Human Stiff-person syndrome IgG induces anxious behavior in rats

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Geis, Christian ^a   Weishaupt, Andreas ^a   Grünewald, Benedikt ^a   Wultsch, Thomas ^a   Reif, Andreas ^a   Gerlach, Manfred ^a   Dirkx, Ron ^c   Solimena, Michele ^c   Perani, Daniela ^d,e   Heckmann, Manfred ^a,b   Toyka, Klaus V ^a   Folli, Franco ^f   Sommer, Claudia ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^e SAN RAFFAELE HOSPITAL   (Italy)

^f Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CARBON 11; FLUMAZENIL; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; IMMUNOGLOBULIN G; 4 AMINOBUTYRIC ACID; CARBON; DIAGNOSTIC AGENT; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 2;

4 AMINOBUTYRIC ACID RELEASE; ADULT; AMYGDALOID NUCLEUS; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ANXIETY DISORDER; ARTICLE; CASE REPORT; CONTROLLED STUDY; FEMALE; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; IN VIVO STUDY; LYMPHOCYTIC INFILTRATION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; PHENOTYPE; POSITRON EMISSION TOMOGRAPHY; RAT; RECEPTOR BINDING; STIFF MAN SYNDROME; SYMPTOMATOLOGY; ANIMAL; ANXIETY; CELL CULTURE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; IMMUNOLOGY; METABOLISM; MIDDLE AGED; NERVE CELL; PATHOLOGY; PSYCHOLOGICAL ASPECT; SCINTISCANNING; SECRETION;

RATTUS;

ADULT; AMYGDALA; ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; CARBON RADIOISOTOPES; CELLS, CULTURED; FEMALE; FLUMAZENIL; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; HIPPOCAMPUS; HUMANS; IMMUNOGLOBULIN G; MIDDLE AGED; NEURONS; POSITRON-EMISSION TOMOGRAPHY; RATS; STIFF-PERSON SYNDROME; YOUNG ADULT;

EID: 79951574944     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016775     Document Type: Article

References (45)

1. Meinck HM, Ricker K, Hulser PJ, Schmid E, Peiffer J, et al. (1994) Stiff man syndrome: clinical and laboratory findings in eight patients. J Neurol 241: 157-166.
2. Henningsen P, Meinck HM, (2003) Specific phobia is a frequent non-motor feature in stiff man syndrome. J Neurol Neurosurg Psychiatry 74: 462-465.
3. Dalakas MC, Fujii M, Li M, McElroy B, (2000) The clinical spectrum of anti-GAD antibody-positive patients with stiff-person syndrome. Neurology 55: 1531-1535.
4. Meinck HM, Thompson PD, (2002) Stiff man syndrome and related conditions. Mov Disord 17: 853-866.
5. Floeter MK, Valls-Sole J, Toro C, Jacobowitz D, Hallett M, (1998) Physiologic studies of spinal inhibitory circuits in patients with stiff-person syndrome. Neurology 51: 85-93.
6. Dalakas MC, (2008) Advances in the pathogenesis and treatment of patients with stiff person syndrome. Curr Neurol Neurosci Rep 8: 48-55.
7. Ameli R, Snow J, Rakocevic G, Dalakas MC, (2005) A neuropsychological assessment of phobias in patients with stiff person syndrome. Neurology 64: 1961-1963.
8. Black JL, Barth EM, Williams DE, Tinsley JA, (1998) Stiff-man syndrome. Results of interviews and psychologic testing. Psychosomatics 39: 38-44.
9. Murinson BB, Vincent A, (2001) Stiff-person syndrome: autoimmunity and the central nervous system. CNS Spectr 6: 427-433.
10. Anagnostaras SG, Craske MG, Fanselow MS, (1999) Anxiety: at the intersection of genes and experience. Nat Neurosci 2: 780-782.
11. Crestani F, Lorez M, Baer K, Essrich C, Benke D, et al. (1999) Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues. Nat Neurosci 2: 833-839.
12. Kalueff AV, Nutt DJ, (2007) Role of GABA in anxiety and depression. Depress Anxiety 24: 495-517.
13. Aroniadou-Anderjaska V, Qashu F, Braga MF, (2007) Mechanisms regulating GABAergic inhibitory transmission in the basolateral amygdala: implications for epilepsy and anxiety disorders. Amino Acids 32: 305-315.
14. Nutt DJ, Malizia AL, (2001) New insights into the role of the GABA(A)-benzodiazepine receptor in psychiatric disorder. Br J Psychiatry 179: 390-396.
15. Bergado-Acosta JR, Sangha S, Narayanan RT, Obata K, Pape HC, et al. (2008) Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memory. Learn Mem 15: 163-171.
16. Seidenbecher T, Laxmi TR, Stork O, Pape HC, (2003) Amygdalar and hippocampal theta rhythm synchronization during fear memory retrieval. Science 301: 846-850.
17. Rakocevic G, Raju R, Dalakas MC, (2004) Anti-glutamic acid decarboxylase antibodies in the serum and cerebrospinal fluid of patients with stiff-person syndrome: correlation with clinical severity. Arch Neurol 61: 902-904.
18. Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P, (1990) Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. N Engl J Med 322: 1555-1560.
19. Solimena M, Folli F, Denis-Donini S, Comi GC, Pozza G, et al. (1988) Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitus. N Engl J Med 318: 1012-1020.
20. Perani D, Garibotto V, Moresco RM, Ortelli P, Corbo M, et al. (2007) PET evidence of central GABAergic changes in stiff-person syndrome. Mov Disord 22: 1030-1033.
21. Manto MU, Laute MA, Aguera M, Rogemond V, Pandolfo M, et al. (2007) Effects of anti-glutamic acid decarboxylase antibodies associated with neurological diseases. Ann Neurol 61: 544-551.
22. Geis C, Weishaupt A, Hallermann S, Grünewald B, Wessig C, et al. (2010) Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition. Brain 2010 doi:101093/brain/awq253.
23. Sommer C, Weishaupt A, Brinkhoff J, Biko L, Wessig C, et al. (2005) Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysin. Lancet 365: 1406-1411.
24. Levy LM, Levy-Reis I, Fujii M, Dalakas MC, (2005) Brain gamma-aminobutyric acid changes in stiff-person syndrome. Arch Neurol 62: 970-974.
25. Malizia AL, Cunningham VJ, Bell CJ, Liddle PF, Jones T, et al. (1998) Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study. Arch Gen Psychiatry 55: 715-720.
26. Kash SF, Tecott LH, Hodge C, Baekkeskov S, (1999) Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci U S A 96: 1698-1703.
27. Eccles JC, Schmidt R, Willis WD, (1963) Pharmacological Studies on Presynaptic Inhibition. J Physiol 168: 500-530.
28. Raju R, Rakocevic G, Chen Z, Hoehn G, Semino-Mora C, et al. (2006) Autoimmunity to GABAA-receptor-associated protein in stiff-person syndrome. Brain 129: 3270-3276.
29. Davis KM, Foos T, Bates CS, Tucker E, Hsu CC, et al. (2000) A novel method for expression and large-scale production of human brain l-glutamate decarboxylase. Biochem Biophys Res Commun 267: 777-782.
30. Lancaster E, Lai M, Peng X, Hughes E, Constantinescu R, et al. (2010) Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol 9: 67-76.
31. Lai M, Huijbers MG, Lancaster E, Graus F, Bataller L, et al. (2010) Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol 9: 776-785.
32. Irani SR, Alexander S, Waters P, Kleopa KA, Pettingill P, et al. (2010) Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. Brain 133: 2734-2748.
33. Irani SR, Bera K, Waters P, Zuliani L, Maxwell S, et al. (2010) N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain 133: 1655-1667.
34. Friston KJ HA, Worsley KJ, Poline JB, Frith C, Frackowiack R, (1995) Statistical parametric maps in functional imaging: a general linear approach. Hum Brain Mapp pp. 189-210.
35. Yaksh TL, Rudy TA, (1976) Chronic catheterization of the spinal subarachnoid space. Physiol Behav 17: 1031-1036.
36. Kunkel-Bagden E, Dai HN, Bregman BS, (1993) Methods to assess the development and recovery of locomotor function after spinal cord injury in rats. Exp Neurol 119: 153-164.
37. Wultsch T, Chourbaji S, Fritzen S, Kittelt S, Grunblatt E, et al. (2007) Behavioural and expressional phenotyping of nitric oxide synthase-I knockdown animals. J Neural Transm Suppl pp. 69-85.
38. Lee JK, Emch GS, Johnson CS, Wrathall JR, (2005) Effect of spinal cord injury severity on alterations of the H-reflex. Exp Neurol 196: 430-440.
39. Barron DH, Matthews BH, (1938) The interpretation of potential changes in the spinal cord. J Physiol 92: 276-321.
40. Schmidt RF, (1971) Presynaptic inhibition in the vertebrate central nervous system. Ergeb Physiol 63: 20-101.
41. Paxinos G, Watson C, (1998) The Rat Brain in Stereotaxic Coordinates. San Diego Academic Press.
42. Byts N, Samoylenko A, Fasshauer T, Ivanisevic M, Hennighausen L, et al. (2008) Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin. Cell Death Differ 15: 783-792.
43. Ferguson SM, Brasnjo G, Hayashi M, Wolfel M, Collesi C, et al. (2007) A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. Science 316: 570-574.
44. Hayashi M, Raimondi A, O'Toole E, Paradise S, Collesi C, et al. (2008) Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neurons. Proc Natl Acad Sci U S A 105: 2175-2180.
45. Gerlach M, Gsell W, Kornhuber J, Jellinger K, Krieger V, et al. (1996) A post mortem study on neurochemical markers of dopaminergic, GABA-ergic and glutamatergic neurons in basal ganglia-thalamocortical circuits in Parkinson syndrome. Brain Res 741: 142-152.