DAMGO and 6β-glycine substituted 14-O-methyloxymorphone but not morphine show peripheral, preemptive antinociception after systemic administration in a mouse visceral pain model and high intrinsic efficacy in the isolated rat vas deferens

Brain Research Bulletin

Volumn 74, Issue 5, 2007, Pages 369-375

  Al Khrasani, Mahmoud ^a   Spetea, Mariana ^b   Friedmann, Tamas ^a   Riba, Pal ^a   Király, Kornel ^a   Schmidhammer, Helmut ^b   Furst, Susanna ^a,c  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b UNIVERSITY OF INNSBRUCK   (Austria)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Central and peripheral antinociception; Mouse visceral pain model; Opioids; Systemic and central administration

Indexed keywords

ACETIC ACID; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLARGINYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; HS 731; MORPHINE; MU OPIATE RECEPTOR AGONIST; NALOXONE; UNCLASSIFIED DRUG; 2 ((4,5ALPHA EPOXY 3 HYDROXY 14BETA METHOXY 17 METHYLMORPHINAN 6BETA YL)AMINO)ACETIC ACID; 2-((4,5ALPHA-EPOXY-3-HYDROXY-14BETA-METHOXY-17-METHYLMORPHINAN-6BETA-YL)AMINO)ACETIC ACID; CONNECTIVE TISSUE ACTIVATING PEPTIDE; CONNECTIVE TISSUE-ACTIVATING PEPTIDE; EPOXIDE; MORPHINAN DERIVATIVE; NARCOTIC ANALGESIC AGENT; PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; IN VITRO STUDY; MALE; MOUSE; NEUROPATHOLOGY; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; RECEPTOR INTRINSIC ACTIVITY; VAS DEFERENS; VISCERAL PAIN; WRITHING TEST; ANIMAL; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG ADMINISTRATION ROUTE; DRUG INTERACTION; PAIN; PAIN ASSESSMENT; PHYSIOLOGY; TIME; WISTAR RAT;

ACETIC ACID; ANALGESICS, OPIOID; ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; EPOXY COMPOUNDS; MALE; MICE; MORPHINANS; MORPHINE; PAIN; PAIN MEASUREMENT; PEPTIDES; RATS; RATS, WISTAR; TIME FACTORS; VAS DEFERENS;

EID: 34548437956     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2007.07.008     Document Type: Article

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