Synthesis and pharmacological activities of 6-glycine substituted 14-phenylpropoxymorphinans, a novel class of opioids with high opioid receptor affinities and antinociceptive potencies

Journal of Medicinal Chemistry

Volumn 54, Issue 4, 2011, Pages 980-988

  Spetea, Mariana ^a   Windisch, Petra ^a   Guo, Yan ^b   Bileviciute Ljungar, Indre ^b   Schütz, Johannes ^a   Asim, Muhammad Faheem ^a   Berzetei Gurske, Ilona P ^c   Riba, Pal ^d   Kiraly, Kornel ^d   Fürst, Susanna ^d   Al Khrasani, Mahmoud ^d   Schmidhammer, Helmut ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b KAROLINSKA INSTITUTE   (Sweden)

^c SRI INTERNATIONAL   (United States)

^d SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

14 PHENYLPROPOXYMORPHINAN; ANALGESIC AGENT; ANTINOCICEPTIVE AGENT; METHYL GROUP; MORPHINE DERIVATIVE; OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; DRUG BINDING; HYPERALGESIA; RECEPTOR AFFINITY; SYNTHESIS; TAIL FLICK TEST;

ANALGESICS; ANIMALS; BINDING, COMPETITIVE; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MAGNETIC RESONANCE SPECTROSCOPY; MORPHINANS; N-SUBSTITUTED GLYCINES; PAIN; RATS; RECEPTORS, OPIOID; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79951818681     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101211p     Document Type: Article

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