Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis

Gastroenterology

Volumn 126, Issue 7, 2004, Pages 1844-1859

  Namkung, Wan ^a   Han, Wonsun ^a   Luo, Xiang ^b   Muallem, Shmuel ^b   Cho, Kyung Hee ^a   Kim, Kyung Hwan ^a   Lee, Min Goo ^a  

^a Yonsei University College of Medicine   (South Korea)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE; PROTEASE ACTIVATED RECEPTOR 2 AGONIST; PROTEASE ACTIVATED RECEPTOR ACTIVATING PEPTIDE; PROTEINASE ACTIVATED RECEPTOR 2; TAUROCHOLIC ACID; TRYPSIN; UNCLASSIFIED DRUG;

ACINAR CELL; ACUTE HEMORRHAGIC PANCREATITIS; ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE; CALCIUM SIGNALING; CELL DAMAGE; CELL LINE; CONTROLLED STUDY; DISEASE MODEL; HEMODYNAMICS; HUMAN; HUMAN CELL; INFLAMMATION; MALE; MORTALITY; NONHUMAN; PANCREAS CELL; PANCREAS DUCT; PATHOGENESIS; PRIORITY JOURNAL; PROTECTION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION;

EID: 2942590747     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2004.03.019     Document Type: Article

References (46)

1. Neoptolemos JP, Raraty M, Finch M, Sutton R. Acute pancreatitis: the substantial human and financial costs. Gut 1998;42:886-891.
2. Baron TH, Morgan DE. Acute necrotizing pancreatitis. N Engl J Med 1999;340:1412-1417.
3. Hartwig W, Jimenez RE, Werner J, Lewandrowski KB, Warshaw AL, Fernandez-del Castillo C. Interstitial trypsinogen release and its relevance to the transformation of mild into necrotizing pancreatitis in rats. Gastroenterology 1999;117:717-725.
4. Hartwig W, Werner J, Jimenez RE, Z'graggen K, Weimann J, Lewandrowski KB, Warshaw AL, Fernandez-del Castillo C. Trypsin and activation of circulating trypsinogen contribute to pancreatitis-associated lung injury. Am J Physiol 1999;277:G1008-G1016.
5. DiMagno EP, Chari S. Acute pancreatitis. In: Feldman M, Friedman LS, Sleisenger MH, eds. Sleisenger & Fordtran's gastrointestinal and liver disease: pathophysiology, diagnosis, management. (7th ed). Philadelphia: Saunders, 2002:913-941.
6. Cocks TM, Moffatt JD. Protease-activated receptors: sentries for inflammation? Trends Pharmacol Sci 2000;21:103-108.
7. Bohm SK, Kong W, Bromme D, Smeekens SP, Anderson DC, Connolly A, Kahn M, Nelken NA, Coughlin SR, Payan DG, Bunnett NW. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem J 1996;314: 1009-1016.
8. Vergnolle N. Review article: proteinase-activated receptors-novel signals for gastrointestinal pathophysiology. Aliment Pharmacol Ther 2000;14:257-266.
9. Fiorucci S, Distrutti E. Role of PAR2 in pain and inflammation. Trends Pharmacol Sci 2002;23:153-155.
10. Al-Ani B, Saifeddine M, Hollenberg MD. Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Can J Physiol Pharmacol 1995;73:1203-1207.
11. Schmidlin F, Amadesi S, Vidil R, Trevisani M, Martinet N, Caughey G, Tognetto M, Cavallesco G, Mapp C, Geppetti P, Bunnett NW. Expression and function of proteinase-activated receptor 2 in human bronchial smooth muscle. Am J Respir Crit Care Med 2001;164:1276-1281.
12. Lindner JR, Kahn ML, Coughlin SR, Sambrano GR, Schauble E, Bernstein D, Foy D, Hafezi-Moghadam A, Ley K. Delayed onset of inflammation in protease-activated receptor-2-deficient mice. J Immunol 2000;165:6504-6510.
13. Steinhoff M, Vergnolle N, Young SH, Tognetto M, Amadesi S, Ennes HS, Trevisani M, Hollenberg MD, Wallace JL, Caughey GH, Mitchell SE, Williams LM, Geppetti P, Mayer EA, Bunnett NW. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med 2000;6:151-158.
14. Howells GL, Macey MG, Chinni C, Hou L, Fox MT, Harriott P, Stone SR. Proteinase-activated receptor-2: expression by human neutrophils. J Cell Sci 1997;110:881-887.
15. Cocks TM, Fong B, Chow JM, Anderson GP, Frauman AG, Goldie RG, Henry PJ, Carr MJ, Hamilton JR, Moffatt JD. A protective role for protease-activated receptors in the airways. Nature 1999; 398:156-160.
16. Fiorucci S, Mencarelli A, Palazzetti B, Distrutti E, Vergnolle N, Hollenberg MD, Wallace JL, Morelli A, Cirino G. Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc Natl Acad Sci U S A 2001;98:13936-13941.
17. 2+ influx. J Biol Chem 1994;269:12645-12653.
18. 2+-dependent cell death in rat pancreatic acinar cells. Gastroenterology 2002;122:1941-1953.
19. - transport in pancreatic duct cells. J Biol Chem 2003;278:200-207.
20. Kim KH, Lee MG, Kim DG. The cholecystokinin receptor antagonist L-364, 718 reduces taurocholate-induced pancreatitis in rats. Int J Pancreatol 1996;20:205-211.
21. Steven FS, Griffin MM. Studies on the molecular mechanism of mersalyl and 4-aminophenylmercuric acetate re-activation of trypsin-thiol complexes. Eur J Biochem 1980;109:567-573.
22. Kawabata A, Nishikawa H, Kuroda R, Kawai K, Hollenberg MD. Proteinase-activated receptor-2 (PAR-2): regulation of salivary and pancreatic exocrine secretion in vivo in rats and mice. Br J Pharmacol 2000;129:1808-1814.
23. Williams JA, Sans MD, Tashiro M, Schafer C, Bragado MJ, Dabrowski A. Cholecystokinin activates a variety of intracellular signal transduction mechanisms in rodent pancreatic acinar cells. Pharmacol Toxicol 2002;91:297-303.
24. Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002;298:1911-1912.
25. Saluja AK, Bhagat L, Lee HS, Bhatia M, Frossard JL, Steer ML. Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini. Am J Physiol 1999;276:G835-G842.
26. Nguyen TD, Moody MW, Steinhoff M, Okolo C, Koh DS, Bunnett NW. Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2. J Clin Invest 1999;103: 261-269.
27. Olejar T, Matej R, Zadinova M, Pouckova P. Expression of proteinase-activated receptor 2 during taurocholate-induced acute pancreatic lesion development in Wistar rats. Int J Gastrointest Cancer 2001;30:113-121.
28. Johansen PG, Anderson CM, Hadorn B. Cystic fibrosis of the pancreas. A generalised disturbance of water and electrolyte movement in exocrine tissues. Lancet 1968;1:455-460.
29. - exchange in mouse submandibular and pancreatic ducts. J Biol Chem 1999;274:14670-14677.
30. - salvage across the luminal membrane of the main pancreatic duct. J Clin Invest 2000;105:1651-1658.
31. - salvage mechanisms in model systems and the mouse pancreatic duct. J Biol Chem 2001;276:17236-17243.
32. - transport in cystic fibrosis. EMBO J 2002;21:5662-5672.
33. Rinderknecht H. Pancreatic secretory enzymes. In: Go VLW, Gardner JD, Brooks FP, Lebenthal E, DiMagno EP, Scheele GA. ed. The exocrine pancreas: biology, pathobiology, and diseases. New York: Raven, 1986:163-183.
34. Liu R, Aupperle K, Terkeltaub R. Src family protein tyrosine kinase signaling mediates monosodium urate crystal-induced IL-8 expression by monocytic THP-1 cells. J Leukoc Biol 2001;70:961-968.
35. Donnelly SC, Strieter RM, Kunkel SL, Walz A, Robertson CR, Carter DC, Grant IS, Pollok AJ, Haslett C. Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups. Lancet 1993;341:643-647.
36. Zhao X, Andersson R, Wang X, Dib M, Wang X. Acute pancreatitis-associated lung injury: pathophysiological mechanisms and potential future therapies. Scand J Gastroenterol 2002;37:1351-1358.
37. Possel H, Noack H, Augustin W, Keilhoff G, Wolf G. 2,7-Dihydrodichlorofluorescein diacetate as a fluorescent marker for peroxynitrite formation. FEBS Lett 1997;416:175-178.
38. DeFea KA, Zalevsky J, Thoma MS, Dery O, Mullins RD, Bunnett NW. β-Arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol 2000;148:1267-1281.
39. Argent BE, Case RM. Pancreatic ducts: cellular mechanism and control of bicarbonate secretion. In: Johnson LR, Alpers DH, Christensen J, Jacobson E. ed. Physiology of the gastrointestinal tract. (3rd ed), New York: Raven, 1994:1473-1497.
40. Warshaw AL. Damage prevention versus damage control in acute pancreatitis. Gastroenterology 1993;104:1216-1219.
41. Yoshida T. Gabexate mesilate in human acute pancreatitis. Gastroenterology 1993;105:1922-1923.
42. Pederzoli P, Cavallini G, Falconi M, Bassi C. Gabexate mesilate vs aprotinin in human acute pancreatitis (GA.ME.P.A.). A prospective, randomized, double-blind multicenter study. Int J Pancreatol 1993;14:117-124.
43. Büchler M, Malfertheiner P, Uhl W, Schölmerich J, Stöckmann F, Adler G, Gaus W, Rolle K, Beger HG. Gabexate mesilate in human acute pancreatitis. German Pancreatitis Study Group. Gastroenterology 1993;104:1165-1170.
44. Vergnolle N, Bunnett NW, Sharkey KA, Brussee V, Compton SJ, Grady EF, Cirino G, Gerard N, Basbaum AI, Andrade-Gordon P, Hollenberg MD, Wallace JL. Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway. Nat Med 2001;7:821-826.
45. Bhatia M, Saluja AK, Hofbauer B, Frossard JL, Lee HS, Castagliuolo I, Wang CC, Gerard N, Pothoulakis C, Steer ML. Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury. Proc Natl Acad Sci U S A 1998;95:4760-4765.
46. Bhatia M, Slavin J, Cao Y, Basbaum Al, Neoptolemos JP. Preprotachykinin-A gene deletion protects mice against acute pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol 2003;284:G830-G836.