Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep

Veterinary Parasitology

Volumn 173, Issue 3-4, 2010, Pages 228-235

  Keiser, Jennifer ^a,b   Kirchhofer, Carla ^a,b   Haschke, Manuel ^c   Huwyler, Jörg ^d   Dong, Yuxiang ^e   Vennerstrom, Jonathan L ^e   Vanhoff, Kathleen ^f   Kaminsky, Ronald ^g   Malikides, Nick ^f  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d UNIVERSITY OF APPLIED SCIENCES AND ARTS NORTHWESTERN SWITZERLAND   (Switzerland)

^e UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^f Yarrandoo Rand Centre   (Australia)

^g Novartis Centre de Recherche Samté Animale SA   (Switzerland)

Author keywords

1,2,4 Trioxolane; Egg count; Experimental infection; Fasciola hepatica; Fascioliasis; Lamb; LC MS; OZ78; Ozonide; Pharmacokinetics; Safety; Sheep; Worm burden

Indexed keywords

1,2,4 TRIOXOLONE; ANTHELMINTIC AGENT; OZ 78; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD CLOTTING DISORDER; BLOOD TOXICITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG ELIMINATION; DRUG MONITORING; DRUG SAFETY; DRUG STRUCTURE; DRUG TOLERABILITY; FASCIOLIASIS; FECES ANALYSIS; HALF LIFE TIME; INJECTION SITE SWELLING; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; SHEEP; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALIA; FASCIOLA HEPATICA; MAMMALIA; OVIS ARIES; RATTUS; RODENTIA;

EID: 77956230893     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetpar.2010.06.031     Document Type: Article

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