Rapid discovery of potent sulfotransferase inhibitors by diversity-oriented reaction in microplates followed by in situ screening

ChemBioChem

Volumn 5, Issue 6, 2004, Pages 811-819

  Best, Michael D ^a   Brik, Ashraf ^a   Chapman, Eli ^a   Lee, Lac V ^a   Cheng, Wei Chieh ^a   Wong, Chi Huey ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Combinatorial chemistry; Enzymes; High throughput screening; Inhibitors; Sulfotransferases

Indexed keywords

1 N (4 FLUORO 3 HYDROXYBENZOYL) 1 N (4,8 DIHYDROXYQUINOLINE 2 CARBONYL)DIAMINODODECANE; 1 N (4 FLUORO 3 HYDROXYBENZOYL) 1 N (5 FLUOROINDOL 3 ACETYL) DIAMINODODECANE; 1 N (4 FLUORO 3 HYDROXYBENZOYL) 1 N (INDOL 3 ACETYL)DIAMINODODECANE; 1,12 N,N BIS(4 FLUORO 3 HYDROXYBENZOYL)DIAMINODODECANE; 2 CHLORO 6 [12 (N 4 FLUORO 3 HYDROXYBENZOYLAMINO)DODECYLAMINO]PURINE; 6 [(12 AMMONIUM TRIFLUOROACETATE)DODECYLAMINO]PURINE; 6 [(2 AMMONIUM TRIFLUOROACETATE)ETHYLAMINO]PURINE; 6 [12 (N 4 FLUORO 3 HYDROXYBENZOYLAMINO)DODECYLAMINO]PURINE; 6 [2 (N 4 FLUORO 3 HYDROXYBENZOYLAMINO)ETHYLAMINO]PURINE; DODECANE; PURINE DERIVATIVE; SULFOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG DETERMINATION; DRUG SYNTHESIS; ENZYME INHIBITION; FLUORESCENCE; MICHAELIS CONSTANT; PRIORITY JOURNAL; SCREENING;

BINDING SITES; CATALYSIS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FLUORESCENCE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFOTRANSFERASES;

EID: 4544387724     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200300841     Document Type: Article

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