Proteinase-activated receptor 2 mediates thermal hyperalgesia and is upregulated in a rat model of chronic pancreatitis

Pancreas

Volumn 40, Issue 2, 2011, Pages 300-307

  Zhang, Wei ^a   Gao, Jun ^a   Zhao, Tao ^a   Wei, Lei ^a   Wu, Wenbin ^a   Bai, Yu ^a   Zou, Duowu ^a   Li, Zhaoshen ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

chronic pancreatitis; PAR2; thermal hyperalgesia; TRPV1

Indexed keywords

MESSENGER RNA; PROTEINASE ACTIVATED RECEPTOR 2; TRINITROBENZENESULFONIC ACID; ULINASTATIN; VANILLOID RECEPTOR 1;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC PANCREATITIS; CLINICAL EVALUATION; CONTROLLED STUDY; HYPERALGESIA; IMMUNOFLUORESCENCE; MALE; NONHUMAN; PANCREAS DUCT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; THERMAL HYPERALGESIA; UPREGULATION; WESTERN BLOTTING; WITHDRAWAL REFLEX;

ABDOMINAL PAIN; ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT ANTIBODY TECHNIQUE; GANGLIA, SPINAL; GLYCOPROTEINS; HYPERALGESIA; MALE; PAIN MEASUREMENT; PAIN THRESHOLD; PANCREATITIS, CHRONIC; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RECEPTOR, PAR-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TRINITROBENZENESULFONIC ACID; TRPV CATION CHANNELS; UP-REGULATION;

EID: 79951689521     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e318201cbc1     Document Type: Article

References (29)

1. Nystedt S, Emilsson K, Wahlestedt C, et al. Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci U S A. 1994;91:9208-9212. (Pubitemid 24297883)
2. Hoogerwerf WA, Shenoy M, Winston JH, et al. Trypsin mediates nociception via the proteinase-activated receptor 2: a potentially novel role in pancreatic pain. Gastroenterology. 2004;127:883-891. (Pubitemid 39208420)
3. Amadesi S, Nie J, Vergnolle N, et al. Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. J Neurosci. 2004;24:4300-4312. (Pubitemid 38608141)
4. Namkung W, Han W, Luo X, et al. Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis. Gastroenterology. 2004;126:1844-1859. (Pubitemid 38736349)
5. Maeda K, Hirota M, Kimura Y, et al. Proinflammatory role of trypsin and protease-activated receptor-2 in a rat model of acute pancreatitis. Pancreas. 2005;31:54-62. (Pubitemid 40911503)
6. Dai Y, Wang S, Tominaga M, et al. Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest. 2007;117:1979-1987. (Pubitemid 47036332)
7. Zhu WJ, Yamanaka H, Obata K, et al. Expression of mRNA for four subtypes of the proteinase-activated receptor in rat dorsal root ganglia. Brain Res. 2005;1041:205-211.
8. Hoogerwerf WA, Zou L, Shenoy M, et al. The proteinase-activated receptor 2 is involved in nociception. J Neurosci. 2001;21:9036-9042. (Pubitemid 33054865)
9. Zhang W, Gao J, Zhao T, et al. High-dose naproxen aggravates pancreatic fibrosis in a rat model of chronic pancreatitis. Pancreas. 2010;39:293-300.
10. Xu GY, Winston JH, Shenoy M, et al. Transient receptor potential vanilloid 1 mediates hyperalgesia and is up-regulated in rats with chronic pancreatitis. Gastroenterology. 2007;133:1282-1292. (Pubitemid 47494443)
11. Vera-Portocarrero LP, Lu Y, Westlund KN. Nociception in persistent pancreatitis in rats: effects of morphine and neuropeptide alterations. Anesthesiology. 2003;98:474-484. (Pubitemid 36592817)
12. Zhu WJ, Dai Y, Fukuoka T, et al. Agonist of proteinase-activated receptor 2 increases painful behavior produced by alpha, beta-methylene adenosine 5′-triphosphate. Neuroreport. 2006;17:1257-1261. (Pubitemid 44337062)
13. Vergnolle N, Bunnett NW, Sharkey KA, et al. Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway. Nat Med. 2001;7:821-826. (Pubitemid 32691637)
14. Coelho AM, Vergnolle N, Guiard B, et al. Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats. Gastroenterology. 2002;122:1035-1047. (Pubitemid 34267286)
15. Cenac N, Andrews CN, Holzhausen M, et al. Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest. 2007;117:636-647. (Pubitemid 46348522)
16. it-Belgnaoui A, Bradesi S, Fioramonti J, et al. Acute stress-induced hypersensitivity to colonic distension depends upon increase in paracellular permeability: role of myosin light chain kinase. Pain. 2005;113:141-147.
17. Reichling DB, Levine JD. The primary afferent nociceptor as pattern generator. Pain. 1999;(suppl 6):S103-S109.
18. Steinhoff M, Vergnolle N, Young SH, et al. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med. 2000;6:151-158. (Pubitemid 30082358)
19. Linley JE, Rose K, Patil M, et al. Inhibition of M current in sensory neurons by exogenous proteases: a signaling pathway mediating inflammatory nociception. J Neurosci. 2008;28:11240-11249.
20. Kirkup AJ, Jiang W, Bunnett NW, et al. Stimulation of proteinase-activated receptor 2 excites jejunal afferent nerves in anaesthetised rats. J Physiol. 2003;552:589-601. (Pubitemid 37321854)
21. Reed DE, Barajas-Lopez C, Cottrell G, et al. Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons. J Physiol. 2003;547:531-542. (Pubitemid 36304985)
22. Nystedt S, Ramakrishnan V, Sundelin J. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor. J Biol Chem. 1996;271:14910-14915. (Pubitemid 26197572)
23. Hoogerwerf WA, Gondesen K, Xiao SY, et al. The role of mast cells in the pathogenesis of pain in chronic pancreatitis. BMC Gastroenterol. 2005;5:8.
24. Gachago C, Draganov PV. Pain management in chronic pancreatitis. World J Gastroenterol. 2008;14:3137-3148.
25. Dai Y, Moriyama T, Higashi T, et al. Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. J Neurosci. 2004;24:4293-4299. (Pubitemid 38612819)
26. Amadesi S, Cottrell GS, Divino L, et al. Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice. J Physiol. 2006;575:555-571. (Pubitemid 44270181)
27. Surprenant A. Pain TRP-ed up by PARs. J Physiol. 2007;578:631. (Pubitemid 46165499)
28. Vergnolle N. Protease-activated receptors as drug targets in inflammation and pain. Pharmacol Ther. 2009;123:292-309.
29. Kawabata A, Matsunami M, Tsutsumi M, et al. Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice. Br J Pharmacol. 2006;148:54-60. (Pubitemid 43675600)