-794.
19. Scholl P, Byers RM, Batsakis JG, et al. Microscopic cut-through of cancer in the surgical treatment of squamous carcinoma of the tongue: prognostic and therapeutic implications. Am J Surg. 1986;152:354-360.
20. Sieczka E, Datta R, Singh A, et al. Cancer of the buccal mucosa: are margins and T-stage accurate predictors of local control? Am J Orolaryngol. 2001;22:395-399.
21. Slootweg PJ, Hordijk GJ, Schade Y, et al. Treatment failure and margin status in head and neck cancer: a critical view on the potential value of molecular pathology. Oral Oncol. 2002;38:500-503.
22. Spiro RH, Guillamondegui O, Paulino AF, et al. Pattern of invasion and margin assessment in patients with oral tongue cancer. Head Neck. 1999;21:408-413.
23. van Es RJ, van Nieuw Amerongen N, Slootweg PJ, et al. Resection margin as a predictor of recurrence at the primary site for T1 and T2 oral cancers: evaluation of histopathologic variables. Arch Otolaryngol Head Neck Surg. 1996;122:521-525.
24. Yamamoto E, Miyakawa A, Kohama GI. Mode of invasion and lymph node metastasis in squamous cell carcinoma of the oral cavity. Head Neck Surg. 1984;6:938-947.
25. Yuen APW, Lam KY, Lam LK, et al. Prognostic factors of clinically Stage I and Stage II oral tongue carcinoma: a comparative study of stage, thickness, shape, growth pattern, grading, Martinez-Gimeno score, and pathologic features. Head Neck. 2002;24:513-520.