Somatic diversity in CDR3 loops allows single V-genes to encode innate immunological memories for multiple pathogens

Journal of Immunology

Volumn 186, Issue 4, 2011, Pages 2291-2298

  Thomson, Christy A ^a   Little, Ken Q ^a   Reason, Donald C ^b   Schrader, John W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b CHILDREN S HOSPITAL OAKLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

23F ANTIBODY; AMINO ACID; ANTIBODY; ANTIGEN; DNA; IMMUNOGLOBULIN G; PNEUMOCOCCUS POLYSACCHARIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; COMPLEMENTARITY DETERMINING REGION; COMPLEMENTARITY DETERMINING REGION 3; CONTROLLED STUDY; DNA SEQUENCE; ENCAPSULATION; GENE; HEAVY CHAIN; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IGVH3-30 GENE; IGVK3-11 GENE; IMMUNOLOGICAL MEMORY; INNATE IMMUNITY; LIGHT CHAIN; NEUTROPHIL; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PHAGOCYTOSIS; PRIORITY JOURNAL; SEROTYPE; SOMATIC MUTATION; STREPTOCOCCUS PNEUMONIAE; V-GENE;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; BINDING SITES, ANTIBODY; CELLS, CULTURED; COMPLEMENTARITY DETERMINING REGIONS; HUMANS; IMMUNITY, INNATE; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGIC MEMORY; MOLECULAR SEQUENCE DATA; NEUTROPHILS; RESPIRATORY SYNCYTIAL VIRUSES; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; STREPTOCOCCUS PNEUMONIAE;

EID: 79951828171     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0904092     Document Type: Article

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