Predose blood gene expression profiles might identify the individuals susceptible to carbon tetrachloride-induced hepatotoxicity

Toxicological Sciences

Volumn 115, Issue 1, 2010, Pages 12-21

  Yun, Jun Won ^a,b   Lee, Tae Ryong ^a   Kim, Chae Wook ^a   Park, Young Ho ^a   Chung, Jin Ho ^c   Lee, Yong Soon ^b   Kang, Kyung Sun ^b   Lim, Kyung Min ^a  

^a AmorePacific Corporation   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Blood; Carbon tetrachloride; Hepatotoxicity; Individual variation; Microarray analysis

Indexed keywords

CARBON TETRACHLORIDE; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY C; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE 6; TETRASPANIN; TETRASPANIN 12; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; UNCLASSIFIED DRUG; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; GENE EXPRESSION; GENETIC SUSCEPTIBILITY; GENOME; LIVER TOXICITY; MALE; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; BLOOD; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; GERMFREE ANIMAL; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; TOXIC HEPATITIS;

ANIMALIA;

ANIMALS; CARBON TETRACHLORIDE; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 79951876140     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq037     Document Type: Article

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