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Volumn 27, Issue 2, 2011, Pages 139-148

Regulation of serotonin transport in human platelets by tyrosine kinase syk

Author keywords

Human platelets; Serotonin transport; Syk tyrosine kinase

Indexed keywords

IMIPRAMINE; MEMBRANE PROTEIN; MONENSIN; PICEATANNOL; PROTEIN KINASE SYK; PROTEIN SERT; PROTEIN TYROSINE KINASE; SEROTONIN; UNCLASSIFIED DRUG;

EID: 79951609888     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000325216     Document Type: Article
Times cited : (15)

References (60)
  • 1
    • 0026515597 scopus 로고
    • Structure and function of the brain serotonin system
    • Jacobs BL, Amzitia EC: Structure and function of the brain serotonin system. Physiol Rev 1992;72:165-229.
    • (1992) Physiol Rev , vol.72 , pp. 165-229
    • Jacobs, B.L.1    Amzitia, E.C.2
  • 2
    • 34548720405 scopus 로고    scopus 로고
    • Serotonin
    • Segel G, Albers RW, Brady S, Price D (eds) seventh ed., Elsevier Academic Press, Burlington, M.A.
    • Hensler JG: Serotonin, in Segel G, Albers RW, Brady S, Price D (eds): Basic Neurochemistry. Molecular, cellular and medical aspects, seventh ed., Elsevier Academic Press, Burlington, MA, 2006, pp 227-248.
    • (2006) Basic Neurochemistry. Molecular, Cellular and Medical Aspects , pp. 227-248
    • Hensler, J.G.1
  • 3
    • 33846347644 scopus 로고    scopus 로고
    • The serotonin signaling system: from basic understanding to drug development for functional GI disorders
    • DOI 10.1053/j.gastro.2006.11.002, PII S001650850602436X
    • Gershon MD, Tack J: The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterol 2007;132:397-414. (Pubitemid 46127672)
    • (2007) Gastroenterology , vol.132 , Issue.1 , pp. 397-414
    • Gershon, M.D.1    Tack, J.2
  • 4
    • 79951604811 scopus 로고    scopus 로고
    • Antidepressant effect on neurotransmitters
    • Kasper S den Boer JA Ad Sitsen J (eds) second ed. Taylor & Francis Publ., London
    • Leonard BE: Antidepressant effect on neurotransmitters, in Kasper S, den Boer JA, Ad Sitsen J (eds): Handbook of depression and anxiety, second ed., Taylor & Francis Publ., London, 2007, pp 560-582.
    • (2007) Handbook of Depression and Anxiety , pp. 560-582
    • Leonard, B.E.1
  • 5
    • 65049083026 scopus 로고    scopus 로고
    • 5-HT(1A) receptor function in major depressive disorders
    • Savitz J, Lucki I, Drevets WC: 5-HT(1A) receptor function in major depressive disorders. Progr Neurobiol 2009;88:17-31.
    • (2009) Progr Neurobiol , vol.88 , pp. 17-31
    • Savitz, J.1    Lucki, I.2    Drevets, W.C.3
  • 7
    • 0027212698 scopus 로고
    • Primary structure of the human platelet serotonin uptake site: Identity with the brain serotonin transporter
    • Lesch KP, Wolozin BL, Murphy DL, Reiderer P: Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J Neurochem 1993;160:2319-2322. (Pubitemid 23148809)
    • (1993) Journal of Neurochemistry , vol.60 , Issue.6 , pp. 2319-2322
    • Lesch, K.-P.1    Wolozin, B.L.2    Murphy, D.L.3    Riederer, P.4
  • 10
    • 0030972751 scopus 로고    scopus 로고
    • Protein kinase C-mediated phosphorylation and functional regulation of dopamine transporters in striatal synaptosomes
    • DOI 10.1074/jbc.272.24.15541
    • Aughan RA, Huff RA, Uhl GR, Kuhar MJ: Protein kinase C-mediated phosphorylation and functional regulation of dopamine transporters in striatal synaptosomes. J Biol Chem 1997:272:15541-15546. (Pubitemid 27255584)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.24 , pp. 15541-15546
    • Vaughan, R.A.1    Huff, R.A.2    Uhl, G.R.3    Kuhar, M.J.4
  • 11
    • 0031915461 scopus 로고    scopus 로고
    • Phosphorylation and regulation of antidepressant-sensitive serotonin transporters
    • DOI 10.1074/jbc.273.4.2458
    • Ramamoorthy S, Giovanetti E, Qian Y, Blakely RD: Phosphorylation and regulation of antidepressant-sensitive serotonin transporters. J Biol Chem 1998:273:2458-2466. (Pubitemid 28069306)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.4 , pp. 2458-2466
    • Ramamoorthy, S.1    Giovanetti, E.2    Qian, Y.3    Blakely, R.D.4
  • 12
    • 21744442114 scopus 로고    scopus 로고
    • Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation
    • DOI 10.1124/mol.104.009555
    • Jayanthi LD, Samuvel DJ, Blakely RD, Ramamoorthy S: Evidence for biphasic effect of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation. Molec Pharmacol 2005;67:2077-2087. (Pubitemid 41007790)
    • (2005) Molecular Pharmacology , vol.67 , Issue.6 , pp. 2077-2087
    • Jayanthi, L.D.1    Samuvel, D.J.2    Blakely, R.D.3    Ramamoorthy, S.4
  • 13
    • 34249678451 scopus 로고    scopus 로고
    • Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP
    • DOI 10.1074/jbc.M611353200
    • Ramamoorthy S, Samuvel DJ, Buck ER, Rudnick G, Jayanthi LD: Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP. J Biol Chem 2007;282:11639-11647. (Pubitemid 47100698)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.16 , pp. 11639-11647
    • Ramamoorthy, S.1    Samuvel, D.J.2    Buck, E.R.3    Rudnick, G.4    Jayanthi, L.D.5
  • 14
    • 0026433037 scopus 로고
    • Expression cloning of a cocaine-and antidepressant-sensitive human noradrenaline transporter
    • Pacholczyk T, Blakely RD, Amara SG: Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature 1991;350:350-354. (Pubitemid 21912229)
    • (1991) Nature , vol.350 , Issue.6316 , pp. 350-354
    • Pacholczyk, T.1    Blakely, R.D.2    Amara, S.G.3
  • 15
    • 0032524637 scopus 로고    scopus 로고
    • Determination of external loop topology in the serotonin transporter by site-directed chemical labeling
    • DOI 10.1074/jbc.273.20.12675
    • Chen JG, Liu-Chen S, Rudnick G: Determination of external loop topology in the serotonin transporter by site-directed chemical labeling. J Biol Chem 1998;273:12675-12681. (Pubitemid 28240647)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.20 , pp. 12675-12681
    • Chen, J.-G.1    Liu-Chen, S.2    Rudnick, G.3
  • 16
    • 0036812497 scopus 로고    scopus 로고
    • Accessibility and conformational coupling in serotonin transporter predicted internal domains
    • Androutsellis-Theotokis A, Rudnick G: Accessibility and conformational coupling in serotonin transporter predicted internal domains. J Neurosci 2002;22:8370-8378. (Pubitemid 35387577)
    • (2002) Journal of Neuroscience , vol.22 , Issue.19 , pp. 8370-8378
    • Androutsellis-Theotokis, A.1    Rudnick, G.2
  • 17
    • 0027960964 scopus 로고
    • - -dependent serotonin transporter expressed using recombinant baculovirus in insect cells
    • - -dependent serotonin transporter expressed using recombinant baculovirus in insect cells. J Biol Chem 1994;269:26303-26310.
    • (1994) J Biol Chem , vol.269 , pp. 26303-26310
    • Tate, C.1    Blakely, R.2
  • 18
    • 0026637542 scopus 로고
    • P-Chloroamphetamine induces serotonin release through serotonin transporters
    • Rudnick G, Wall SC: p-Chloroamphetamine induces serotonin release through serotonin transporters. Biochemistry 1992;31:6710-6718.
    • (1992) Biochemistry , vol.31 , pp. 6710-6718
    • Rudnick, G.1    Wall, S.C.2
  • 19
    • 26944489620 scopus 로고    scopus 로고
    • Serotonin-transporter mediated efflux: A pharmacological analysis of amphetamines and non-amphetamines
    • DOI 10.1016/j.neuropharm.2005.08.008, PII S002839080500314X, New Perspectives in Neurotransmitter Transporter Biology
    • Hilber B, Scholze P, Dorostkar MM, Sandtner W, Holy M, Boehm S, Singer EA, Sitte HH: Serotonin-transporter mediated efflux: a pharmacological analysis of amphetamins and non-amphetamines. Neuropharmacol 2005;49:811-819. (Pubitemid 41483887)
    • (2005) Neuropharmacology , vol.49 , Issue.6 , pp. 811-819
    • Hilber, B.1    Scholze, P.2    Dorostkar, M.M.3    Sandtner, W.4    Holy, M.5    Boehm, S.6    Singer, E.A.7    Sitte, H.H.8
  • 20
    • 0017671115 scopus 로고
    • + gradients by ionophores (nigericin, monensin) on serotonin transport in human blood platelets
    • + gradients by ionophores (nigericin, monensin) on serotonin transport in human blood platelets. Biochim Biophys Acta 1977;468:284-295. (Pubitemid 8180759)
    • (1977) Biochimica et Biophysica Acta , vol.468 , Issue.2 , pp. 284-295
    • Feinstein, M.B.1    Henderson, E.G.2    Sha'afi, R.I.3
  • 21
    • 0027428320 scopus 로고
    • Carrier-mediated release of neurotransmitters
    • DOI 10.1016/0166-2236(93)90010-J
    • Levi G, Raiteri M: Carrier-mediated release of neurotransmitters. Trends Neurosci 1993;16:415-419. (Pubitemid 23283403)
    • (1993) Trends in Neurosciences , vol.16 , Issue.10 , pp. 415-419
    • Levi, G.1    Raiteri, M.2
  • 22
    • 0035037523 scopus 로고    scopus 로고
    • Quantitative analysis of inward and outward transport rates in cells stably expressing the cloned human serotonin transporter: Inconsistencies with the hypothesis of facilitated exchange diffusion
    • Sitte HH, Hiptmair B, Zwach J, Pifl C, Singer EA, Scholze P: Quantitative analysis of inward and outward transport rates in cells stably expressing the cloned human serotonin transporter: inconsistencies with the hypothesis of facilitated exchange diffusion. Mol Pharmacol 2001;59:1129-1137. (Pubitemid 32381593)
    • (2001) Molecular Pharmacology , vol.59 , Issue.5 , pp. 1129-1137
    • Sitte, H.H.1    Hiptmair, B.2    Zwach, J.3    Pifl, C.4    Singer, E.A.5    Scholze, P.6
  • 24
  • 25
    • 33746671852 scopus 로고    scopus 로고
    • The Syk tyrosine kinase: A new negative regulator in tumor growth and progression
    • DOI 10.1016/j.canlet.2005.11.004, PII S0304383505009869
    • Coopman PJ, Mueller SC: The Syk tyrosine kinase a new negative regulator in tumour growth and progression. Cancer Lett 2006;241:159-173. (Pubitemid 44163045)
    • (2006) Cancer Letters , vol.241 , Issue.2 , pp. 159-173
    • Coopman, P.J.1    Mueller, S.C.2
  • 26
    • 75749123824 scopus 로고    scopus 로고
    • Spleen tyrosine kinase: An Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases
    • Ghosh D, Tsokos GC: Spleen tyrosine kinase: an Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases. Autoimmunity 2010;43:48-55.
    • (2010) Autoimmunity , vol.43 , pp. 48-55
    • Ghosh, D.1    Tsokos, G.C.2
  • 31
    • 77949308494 scopus 로고    scopus 로고
    • RGD-ligand mimetic antagonists of integrin alphaIIbbeta3 paradoxically enhance GPVI-induced human platelet activation
    • Jones ML, Harper MT, Aitken EW, Williams CM, Poole AW: RGD-ligand mimetic antagonists of integrin alphaIIbbeta3 paradoxically enhance GPVI-induced human platelet activation. J Thromb Haemost 2010;8:567-576.
    • (2010) J Thromb Haemost , vol.8 , pp. 567-576
    • Jones, M.L.1    Harper, M.T.2    Aitken, E.W.3    Williams, C.M.4    Poole, A.W.5
  • 33
    • 0036065265 scopus 로고    scopus 로고
    • 2+ and protein kinase C in the serotonin (5-HT) transport in human platelets
    • DOI 10.1016/S0143-4160(02)00052-0
    • Turetta L, Bazzan E, Bertagno K, Musacchio E, Deana R: Role of Ca(2+) and protein kinase C in the serotonin (5-HT) transport in human platelets. Cell Calcium 2002;31:235-244. (Pubitemid 34778059)
    • (2002) Cell Calcium , vol.31 , Issue.5 , pp. 235-244
    • Turetta, L.1    Bazzan, E.2    Bertagno, K.3    Musacchio, E.4    Deana, R.5
  • 34
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantitites of protein utilizing the principle of protein-dye binding
    • Bradford MM: A rapid and sensitive method for the quantitation of microgram quantitites of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 35
    • 38349183667 scopus 로고    scopus 로고
    • Serotonin (5-HT) transport in human platelets is modulated by Src-catalysed Tyr-phosphorylation of the plasma membrane transporter SERT
    • Zarpellon A, Donella-Deana A, Folda A, Turetta L, Pavanetto M, Deana R: Serotonin (5-HT) transport in human platelets is modulated by Src-catalysed Tyr-phosphorylation of the plasma membrane transporter SERT. Cell Physiol Biochem 2008;21:87-94.
    • (2008) Cell Physiol Biochem , vol.21 , pp. 87-94
    • Zarpellon, A.1    Donella-Deana, A.2    Folda, A.3    Turetta, L.4    Pavanetto, M.5    Deana, R.6
  • 36
    • 0037392942 scopus 로고    scopus 로고
    • The specificities of protein kinase inhibitors: An update
    • DOI 10.1042/BJ20021535
    • Bain J, McLauchlan H, Elliott M, Cohen P: The specificities of protein kinase inhibitors: an update. Biochem J 2003;371:199-204. (Pubitemid 36458094)
    • (2003) Biochemical Journal , vol.371 , Issue.1 , pp. 199-204
    • Bain, J.1    McLauchlan, H.2    Elliott, M.3    Cohen, P.4
  • 37
    • 38349159571 scopus 로고    scopus 로고
    • Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2,3-dihydro-1H- indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets
    • Bhavaraju K, Kim S, Daniel JL, Kunapuli SP: Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets. Eur J Pharmacol 2008;580:285-290.
    • (2008) Eur J Pharmacol , vol.580 , pp. 285-290
    • Bhavaraju, K.1    Kim, S.2    Daniel, J.L.3    Kunapuli, S.P.4
  • 38
    • 0019958952 scopus 로고
    • Storage of biogenic amines in intact blood platelets of man Dependence on proton gradient
    • Affolter H, Pletscher A: Storage of biogenic amines in intact blood platelets of man. Dependence on proton gradient. Molec Pharmacol 1988;22:94-98.
    • (1988) Molec Pharmacol , vol.22 , pp. 94-98
    • Affolter, H.1    Pletscher, A.2
  • 42
    • 0031631358 scopus 로고    scopus 로고
    • Co-immuno-precipitation: Identification of interacting proteins
    • Clegg RA, (ed) Humana Press, Totowa NJ
    • Anderson NG: Co-immuno-precipitation: identification of interacting proteins, in: Clegg RA, (ed): Methods in Molecular Biology. Humana Press, Totowa NJ, 1998, vol. 88, pp 35-45.
    • (1998) Methods in Molecular Biology , vol.88 , pp. 35-45
    • Anderson, N.G.1
  • 43
    • 0036484302 scopus 로고    scopus 로고
    • Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation
    • Negro A, Brunati AM, Donella-Deana A, Massimino ML, Pinna LA: Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation. FASEB J 2002;16:210-212.
    • (2002) FASEB J , vol.16 , pp. 210-212
    • Negro, A.1    Brunati, A.M.2    Donella-Deana, A.3    Massimino, M.L.4    Pinna, L.A.5
  • 45
    • 0036323094 scopus 로고    scopus 로고
    • Initial serotonin transport into viable platelets and imipramine binding to platelet membranes
    • DOI 10.1007/s007020200045
    • Rao ML, Frahnert C, Zagorski O: Initial serotonin transport into viable platelets and imipramine binding to platelet membranes. J Neural Transm 2002;109:547-556. (Pubitemid 34810755)
    • (2002) Journal of Neural Transmission , vol.109 , Issue.5-6 , pp. 547-556
    • Rao, M.L.1    Frahnert, C.2    Zagorski, O.3
  • 46
    • 0026497543 scopus 로고
    • Activators of protein kinase C decrease serotonin transport in human platelets
    • Anderson GM, Horne WC: Activators of protein kinase C decrease serotonin transport in human platelets. Biochim Biophys Acta 1992;1137:331-337.
    • (1992) Biochim Biophys Acta , vol.1137 , pp. 331-337
    • Anderson, G.M.1    Horne, W.C.2
  • 47
    • 0030952538 scopus 로고    scopus 로고
    • Modulation of serotonin transporter activity by a protein kinase C activator and an inhibitor of type 1 and 2A serine/threonine phosphatases
    • Sakai N, Sasaki K, Nakashita M, Honda S, Ikegaki N, Saito N: Modulation of serotonin transporter activity by a protein kinase C activator and an inhibitor of type 1 and 2A serine/ threonine phosphatases. J Neurochem 1997;68:2618-2624. (Pubitemid 27218187)
    • (1997) Journal of Neurochemistry , vol.68 , Issue.6 , pp. 2618-2624
    • Sakai, N.1    Sasaki, K.2    Nakashita, M.3    Honda, S.4    Ikegaki, N.5    Saito, N.6
  • 48
    • 33747698421 scopus 로고    scopus 로고
    • Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter
    • DOI 10.1074/jbc.M603877200
    • Carneiro AM, Blakely RD: Serotonin, protein kinase C and HIC-5 associated redistribution of the platelet serotonin transporter. J Biol Chem 2006;281:24769-24780. (Pubitemid 44274251)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.34 , pp. 24769-24780
    • Carneiro, A.M.D.1    Blakely, R.D.2
  • 49
    • 12144279565 scopus 로고    scopus 로고
    • A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: Evidence for distinct cellular mechanisms involved in transporter surface expression
    • DOI 10.1523/JNEUROSCI.3754-04.2005
    • Samuvel DJ, Jayanthi LD, Bhat NR, Ramamoorthy SA: A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression. J Neurosci 2005;25:29-41. (Pubitemid 40110763)
    • (2005) Journal of Neuroscience , vol.25 , Issue.1 , pp. 29-41
    • Samuvel, D.J.1    Jayanthi, L.D.2    Bhat, N.R.3    Ramamoorthy, S.4
  • 50
    • 18144373742 scopus 로고    scopus 로고
    • P38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process
    • DOI 10.1074/jbc.M410858200
    • Zhu CB, Carneiro AM, Dostmann WR, Hewlett WA, Blakely RD: p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process. J Biol Chem 2005;280:15649-15658. (Pubitemid 40616683)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.16 , pp. 15649-15658
    • Zhu, C.-B.1    Carneiro, A.M.2    Dostmann, W.R.3    Hewlett, W.A.4    Blakely, R.D.5
  • 51
    • 33745908304 scopus 로고    scopus 로고
    • Modulation of the trafficking of the human serotonin transporter by human alpha-synuclein
    • DOI 10.1111/j.1460-9568.2006.04900.x
    • Wersinger C, Rusnak M, Sidhu A: Modulation of the trafficking of the human serotonin transporter by human alpha-synuclein. Eur J Neurosci 2006;24:55-64. (Pubitemid 44050666)
    • (2006) European Journal of Neuroscience , vol.24 , Issue.1 , pp. 55-64
    • Wersinger, C.1    Rusnak, M.2    Sidhu, A.3
  • 52
    • 0026557427 scopus 로고
    • Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter
    • Wolfel R, Graefe K-H: Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter. Arch Pharmacol 1992;345:129-136.
    • (1992) Arch Pharmacol , vol.345 , pp. 129-136
    • Wolfel, R.1    Graefe, K.-H.2
  • 53
    • 0020536384 scopus 로고
    • The serotonin transporter-imipramine 'receptor'. Different sodium requirements for imipramine binding and serotonin translocation
    • Talvenheimo J, Fishkes H, Nelson PJ, Rudnick G: The serotonin transporter-imipramine 'receptor': Different sodium requirements for imipramine binding and serotonin translocation. J Biol Chem 1983;258:6115-6119. (Pubitemid 13106787)
    • (1983) Journal of Biological Chemistry , vol.258 , Issue.10 , pp. 6115-6119
    • Talvenheimo, J.1    Fishkes, H.2    Nelson, P.J.3    Rudnick, G.4
  • 56
    • 0029053978 scopus 로고
    • Tyrosine kinase inhibitors regulate serotonin uptake in platelets
    • Helmeste DM, Tang SW: Tyrosine kinase inhibitors regulate serotonin uptake in platelets. Eur J Pharmacol 1995;280:R5-R7.
    • (1995) Eur J Pharmacol , vol.280
    • Helmeste, D.M.1    Tang, S.W.2
  • 57
    • 72849113289 scopus 로고    scopus 로고
    • - -coupled neurotransmitter transporter - Why amphetamine take two to tango
    • - -coupled neurotransmitter transporter - why amphetamine take two to tango. J Neurochem 2010;112:340-355.
    • (2010) J Neurochem , vol.112 , pp. 340-355
    • Sitte, H.H.1    Fressmuth, M.2
  • 59
    • 0028950155 scopus 로고
    • Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies
    • Qian Y, Melikian HE, Rye DB, Levey AI, Blakely RD: Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies. J Neurosci 1995;15:1261-1274.
    • (1995) J Neurosci , vol.15 , pp. 1261-1274
    • Qian, Y.1    Melikian, H.E.2    Rye, D.B.3    Levey, A.I.4    Blakely, R.D.5
  • 60
    • 52449098689 scopus 로고    scopus 로고
    • Recent developments in the design of anti-depressive therapies: Targeting the serotonin transporter
    • Butler SG, Meegan MJ: Recent developments in the design of anti-depressive therapies: targeting the serotonin transporter. Curr Med Chem 2008;15:1737-1761.
    • (2008) Curr Med Chem , vol.15 , pp. 1737-1761
    • Butler, S.G.1    Meegan, M.J.2


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