Solution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 5, 2011, Pages 1320-1324

  Su, Yuan Hsiao ^a   Chiang, Li Wu ^a   Jeng, Kee Ching ^b   Huang, Ho Lien ^a   Chen, Jenn Tzong ^c   Lin, Wuu Jyh ^c   Huang, Chia Wen ^a   Yu, Chung Shan ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^c INSTITUTE OF NUCLEAR ENERGY RESEARCH   (Taiwan)

Author keywords

1 Amino 4 azidobutane; 1 4 (4 Aminobutylaminooxy)methyl 2,3 dichlorophenyl 2 methylenebutan 1 one; Cell based screening; Library; N (4 Aminobutyl) 4 (biphenyl 4 yl) 4 oxobutanamide

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMIDE; CARBOXYLIC ACID; CISPLATIN; ETACRYNIC ACID; FENBUFEN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN MCF 7; COLORIMETRY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PARALLEL SOLUTION PHASE SYNTHESIS; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME INHIBITORS; ETHACRYNIC ACID; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR STRUCTURE; NEOPLASMS; PHENYLBUTYRATES; SMALL MOLECULE LIBRARIES;

MURINAE;

EID: 79951724545     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.068     Document Type: Article

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