PET evidence of central GABAergic changes in stiff-person syndrome

Movement Disorders

Volumn 22, Issue 7, 2007, Pages 1030-1033

  Perani, Daniela ^a,b   Garibotto, Valentina ^b,c   Panzacchi, Andrea ^b,d   Moresco, Rosa Maria ^b,c,d   Ortelli, Paola ^b   Corbo, Massimo ^e   Fazio, Ferruccio ^b,c,d   Folli, Franco ^f  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d INSTITUTE OF MOLECULAR BIOIMAGING AND PHYSIOLOGY   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

^f Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

11C flumazenil; GABA; Positron emission tomography; Stiff person syndrome

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CARBON 11; DIAZEPAM; FLUMAZENIL;

ADULT; ANXIETY DISORDER; APPARATUS; ARTICLE; CASE REPORT; CEREBELLUM NUCLEUS; CLINICAL FEATURE; DIAGNOSTIC IMAGING; FALLING; FEMALE; HUMAN; IMAGE ANALYSIS; IMAGE RECONSTRUCTION; MALE; MOTOR CORTEX; MOTOR DYSFUNCTION; MUSCLE RIGIDITY; MUSCLE SPASM; NEUROIMAGING; POSITRON EMISSION TOMOGRAPHY; PREMOTOR CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; STIFF MAN SYNDROME; SYMPTOM;

FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POSITRON-EMISSION TOMOGRAPHY; STIFF-PERSON SYNDROME;

EID: 34347272707     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.21441     Document Type: Article

References (11)

1. Loris TR, Thorsteinsson G, Howard FM Jr. Stiff-man syndrome updated. Mayo Clin Proc 1989;64:629-636.
2. Dalakas MC, Li M, Fujii M, Jacobowitz DM. Stiff person syndrome. Quantification, specificity, and intrathecal synthesis of GAD65 antibodies. Neurology 2001;57:780-784.
3. Vasconcelos OM, Dalakas MC. Stiff-person syndrome. Curr Treat Options Neurol 2003;5:79-90.
4. Levy LM, Levy-Reis I, Fujii M, Dalakas MC. Brain aminobutyric acid changes in stiff-person syndrome. Arch Neurol 2005;62:970-974.
5. Hamilton M. Assessment of anxiety states by rating. Br J Med Psychol 1995;32:50-55.
6. Lezak M. Neuropsychological assessment. Oxford: Oxford University Press; 1995.
7. 11C]flumazenil. Neuroimage 2004;22:22-28.
8. Friston KJ, Holmes AP, Worsley KJ, Poline JB, Frith C, Frackowiack R. Statistical parametric maps in functional imaging: A general linear approach. Hum Brain Mapp 1995;2:189-210.
9. Suhara T, Inoue O, Kobayashi K, Suzuki K, Itoh T, Tateno Y. No age-related changes in human benzodiazepine receptor binding measured by PET with [11C]Ro 15-4513. Neurosci Lett 1993;159:207-210.
10. Nutt DJ, Malizia AL. New insights into the role of the GABAA-benzodiazepine receptor in psychiatric disorder. Br J Psych 2001;179:390-396.
11. Levy LM, Hallett M. Impaired brain GABA in focal dystonia. Ann Neurol 2002;51:93-101.