Computational design of the lasso peptide antibiotic microcin J25

Protein Engineering, Design and Selection

Volumn 24, Issue 3, 2011, Pages 275-282

  Pan, Si Jia ^a   Cheung, Wai Ling ^a   Fung, Ho Ki ^a   Floudas, Christodoulos A ^a   Link, A James ^a,b  

^a Princeton University   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

antimicrobial peptide; cyclic peptide; global optimization; lasso peptide; protein design

Indexed keywords

AMINO ACID SUBSTITUTION; ANTI-MICROBIAL ACTIVITY; ANTIMICROBIAL PEPTIDE; COMPUTATIONAL DESIGN; CONSTRAINED STRUCTURE; CYCLIC PEPTIDE; ENERGY MINIMIZATION; LASSO PEPTIDE; MICROCIN; N-TERMINALS; PEPTIDE ANTIBIOTICS; PRODUCTION LEVEL; PROTEIN DESIGN; SELECTION PROCEDURES; SEQUENCE SPACE; TWO STAGE; WILD TYPES;

AMINO ACIDS; ANTIBIOTICS; DESIGN; ESCHERICHIA COLI; GLOBAL OPTIMIZATION; MICROORGANISMS; OPTIMIZATION; POLYPEPTIDES;

PEPTIDES;

MICROCIN J25;

AMINO ACID SUBSTITUTION; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENERGY; ESCHERICHIA COLI; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; BACTERIOCINS; COMPUTATIONAL BIOLOGY; ESCHERICHIA COLI; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN FOLDING; SALMONELLA;

ESCHERICHIA COLI;

EID: 79951870980     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzq108     Document Type: Article

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