Structural determinants of opioid activity in derivatives of 14-aminomorphinones: Effects of changes to the chain linking of the C 14-amino group to the aryl ring

Journal of Medicinal Chemistry

Volumn 49, Issue 20, 2006, Pages 6104-6110

  Rennison, David ^c,d   Moynihan, Humphrey ^a,e   Traynor, John R ^b   Lewis, John W ^c   Husbands, Stephen M ^c  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF MICHIGAN   (United States)

^c University of Bath   (United Kingdom)

^d UNIVERSITY OF AUCKLAND   (New Zealand)

^e UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

14 AMINODIHYDROMORPHINONE; 14 AMINOMORPHINONE DERIVATIVE; ALKENE; AMIDE; AMINO ACID; AROMATIC COMPOUND; CARBON; CODEINE; DRUG ANALOG; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); LIGAND; MORPHINE DERIVATIVE; MORPHINONE; MU OPIATE RECEPTOR; N CYCLOPROPYLMETHYL 14BETA [2' (4'' CHLOROPHENYL)ETHANAMIDO] 7,8 DIHYDRONORMORPHINONE; N CYCLOPROPYLMETHYL 14BETA [3' (4'' CHLOROPHENYL)PROPANAMIDO] 7,8 DIHYDRONORMORPHINONE; N CYCLOPROPYLMETHYL 14BETA [4' (4'' CHLOROPHENYL)BUTANAMIDO] 7,8 DIHYDRONORMORPHINONE; OPIATE; OPIATE ANTAGONIST; PHENYLACETYLAMINOMORPHINONE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; SULFUR 35; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHEMICAL BOND; CHO CELL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; FUNCTION TEST; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN FUNCTION; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

AMINES; ANALGESICS; ANIMALS; CELL LINE; CRICETINAE; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); LIGANDS; MICE; MORPHINE DERIVATIVES; PAIN MEASUREMENT; RADIOLIGAND ASSAY; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33749249732     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060595u     Document Type: Article

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