Proinflammatory role of trypsin and protease-activated receptor-2 in a rat model of acute pancreatitis

Pancreas

Volumn 31, Issue 1, 2005, Pages 54-62

  Maeda, Keisuke ^a   Hirota, Masahiko ^a   Kimura, Yu ^a   Ichihara, Atsushi ^a   Ohmuraya, Masaki ^a   Sugita, Hiroki ^a   Ogawa, Michio ^b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b Nobeoka Prefectural Hospital   (Japan)

Author keywords

Acute pancreatitis; Cytokine; Pancreatic acinar cells; Protease activated receptor 2; Trypsin

Indexed keywords

ANTIBODY; CERULETIDE; GAMMA INTERFERON; INTERLEUKIN 6; NAFAMSTAT MESILATE; PROTEINASE ACTIVATED RECEPTOR 2; TRYPSIN;

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; ORGAN INJURY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT;

ACUTE DISEASE; AMYLASES; ANIMALS; BLOTTING, WESTERN; CALCIUM; CELL LINE, TUMOR; CYTOKINES; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; LIPASE; MALE; PANCREATITIS; RABBITS; RATS; RATS, WISTAR; RECEPTOR, PAR-2; TRYPSIN;

EID: 21344458123     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mpa.0000163178.37050.0d     Document Type: Article

References (32)

1. Dery O, Corvera CU, Steinhoff M, et al. Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am J Physiol. 1998;274:C1429-C1452.
2. Macfarlane SR, Scatter MJ, Kanke T, et al. Proteinase-activated receptors. Pharmacol Rev. 2001;53:245-282.
3. Vergnolle N, Wallace JL, Bunnett NW, et al. Protease-activated receptors in inflammation, neuronal signaling and pain. Trends Pharmacol Sci. 2001;22:146-152.
4. Vu TK, Hung DT, Wheaton VI, et al. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991;64:1057-1068.
5. D'Andrea MR, Derian CK, Leturcq D, et al. Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues. J Histochem Cytochem. 1998;46:157-164.
6. Nystedt S, Emilsson K, Wahlestedt C, et al. Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci USA. 1994;91:9208-9212.
7. Dinarello CA, Gelfand JA, Wolff SM. Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. JAMA. 1993;269:1829-1835.
8. Hirota M, Nozawa F, Okabe A, et al. Relationship between plasma cytokine concentration and multiple organ failure in patients with acute pancreatitis. Pancreas. 2000;21:141-146.
9. Kimura Y, Hirota M, Okabe A, et al. Dynamic aspects of granulocyte activation in rat severe acute pancreatitis. Pancreas. 2003;27:127-132.
10. Ogawa M. Acute pancreatitis and cytokines: "second attack" by septic complication leads to organ failure. Pancreas. 1998;16:312-315.
11. Okamura H, Nagata K, Komatsu T, et al. A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock. Infect Immun. 1995;63:3966-3972.
12. Galanos C, Freudenberg MA, Reutter W Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc Natl Acad Sci USA. 1979;76:5939-5943.
13. Cicala C, Pinto A, Bucci M, et al. Protease-activated receptor-2 involvement in hypotension in normal and endotoxemic rats in vivo. Circulation. 1999;99:2590-2597.
14. Lerner DJ, Chen M, Tram T, et al. Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function. J Biol Chem. 1996;271:13943-13947.
15. Bohm SK, Kong W, Bromme D, et al. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem J. 1996;314:1009-1016.
16. Kawabata A, Nishikawa H, Kuroda R, et al. Proteinase-activated receptor-2 (PAR-2): regulation of salivary and pancreatic exocrine secretion in vivo in rats and mice. Br J Pharmacol. 2000;129:1808-1814.
17. Laboratory Animal Welfare. Public Health Service policy on humane care and use of laboratory animals by awardee institutions; notice. Fed Reg. 1985;50:19584-19585.
18. Corvera CU, Déry O, McConalogue K, et al. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J Clin Invest. 1997;100:1383-1393.
19. Steinhoff M, Corvera CU, Thoma MS, et al. Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase. Exp Dermatol. 1999;8:282-294.
20. Okabe A, Hirota M, Nozawa F, et al. Altered cytokine response in rat acute pancreatitis complicated with endotoxemia. Pancreas. 2001;22:32-39.
21. Harms PG, Ojeda SR. A rapid and simple procedure for chronic cannulation of the rat jugular vein. J Appl Physiol. 1974;36:391-392.
22. Olejar T, Matej R, Zadinova M, et al. Expression of proteinase-activated receptor 2 during taurocholate-induced acute pancreatic lesion development in Wistar rats. Int J Gastrointest Cancer. 2001;30:113-121.
23. Hofbauer B, Saluja AK, Lerch MM, et al. Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats. Am J Physiol. 1998;275:G352-G362.
24. Vergnolle N. Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo. J Immunol. 1999;163:5064-5069.
25. Asokananthan N, Graham PT, Fink J, et al. Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells. J Immunol. 2002;168:3577-3585.
26. Lang R, Song PI, Legat FJ, et al. Human comeal epithelial cells express functional PAR-1 and PAR-2. Invest Ophthalmol Vis Sci. 2003;44:99-105.
27. Namkung W, Han W, Luo X, et al. Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis. Gastroenterology: 2004;126:1844-1859.
28. Seo JY, Kim H, Seo JT, et al. Oxidative stress induced cytokine production in isolated rat pancreatic acinar cells: effects of small-molecule antioxidants. Pharmacology. 2002;64:63-70.
29. Bhatia M, Brady M, Kang YK, et al. MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to cerulein hyperstimulation. Am J Physiol Gastrointest Liver Physiol. 2002;282:G77-G85.
30. Sugita H, Yamaguchi Y, Ikei S, et al. Effects of propentofylline on tumor necrosis factor-alpha and cytokine-induced neutrophil chemoattractant production in rats with cerulein-induced pancreatitis and endotoxemia. Pancreas. 1997;14:267-275.
31. Okabe A, Hirota M, Kimura Y, et al. Functional disturbance of biliary indocyanine green excretion in rat cerulein pancreatitis followed by endotoxemia: role of the prime and the second attack. JOP. 2003;4:178-183.
32. Dejgaard S, Ortapamuk O, Ozer I. The trypsin-inhibitory efficiency of human alpha 2-macroglobulin in the presence of alpha 1-proteinase inhibitor: evidence for the formation of an alpha 2-macroglobulin-alpha 1-proteinase inhibitor complex. J Enzyme Inhib. 1999;14:391-405.