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Helvetica Chimica Acta

Volumn 86, Issue 6, 2003, Pages 2142-2148

Synthesis of 6-amino acid substituted derivatives of the highly potent analgesic 14-O-methyloxymorphone

(6) Schütz, Johannes a Brandt, Wolfgang b Spetea, Mariana a Wurst, Klaus a Wunder, Gerhard a Schmidhammer, Helmut a

a UNIVERSITY OF INNSBRUCK (Austria)

b Institute of Plant Biochemistry (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ESTERS; HYDROLYSIS; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

PHARMACOKINETIC PARAMETERS;

AMINO ACIDS;

14 O METHYLOXYMORPHONE; 2 [(4,5ALPHA EPOXY 3 HDYROXY 14BETA METHOXY 17 METHYLMORPHINAN 6ALPHA YL)AMINO]ACETIC ACID BIS(TETRAFLUOROBORATE); 2 [(4,5ALPHA EPOXY 3 HYDROXY 14BETA METHOXY 17 METHYLMORPHINAN 6ALPHA YL)AMINO] 3 PHENYLPROPANOIC ACID BIS(TETRAFLUOROBORATE); 2 [(4,5ALPHA EPOXY 3 HYDROXY 14BETA METHOXY 17 METHYLMORPHINAN 6ALPHA YL)AMINO]PROPANOIC ACID BIS(TETRAFLUROBORATE); 2 [(4,5ALPHA EPOXY 3 HYDROXY 14BETA METHOXY 17 METHYLMORPHINAN 6BETA YL)AMINO] 3 PHENYLPROPANOATE; 2 [(4,5ALPHA EPOXY 3 HYDROXY 14BETA METHOXY 17 METHYLMORPHINAN 6BETA YL)AMINO] 3 PHENYLPROPANOIC ACID BIS(TETRAFLUOROBORATE); 2 [(4,5ALPHA EPOXY 3 HYDROXY 14BETA METHOXY 17 METHYLMORPHINAN 6BETA YL)AMINO]ACETIC ACID BIS(TETRAFLUOROBORATE); 2 [(4,5ALPHA EPOXY 3 HYDROXY 14BETA METHOXY 17 METHYLMORPHINAN 6BETA YL)AMINO]PROPANOIC ACID BIS(TETRAFLUOROBORATE); AMINO ACID DERIVATIVE; ANALGESIC AGENT; BORIC ACID; ESTER DERIVATIVE; MORPHINAN DERIVATIVE; MU OPIATE RECEPTOR; OXYMORPHONE; TERT BUTYL 2 [(4,5ALPHA EPOXY 3 HYDROXY 14BETA METHOXY 17 METHYLMORPHINAN 6ALPHA YL)AMINO] 3 PHENYLPROPANOATE; TERT BUTYL 2 [(4,5ALPHA EPOXY 3 HYDROXY 14BETA METHOXY 17 METHYLMORPHINAN 6ALPHA YL)AMINO]ACETATE; TERT BUTYL 2 [(4,5ALPHA EPOXY 3 HYDROXY 14BETA METHOXY 17 METHYLMORPHINAN 6ALPHA YL)AMINO]PROPANOATE; TERT BUTYL 2 [(4,5ALPHA EPOXY 3 HYDROXY 14BETA METHOXY 17 METHYLMORPHINAN 6BETA YL)AMINO]ACETATE; TERT BUTYL 2 [(4,5ALPHA EPOXY 3 HYDROXY 14BETA METHOXY 17 METHYLMORPHINAN 6BETA YL)AMINO]PROPANOATE; TETRAFLUOROBORIC ACID; UNCLASSIFIED DRUG;

AMINATION; AMINO ACID SUBSTITUTION; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CALCULATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HYDROLYSIS; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TISSUE LEVEL; HOT PLATE TEST; MOUSE; NONHUMAN; PARAMETER; PHARMACOKINETICS; PRIORITY JOURNAL; REDUCTION; STRUCTURE ANALYSIS; TECHNIQUE; X RAY CRYSTALLOGRAPHY;

EID: 0041303375 PISSN: 0018019X EISSN: None Source Type: Journal
DOI: 10.1002/hlca.200390171 Document Type: Article

Times cited : (19)

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