Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether and their major metabolites dihydroartemisinin and dihydroartemisinin-glucuronide in sheep plasma

Journal of Mass Spectrometry

Volumn 46, Issue 2, 2011, Pages 172-181

  Duthaler, Urs ^a,b   Keiser, Jennifer ^a,b   Huwyler, Jörg ^b  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

artemisinins; fascioliasis; glucuronide; liquid chromatography tandem mass spectrometry; metabolites

Indexed keywords

AMMONIUM FORMATE; ANALYTES; ANALYTICAL COLUMNS; ARTEMISININS; ARTESUNATE; ATLANTIS; AUTOSAMPLERS; DIHYDROARTEMISININ; ELECTROSPRAYS; FASCIOLIASIS; GLUCURONIDE; GLUCURONIDES; INTRA-DAY ACCURACY; IONISATION; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMIT OF QUANTIFICATIONS; MOBILE PHASE; PHARMACOKINETIC PARAMETERS; POSITIVE MODE; PROTEIN PRECIPITATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SELECTED REACTION MONITORING; TANDEM MASS SPECTROMETRY; VALIDATION RESULTS;

ACETONITRILE; AMMONIUM COMPOUNDS; BIOMOLECULES; CHEMICAL ANALYSIS; COLUMN CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; ION CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES; METHANOL; PLASMAS; WOOL;

LIQUIDS;

ACETONITRILE; AMMONIUM FORMATE; ARTEMETHER; ARTESUNATE; DIHYDROARTEMISININ; DIHYDROARTEMISININ 12 ALPHA 2 BETA DEXTRO GLUCURONIDE; GLUCURONIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG BLOOD LEVEL; ELECTROSPRAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SHEEP; TANDEM MASS SPECTROMETRY;

ANIMALS; ARTEMISININS; CALIBRATION; CHROMATOGRAPHY, LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; GLUCURONIDES; LOGISTIC MODELS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SHEEP; TANDEM MASS SPECTROMETRY;

ARTESUNATE; OVIS ARIES; RATTUS;

EID: 79951680096     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1883     Document Type: Article

References (34)

1. N. J. White,. Qinghaosu (artemisinin): the price of success. Science 2008, 320, 330.
2. S. K. Mishra, S. Mohanty, A. Mohanty, B. S. Das,. Management of severe and complicated malaria. J. Postgrad. Med. 2006, 52, 281.
3. J. L. Maggs, S. Madden, L. P. Bishop, P. M. O'Neill, B. K. Park,. The rat biliary metabolites of dihydroartemisinin, an antimalarial endoperoxide. Drug Metab. Dispos. 1997, 25, 1200.
4. K. Ramu, J. K. Baker,. Synthesis, characterization, and antimalarial activity of the glucuronides of the hydroxylated metabolites of arteether. J. Med. Chem. 1995, 38, 1911.
5. J. Keiser, S. H. Xiao, M. Tanner, J. Utzinger,. Artesunate and artemether are effective fasciolicides in the rat model and in vitro. J. Antimicrob. Chemother. 2006, 57, 1139.
6. J. Keiser, J. Utzinger,. Food-borne trematodiases. Clin. Microbiol. Rev. 2009, 22, 466.
7. M. W. Robinson, J. P. Dalton,. Zoonotic helminth infections with particular emphasis on fasciolosis and other trematodiases. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2009, 364, 2763.
8. I. Fairweather, J. C. Boray,. Fasciolicides: efficacy, actions, resistance and its management. Vet. J. 1999, 158, 81.
9. J. Keiser, J. Utzinger, J. L. Vennerstrom, Y. Dong, G. Brennan, I. Fairweather,. Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica. Trans. R. Soc. Trop. Med. Hyg. 2007, 101, 1219.
10. M. Rajanikanth, K. P. Madhusudanan, R. C. Gupta,. An HPLC-MS method for simultaneous estimation of alpha,beta-arteether and its metabolite dihydroartemisinin, in rat plasma for application to pharmacokinetic study. Biomed. Chromatogr. 2003, 17, 440.
11. M. Rajanikanth, K. P. Madhusudanan, R. C. Gupta,. Liquid chromatographic-mass spectrometric method for the determination of alpha-,beta-arteether in rat serum. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2003, 783, 391.
12. C. Souppart, N. Gauducheau, N. Sandrenan, F. Richard,. Development and validation of a high-performance liquid chromatography-mass spectrometry assay for the determination of artemether and its metabolite dihydroartemisinin in human plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2002, 774, 195.
13. Y. Gu, Q. Li, V. Melendez, P. Weina,. Comparison of HPLC with electrochemical detection and LC-MS/MS for the separation and validation of artesunate and dihydroartemisinin in animal and human plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2008, 867, 213.
14. W. Hanpithakpong, B. Kamanikom, A. M. Dondorp, P. Singhasivanon, N. J. White, N. P. Day, N. Lindegardh,. A liquid chromatographic-tandem mass spectrometric method for determination of artesunate and its metabolite dihydroartemisinin in human plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2008, 876, 61.
15. S. A. Van Quekelberghe, S. A. Soomro, J. A. Cordonnier, F. H. Jansen,. Optimization of an LC-MS method for the determination of artesunate and dihydroartemisinin plasma levels using liquid-liquid extraction. J. Anal. Toxicol. 2008, 32, 133.
16. H. Naik, D. J. Murry, L. E. Kirsch, L. Fleckenstein,. Development and validation of a high-performance liquid chromatography-mass spectroscopy assay for determination of artesunate and dihydroartemisinin in human plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2005, 816, 233.
17. C. S. Lai, N. K. Nair, S. M. Mansor, P. L. Olliaro, V. Navaratnam,. An analytical method with a single extraction procedure and two separate high performance liquid chromatographic systems for the determination of artesunate, dihydroartemisinin and mefloquine in human plasma for application in clinical pharmacological studies of the drug combination. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2007, 857, 308.
18. C. S. Lai, N. K. Nair, A. Muniandy, S. M. Mansor, P. L. Olliaro, V. Navaratnam,. Validation of high performance liquid chromatography- electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in clinical pharmacological studies of artesunate-amodiaquine drug combination. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2009, 877, 558.
19. E. M. Hodel, B. Zanolari, T. Mercier, J. Biollaz, J. Keiser, P. Olliaro, B. Genton, L. A. Decosterd,. A single LC-tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2009, 877, 867.
20. I. C. Cesar, J. A. de Aquino Ribeiro, L. de Souza Teixeira, K. B. Bellorio, F. C. de Abreu, J. M. Moreira, P. R. Chellini, G. A. Pianetti,. Liquid chromatography-tandem mass spectrometry for the simultaneous quantitation of artemether and lumefantrine in human plasma: application for a pharmacokinetic study. J. Pharm. Biomed. Anal. 2011, 54, 114.
21. J. Keiser, L. Rinaldi, V. Veneziano, L. Mezzino, M. Tanner, J. Utzinger, G. Cringoli,. Efficacy and safety of artemether against a natural Fasciola hepatica infection in sheep. Parasitol. Res. 2008, 103, 517.
22. J. Keiser, V. Veneziano, L. Rinaldi, L. Mezzino, U. Duthaler, G. Cringoli,. Anthelmintic activity of artesunate against Fasciola hepatica in naturally infected sheep. Res. Vet. Sci. 2010, 88, 107.
23. K. F. Ilett, B. T. Ethell, J. L. Maggs, T. M. Davis, K. T. Batty, B. Burchell, T. Q. Binh, T. A. Thu le, N. C. Hung, M. Pirmohamed, B. K. Park, G. Edwards,. Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases. Drug Metab. Dispos. 2002, 30, 1005.
24. K. Ramu, J. K. Baker,. Identification of the glucuronides of the hydroxylated metabolites of the antimalarial arteether in rat plasma and urine by thermospray high-performance liquid chromatography/mass spectrometry. J. Pharm. Sci. 1997, 86, 915.
25. J. Keiser, M. S. Gruyer, N. Perrottet, B. Zanolari, T. Mercier, L. Decosterd,. Pharmacokinetic parameters of artesunate and dihydroartemisinin in rats infected with Fasciola hepatica. J. Antimicrob. Chemother. 2009, 63, 543.
26. B. P. Imbimbo, E. Imbimbo, S. Daniotti, D. Verotta, G. Bassotti,. A new criterion for selection of pharmacokinetic multiexponential equations. J. Pharm. Sci. 1988, 77, 784.
27. US Department of Health and Human Services. FDA guidance for industry bioanalytical method validation, US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Center for Veterinary Medicine: 2001.
28. J. Keiser, C. Kirchhofer, M. Haschke, J. Huwyler, Y. Dong, J. L. Vennerstrom, K. Vanhoff, R. Kaminsky, N. Malikides,. Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep. Vet. Parasitol. 2010, 173, 228.
29. S. Fekete, J. Fekete, K. Ganzler,. Characterization of new types of stationary phases for fast liquid chromatographic applications. J. Pharm. Biomed. Anal. 2009, 50, 703.
30. G. Hopfgartner, C. Husser, M. Zell,. High-throughput quantification of drugs and their metabolites in biosamples by LC-MS/MS and CE-MS/MS: possibilities and limitations. Ther. Drug. Monit. 2002, 24, 134.
31. J. Xing, H. Yan, S. Zhang, G. Ren, Y. Gao,. A high-performance liquid chromatography/tandem mass spectrometry method for the determination of artemisinin in rat plasma. Rapid Commun. Mass Spectrom. 2006, 20, 1463.
32. A. Cappiello, G. Famiglini, P. Palma, E. Pierini, V. Termopoli, H. Trufelli,. Overcoming matrix effects in liquid chromatography-mass spectrometry. Anal. Chem. 2008, 80, 9343.
33. N. Lindegardh, W. Hanpithakpong, B. Kamanikom, P. Singhasivanon, D. Socheat, P. Yi, A. M. Dondorp, R. McGready, F. Nosten, N. J. White, N. P. Day,. Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2008, 876, 54.
34. C. L. French, S. S. Yaun, L. A. Baldwin, D. A. Leonard, X. Q. Zhao, E. J. Calabrese,. Potency ranking of methemoglobin-forming agents. J. Appl. Toxicol. 1995, 15, 167.