Combining a solution-phase derived library with in-situ cellular bioassay: Prompt screening of amide-forming minilibraries using MTT assay

Chemical and Pharmaceutical Bulletin

Volumn 57, Issue 7, 2009, Pages 714-718

  Chiang, Li Wu ^a   Pei, Kai ^a   Chen, Shao Wei ^a   Huang, Ho Lien ^a   Lin, Kun Ju ^b   Yen, Tzu Chen ^b   Yu, Chung Shan ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Amide; Assay; In situ; Library; Molecular docking; Solution phase

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 5' AMINO 2',5' DI DEOXY ARABINOSYL URIDINE; 5' AMINO 5' DEOXY URIDNE; AMINO ACID MIXTURE; BUTAN 1 AMINE; BUTYL ETHACRYNIC AMIDE C18; BUTYLFENBUFEN C15; CARBOXYLIC ACID; CARRIER PROTEIN; CERAMIDE; CERAMIDE TRANSPORT PROTEIN; CYCLOOXYGENASE 2; DICLOFENAC; ETACRYNIC ACID; FENBUFEN; FENOPROFEN; FLURBIPROFEN; MEMBRANE RECEPTOR; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE; PROTEIN BCL 2; PROTEIN BCL X; SPHINGOSINE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID COMPOSITION; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; BREAST CANCER; CANCER GROWTH; CANCER INHIBITION; CANCER INVASION; CELL ASSAY; CELL STRAIN MCF 7; CELL SURVIVAL; CELL TRANSPORT; CONTROLLED STUDY; COUPLING FACTOR; CRYSTAL STRUCTURE; CYTOTOXICITY; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; LEUKEMIA CELL; LIBRARY; LUNG EDEMA; MOLECULAR DOCKING; OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; SOLUTION AND SOLUBILITY; STRUCTURE ACTIVITY RELATION; X RAY DIFFRACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL LINE, TUMOR; CISPLATIN; COMBINATORIAL CHEMISTRY TECHNIQUES; IFOSFAMIDE; MITOMYCIN; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SMALL MOLECULE LIBRARIES;

EID: 67650822658     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.57.714     Document Type: Article

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