Bile acid retention and activation of endogenous hepatic farnesoid-X-receptor in the pathogenesis of fatty liver disease in ob/ob-mice

Biological Chemistry

Volumn 391, Issue 12, 2010, Pages 1441-1449

  Martin, Ina V ^a,b,d   Schmitt, Johannes ^b   Minkenberg, Alexander ^a   Mertens, Joachim C ^b   Stieger, Bruno ^b,c   Mullhaupt, Beat ^b   Geier, Andreas ^a,b,c  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Bile acid transporters; Cholestasis; FXR; Nonalcoholic fatty liver disease; Nuclear receptors; Ob ob mouse

Indexed keywords

BILE ACID; CELL NUCLEUS RECEPTOR; FARNESOID X RECEPTOR; FATTY ACID SYNTHASE; MESSENGER RNA; ORGANIC ANION TRANSPORTER; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID BLOOD LEVEL; CHOLESTASIS; CONTROLLED STUDY; DNA BINDING; ELECTROPHORETIC MOBILITY; ENZYME ACTIVATION; FATTY LIVER; GENE EXPRESSION; GENE TARGETING; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; GENETICS; METABOLISM; MOUSE MUTANT; UPREGULATION;

ANIMALIA; MUS; RODENTIA;

ANIMALS; BILE ACIDS AND SALTS; FATTY LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; UP-REGULATION;

EID: 79951669043     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2010.141     Document Type: Article

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